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Mengying Cui,Yingchao Lin,YUANGANG ZU,Thomas Efferth,Dewen Li,Zhonghua Tang 한국식물학회 2015 Journal of Plant Biology Vol.58 No.3
Ethylene (ET) plays an important role as signal transducer in plants in response to environmental stimuli. Under water deficient conditions, fine adjustment of osmosis and redox states through phytohormones is vital for plant resistance to drought. Here, physiological and cellular responses of ET insensitive mutants (ein2-5 and ein3-1) were analyzed under water deficiency stimulated by polyethylene glycol 6000 (PEG-6000), and compared with wild type plants (Col-0) as controls. The accumulation of compatible solutes was higher in Col-0 than in ein2-5 and ein3-1. In Col-0 plants, water stress also increased transcription of P5CS1, which encoded a key rate-limiting enzyme in proline biosynthesis. These results suggested that ET signaling is involved in increasing the up-regulation of soluble sugar and proline accumulation to adjust to osmotic stress. In addition, oxidative stress was higher in ET defective mutants than in Col-0 wild-type plants. Meanwhile, increased activities of the reactive oxygen species (ROS)-scavenging enzymes superoxide dismutase (SOD) and peroxidase (POD) were observed in ET insensitive mutants, indicating aggravated oxidative stress in ET-defective plants under drought. In conclusion, ET signaling is involved in modulating plant oxidative stress under drought conditions.
TFPI inhibits breast cancer progression by suppressing ERK/p38 MAPK signaling pathway
Xing Mengying,Yang Ying,Huang Jiaxue,Fang Yaqun,Jin Yucui,Li Lingyun,Chen Xiang,Zhu Xiaoxia,Ma Changyan 한국유전학회 2022 Genes & Genomics Vol.44 No.7
Background: Tissue factor pathway inhibitor-1 (TFPI) is a serine protease inhibitor, which is responsible for inactivating TF-induced coagulation. Recently, increasing studies revealed that TFPI was lowly expressed in tumor cells and exhibited the antitumor activity. Objective: The aim of this study was to explore the role and underlying molecular mechanisms of TFPI in breast cancer. Methods: The expression and prognostic value of TFPI were analyzed using UALCAN and Kaplan-Meier plotter website. The expression level of TFPI in breast cancer tissues and cells was examined by immunohistochemistry (IHC) and western blot analysis, respectively. Cellular proliferation was evaluated by CCK-8 and colony formation assays. Cell migration and invasion were determined by transwell assay. The methylation level of TFPI promoter was determined by methylation-specific PCR. Results: TFPI expression was significantly lower in breast cancer tissues and cells compared to normal breast tissues and normal breast cells. Patients with low TFPI levels showed worse overall survival (OS). Furthermore, overexpression of TFPI significantly inhibited the proliferation, migration and invasion of breast cancer cells. Conversely, knockdown of TFPI promoted the proliferation, migration and invasion of breast cancer cells. Mechanistically, TFPI inhibited the ERK/p38 MAPK signaling pathway in breast cancer. Moreover, DNA hypermethylation of TFPI promoter was responsible for the downregulation of TFPI in breast cancer cells. Conclusion: TFPI inhibited breast cancer cell proliferation, migration and invasion through inhibition of the ERK/p38 MAPK signaling pathway, suggesting that TFPI may serve as a novel prognostic biomarker and therapeutic target for breast cancer.
Duan, Mengying,Liu, Yidong,Ao, Jun,Xue, Lu,Luo, Shilong,Tan, Yu,Qin, Wenling,Song, Choong Eui,Yan, Hailong American Chemical Society 2017 ORGANIC LETTERS Vol.19 No.9
<P>A chiral, fluoride-catalyzed asymmetric cascade sulfaMichael/aldol condensation reaction of 1,4-dithiane-2,5-diol and a series of alpha,beta-unsaturated ketones is described to access chiral trisubstituted tetrahydrothiophene derivatives. The target products, including the spiro tetrahydrothiophene derivatives bearing a five-, six-, and seven-membered ring, were highly functionalized and showed high ee value. This established protocol realized a highly enantioselective reaction with a catalytic amount of KF and Song's chiral oligoEG via in situ generated chiral fluoride to construct useful heterocyclic skeletons with great complexity.</P>
Xuehua Puyang,Mengying An,Lixin Xu,Liebao Han,Xunzhong Zhang 한국원예학회 2016 Horticulture, Environment, and Biotechnology Vol.57 No.1
Spermidine (Spd) acts as a plant protectant under salinity stress. The objective of this study was to determine whether exogenous Spd pre-treatment could improve the salinity tolerance of Kentucky bluegrass (Poa pratensis L.). Exogenous Spd was applied before the grass was exposed to 200 mM sodium chloride (NaCl) for 28 d in the growth chamber. Salinity stress decreased chlorophyll (Chl) content, K+/Na+ratio and K+, Ca2+, and Mg2+ contents, and increased electrolyte leakage (EL), proline, Na+, putrescine (Put), Spd and Spermine (Spm) levels and the activities of arginine decarboxylase (ADC), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (SAMDC) and polyamine oxidase (PAO). Pre-treatment with 1 mM Spd effectively alleviated the decline of Chl content, K+/Na+ratio and K+, Ca2+, and Mg2+ contents under salinity stress conditions. Spd pre-treatment also reduced EL, Na+ content, Put levels and the activities of ADC and PAO, but increased proline content, endogenous Spd and Spm levels and the activities of ODC and SAMDC upon salinity stress. These results indicate that exogenous Spd pre-treatment could enhance salinity tolerance by increasing proline levels and regulating ion and polyamine metabolism.
Binbin Zhang,Mengying Qiao,Guojun Ji,Baorong Hou 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
Due to their unique interface functions, superhydrophobic materials have a wide range of applications. However, the majority of current superhydrophobic surfaces are designed and manufactured using fluorinatedchemical reagents. Moreover, high temperature water droplets with lower surface tension easilypinning to the surface, resulting in interfacial property failures. To overcome these deficiencies, herein wefabricated a superhydrophobic bilayer coating on Q235 carbon steel based on fluorine-free chemicals ofpolydimethylsiloxane (PDMS) and hexadecyltrimethoxysilane modified aluminum oxide nanoparticles(Al2O3@HDTMS). Field-emission scanning electron microscopy (FE-SEM), Energy dispersive spectroscopy(EDS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), Contactangle meter, and Electrochemical impedance spectroscopy (EIS) techniques were utilized to characterizethe constructed superhydrophobic bilayer coating. The results show that the superhydrophobic bilayercoating exhibits non-wetting, anti-fouling and self-cleaning capacities towards various solid and liquidpollutants. The superhydrophobic bilayer coating possesses superior anti-corrosion and weather resistingproperties with |Z|0.01Hz and Rct values increased by more than eight orders of magnitude, withstanding720 h accelerated salt-spray and 50 days outdoor atmospheric corrosion attack. Furthermore, the superhydrophobicbilayer coating features super-repellency towards water droplets in a wide temperaturerange (30 90 C) and accompanied with high mechanical stability against continuous sandpaper abrasionand tape-peeling cycles.
A Study on Adaptive Direction Teaching-Learning-Based Optimization Algorithm
Xu Sun,Mengying He,Leilei Kong,Haoliang Qi 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.4
In the real life learning process, the teacher communicates with the students for a better learning outcome. The teaching-learning-based optimization (TLBO) algorithm simulates this procedure and shows its great performance in solving the constrained and unconstrained nonlinear optimization problem. This paper presents an adaptive direction strategy(ADS )t o improve the searching ability for the TLBO algorithm. The improved algorithm is tested through searching the optimal points for a few typical testing functions. The testing result shows that the improved TLBO algorithm could obtain better optimal solutions in shorter time. Compared to the normal TLBO algorithm, the stability and effectiveness of the improved algorithm are increased greatly.
Binbin Zhang,Mengying Qiao,Weichen Xu,Baorong Hou 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-
Water-repellent and interfacial non-wetting superhydrophobicity has great potential to addresscorrosion/icing-induced material-deterioration problems. Herein, an all-organic superhydrophobic coatingwas constructed using facile and substrate-independent spray-coating method based on PTFE andPDMS. FE-SEM, EDS, and XPS techniques were used to analyze the surface topographies and chemicalcompositions. The coating exhibits superior anti-fouling and self-cleaning properties against various liquidand solid contaminants due to the synergic effect of low surface energy and hierarchical structures. The EIS and potentiodynamic polarization results show improved charge transfer resistance (Rct), positiveshifted corrosion potential (Ecorr), and decreased corrosion current density (Icorr), implying significantlyenhanced anti-corrosion performance with 99.83 % inhibition efficiency. Besides, the delay rate of icefreezingtime of the coating is 232 % at 5C, 137 % at 10 C and 204 % at 15 C compared withuncoated Q235 substrate respectively. The ice adhesion strength of the coating accounts for only6.55 % at 5C, 7.03 % at 10 C and 9.35 % at 15 C than that of the bare Q235 carbon steel, demonstratingultra-low ice adhesion force and anti-icing capabilities. The hygroscopic and deliquesce behaviorsof NaCl salt particles reveal an intriguing salt-deliquescence self-coalescence phenomenon andprospective anti-corrosion mechanism for superhydrophobic materials in high-humidity marine atmosphericenvironments.