마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

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국내 위암 정보에 관한 웹사이트 평가

김미예,태영숙,정귀임 한국간호과학회 간호행정학회 2009 간호행정학회지 Vol.15 No.1

Purpose: The purpose of this study was to evaluate the quality of service and appropriateness of information provided in gastric cancer web sites. Method: The study investigated the status of the web sites retrieved when the keyword "gastric cancer" was searched on seven(7) different Internet portal sites. Among the retrieved information sites, 51 domestic websites, available on June and July 2008, were selected. They were evaluated based on two criteria, quality of service (7 items) and appropriateness of the information (11 items) on a 4-point scale(0~3). The analysis of data was done using SPSS 12.0 PC+ program for descriptive statistics and ANOVA tests. Results: Findings revealed that the quality of service provided by the web sites had an average of 1.61±.55 The score of information appropriateness was .79±.64. Among the studied websites, only 4(7.8%) scored higher than 22, placing them in the top 30%. Conclusion: This study suggests that most sites do not provide diverse types of gastric cancer-related information and that reliability is important in developing web-based programs related to gastric cancer in order to effectively promote and disseminate health information to the general public.

감각조절장애 아동의 문제행동에 무게감 있는 조끼 착용이 미치는 영향

한미애,김지연,장기연,박미진 대한감각통합치료학회 2010 대한감각통합치료학회지 Vol.8 No.1

목적 : 본 연구는 주변 환경에 민감하고 감정기복이 심한 감각조절장애 아동에게 무게감 있는 조끼 착용을 통한 고유수용성 감각을 제공하여 아동의 문제행동에 미치는 영향을 알아보기 위하여 실시하였다. 연구 방법 : 연구 대상자는 일반초등학교 1학년에 재학 중인 만 7세 남아로 연구설계는 ABA’단일사례연구를 사용하였고, 14회기 실험을 실시하였다. 중재기간(B)동안 1.3kg의 무게를 첨부한 조끼를 착용하고 학습인지교육을 받았다. 결과 : 치료회기가 진행될수록 의자에서 엉덩이를 떼고 일어나거나 몸을 앞/뒤, 좌/우로 흔드는 경우 및 엄지손가락을 입에 넣기, 손등 입으로 가져가기, 손장난하기 등 행동적 측면에서의 문제행동은 점차 감소되는 경향을 보였다. 결론 : 연구결과 무게감 있는 조끼를 착용한 후 아동의 문제행동이 회기가 지날수록 감소되는 양상을 보였다. 무게감 있는 조끼가 감각조절장애 아동의 문제행동에 대한 감각통합치료의 효과 유지에 미치는 영향을 설명하는데 본 연구설계 및 중재기간상 제한점이 있어서, 무게감 있는 조끼가 감각조절장애 아동의 문제행동에 영향을 주었다기보다는 감각통합치료를 지속적으로 실시한 결과로 생각할 수 있다. 따라서 추후 연구에서는 연구설계의 변형이나 연구회기의 증가를 통해 무게감 있는 조끼가 감각통합치료의 효과를 지속하는지에 대해 명확히 알아보는 것이 필요하고, 감각조절장애 아동에게 무게감 있는 조끼를 착용시키는 것에 대한 적용방법, 무게, 적용시간에 대한 효율적인 프로토콜을 제시하는 연구가 필요할 것이다. Purpose : The purpose of the study is to find out the effect of wearing a weighted vest for sensory modulation disorder children. Methods : The participant of the study was an elementary school student, male, aged 7. The ABA single case study was used to design the study which was performed for 14 sessions. During the mediation period(B), the participant received the study cognitive education wearing weighted vest weighing 1.3kg. Results : Abnormal behaviors such as suddenly standing up from the chair, shaking body front and back, and left and right, sucking his thumb and putting the back of his hand to his mouth showed tendency to decrease gradually. Discussion : The participant's abnormal behaviors decreased as the sessions went by, which means the sensory integration therapy can improve the behavior of the child suffering the sensory modulation disorder. The design of the study had certain limitation to explain the influence a weighted vest to sustain the effect of the sensory integration therapy. New study design is needed for the extended studies to prove the lasting effect of a weighted vest for the sensory integration therapy and to suggest protocols incorporating wearing know-hows, proper wearing time, and the weight of a weighted vest.

그룹 감각통합치료가 발달장애 아동의 운동기능 및 사회성 증진에 미치는 영향

한미애,장기연,김지연,한수연 대한감각통합치료학회 2009 대한감각통합치료학회지 Vol.7 No.2

목적: 본 연구의 목적은 발달장애 아동에게 그룹 감각통합치료를 적용하여 아동의 운동기능 및 사회성 증진에 어떠한 영향을 미치는지 알아보고자 한다. 연구방법: 대전 S아동연구소 감각통합치료실을 이용하는 아동 중, 발달장애 및 정신지체로 진단받은 아동 10명을 대상으로 하였다. 실험군은 그룹 감각통합치료에 참여하는 아동 5명, 대조군은 개별 감각통합치료에 참여하는 아동 5명으로 주 1회 90분, 20주 동안 적용하였다. 아동의 운동기능 및 사회성 증진 정도를 측정하기 위한 사전·사후 검사로 운동적합성 검사(Bruini nks-Oseretsky test of Motor Proficiency 2), 한국판 적응행동검사(Korean-Scales of Independent Behavior­Revised) 그리고 사회성숙도 검사(Social Maturity Scale)를 사용하였다 . 결과: 그룹 감각통합치료 적용 전·후 실험군 대부분의 아동이 손/상지협응(Manual coordination)과 신체협응(Body coordination), 사회성 전반적 영역에서 기능향상을 보였지만, 통계적으로 유의미하지 않았다. 그러나 그룹 감각통합치료 프로그램 전후 운동기능 및 사회성 향상의 차이는 실험군 아동이 대조군 아동보다 더 크게 나타났으며 특히 손/상지협응(Manual coordination), 손기민성(Manual dexterity) 하위항목, 사회성숙도 검사의 사회연령, 사회지수에서 통계적으로 유의미하게 나타났다. 결론: 본 연구결과를 통하여 그룹 감각통합치료 프로그램이 발달장애 아동의 운동기능 및 사회성 기능증진에 효과가 있음을 알 수 있었다. 추후 보다 다양한 장애 유형의 아동을 대상으로 그룹 감각통합치료 프로그램을 적용하여 그 효과를 증명하는 연구가 진행되어야 할 것이다. Objective : The purpose of this study is to understand whether group Sensory Integration(SI) therapy has the effect on improvement of motor skill and social function for children with developmental disorder. Method : The subjects were recruited among children received sensory integration therapy at a Children’s Development Institute in Dae-Jeon, experimental group is total 5 participating in group sensory in­tegration therapy and control group is also 5 participating in individual sensory integration therapy. The program was constructed for 90 minutes and all children either in the experimental or in the control group went through intervention for 20 weeks. Bruininks-Oseretsky test of Motor Proficiency II, Korean-Scales of Independent Behavior-Revised and Social Maturity Scale were used in order to eval­uate the degree of improvement in motor skill and social function. Results : Most children in the experimental group showed improvement in overall aspects of motor skill and the social function comparing pre-intervention with post-intervention, but they did not show any statistically significant differences. However, comparing experimental group with control group, children in the experimental group showed improvement in motor skill and social function. Futhermore, there is statistically significant improvement especially in manual coordination, manual dexterity, and social age and social quotient in Behavior-Revised and Social Maturity Scale. Conclusions : It is found that a group Sensory Integration therapy program has effect on motor skill and social function for children with developmental disorder in this study. In the future study, group SI therapy should be applied for children with diverse diagnosis in order to generalize the effectiveness of therapy.

A Study on Integration and Authentication of Medical Information in Multi-Cloud Environment

Mi-Kyeong You,Sang-Ho Lee,Mi-Yea Shin 중소기업정보기술융합학회 2014 중소기업융합학회 국제학술대회논문집 Vol.1 No.1

USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer

Mi Yea Lee,Min-Jee Kim,Jun-O Jin,Peter Chang-Whan Lee 생화학분자생물학회 2023 BMB Reports Vol.56 No.8

Deubiquitinases (DUBs) are an essential component of theubiquitin-proteasome system (UPS). They trim ubiquitin fromsubstrate proteins, thereby preventing them from degradation,and modulate different cellular processes. Ubiquitin-specificprotease 14 (USP14) is a DUB that has mainly been studied forits role in tumorigenesis in several cancers. In the present study,we found that the protein levels of USP14 were remarkablyhigher in gastric cancer tissues than in the adjacent normaltissues. We also demonstrated that the inhibition of USP14activity using IU1 (an USP14 inhibitor) or the inhibition ofUSP14 expression using USP14-specific siRNA markedly reducedthe viability of gastric cancer cells and suppressed their migratoryand invasive abilities. The reduction in gastric cancercell proliferation due to the inhibition of USP14 activity was aresult of the increase in the degree of apoptosis, as evidencedby the increased expression levels of cleaved caspase-3 andcleaved PARP. Furthermore, an experiment using the USP14inhibitor IU1 revealed that the inhibition of USP14 activitysuppressed 5-fluorouracil (5-FU) resistance in GC cells. Collectively,these findings indicate that USP14 plays critical roles ingastric cancer progression and suggest its potential to serve asa novel therapeutic target for gastric cancer treatment.

Effects of green Tea Catechins (gTC) on the Treatment of Hangover and Prevention of Liver Disease

( Mi Yea Lee ),( Won Shik Kim ),( Yong Lim ) 대한임상검사과학회 2014 대한임상검사과학회지(KJCLS) Vol.46 No.4

Over-consumption of alcohol leads to many side-effects such as malnutrition, liver disease, and neuronal disorders and many investigators have tried to identify methods for preventing the side-effects of drinking. This study was carried out to investigate the effect of the beverage contained green tea catechins (gTC) on the alcohol administered rats. We observed that blood alcohol concentration level decreased significantly in plasma. gTC (200 mg/kg) also reduced the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) level of the intoxicated rats. These results suggest that gTC may be useful for the prevention and therapy of hepatotoxic pathogenesis.

Community Engagement and Community Identification in Social Community

Mi-na Jun,Mi-yea Kim,Jeong-soo Han 인문사회과학기술융합학회 2018 예술인문사회융합멀티미디어논문지 Vol.8 No.8

We examined the relationship between how the engaging in social community and how the members identify themselves with their communities. In addition, we also investigated that how collective efficacy, belief in group capacity, emerged from community engagement mediate the relationship. Analysis by using data from various fan communities of celebrities (N=333) showed that community engagement is positively associated with community identification. More importantly, collective efficacy partially mediated the relationship. Our finding contributes to social community literature as it revealed an underlying mechanism of how community engagement increases community identification by strengthening a sense of collective efficacy. In addition, it would be worthwhile if further studies examine other mediators or moderators in order to provide deeper understanding how community engagement leads community identification.

'엿보기'와 '엿듣기'

김미예(Mi Yea Kim) 한국셰익스피어학회 1999 셰익스피어 비평 Vol.35 No.4

Smart Vehicle User Authentication Protocol

Shin Mi-Yea,Lee Sang-Ho,Jeong Yun-Su,Yoo Mi-Kyeong 중소기업정보기술융합학회 2014 중소기업융합학회 국제학술대회논문집 Vol.1 No.1