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( Milljae Shin ),( Doop Yo Hong ),( Zheng Yun Zhang ),( You Min Kim ),( Wook Jong Lee ),( Jong Man Kim ),( Choon Hyuck David Kwon ),( Jae Won Joh ),( Sung Joo Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Purpose: Erythropoietin (Epo), through its specific erythropoie tireceptor (Epo-R) may induce responses in a variety of non-hematopoietic tissues including malignant cells. In this study, we examined the expression of Epo-R in hepatocellular carcinoma (HCC) and tested the correlations of Epo-R expression with clinicopathological properties of HCC and with tumor recurrence. Methods: The study included 134 patients who underwent curative hepatectomy for HBV-related primary HCC. The medical records and laboratory or pathologic data from these patients were collected and analyzed. The expression of Epo-R mRNA and protein were evaluated by RT-PCR and western blot analysis, respectively. Results: We found intense expression of Epo-R mRNA in both non-tumor cirrhotic liver and HCC. Expression of Epo-R mRNA in the cirrhotic liver correlated significantly and negatively with tumor size, and positively with tumor cell differentiation and p53 staining; Epo-R mRNA expression in the HCC correlated with differentiation and p53 staining. The expression of Epo-R mRNA in cirrhotic liver or HCC was positively correlated with disease-free survival. Tumor recurrence showed stronger dependence on the expression of Epo-R protein in non-malignant cirrhotic liver than in the HCC. Conclusion: In HBV-related HCC, levels of Epo-R mRNA and protein in the non-malignant cirrhotic liver were positively correlated with tumor cell differentiation and p53 expression, which are favorable predictors of disease-specific survival.
( Milljae Shin ),( Doopyo Hong ),( Zhengyun Zhang ),( You Min Kim ),( Wookjong Lee ),( Jong Man Kim ),( Choon Hyuck David Kwon ),( Jae Won Joh ),( Sung Joo Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Purpose: Erythropoietin (Epo), through its specific erythropoietin receptor (Epo-R) may induce responses in a variety of non-hematopoietic tissues including malignant cells. In this study, we examined the expression of Epo-R in hepatocellular carcinoma (HCC) and tested the correlations of Epo-R expression with clinicopathological properties of HCC and with tumor recurrence. Methods: The study included 134 patients who underwent curative hepatectomy for HBV-related primary HCC. The medical records and laboratory or pathologic data from these patients were collected and analyzed. The expression of Epo-R mRNA and protein were evaluated by RT-PCR and western blot analysis, respectively. Results: We found intense expression of Epo-R mRNA in both non-tumor cirrhotic liver and HCC. Expression of Epo-R mRNA in the cirrhotic liver correlated significantly and negatively with tumor size, and positively with tumor cell differentiation and p53 staining; Epo-R mRNA expression in the HCC correlated with differentiation and p53 staining. The expression of Epo-R mRNA in cirrhotic liver or HCC was positively correlated with disease-free survival. Tumor recurrence showed stronger dependence on the expression of Epo-R protein in non-malignant cirrhotic liver than in the HCC. Conclusion: In HBV-related HCC, levels of Epo-R mRNA and protein in the non-malignant cirrhotic liver were positively correlated with tumor cell differentiation and p53 expression, which are favorable predictors of disease-specific survival.
Graft-versus-host disease after kidney transplantation
김종만,김성주,조재원,권준혁,장기택,안정석,기창석,강은숙,Milljae Shin,Bok Nyeo Kim,이석구 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.80 No.6
Graft-versus-host disease (GVHD) is a rare complication after kidney transplantation. We describe a 62-year-old female with end-stage renal disease due to hypertension. She received a kidney with 4 mismatched human leukocyte antigen (HLA) out of 6 HLA - A, B, DR from a deceased donor. After the procedure, the patient showed watery diarrhea on postoperative day (POD) 45. An endoscopic biopsy of the colon revealed some apoptotic cells consistent with GVHD. Thrombocytopenia was gradually developed on POD 54. She received steroid pulse therapy, and thrombocytopenia did not progress. However, pneumonia, renal failure, and cardiac failure occurred. She died due to multiple organ failure. We must consider GVHD in renal transplant recipients without homozygous or identical HLA, who had only watery diarrhea without other typical GVHD symptoms such as skin rash and fever, although GVHD is rare in renal transplant recipients.
( Tae Seok Kim ),( Hyung Hwan Moon ),( Sanghoon Lee ),( Sang Hyun Song ),( Milljae Shin ),( Jong Man Kim ),( Choon Hyuckdavid Kwon ),( Sung Joo Kim ),( Suk Koo Lee ),( Jae Won Joh ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: The prognosis of FHF depends on the etiology and reversibility. Although the King’s College Hospital (KCH) criteria and Clichy/Villejuif criteria remain the most widely used prognostic criteria of FHF, there are also limitations due to geographically various and different causes of disease. Furthermore it is difficult to estimate prognosis after liver transplantation (LT) according to these criteria. Therefore, we identified the etiologic difference of FHF in Korea, and analyzed the prognostic factors after LT for FHF. Methods: We retrospectively reviewed medical records of 42 patients diagnosed with FHF and underwent LT from April 1999 to April 2011 at Samsung Medical Center, Seoul, Korea. We evaluated the etiologic change and difference compared with western countries. The patients were categorized into two groups according to the in-hospital result of LT; survival group (n=35) and mortality group (n=7). Perioperative profiles were compared between groups to identify the in-hospital poor prognostic factors after LT for FHF. Results: The most common cause of FHF underwent LT was toxic hepatitis (45.2%). Unlike western countries, there was no paracetamol-related FHF but herbal medication or folk remedies are the most frequent causes of toxic hepatitis (58%). There was no patient underwent LT due to HAV-related FHF until 2005, however HAV-related FHF increased significantly and comprised the main portion of FHF (34.5%) after 2005. Encephalopathy grade, onset time, pre-transplantation need of renal replacement and ventilator treatment were significant prognostic factors after LT for FHF in univariate analysis. In multivariate analysis, pre-transplantation renal replacement treatment was the independent prognostic factor after LT for FHF. Conclusions: In this study, we showed the different etiology of FHF in Korea and identified the renal replacement treatment as an independent prognostic factor after LT for FHF. In order to confirm the prognostic factors after LT for FHF, large size of studies are needed.