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Michailidou, Kyriaki,Beesley, Jonathan,Lindstrom, Sara,Canisius, Sander,Dennis, Joe,Lush, Michael J,Maranian, Mel J,Bolla, Manjeet K,Wang, Qin,Shah, Mitul,Perkins, Barbara J,Czene, Kamila,Eriksson, Mi Nature Publishing Group, a division of Macmillan P 2015 Nature genetics Vol.47 No.4
Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10<SUP>−8</SUP>. Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.
홍승수(Seung-Soo Hong),신용현(Yong-Hyeon Shin),임종연(Jong-Yeon Lim),이상균(Sang-Kyun Lee),정광화(Kwang-Hwa Chung),David Simpson,Fiona Redgrave,Michael Perkin,Bernard Waller,M. Hirata$ 한국진공학회(ASCT) 1997 Applied Science and Convergence Technology Vol.6 No.4
Capacitance Diaphragm Gauge(CDG)를 전달표준기로 사용하여 한국과 영국의 저진공표준의 국제 비교를 수행한 결과 양국 표준기에서 교정한 CDG의 압력비의 차이는 0.05% 이었다. 또한 두 개의 Spinning Rotor Gauge(SRG)를 이용하여 한국과 일본의 고진공표준의 국제비교를 수행한 결과 양국 표준기에서 교정한 SRG의 accommodation coefficient(σ)의 차이가 0.4% 이내이었다. CDG와 SRG를 이용한 한국과 영국의 저진공표준기 및 한국과 일본의 고진공표준기의 국제비교 결과 CDG 및 SRG 자체의 고유오차범위 이내에서 결과가 일치함을 확인할 수 있었다. The international intercomparison of low vacuum standards between Korea and United Kingdom was performed using a Capacitance Diaphragm Gauge (CDG) as a transfer standards. The resultant difference in pressure of the CDG was 0.05%. Similialy, the difference in accommodation coefficient of a spinning rotor gauge (SRG) between Japan and Korea was verified within 0.4% for high vacuum standards. The intercomparisons of low and high vaccum standards of Korea, United Kingdom, and Japan using a CDG and SRG show that the vacuum standards agree within the inherent uncertainty limits.