Microchips and their Significance in Isolation of Circulating Tumor Cells and Monitoring of Cancers

Sahmani, Mehdi,Vatanmakanian, Mousa,Goudarzi, Mehdi,Mobarra, Naser,Azad, Mehdi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3

In micro-fluid systems, fluids are injected into extremely narrow polymer channels in small amounts such as micro-, nano-, or pico-liter scales. These channels themselves are embedded on tiny chips. Various specialized structures in the chips including pumps, valves, and channels allow the chips to accept different types of fluids to be entered the channel and along with flowing through the channels, exert their effects in the framework of different reactions. The chips are generally crystal, silicon, or elastomer in texture. These highly organized structures are equipped with discharging channels through which products as well as wastes of the reactions are secreted out. A particular advantage regarding the use of fluids in micro-scales over macro-scales lies in the fact that these fluids are much better processed in the chips when they applied as micro-scales. When the laboratory is miniaturized as a microchip and solutions are injected on a micro-scale, this combination makes a specialized construction referred to as "lab-on-chip". Taken together, micro-fluids are among the novel technologies which further than declining the costs; enhancing the test repeatability, sensitivity, accuracy, and speed; are emerged as widespread technology in laboratory diagnosis. They can be utilized for monitoring a wide spectrum of biological disorders including different types of cancers. When these microchips are used for cancer monitoring, circulatory tumor cells play a fundamental role.

Basilar Skull Fractures and Their Complications in Patients With Traumatic Brain Injury

Mehdi Shafiei,Bahram Aminmansour,Mehdi Mahmoodkhani,Mohammadamin Seyedmoalemi,Donya Sheibani Tehrani 대한신경손상학회 2023 Korean Journal of Neurotrauma Vol.19 No.1

Since traumatic brain injury is more common in young people, who are the main workforce and builders of society, it is important to consider the effects caused by brain injury on them. In this study, we investigated the clinical manifestations, complications, and prognosis of patients with basilar skull fractures.

Incorporating a Multivariate Approach in Taekwondo Talent Identification by SAFIR Software

( Mehdi Shahbazi ),( Mehdi Naadi Ghafouri Yazdi ),( Sima Dastamooz ) 국제태권도학회 2017 International Symposium for Taekwondo Studies Vol.2017 No.-

Purpose: Talent identification is defined as predicting performance by evaluating physical, psychological, and social features as well as technical ability. What athletes need in order to progress in Taekwondo is to be able to evaluate their current situations and somehow predict how the sport will affect their lives. From this, they can improve their possibilities of success. Therefore, the purpose of this study was to determine if a multivariate approach in Taekwondo talent identification by SAFIR software can improve athletes’ lives after their competitive careers. Methods: SAFIR software is composed three parts: 1) the evaluation of health indexes, 2) sport talent identification, and 3) and the comparison of subjects with elite athletes. Results: In part one (evaluating health indexes) of this study, subject’s health situation was determined in a report that combines: height, weight, computing standard weight, height growth rate, the level of total body’s water, adult height, body type (ectomorph, mesomorph, and endomorph), Basal metabolic rate (BMR), waist-hip ratio (WHR), and body mass index (BMI). The target group in part two (sport talent identification) was 8-16 years old individuals. One of the most important features that this software offers is the ability to analyze athletes according sports according to their individual characteristics. In this part, anthropometrics features; physiological indexes; and motor perceptual features like personality, speed, agility, flexibility, coordination, balance, and reaction time were examined. In part three, individuals were compared to elite athletes. The data obtained during this step allows athletes to recognize the characteristics and strengths they share with elite athletes. Conclusions: SAFIR’s software allows youth athletes in physical education and sports programs to achieve their desired results. The Islamic Republic of Iran Taekwondo Federation is currently using SAFIR software in all of its talent identification programs.

The Impact of Depression, Personality, and Mental Health on Outcomes of Total Knee Arthroplasty

Mehdi Moghtadaei,Ali Yeganeh,Nima Hosseinzadeh,Amir Khazanchin,Mehdi Moaiedfar,Atefeh Ghanbari Jolfaei,Shirin Nasiri 대한정형외과학회 2020 Clinics in Orthopedic Surgery Vol.12 No.4

Background: Precise assessment of preoperative mental health and psychological determinants may be useful in identifying patients at risk for poor postoperative outcomes of total knee arthroplasty (TKA). The aim of this study was to investigate the influence of psychological status and physical and mental health on the outcome of patients undergoing TKA. Methods: Fifty-two patients undergoing unilateral TKA were assessed preoperatively with Oxford Happiness Inventory, Eysenck Personality Inventory, 12-item short form health survey (SF-12), and Knee Injury and Osteoarthritis Outcome Score (KOOS) for evaluating depression, personality traits, physical and mental health, and function, respectively. At 1 year after surgery, health-related quality of life (HRQL) and function were assessed using the SF-12 and KOOS. Results: HRQL and function of all personality traits increased significantly after TKA, without significant difference among them. Extroversion and neuroticism did not have significant correlation with subjective well-being, HRQL, and function before and after surgery. Subjective well-being and the baseline physical and mental health scores were correlated strongly and directly with postoperative physical component summary, mental component summary, and KOOS scores and their improvement. Among many factors that significantly affected the outcomes of TKA, the only independent predictor of physical, mental, and functional outcome was depression. Conclusions: Outcomes of surgery were not significantly different among diverse personality traits. Patients with less depressive symptoms and higher baseline mental and physical scores had significantly greater improvement in HRQL after surgery. The only independent factor affecting the physical, mental, and functional outcome was depression.

Feasibility Study and Measuring Some Effects of the Activity Based ManAgement (ABM) in the Iran Railway

Mohammad Mehdi Movahedi,Mehdi Zaribaf,Mohammad Ali Moradi 한국철도학회 2010 International Journal of Railway Vol.3 No.1

The research is to develop cost methodology to support railway managers for identifying principles, tools and methods of activity based management correctly and precisely, and can be useful and effective for managers for realizing their goals. The research result a ministry can be suitable guideline in terms of how to execute activity based management. Since in this research, main and secondary activities are studied completely in the Railway organization, it can be an explanatory research. The research population is headquarter managers and experts of railway organization and the sampling procedure is goal ?oriented and judgmental. 74 people were selected by using a formula. All hypotheses were tested in 95% significance level. Meanwhile a proposed process of applying .activity based management was offered.

Analysis of a functionally graded nanocomposite sandwich beam considering porosity distribution on variable elastic foundation using DQM: Buckling and vibration behaviors

Mohammad Mehdi Nejadi,Mehdi Mohammadimehr 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.25 No.3

In the present study, according to the important of porosity in low specific weight in comparison of high stiffness of carbon nanotubes reinforced composite, buckling and free vibration analysis of sandwich composite beam in two configurations, of laminates using differential quadrature method (DQM) is studied. Also, the effects of porosity coefficient and three types of porosity distribution on critical buckling load and natural frequency are discussed. It is shown the buckling loads and natural frequencies of laminate 1 are significantly larger than the results of laminate 2. When configuration 2 (the core is made of FRC) and laminate 1 ([0/90/0/45/90]s) are used, the first natural frequency rises noticeably. It is also demonstrated that the influence of the core height in the case of lower carbon volume fractions is negligible. Even though, when volume fraction of fiber increases, the critical buckling load enhances smoothly. It should be noticed the amount of decline has inverse relationship with the beam aspect ratio. Investigating three porosity patterns, beam with the distribution of porosity Type 2 has the maximum critical buckling load and first natural frequency. Among three elastic foundations (constant, linear and parabolic), buckling load and natural frequency in linear variation has the least amount. For all kind of elastic foundations, when the porosity coefficient increases, critical buckling load and natural frequency decline significantly.

Genetic Connection between Some Persian and Far East Germplasms of Pyrus Assessed by SSR Markers

M. Mehdi Sharifani,Chikako Nishtani,T. Kimura,Vahid Erfani,Mehdi Shahsavand,Toshiya Yamamoto 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Identification of a Novel Cassette Array in Integron-bearing Helicobacter Pylori Strains Isolated from Iranian Patients

Goudarzi, Mehdi,Seyedjavadi, Sima Sadat,Fazeli, Maryam,Roshani, Maryam,Azad, Mehdi,Heidary, Mohsen,Navidinia, Masoumeh,Goudarzi, Hossein Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7

Helicobacter pylori as the second most common cause of gastric cancer in the world infects approximately half of the developed countries population and 80% of the population living in developing countries. Integrons as genetic reservoirs play major roles in dissemination of antimicrobial resistance genes. To the best of our knowledge, this is the first study to report carriage of class 1 and 2 integrons and associated gene cassettes in H. pylori isolates from Iran. This cross-sectional study was conducted in Tehran among 110 patients with H. pylori infection. Antimicrobial susceptibility testing (AST) for H. pylori strains were assessed by the micro broth dilution method. Class 1 and 2 integrons were detected using PCR. In order to determine gene cassettes, amplified fragments were subjected to DNA sequencing of both amplicon strands. The prevalence of resistance to clarithromycin, metronidazole, clarithromycin, tetracycline, amoxicillin, rifampin, and levofloxacin were 68.2% (n=75), 25.5% (n=28), 24.5% (n=27), 19.1% (n=21), 18.2% (n=20) and 16.4% (n=18), respectively. Frequency of multidrug resistance among H. pylori isolates was 12.7%. Class 2 integron was detected in 50 (45.5%) and class 1 integron in 10 (9.1%) H. pylori isolates. The most predominant gene cassette arrays in class 2 integron-bearing H. pylori were included sat-era-aadA1, dfrA1-sat2-aadA1, blaoxa2 and, aadB whereas common gene cassette arrays in class 1 integron were aadB-aadA1-cmlA6, aacA4, blaoxa2, and catB3. The high frequency of class 2 integron and multidrug resistance in the present study should be considered as a warning for clinicians that continuous surveillance is necessary to prevent the further spread of resistant isolates.

Treatment of industrial wastewater contaminated with recalcitrant metal working fluids by the photo-Fenton process as post-treatment for DAF

Mohammad Mehdi Amin,Mohammad Mehdi Golbini Mofrad,Hamidreza Pourzamani,Seyed Mohammad Sebaradar,Karim Ebrahim 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.45 No.-

Post-treatment of the industrial wastewater polluted by metalworkingfluids (MWFs) was performedusing the photo-Fenton process in following of the chemical addition-dissolved airflotation (CA-DAF)unit. Prior to this study, the CA-DAF was operated as full-scale by trial and error. For the photo-Fentonprocess as a pilot-scale batch reactor, initial pH value, FeSO4, and H2O2 concentrations were considered tostudy the effect of different operating conditions on chemical oxygen demand (COD) and total petroleumhydrocarbon (TPH) removals. This hybrid approach revealed removal efficiencies of 99.85% and 98.9% forCOD and TPH in the optimized photo-Fenton process as pH 3, FeSO4: 100 mg/l, and H2O2: 17.8 g/l. The CODdegradation results for the photo-Fenton system indicated that it could be wellfit using a pseudofirstorderkinetic model. By the GC–MS analysis of DAF and applied photo-Fenton effluents, a 73% removalrate of mono(2-ethylhexyl) phthalate was detected. It is likely favorable to increase the biodegradability. The cost analysis of this process for the consumed energy (6 kWh) and chemicals (0.01818 kg FeSO4 and17.15 kg H2O2) was estimated at approximately 26 $ per 1 m3 of DAF effluent. Generally, these resultsimply that the CA-DAF unit followed by photo-Fenton is an effective and practical method for treatingMWFs wastewater.

The activation of NF-κB and MAPKs signaling pathways of RAW264.7 murine macrophages and natural killer cells by fucoidan from <i>Nizamuddinia zanardinii</i>

Tabarsa, Mehdi,Dabaghian, Elham Hashem,You, SangGuan,Yelithao, Khamphone,Cao, RongAn,Rezaei, Masoud,Alboofetileh, Mehdi,Bita, Seraj Elsevier 2020 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.148 No.-

<P><B>Abstract</B></P> <P>Polysaccharides from <I>Nizamuddinia zanardinii</I> were extracted using water at elevated temperature and fractionated by a DEAE Sepharose FF column yielding four fractions (F<SUB>1</SUB>-F<SUB>4</SUB>). Crude and fractions were composed of neutral sugars (50.8–57.4%), proteins (10.8–18.1%), sulfates (7.5–17.3%) and uronic acids (3.5–7.7%). Various levels of galactose (13.4–44.4%), fucose (34.1–40.1%), mannose (14.1–33.2%) and xylose (7.4–15.2%) formed the building blocks of the polysaccharide structures. The weight average molecular weights (<I>M</I> <SUB>w</SUB>) of polysaccharides varied between 40.3 and 1254.4 × 10<SUP>3</SUP> g/mol. F<SUB>3</SUB> polysaccharide was the most active fraction stimulating RAW264.7 murine macrophage cells to secrete NO, TNF-α, IL-1β and IL-6, and activating NK cells to release TNF-α, INF-γ, granzyme-B, perforin, NKG2D and FasL through NF-κB and MAPKs signaling pathways. Highly-branched F<SUB>3</SUB> polysaccharide mainly consisted of (1 → 2)-Fuc<I>p</I>, (1 → 2,3)-Man<I>p</I>, (1 → 3)-Gal<I>p</I>, (1 → 2)-Man<I>p</I>, (1 → 3)-Man<I>p</I>, (1 → 2,3,4)-Man<I>p</I> and (1 → 2,3,6)-Man<I>p</I> residues with great amount of (→1)-Fuc<I>p</I> and (→1)-Xyl<I>p</I>. Sulfates substituted at C-2 of fucose and galactose residues. Overall, fucoidan from <I>N. zanardinii</I> showed immense potency in boosting immune system through macrophages and NK cells activations and therefore suitable for further exploration in immune-mediated biomedical applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Water-soluble fucoidans were isolated from <I>Nizamuddinia zanardinii</I>. </LI> <LI> Fucoidans activated RAW264.7 cells to release proinflammatory mediators. </LI> <LI> Fucoidans stimulated natural killer cells to produce TNF-α, INF-γ and perforin. </LI> <LI> RAW264.7 and NK cells were activated through NF-κB and MAPK signaling pathways. </LI> <LI> Most immunoenhancing polysaccharide contained high (1 → 2)-fucopyranosyl units. </LI> </UL> </P>