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Could cluster of risk factors predict clinical outcome in patients with acute myocardial infarction?
( Sang Mi Park ),( Hong Nyun Kim ),( Se Yong Jang ),( Myung Hwan Bae ),( Dong Heon Yang ),( Hun Sik Park ),( Yongkeun Cho ),( Shung Chull Chae ),( Jang Hoon Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Purpose: Conventional risk factors are differently contributed to short-term prognosis of acute myocardial infarction (AMI); hypertension and diabetes increase adverse outcome, whereas hyperlipidemia, smoking, and obesity paradoxically decrease adverse outcome of post-MI patients. The aim of this study is to assess whether cluster of conventional risk factors, PARADOCS (Pressure of ARtery Abnormality, Diabetes, Obesity, Cholesterol, Smoking) score, would improve the ability to predict major adverse cardiac events (MACEs) in patients with AMI. Methods: Between November 2005 and July 2011, 24,020 patients (17,232 men; mean age=63.0±12.8) with AMI were analyzed from Korean AMI registry. PARADOCS score was calculated as follows; [number of non-paradoxical risk factors (NRF) -number of paradoxical risk factors (PRF)]+3 in which non-paradoxical risk factors are hypertension and diabetes, and paradoxical risk factors are the rest. The 1-year MACEs were defined as death and non-fatal MI. Results: NRF including hypertension and diabetes were present in 49.6% and 27.0%, whereas PRF including hyperlipidemia, smoking, and obesity were present in 12.3%, 43.0%, and 34.6%, respectively. During the follow-up, 1,409 (5.9%) MACEs occurred. PARADOCS score was significantly higher in patients with 1-year MACEs (3.38±1.03 versus 2.81±1.08, p<0.001). In Cox proportional hazards model, PARADOCS score was an independent predictor of 1-year MACEs (hazards ratio 1.26, 95% confidence interval 1.18-1.34; p<0.001) after adjusting for confounding variables. Patients were categorized into 3 groups according to the PARADOCS score; PARADOCSLOW (0-1, n=2,446), PARADOCSMID (2-3, n=14,594), and PARADOCSHIGH (4-5, n= 6,980). Kaplan-Meier survival curve showed that there were significant differences in the 1-year MACEs among three groups including 3.5% in PARADOCSLOW, 8.5% in PARADOCSMID, and 16.4% in PARADOCSHIGH, respectively (long-rank p<0.001). Conclusions: In post-MI patients, conventional risk factors are differently associated with short-term prognosis, and score of these risk factors, PARADOCS score, can provide useful prognostic information to clinicians.
모세관 전기영동법을 이용한 베타차단제 광학이성질체의 분석
임환미,린팜두안,강종성 충남대학교 약학대학 의약품개발연구소 2000 藥學論文集 Vol.16 No.-
The effects of type of chiral selectors, pH and concentration of electrolyte on the resolution of the enantiomers of β-blockers by capillary electrophoresis were examined and the analysis of β-blocker enantiomer was attempted using various chiral selectors, such as carboxymethyl-, methyl-, succinyl, hydroxypropyl and dimethyl-β-cyclodextrin. Among the used chiral selectors, carboxymethyl-β-cyclodextrin (CM-β-CD) was the best for the separation of β-blockers. The optimum separation of the enantiomers of β-blocker was achieved on fused silica capillary (75 um i.d.×47 cm, 40 cm to detector) with phosphate buffer (pH 6, 70 mM) containing 10 mM of CM-β-CD as electrolyte at 10 KV running voltage. Injection was hydrodynamically for 3 psi×s and detection was carried out at UV 210nm.
강미정,윤경영,성종환,이광희,김광수 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.4
Studies on extraction and color stability of carotenoids from astringent persimmon(Diospyros kaki) were performed to provide the basic information for the utilization of persimmon pigment as a new source of natural food colorant. The major carotenoids in astringent persimmon were beta-cryptoxanthin, lycopene and beta-carotene. Beta-cryptoxanthin was the first major pigment and lycopene the next. Total carotenoid content in persimmon calculated as beta-carotene equivalent was 107.4 ㎍/g. The data indicated that the astringent persimmon was a good source of carotenoid pigment. The physical and chemical stabilities of carotenoid from astringent persimmon were investigated at various conditions of temperature, pH and antioxidant. The effects of oxygen and light on the stability of carotenoid pigment has been investigated. The factors that cause the discoloration were visible light, temperature above 60, pH below 5 and oxygen. Especially, the carotenoid pigment was very sensitive to light and oxygen. Carotenoid stability was much improved with increasing nitrogen concentration in the atmosphere. Persimmon pigments have been found to be most stable at 5~10. And tocopherol was the most effective inhibitor of the pigment discoloration.
Cisplatin 병용화학요법시 발생한 오심, 구토에 대한 Ondansetron과 Metoclopramide의 효과에 대한 비교
김미자,국기용,김태원,박유환,김완중,허경,정춘해,홍순표 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
Inspite of possible effects for emesis following chemotherapy including cisplatin, nausea and vomiting are the most unpleasant side effects of cancer chemotherapy. None of the currently available antiemetic agents is entirely effective preventing emesis. Ondansetron, a 5-HT(5-hydroxytryptamine)_(3) receptor antagonist, has been shown to be effective antiemetic agent in the control of cisplatin induced emesis. Twenty solid tumor patients who are scheduled to receive cisplatin containing combination chemotherapy participated in a prospectively randomized study to compare the antiemetic efficacy and safety of ondansetron and metoclopramide. Ondansetron was given in dose of 8mg intravenous 30min before cisplatin and then 4hours and 8hours after cisplatin on day 1, and Ⅰ.Ⅴ. every 8hours from day 2 to 5. In the metoclopramide group, metoclopramide was given in dose of 2 ㎎/㎏ intravenous every 8hours from day 1 to 5. The control of emesis was graded in the following way : complete response, no vomiting : major response, 1-2 emetic episodes : minor response, 3-5 emetic episodes : failure, above 5 emetic episodes. Complete or major response of emesis was achieved 10 of 12(83.2%) patients receiving ondansetron and in 5 of 8(62.5%) patients receiving metoclopramide, but effectiveness was not significantly different. Ondansetron was at least as effective as metoclopramide therapy in controlling cisplatin induced emesis. Side effects in ondansetron was less than in Metoclopramide.
서주환,성미성 경희대학교 디자인연구원 2001 예술· 디자인학연구 Vol.4 No.1
The purpose of this study is to research the influence of acoustic information in landscape elemental. Specifically study on a theory of the auditory none, impact of sound, noise pollution and concept of soundscape. The level of visual preferences was measured by acoustic information and visual information in the landscape. The nerve of landscape preference was different by the type of acoustic information and visual information in landscape. These research were showing surely influence of sounds affecting decision of landscape preference.
광중합형 복합레진과 콤포머에서 두께와 배경색에 따른 색변화
임주환,임미경 원광대학교 생체재료·매식연구소 1999 원광생체재료·매식 Vol.8 No.1
The color of an esthetic restorative material is controlled primarily by thickness of the material and background color. Although the effects of the two factors on the color coordinates of esthetic dental materials have been reported, the mechanism has not been clarified well enough to explain the effects quantitatively. The purpose of this study was to evaluate the effect of thickness and background color on the color of tooth colored restorative materials quantitatively. One hundred sixty samples were fabricated from two commercial light-cured composite resins and two commercial compomer and the shade was Vita A3. The color characteristics and changes in the color coordinates were measured by a tristmulus colorimeter (Model TC-6FX, Tokyo Denshoku Co. Japan) using the CIELAB system. The results were as follows: 1. As thickness increased from 1.0 to 4.0mm, values of L^* a^* b^* changed irregulary for white and dentin color background, but showed no obvious difference in color for black background. 2. The colors of composite resins and compomers were significantly influenced by background color. 3. The color difference was recognized even the same shade name in four representative kinds of composite resins and compomers. 4. As thickness changed, values of color difference for same products and same background color showed constancy but showed difference for different background color.
Asimina triloba 씨앗으로부터 분리된 Annonaceous acetogenin 으로서의 Xylomaticin
우미희,김달환 대구효성카톨릭대학교 1997 연구논문집 Vol.56 No.2
Most Annonaceous acetogenins are potently bioactive and offer exciting potential as new antitumor, pesticidal and other bioactives. The major mode of action of the acetogenins is inhibition of electron transport in the mitochondria. Acetogenins are waxy substances consisting of C32 or C34 long chain fatty acids which have been combined with a propan-2-ol unit at C-2 to form a Y-lactone. Acetogenins have been isolated from an extract of the seeds of Asimina triloba by directing the fractionation with brine shrimp lethality. The structures were characterized on the basis of chemical and spectral data. Xylomaticin, which is known but is first isolated in this species, was obtained. In brine shrimp lethality test(BST), xylomaticin exhibited cytotoxicity.