심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

An S-locus receptor-like kinase in plasma membrane interacts with calmodulin in <i>Arabidopsis</i>

Kim, Ho Soo,Jung, Mi Soon,Lee, Kyunghee,Kim, Kyung Eun,Yoo, Jae Hyuk,Kim, Min Chul,Kim, Doh Hoon,Cho, Moo Je,Chung, Woo Sik Elsevier 2009 FEBS letters Vol.583 No.1

<P><B>Abstract</B></P><P>Calmodulin-regulated protein phosphorylation plays a pivotal role in amplifying and diversifying the action of calcium ion. In this study, we identified a calmodulin-binding receptor-like protein kinase (CBRLK1) that was classified into an S-locus RLK family. The plasma membrane localization was determined by the localization of CBRLK1 tagged with a green fluorescence protein. Calmodulin bound specifically to a Ca<SUP>2+</SUP>-dependent calmodulin binding domain in the C-terminus of CBRLK1. The bacterially expressed CBRLK1 kinase domain could autophosphorylate and phosphorylates general kinase substrates, such as myelin basic proteins. The autophosphorylation sites of CBRLK1 were identified by mass spectrometric analysis of phosphopeptides.</P><P><B>Structured summary</B></P><P>MINT-6800947:<I>CBRLK1</I> (uniprotkb:Q9ZT06) and <I>AtCaM2</I> (uniprotkb:P25069) <I>bind</I> (MI:0407) by <I>electrophoretic mobility shift assay</I> (MI:0413)</P><P>MINT-6800966:<I>AtCaM2</I> (uniprotkb:P25069) and <I>CBRLK1</I> (uniprotkb:Q9ZT06) <I>bind</I> (MI:0407) by <I>competition binding</I> (MI:0405)</P><P>MINT-6800930:<I>CBRLK1</I> (uniprotkb:Q9ZT06) <I>binds</I> (MI:0407) to <I>AtCaM2</I> (uniprotkb:P25069) by <I>far Western blotting</I> (MI:0047)</P><P>MINT-6800978:<I>AtCaM2</I> (uniprotkb:P25069) <I>physically interacts</I> (MI:0218) with <I>CBRLK1</I> (uniprotkb:Q9ZT06) by <I>cytoplasmic complementation assay</I> (MI:0228)</P>

황색포도알균에 의한 급성 화농성 천골장골관절염 1예

문수연,신준범,김경엽,김석연,문수영,문송미,이미숙 대한감염학회 2007 감염과 화학요법 Vol.39 No.5

저자들은 특별한 위험 인자 없이 심한 허리 및 왼쪽 둔부 통증으로 내원하여 황색포도알균에 의한 균혈증이 진단된 젊은 여성에서 드문 감염질환인 화농성 천골장골관절염과 엉덩근 및 엉덩허리근 농양이 발생된 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Pyogenic sacroiliits is a rare disease and the diagnosis is difficult because of unawareness of the disease and nonspecific symptoms and signs mimicking septic hip, iliopsoas muscle abscess and herniation of intervertebral disk. There are some predisposing factors related to the disease like trauma, pregnancy, intravenous drug abuse and infection of other systems such as skin, genitourinary system and heart. Staphylococcus aureus is the most common causative bacteria. Here we describe a case of 27-year-old woman presented with acute onset of back and left buttock pain. Bone scintigraphy revealed increased uptake at left sacroiliac joint and computed tomography of the pelvis showed left sacroiliitis with left iliacus and iliopsoas abscess. There was no history of usual predisposing conditions. S. aureus was grown from blood cultures and the patient improved with 2 weeks of intravenous cefazolin followed by 4 weeks of oral clindamycin treatment.

향기요법이 통증을 주소증으로 입원한 환자의 수면장애에 미치는 영향

박수곤 ( Soo Gon Park ),양미성 ( Mi Sung Yang ),김오영 ( Oh Young Kim ),조희근 ( Hee Guen Jo ),최진봉 ( Jin Bong Choi ),김선종 ( Sun Jong Kim ),설재욱 ( Jae Uk Sul ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.4

Objectives :The purpose of this study is to investigate the effects of aroma therapy on sleep disorder patients with musculoskeletal pain. Methods :The 44 patients were divided into 2 groups: Experimental group(Exp. group) was treated with aroma therapy and control group was treated except aroma therapy. To evaluate the efficiency of aroma therapy, the Korean sleep scale A(Jin-Joo Oh, Mi-Soon Song, Sin-Mi Kim. 1998) and visual analogue scale(VAS) were applied before treatment and after 5 days treatment. Results :1. The Experimental group has improved statistical significance in sleep disorder score as compare to the control group. 2. The improvement of sleep disorder score of Exp.group has difference according to impression. 3. The improvement of sleep disorder has an effect on pain decrease. Conclusions :Aroma therapy has effects of improvement on sleep disorder with musculoskeletal pain.

Myocardial Protection by Recombinant Soluble P-selectin Glycoprotein Ligand-1 Suppression of Neutrophil and Platelet Interaction Following Ischemia and Reperfusion

Sang Soo Ham,Yoon Young Jang,Jin Ho Song,Hyang Mi Lee,Kwang Joon Kim,Jun Sik Hong,Yong Kyoo Shin 대한생리학회-대한약리학회 2000 The Korean Journal of Physiology & Pharmacology Vol.4 No.6

<P> Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects of PMNs and platelets separately and together in provoking cardiac dysfunction in isolated perfused rat hearts following ischemia and reperfusion. Additional control rat hearts were perfused with 75⁓10<SUP>6</SUP> PMNs, with 75⁓10<SUP>6</SUP> platelets, or with 75⁓10<SUP>6</SUP> PMNs⁢75⁓10<SUP>6</SUP> platelets over a five minute perfusion followed by a 75 min observation period. No significant reduction in coronary flow (CF), left ventricular developed pressure (LVDP), or the first derivative of LVDP (dP/dt max) was observed at the end of the observation period in any non-ischemic group. Similarly, global ischemia (I) for 20 min followed by 45 minutes of reperfusion (R) produced no sustained effects on the final recovery of any of these parameters in any group of hearts perfused in the absence of blood cells. However, I/R hearts perfused with either PMNs or platelets alone exhibited decreases in these variables of 5∼10% (p<0.05 from control). Furthermore, I/R hearts perfused with both PMNs and platelets exhibited decreases of 50 to 60% in all measurements of cardiac function (p<0.01). These dual cell perfused I/R hearts also exhibited marked increases in cardiac myeloperoxidase (MPO) activity indicating a significant PMN infiltration, and enhanced P-selectin expression on the coronary microvascular endothelium. All cardiaodynamic effects as well as PMN accumulation and P-selectin expression were markedly attenuated by a recombinant soluble PSGL-1 which inhibits selectin mediated cell adhesion. These results provide evidence that platelets and PMNs act synergistically in provoking post-reperfusion cardiac dysfunction, and that this may be largely due to cell to cell interactions mediated by P-selectin. These results also demonstrate that a recombinant soluble PSGL-1 reduces myocardial reperfusion injury by platelet and PMNs interaction.

장단기 조세회피활동과 경영자보상

서갑수(Seo Gab-Soo),박미영(Park Mi-Young) 한국국제회계학회 2017 국제회계연구 Vol.0 No.71

조세회피와 기업가치의 관계는 조세회피활동이 단기적인가 아니면 장기적인가에 따라 달라질 수 있다. 특히 조세회피가 장기적이고 지속적으로 이루어질수록 조세회피로 인한 위험성이 증가하고, 기업가치가 감소할 가능성이 커질 수 있다. 장기적 관점에서 조세회피가 기업가치를 하락시킨다고 본다면 주주는 장기적 조세회피활동과 경영자보상의 관계를 단기적 조세회피활동과는 다르게 설정할 가능성이 있다. 본 연구에서는 조세회피활동과 경영자보상의 관계를 단기적 조세회피활동과 장기적 조세회피 활동으로 나누어 분석하였다. 가설검증을 위해 2005년부터 2013년까지 유가증권시장 계속 상장기업 중 표본 선정 조건을 충족하는 2,709개 기업-연도를 표본으로 선정하고, 조세회피측정치를 단기와 장기로 구분하여 단기 조세회피활동 측정치 3개, 장기 조세회피활동 2개 등 총 5개의 조세회피활동 측정치를 사용하였다. 경영자 보상은 사업보고서에 공시되는 등기임원(감사 및 사외이사 제외) 1인당 평균 현금보상액으로 측정하였다. 분석 결과, 단기 조세회피활동과 경영자보상은 전반적으로 유의적인 양(+)의 관계를 가지는 것으로 나타났다. 그러나 장기 조세회피활동 측정치의 경우 단기 조세회피활동 측정치와 달리, 경영자보상과 음(-)의 관계를 가지는 것으로 나타났다. 이러한 실증 분석 결과는 주주 입장에서 경영자의 단기적 조세회피활동은 긍정적으로 평가하나, 장기적이고 지속적인 조세회피활동에 대해서는 부정적으로 평가하고 있음을 보여준다. The relationship between tax avoidance activity and executive compensation can be different on whether tax avoidance is done only in the short term or not. If tax avoidance is done in the long run, the risk of tax avoidance can be increased even more and firm value can be decreased. If shareholders think that long-term tax avoidance decreases firm value, they would set differently the relatinship between long term tax avoidance and executive compenstion with short term one. We classify short term tax avoidance and long term one, examine the relationship between tax avoidance and executive compensation. For the analyses, the sample consists of 2,709 firmyears(non-banking firms) of listed on Korean Stock Exchange during 2005 to 2013. We use three short term tax avoidance measures, two long term tax avoidance measures and an average cash compensation per executive. The result shows that there is the positive relationship between short term tax avoidance and executive compensation, on the other hand, there is the negative relationship between long term tax avoidance and executive compensation. This means shareholders assess short term tax avoidance positively, but not about long term tax avoidance.

Mycobacterium intracellulare에 의한 요추부 척추염 1예

장은영,김미영,김정욱,송은희,백관미,정용필,성흥섭,김미나,김양수,우준희,이상호 대한감염학회 2007 감염과 화학요법 Vol.39 No.3

비결핵성 미코박테리아에 의한 척추염에 대한 증례 보고가 국내에서는 아직 없었다. 저자들은 기저질환이 없는 환자에서 M. intracellulare에 의한 척추염을 rpoB 유전자에 대한 PCR-RFLP 방법을 통해 진단하였고 수술적 치료와 3제 병합 항균 요법으로 성공적인 임상 경과를 보인 1예를 경험하였기에 보고하는 바이다. We report a case of vertebral osteomyelitis due to Mycobacterium intracellulare in a 60-year-old man without predisposing conditions. He was successfully treated with surgical excision of the inflamed tissue and combined antimycobacterial therapy consisting of clarithromycin, ethambutol, and rifampin. In this case, polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) based on the rpo B gene of cultured isolates allowed rapid identification of M. intracellulare. Although very rare, nontuberculous mycobacteria (NTM) should be suspected as a causative pathogen of vertebral osteomyelitis. To the best of our knowledge, this is the first case of vertebral osteomyelitis caused by NTM reported in the Korean literature.

Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

농촌 자활사업참여자의 음주 문제 개입프로그램 개발: 동기강화상담의 적용

이종례(Jong Rea Lee),장수미(Soo Mi Jang),허성희(Seong Hui Heo) 한국지역사회복지학회 2022 한국지역사회복지학 Vol.- No.83

본 연구의 목적은 동기강화상담(Motivational Interviewing: MI) 모델을 적용하여 농촌 자활사업참여자의 음주 문제 개입프로그램을 개발하는 것이다. 개입연구(Intervention Research: IR)의 절차에 따라 문헌고찰, 실무자 인터뷰를 시행한 후 농촌 자활사업참여자의 음주문제 양상을 파악하고, 동기강화상담의 원리와 전략에 기반하여 1차 프로그램을 구성하였다. 전문가 자문을 통해 수정 보완 후 2차 프로그램을 도출하였고, 음주 문제를 가진 농촌 자활사업참여자를 실험집단(n=10)과 통제집단(n=10)으로 무작위 배치한 후, 실험집단에 동기강화상담 기반 음주 문제 개입프로그램을 실시하였다. 사전‧사후‧추후 조사를 통해 개입프로그램의 효과성을 평가한 결과, 실험집단의 음주 지식, 단주 자기효능감, 변화 동기, 음주 문제, 자활 성과의 사전‧사후 점수에서 유의미한 변화가 발생하였고, 음주 문제를 제외한 모든 변인에서 사전‧추후 점수의 유의미한 변화가 나타났다. 음주 문제의 경우 사전‧추후, 사후‧추후 모두 유의미한 변화가 발생하지 않아 효과성이 유지되지 않음을 확인하였다. 이후 현장 실험 결과에 대한 피드백을 반영하여 최종(3차) 프로그램을 개발하였다. 결론에서는 주요 연구 결과를 바탕으로 논의하고, 자활 현장을 중심으로 사회복지 실천 및 정책에의 함의를 제시하였다. The purpose of this study is to develop an intervention program for the drinking problem of participants in rural self-sufficiency center by applying the Motivational Interviewing(MI) model. According to the stages of Intervention Research(IR), the aspects of drinking problems of rural self-sufficiency participants was identified through literature review and interviews with practitioners, and the 1st program was constructed based on the principles and strategies of MI. After revising with experts advice, a 2nd program was derived, and rural self-sufficiency participants with drinking problems into an experimental group(n=10) and a control group(n=10) by random assignment, MI was conducted only in the experimental group. As a result of the program, significant changes occurred in the pre and post scores of the experimental group’s drinking knowledge, abstinence self-efficacy, change motive, drinking problem, and self-sufficiency outcomes, and significant changes in pre and 6 weeks later scores were found in all variables except for drinking problems. The drinking problem was not significant in pre and 6 weeks later, post and 6 weeks later, it could be seen that the effectiveness was not maintained. The 3rd(final) program was developed by evaluating the effectiveness of the programs, and reflecting feedbacks from field experiment. In conclusion, the implications for social welfare practices and policies were presented, focusing on the field of self-sufficiency.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.