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1
Creative Primary English in the Era of Globalization: Comparing Mr. Sono’s Grade 5 Class in Japan with Mrs. Alcordo’s in Canada

David McMurray 한국초등영어교육학회 2015 KAPEE International Conference Vol.2015 No.-
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This paper addresses the subject of English education for primary school teachers in this era of globalization. English education teaching techniques useful to elementary school teachers in Japan are explained in this paper about how elementary school teachers with ten years of experience introduce international understanding in their classrooms. By comparing a grade 5 classroom lesson in Japan with one in Canada readers can learn how to teach creatively in English by composing haiku poems, painting pictures, and singing English songs. The synergy can combine to create a magnificent quilt.
2
Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains.

Kim, Wooki,Barhoumi, Rola,McMurray, David N,Chapkin, Robert S Cambridge University Press 2014 The British journal of nutrition Vol.111 No.2
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<P>We have demonstrated previously that n-3 PUFA endogenously produced by fat-1 transgenic mice regulate CD4+ T-cell function by affecting the formation of lipid rafts, liquid-ordered mesodomains in the plasma membrane. In the present study, we tested the effects of dietary sources of n-3 PUFA, i.e. fish oil (FO) or purified DHA, when compared with an n-6 PUFA-enriched maize oil control diet in DO11.10 T-cell receptor transgenic mice. Dietary n-3 PUFA were enriched in CD4+ T-cells, resulting in the increase of the n-3:n-6 ratio. Following antigen-specific CD4+ T-cell activation by B-lymphoma cells pulsed with the ovalbumin 323-339 peptide, the formation of liquid-ordered mesodomains at the immunological synapse relative to the whole CD4+ T-cell, as assessed by Laurdan labelling, was increased (P<?005) in the FO-fed group. The FO diet also suppressed (P<?005) the co-localisation of PKCθ with ganglioside GM1 (monosialotetrahexosylganglioside), a marker for lipid rafts, which is consistent with previous observations. In contrast, the DHA diet down-regulated (P<?005) PKCθ signalling by moderately affecting the membrane liquid order at the immunological synapse, suggesting the potential contribution of the other major n-3 PUFA components of FO, including EPA.</P>
3
Sacubitril/Valsartan in Asian Patients with Heart Failure with Reduced Ejection Fraction

Pooja Dewan,John J.V. McMurray,Kieran F. Docherty 대한심장학회 2019 Korean Circulation Journal Vol.49 No.6
The Prospective comparison of Angiotensin Receptor-neprilysin inhibitor (ARNI) with Angiotensin converting enzyme inhibitor (ACEI) to Determine Impact on Global Mortality and morbidity in Heart Failure (HF) trial (PARADIGM-HF) showed that adding a neprilysin inhibitor (sacubitril) to a renin-angiotensin system blocker (and other standard therapy) reduced morbidity and mortality in ambulatory patients with chronic HF with reduced ejection fraction (HFrEF). In PARADIGM-HF, valsartan combined with sacubitril (a so-called ARNI) was superior to the current gold standard of an ACEI, specifically enalapril, reducing the risk of the primary composite outcome of cardiovascular (CV) death or first HF hospitalization by 20% and all-cause death by 16%. Following the results of PARADIGM-HF, sacubitril/valsartan was approved by American and European regulatory authorities for the treatment of HFrEF. The burden of HF in Asia is substantial, both due to the huge population of the region and as a result of increasing CV risk factors and disease. Both the prevalence and mortality associated with HF are high in Asia. In the following review, we discuss the development of sacubitril/valsartan, the prototype ARNI, and the available evidence for its efficacy and safety in Asian patients with HFrEF.