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Surgical Management of Rhinosinusitis in Onco-Hematological Patients
Stefano Di Girolamo,Sara Mazzone,Roberta Di Mauro,Piergiorgio Giacomini,Maria Cantonetti 대한이비인후과학회 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.4
Objectives. In onco-hematological diseases, the incidence of paranasal sinuses infection dramatically increase and requires a combination of medical and surgical therapy. Balloon dilatation surgery (DS) is a minimally invasive, tissue preserv- ing procedure. The study evaluates the results of DS for rhinosinusitis in immunocompromised patients. Methods. A retrospective chart review was conducted in 110 hematologic patients with rhinosinusitis. Twenty-five patients were treated with DS technique and 85 patients with endoscopic sinus surgery (ESS). We considered the type of an- esthesia and the extent of intra- and postoperative bleeding. Patients underwent Sino-Nasal Outcome Test (SNOT-20) to evaluate changes in subjective symptoms and global patient assessment (GPA) questionnaire to value patient satis- faction. Results. Local anesthesia was employed in 8 cases of DS and in 15 of ESS. In 50 ESS patients, an anterior nasal packing was placed and in 12 cases a repacking was necessary. In the DS group, nasal packing was required in 8 cases and in 2 cases a repacking was placed (P=0.019 and P=0.422, respectively). The SNOT-20 change score showed significant improvement of health status in both groups. However the DS group showed a major improvement in 3 voices: need to blow nose, runny nose, and facial pain/pressure. The 3-month follow-up GPA questionnaire showed an higher sat- isfaction of DS group. Conclusion. Balloon DS represents a potentially low aggressive treatment and appears to be relatively safe and effective in onco-hematologic patients. All these remarks may lead the surgeon to consider a larger number of candidates for sur- gical procedure.
Rosa Ragone,Pasquale Crupi,Sara Piccinonna,Carlo Bergamini,Francesco Mazzone,Francesco P. Fanizzi,Francesco P. Schena,Donato Antonacci 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.3
There is increasing interest in development of methods for wine characterization to guarantee traceability and product safety. Metabolomics represents a valuable tool to trace the metabolic fingerprint of complex mixtures. Wines from 22 pure varieties (autochthonous from Southern Italy and grown in the same area of Apulia) were genetically identified and metabolically characterized using both NMR and HPLC-MS. NMR associated with chemometrics was used to identify amino acid (proline, alanine, and tyrosine), organic acid (malic, lactic, acetic, and succinic acids), alcohol (2-phenylethanol), sugar (sucrose), and polyphenol (gallic acid) contents. Minor components of wines were determined using HPLC-MS analyses. Wines showed potential health-promoting effects with good amounts of phenolic compounds. In particular, consistent levels of trans-resveratrol and flavonoids were found in Negro Amaro, Uva di Troia, Ancellotta, and Montepulciano wines.
Neuropeptide Regulation of Signaling and Behavior in the BNST
Kash, Thomas L.,Pleil, Kristen E.,Marcinkiewcz, Catherine A.,Lowery-Gionta, Emily G.,Crowley, Nicole,Mazzone, Christopher,Sugam, Jonathan,Hardaway, J. Andrew,McElligott, Zoe A. Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.1
Recent technical developments have transformed how neuroscientists can probe brain function. What was once thought to be difficult and perhaps impossible, stimulating a single set of long range inputs among many, is now relatively straight-forward using optogenetic approaches. This has provided an avalanche of data demonstrating causal roles for circuits in a variety of behaviors. However, despite the critical role that neuropeptide signaling plays in the regulation of behavior and physiology of the brain, there have been remarkably few studies demonstrating how peptide release is causally linked to behaviors. This is likely due to both the different time scale by which peptides act on and the modulatory nature of their actions. For example, while glutamate release can effectively transmit information between synapses in milliseconds, peptide release is potentially slower [See the excellent review by Van Den Pol on the time scales and mechanisms of release (van den Pol, 2012)] and it can only tune the existing signals via modulation. And while there have been some studies exploring mechanisms of release, it is still not as clearly known what is required for efficient peptide release. Furthermore, this analysis could be complicated by the fact that there are multiple peptides released, some of which may act in contrast. Despite these limitations, there are a number of groups making progress in this area. The goal of this review is to explore the role of peptide signaling in one specific structure, the bed nucleus of the stria terminalis, that has proven to be a fertile ground for peptide action.
Neuropeptide Regulation of Signaling and Behavior in the BNST
Thomas L. Kash,Kristen E. Pleil,Catherine A. Marcinkiewcz,Emily G. Lowery-Gionta,Nicole Crowley,Christopher Mazzone,Jonathan Sugam,J. Andrew Hardaway,Zoe A. McElligott 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.1
Recent technical developments have transformed how neuroscientists can probe brain function. What was once thought to be difficult and perhaps impossible, stimulating a single set of long range inputs among many, is now relatively straight-forward using optogenetic approaches. This has provided an avalanche of data demonstrating causal roles for circuits in a variety of behaviors. However, despite the critical role that neuropeptide signaling plays in the regulation of behavior and physiology of the brain, there have been remarkably few studies demonstrating how peptide release is causally linked to behaviors. This is likely due to both the different time scale by which peptides act on and the modulatory nature of their actions. For example, while glutamate release can effectively transmit information between synapses in milliseconds, peptide release is potentially slower [See the excellent review by Van Den Pol on the time scales and mechanisms of release (van den Pol, 2012)] and it can only tune the existing signals via modulation. And while there have been some studies exploring mechanisms of release, it is still not as clearly known what is required for efficient peptide release. Furthermore, this analysis could be complicated by the fact that there are multiple peptides released, some of which may act in contrast. Despite these limitations, there are a number of groups making progress in this area. The goal of this review is to explore the role of peptide signaling in one specific structure, the bed nucleus of the stria terminalis, that has proven to be a fertile ground for peptide action.