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Determination of normative reference for the definition of sarcopenia among Filipinos
Michael L. Tee,Cherica A. Tee,Elizabeth B. Montemayor 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.3
Background: At present, there is no normative value that can be used in the definition of sarcopenia in the Philippines. Objective: We identified the reference cut-off values for: 1) muscle mass using bioimpedance analysis; 2) grip strength; 3) usual gait speed; 4) timed get-up-and-go; and 5) short physical performance battery in the Philippines in order to adapt the European Working Group on Sarcopenia in Older People (EWGSOP) criteria for the definition of sarcopenia. Methods: Two hundred seventy six (135 males and 141 females) healthy Filipino adults, between 20 and 40 years, were included in this cross sectional study. A Fresenius Body Composition Monitor was used to measure lean tissue mass (LTM) and lean tissue index (LTI). A dynamometer was used to measure grip strength. Usual gait speed, timed get-up-and-go, and short physical performance battery were also determined. Result: The normative references for males and females, respectively, for LTI were 17.10 þ 2.337 kg/m2 and 12.63 þ 2.119 kg/m2; for usual gait speed were 1.06 þ 0.251 m/sec and 0.930 þ 0.144 m/sec; and for grip strength were 39.76 þ 7.567 kg and 26.68 þ 5.243 kg. The sarcopenia cut-points for the males and females, respectively, for LTI were <12.50 kg/m2 and <8.33 kg/m2; for usual gait speed were <0.55 m/sec and <0.65 m/sec; and for grip strength were <24.54 kg and <16.10 kg. Conclusion: This study presents cut-points for the determination of sarcopenia at-risk population among Filipinos.
Association of obesity and sarcopenia among adult Filipinos
Julie Anne L. Gabat,Antonio L. Faltado Jr.,Myrna B. Sedurante,Michael L. Tee 대한골다공증학회 2018 Osteoporosis and Sarcopenia Vol.4 No.3
Objective: Studies on the association of obesity and sarcopenia are conflicting. Some studies showed that obesity is associated with muscle loss and frailty while others showed that lower body mass index (BMI) is associated with increased sarcopenia. To date, there is paucity of data on sarcopenia and obesity among Filipinos. This study aims to determine the association of obesity and sarcopenia among Filipinos. Methods: This is a cross sectional analytic study comparing sarcopenic versus nonsarcopenic in terms of obesity as measured by BMI and waist circumference (WC). Filipinos older than 40 years were included. Obesity was defined using the World Health Organization (WHO) cutoff for BMI and WC. Sarcopenia was defined as low muscle mass and low muscle strength or physical performance. Population-specific cutoff points were used to define low muscle mass, strength, and performance. Results: A total of 164 participants were included. The mean age is 60.33 years. Ten (6.1%) were sarcopenic and 4 (40%) of them were obese. Regression analysis showed that obesity is not significantly associated with increased sarcopenia (incidence risk ratio [IRR], 14.62; 95% confidence interval [CI], 0.96 e221.92; P ¼ 0.05). However, age (IRR, 1.15; 95% CI, 1.09e1.21; P 0.01),WC (IRR, 0.92; 95% CI, 0.85e0.99; P ¼ 0.02), smoking (IRR, 3.17; 95% CI, 1.11e9.03; P ¼ 0.03), and alcoholic beverage drinking (IRR, 3.71; 95% CI, 1.26e10.89; P ¼ 0.02) were found to be significant predictors of sarcopenia. Conclusions: There is no statistically significant association between obesity and increased risk of sarcopenia among participants, however, older age, smaller WC, smoking, and alcoholic beverage drinking were significant predictors of sarcopenia.
Association of sarcopenia with osteoporosis in patients with chronic obstructive pulmonary disease
Jamie R. Chua,Michael L. Tee 대한골다공증학회 2020 Osteoporosis and Sarcopenia Vol.6 No.3
Objectives: Systemic consequence of Chronic Obstructive Pulmonary Disease (COPD) is associated with progressive loss of muscle mass and function. Preliminary studies showed presence of sarcopenia in COPD leads to reduced pulmonary function and quality of life; studies on whether this condition results in consequent loss of bone mineral density (BMD) is still inconsistent. This study aims to examine the association of sarcopenia in COPD with osteoporosis. Methods: This is a post-hoc analysis of a study on forty-one (n ¼ 41) participants with COPD seen in a tertiary public hospital in Manila, Philippines who underwent pulmonary function test and dual-energy x-ray absorptiometry. Sarcopenia was defined using a Philippine-based criteria of low fat free mass index (FFMI) and low muscle strength - hand grip strength, and osteoporosis using World Health Organization T-score diagnostic criteria. Results: The prevalence of osteoporosis among COPD is 44%, and 63% in COPD with sarcopenia. There was no statistical difference seen in pulmonary function variables between COPD with and without osteoporosis. Significant positive correlations were observed between Forced Expiratory Volume in 1 s, FFMI, and appendicular lean muscle with total body BMD. Sarcopenia in COPD was associated with significantly increased risk for osteoporosis. Conclusions: High prevalence rate of osteoporosis, and even higher among sarcopenic Filipino COPD patients should be further studied. The findings also suggest that sarcopenia in COPD is associated with increased risk of osteoporosis, and osteoporosis alone does not seem to affect lung function.