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Reflections on Human Resources Management in Globalization: Some Critical Aspects
Mica Jovanovic,Ana Langovic Milicevic,Tanja Cvetkovski 동아대학교 동아시아연구원 2011 동아시아 : 비교와 전망 Vol.9 No.3
The paper deals with necessity and importance of human resources management of especially those MNCs operating in global context of cultural diversity and complexity. This is conditio sine qua non for corporate leadership experienced and versed in different languages, religions, beliefs, value system, etc. Further it is stressed that MNCs and managers have to develop conative capability along with trajectories of flexible intercultural management and communication system rooted in different values and traditions.
Global Talent Management as New Globalization Strategy
Mica Jovanovic,Ana Langovic Milicevic,Tanja Cvetkovski 동아대학교 동아시아연구원 2011 동아시아 : 비교와 전망 Vol.10 No.1
Many theorists argue that literature is becoming less and less relevant to the education of young managers. They believe that genuine knowledge is gained by those who "work" since modern environment imposes global business which changes the traditional approach to education. Companies strive to expand their operations abroad, manage "talent" in a more strategic way and change traditional bureaucratic structures. Business communications is becoming intercultural, virtual and horizontal. The situation poses a dilemma- Does the literature appropriately follow these changes? In fact, bridging the gap of academic approach, that is, theory and practice – is the way to create a high-quality manager in the business world. The essential question is- Why does the gap exist? In fact, several studies have shown that managers rarely publish their business practices that can be analyzed from theoretical aspects as well and become useful for the future generations of managers. Some say that is because managers and theoreticians observe the problem from different aspects. Whatever the reason is, if the scholars do researches for themselves, there is the danger that the researches will exclude real world of business. In today's business world where changes are rapid, large and unpredictable, it seems more important than ever for academics to bridge the gap and establish cooperation with the people from practice. The reasons for this are very clear. Firstly, business people, that is, practitioners, can benefit from the theoretical knowledge management. Secondly, scientists will conduct better researches and convey the required knowledge to students and provide them with better understanding of the modern business environment and actions faced by practitioners. And thirdly, bridging this gap is likely to increase our credibility with the business community. The purpose of this research is to provide a brief overview of the forces that shape the environment, including changes that are manifested in the governance of business systems, but in the first place in human resource management.
Environmental Variable and Global Competition for Talent : The Case of Serbia
Mica Jovanovic,Ana Langovic Milicevic,Tanja Cvetkovski 동아대학교 동아시아연구원 2012 동아시아 : 비교와 전망 Vol.11 No.1
Many theorists argue that literature is becoming less and less relevant to the education of young managers. They believe that genuine knowledge is gained by those who "work" since modern environment imposes global business which changes the traditional approach to education. Companies strive to expand their operations abroad, manage "talent" in a more strategic way and change traditional bureaucratic structures. Business communications is becoming intercultural, virtual and horizontal. The situation poses a dilemma- Does the literature appropriately follow these changes? In fact, bridging the gap of academic approach, that is, theory and practice–is the way to create a high-quality manager in the business world. The essential question is- Why does the gap exist? In fact, several studies have shown that managers rarely publish their business practices that can be analyzed from theoretical aspects as well and become useful for the future generations of managers. Some say that is because managers and theoreticians observe the problem from different aspects. Whatever the reason is, if the scholars do researches for themselves, there is the danger that the researches will exclude real world of business. In today's business world where changes are rapid, large and unpredictable, it seems more important than ever for academics to bridge the gap and establish cooperation with the people from practice. The reasons for this are very clear. Firstly, business people, that is, practitioners, can benefit from the theoretical knowledge management. Secondly, scientists will conduct better researches and convey the required knowledge to students and provide them with better understanding of the modern business environment and actions faced by practitioners. And thirdly, bridging this gap is likely to increase our credibility with the business community. The purpose of this research is to provide a brief overview of the forces that shape the environment, including changes that are manifested in the governance of business systems, but in the first place in human resource management.
Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy
Ohara-Imaizumi, Mica,Kim, Hail,Yoshida, Masashi,Fujiwara, Tomonori,Aoyagi, Kyota,Toyofuku, Yukiko,Nakamichi, Yoko,Nishiwaki, Chiyono,Okamura, Tadashi,Uchida, Toyoyoshi,Fujitani, Yoshio,Akagawa, Kimio National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.48
<P>In preparation for the metabolic demands of pregnancy, beta cells in the maternal pancreatic islets increase both in number and in glucose-stimulated insulin secretion (GSIS) per cell. Mechanisms have been proposed for the increased beta cell mass, but not for the increased GSIS. Because serotonin production increases dramatically during pregnancy, we tested whether flux through the ionotropic 5-HT3 receptor (Htr3) affects GSIS during pregnancy. Pregnant Htr3a(-/-) mice exhibited impaired glucose tolerance despite normally increased cell mass, and their islets lacked the increase in GSIS seen in islets from pregnant wild-type mice. Electrophysiological studies showed that activation of Htr3 decreased the resting membrane potential in beta cells, which increased Ca2+ uptake and insulin exocytosis in response to glucose. Thus, our data indicate that serotonin, acting in a paracrine/autocrine manner through Htr3, lowers the beta cell threshold for glucose and plays an essential role in the increased GSIS of pregnancy.</P>
4-Methylcoumarin Derivatives Inhibit Human Neutrophil Oxidative Metabolism and Elastase Activity
Luciana M. Kabeya,Carolina N. Fuzissaki,Mica´ssio F. Andrade,Ana Elisa C.S. Azzolini,Silvia H. Taleb-Contini,Roberta B. Vermelho,Joa˜o Luis C. Lopes,Yara Maria Lucisano-Valim 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.8
Increased neutrophil activation significantly contributes to the tissue damage in inflammatory illnesses; this phenomenon has motivated the search for new compounds to modulate their effector functions. Coumarins are natural products that are widely consumed in the human diet. We have evaluated the antioxidant and immunomodulator potential of five 4-methylcoumarin derivatives. We found that the 4-methylcoumarin derivatives inhibited the generation of reactive oxygen species by human neutrophils triggered by serum-opsonized zymosan or phorbol-12-myristate-13-acetate; this inhibition occurred in a concentration-dependent manner, as revealed by lucigenin- and luminol-enhanced chemiluminescence assays. Cytotoxicity did not mediate this inhibitory effect. The 7,8-dihydroxy-4-methylcoumarin suppressed the neutrophil oxidative metabolism more effectively than the 6,7- and 5,7-dihydroxy-4-methylcoumarins, but the 5,7- and 7,8-diacetoxy-4-methylcoumarins were less effective than their hydroxylated counterparts. An analysis of the biochemical pathways suggested that the 6,7- and 7,8-dihydroxy-4-methylcoumarins inhibit the protein kinase C-mediated signaling pathway, but 5,7-dihydroxy-4-methylcoumarin, as well as 5,7- and 7,8-diacetoxy-4-methylcoumarins do not significantly interfere in this pathway of the activation of the human neutrophil oxidative metabolism. The 4-methylcoumarin derivatives bearing the catechol group suppressed the elastase and myeloperoxidase activity and reduced the 1,1-diphenyl-2-picrylhydrazyl free radical the most strongly. Interestingly, the 5,7-dihydroxy-4-methylcoumarin scavenged hypochlorous acid more effectively than the o-dihydroxy-substituted 4-methylcoumarin derivatives, and the diacetoxylated 4-methylcoumarin derivatives scavenged hypochlorous acid as effectively as the 7,8-dihydroxy-4-methylcoumarin. The significant influence of small structural modifications in the inhibitory potential of 4-methylcoumarin derivatives on the effector functions of neutrophil makes them interesting candidates to develop new drugs for the treatment of inflammatory diseases mediated by increased neutrophil activation.
Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.
Kim, Kyuho,Oh, Chang-Myung,Ohara-Imaizumi, Mica,Park, Sangkyu,Namkung, Jun,Yadav, Vijay K,Tamarina, Natalia A,Roe, Michael W,Philipson, Louis H,Karsenty, Gerard,Nagamatsu, Shinya,German, Michael S,Kim The Endocrine Society 2015 Endocrinology Vol.156 No.2
<P>The physiological role of serotonin, or 5-hydroxytryptamine (5-HT), in pancreatic β-cell function was previously elucidated using a pregnant mouse model. During pregnancy, 5-HT increases β-cell proliferation and glucose-stimulated insulin secretion (GSIS) through the Gαq-coupled 5-HT2b receptor (Htr2b) and the 5-HT3 receptor (Htr3), a ligand-gated cation channel, respectively. However, the role of 5-HT in β-cell function in an insulin-resistant state has yet to be elucidated. Here, we characterized the metabolic phenotypes of β-cell-specific Htr2b(-/-) (Htr2b βKO), Htr3a(-/-) (Htr3a knock-out [KO]), and β-cell-specific tryptophan hydroxylase 1 (Tph1)(-/-) (Tph1 βKO) mice on a high-fat diet (HFD). Htr2b βKO, Htr3a KO, and Tph1 βKO mice exhibited normal glucose tolerance on a standard chow diet. After 6 weeks on an HFD, beginning at 4 weeks of age, both Htr3a KO and Tph1 βKO mice developed glucose intolerance, but Htr2b βKO mice remained normoglycemic. Pancreas perfusion assays revealed defective first-phase insulin secretion in Htr3a KO mice. GSIS was impaired in islets isolated from HFD-fed Htr3a KO and Tph1 βKO mice, and 5-HT treatment improved insulin secretion from Tph1 βKO islets but not from Htr3a KO islets. Tph1 and Htr3a gene expression in pancreatic islets was not affected by an HFD, and immunostaining could not detect 5-HT in pancreatic islets from mice fed an HFD. Taken together, these results demonstrate that basal 5-HT levels in β-cells play a role in GSIS through Htr3, which becomes more evident in a diet-induced insulin-resistant state.</P>