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Meejung Ahn,Poornima D. E. Weerasinghe-Mud,Hyobin Kim,Minju Kwon,Jeongtae Kim,Taekyun Shin 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Progranulin (PGRN) which is a secreted neurotrophin mediates cell cycle progression and cell motility that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. To evaluate the involvement of PGRN in experimental autoimmune neuritis (EAN) pathogenesis, as a model of human demyelinating diseases such as Guillain- Barré Syndrome. The expression of PGRN in rat sciatic nerves with EAN was studied. PGRN expression was increased significantly in EAN-affected sciatic nerves compared with normal rat sciatic nerves. The elevated levels of PGRN in the sciatic nerves of rats with EAN at the peak stage and then its expression was decreased significant at the recovery stage. The cellular phenotype of PGRN in EAN lesions consisted mainly of inflammatory cells including macrophages and Schwann cells whereas it was expressed constitutively in axons. Collectively, this study suggests that PGRN secreted by a variety of cells including macrophage, vascular endothelial cells and Schwann cells, plays either pro-inflammatory or tissue regenerative effects, or both depending on PGRN containing cell type, during the course of EAN, an animal model of human demyelinating disease. (Acknowledgement: This work was supported by the National Research Foundation of Korea: Grant number NRF-2017R1A2B4012478)
Meejung Kim,강봉주,Ga Eun Park 대한자기공명의과학회 2022 Investigative Magnetic Resonance Imaging Vol.26 No.2
Purpose: To assess clinically significant imaging findings of malignant intramammary lymph nodes (IMLNs) in breast cancer patients and to evaluate their diagnostic performance in predicting malignant IMLN. Materials and Methods: A total of 110 cases with IMLN of BI-RADS category 3 or more, not typical benign IMLN, in MR of breast cancer patients between January 2016 and January 2021 were retrospectively reviewed. After excluding 33 cases, 77 cases were finally included. Among them, 58 and 19 were confirmed as benign and malignant, respectively. Qualitative and quantitative MR imaging features of the IMLN were retrospectively analyzed. Sizes and final assessment categories of IMLN on MRI, mammography, and ultrasound were reviewed. Diagnostic performances of imaging features on MRI, mammography, and ultrasound were then evaluated. Results: For qualitative MR features, shape, margin, and preserved central hilum were significantly different between benign and malignant groups (P < 0.05). For quantitative MR features, long diameter over 6 mm, short diameter over 4 mm, and cortical thickening over 3 mm showed high sensitivities in predicting malignant IMLNs (89.5%, 94.7%, and 100%, respectively). Size exceeding 1 cm showed high specificity and accuracy in predicting malignant IMLN on MR, mammography, and ultrasound (91.4% and 80.5%; 96.6% and 79.25; 98.3% and 80.5%, respectively). Conclusion: Various MR imaging features and size can be helpful for predicting malignant IMLN in breast cancer patients.
Factors Associated with the Timeliness of Electronic Nursing Documentation
Meejung Ahn,최모나,YoungAh Kim 대한의료정보학회 2016 Healthcare Informatics Research Vol.22 No.4
Objectives: To investigate the factors associated with the timeliness of electronic nursing documentation using the entry time on the Electronic Medical Record (EMR) system. Methods: As a retrospective study, data were extracted from January 1 to February 28, 2014 from a hospital EMR system and a nurses’ personnel information system. The timeliness of instances of nursing documentation was categorized into ‘timely’ or ‘untimely’ according to whether the entry time was time-stamped within the working hours during each day, evening, or night shift. Factors associated with the timeliness of the electronic nursing documentation were included in the logistic regression models as nurse- and patient-associated factors. Results: Among 1,700,247 instances of electronic nursing documentation, 79.3% (n = 1,347,711) were completed within the working hours. Years of nursing experience, nursing shift, days of the week, patients’ age, and medical department had a statistically significant associated with the timeliness of nursing records. Nurses with experience of more than 1 year entered nursing records over 2 times more during their working hours than did less experienced nurses. During the evening and night shifts, nurses were 1.49 times and 9.19 times more likely to enter nursing documents in a timely manner, respectively, as compared to those in the day shift. Conclusions: Nursing documentation was typically completed outside of working hours when a nurse had little experience, worked during the day shift or weekdays, and when tasks were unpredictable. This shows that new nurses need support to familiarize them with various tasks and the overall workflow.
제4차 건강가정기본계획의 비판적 검토와 가족정책의 과제
진미정(Meejung Chin) 한국가족정책학회 2021 가족정책연구 Vol.1 No.2
이 글은 2021년 4월 발표된 제4차 건강가정기본계획의 기조와 내용을 가족정책 관점에서 비판적으로 검토한 것이다. 건강가정기본법에 근거하여 2021~2025년의 가족정책을 총괄할 4차 기본계획은 가족제도의 개선을 위한 내용은 강조되어 있으나 가족관계와 가족생활의 향상을 지원한 정책 내용은 미흡하여 편향적인 기본계획이 되었다. 특히, 코로나19 장기화로 가족생활의 어려움이 커지고 관계상의 갈등과 문제를 초래할 수 있는 상황에서 4차 기본계획이 대응 정책을 제시하지 못하였다는 점에서 한계점이 있다. 이러한 한계점은 보편적, 예방적 성격의 가족정책에 대한 몰이해, 가족 변화에 대한 단편적인 접근에서 비롯된 것이다. 구조와 행위의 복잡한 상호작용을 파악하기 위해서는 이념이 아닌 과학에 기초한 가족 연구가 필요하다. 또한, 기본계획의 한계를 보완하기 위해서는 실행계획을 추가로 수립하고, 건강가정지원센터와 다문화가족지원센터 등 지역사회 전달체계에서 실제 주민의 가족관계와 가족생활 향상을 위한 서비스와 프로그램을 적극적으로 시행할 필요가 있다. This study aims to review the 4th National Plan for Healthy Families from a critical perspective. This plan, which will be implemented during 2021 to 2025, challenges traditional family norms by presenting alternative laws and leads to an advance in family laws. This plan, however, leaves policy gaps in terms of enhancing family life and relationship, especially for those families who have experienced economic and relational hardships due to COVID-19. This study offers suggestions to complement the resultant policy gaps.