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- 저자 : Mazza, (검색결과 13 건)
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Mazza, Fabio,Vulcano, Alfonso Techno-Press 2007 Wind and Structures, An International Journal (WAS Vol.10 No.3
The insertion of steel braces has become a common technique to limit the deformability of steel framed buildings subjected to wind loads. However, when this technique is inadequate to keep floor accelerations within acceptable levels of human comfort, dampers placed in series with the steel braces can be adopted. To check the effectiveness of braces equipped with viscoelastic (VEDs) or friction dampers (FRDs), a numerical investigation is carried out focusing attention on a three-bay fifteen-storey steel framed building with K-braces. More precisely, three alternative structural solutions are examined for the purpose of controlling wind-induced vibrations: the insertion of additional diagonal braces; the insertion of additional diagonal braces equipped with dampers; the insertion of both additional diagonal braces and dampers supported by the existing K-braces. Additional braces and dampers are designed according to a simplified procedure based on a proportional stiffness criterion. A dynamic analysis is carried out in the time domain using a step-by-step initial-stress-like iterative procedure. Along-wind loads are considered at each storey assuming the time histories of the wind velocity, for a return period $T_r=5$ years, according to an equivalent wind spectrum technique. The behaviour of the structural members, except dampers, is assumed linear elastic. A VED and an FRD are idealized by a six-element generalized model and a bilinear (rigid-plastic) model, respectively. The results show that the structure with damped additional braces can be considered, among those examined, the most effective to control vibrations due to wind, particularly the floor accelerations. Moreover, once the stiffness of the additional braces is selected, the VEDs are slightly more efficient than the FRDs, because they, unlike the FRDs, dissipate energy also for small amplitude vibrations.
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Fabio Mazza,Alfonso Vulcano 한국풍공학회 2007 Wind and Structures, An International Journal (WAS Vol.10 No.3
The insertion of steel braces has become a common technique to limit the deformability of steel framed buildings subjected to wind loads. However, when this technique is inadequate to keep floor accelerations within acceptable levels of human comfort, dampers placed in series with the steel braces can be adopted. To check the effectiveness of braces equipped with viscoelastic (VEDs) or friction dampers (FRDs), a numerical investigation is carried out focusing attention on a three-bay fifteen-storey steel framed building with K-braces. More precisely, three alternative structural solutions are examined for the purpose of controlling wind-induced vibrations: the insertion of additional diagonal braces; the insertion of additional diagonal braces equipped with dampers; the insertion of both additional diagonal braces and dampers supported by the existing K-braces. Additional braces and dampers are designed according to a simplified procedure based on a proportional stiffness criterion. A dynamic analysis is carried out in the time domain using a step-by-step initial-stress-like iterative procedure. Along-wind loads are considered at each storey assuming the time histories of the wind velocity, for a return period Tr=5 years, according to an equivalent wind spectrum technique. The behaviour of the structural members, except dampers, is assumed linear elastic. A VED and an FRD are idealized by a six-element generalized model and a bilinear (rigid-plastic) model, respectively. The results show that the structure with damped additional braces can be considered, among those examined, the most effective to control vibrations due to wind, particularly the floor accelerations. Moreover, once the stiffness of the additional braces is selected, the VEDs are slightly more efficient than the FRDs, because they, unlike the FRDs, dissipate energy also for small amplitude vibrations.
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Alberto Mazza,Mariaceleste Nicoletti,Salvatore Lenti,Gioia Torin,Gianluca Rigatelli,Marzia Pellizzato,Andrea Fratter 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.1
The effectiveness of statins in the primary and secondary prevention of cardiovascular (CV) diseases has been widely proven. However, the onset of adverse events associated with their use prevents to achieve the therapeutic targets recommended by the guidelines (GL) for the management of dyslipidemia. In the event of statin intolerance, the GL recommend to use bile acid sequestrants, fibrates, and ezetimibe in monotherapy, but their benefits in improving lipid pattern are quite modest. This study aims at evaluating the effectiveness and safety of a nutraceutical compound (NC) associated with ezetimibe (EZE) on the lipid profile in statin-intolerant patients with moderate-to-high CV risk. Ninety-six statin-intolerant hypertensive and hypercholesterolemic subjects treated pharmacologically with EZE 10 mg daily were randomized in open label (n = 48) to take for 3 months a NC containing Monacolin-K (MK), Berberine Hydrochloride (BC), t-Resveratrol (RES), Quercetin (QUER), and Chromium (CH) in the form of a gastro-resistant tablet that improves enteric bioaccessibility and bioavailability of these substances. The control group (n = 48) took only EZE in monotherapy at the same dosage; both groups followed a standardized lipid-lowering diet. The total serum cholesterol (TC), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), triglycerides (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine phosphokinase (CPK) levels were compared at the follow-up in both groups using Student's t-test. TC and LDL levels reduced in both groups, but were lower in the group treated with EZE + NC (−25.9% vs. −15%, P < .05 and −38.7% vs. −21.0%, P < .05, respectively). No changes were observed in either group regarding a decrease in TG (−9.4% vs. −11.7%, NS) and an increase in HDLC (+4.2% vs. +1.1%, NS). The AST, ALT, and CPK levels increased in the group treated with the EZE + NC compared to the control group, but were still within the acceptable range. There was no difference concerning the lipid-lowering treatment between gender, and no patient withdrew from the study. In the short term, the EZE + NC combination therapy is well tolerated and effective in improving TC and LDLC levels in statin-intolerant patients with moderate-to-high CV risk.
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Yvelise Ferro,Elisa Mazza,Mariantonietta Salvati,Emma Santariga,Salvatore Giampà,Rocco Spagnuolo,Patrizia Doldo,Roberta Pujia,Adriana Coppola,Carmine Gazzaruso,Arturo Pujia,Tiziana Montalcini 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.2
Background: A growing number of functional foods have been proposed to reduce cholesterol levels and the Portfolio Diet, which includes a combination of plant sterols, fibres, nuts, and soy protein, reduces low density lipoprotein cholesterol (LDL-C) from 20% to30% in individuals with hyperlipidaemia. In this pilot study, the aim was to investigate whether a Mediterranean Diet incorporating anew and simple combination of cholesterol-lowering foods, excluding soy and nuts (namely the Portfolio-Mediterranean Diet), wouldreduce LDL-C levels, in the short-term, better than a Mediterranean Diet plus a sterol-enriched yogurt or a Mediterranean Diet alone. Methods: We retrospectively evaluated 24 individuals on a Portfolio-Mediterranean Diet and 48 matched individuals on a Mediterranean Diet with or without a sterol-enriched yogurt (24 each groups) as controls. Results: At follow-up (after 48±12 days), we observed an LDL reduction of 21±4, 23±4, and 44±4 mg/dL in the MediterraneanDiet alone, Mediterranean Diet plus yogurt and Portfolio-Mediterranean Diet respectively (P<0.001). Conclusion: A Portfolio-Mediterranean Diet, incorporating a new combination of functional foods such as oats or barley, plant sterols,chitosan, and green tea but not soy and nuts, may reduce LDL of 25% in the short term in individuals with hypercholesterolemia.
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Glinka, Juan,Diaz, Federico,Alva, Augusto,Mazza, Oscar,Claria, Rodrigo Sanchez,Ardiles, Victoria,Santibanes, Eduardo de,Pekolj, Juan,Santibanes, Martin de The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.3
Purpose: Pancreatic cancer (PC) has not changed overall survival in recent years despite therapeutic efforts. Surgery with curative intent has shown the best long-term oncological results. However, 80%-85% of patients with these tumors are unresectable at the time of diagnosis. In those patients, first therapeutic attempts are minimally invasive or surgical procedures to alleviate symptoms. The addition of radiotherapy (RT) to standard chemotherapy, ergo chemoradiation, in patients with locally advanced pancreatic cancer (LAPC) is still controversial. The study aims to compare outcomes in patients with a double bypass surgery due to LAPC treated or not with RT. Materials and Methods: A retrospective cohort study of patients with double bypass for LAPC were registered and divided into two groups: treated or not with postoperative RT. Baseline characteristics, postoperative complications, those related to RT and their relation to the main event (mortality) were compared. Results: Seventy-four patients were included. Surgical complications between the groups did not offer significant differences. Complications related to RT were mostly mild, and 86% of patients completed the treatment. Overall survival at 1 and 2 years for patients in the exposed group was 64% and 35% vs. 50% and 28% in the non-exposed group, respectively (p = 0.11; power 72%; hazard ratio = 0.53; 95% confidence interval, 0.24-1.18). Conclusion: We observed a tendency for survival improvement in patients with postoperative RT. However, we've not had enough power to demonstrate this difference, possibly due to the small sample size. It is indispensable to develop randomized and prospective trials to guide more specific treatment lines in this patients.
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Juan Glinka,Federico Diaz,Augusto Alva,Oscar Mazza,Rodrigo Sanchez Claria,Victoria Ardiles,Eduardo de Santibañ,es,Juan Pekolj,Martí,n de Santibañ,es 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.3
Purpose: Pancreatic cancer (PC) has not changed overall survival in recent years despite therapeutic efforts. Surgery with curative intent has shown the best long-term oncological results. However, 80%–85% of patients with these tumors are unresectable at the time of diagnosis. In those patients, first therapeutic attempts are minimally invasive or surgical procedures to alleviate symptoms. The addition of radiotherapy (RT) to standard chemotherapy, ergo chemoradiation, in patients with locally advanced pancreatic cancer (LAPC) is still controversial. The study aims to compare outcomes in patients with a double bypass surgery due to LAPC treated or not with RT. Materials and Methods: A retrospective cohort study of patients with double bypass for LAPC were registered and divided into two groups: treated or not with postoperative RT. Baseline characteristics, postoperative complications, those related to RT and their relation to the main event (mortality) were compared. Results: Seventy-four patients were included. Surgical complications between the groups did not offer significant differences. Complications related to RT were mostly mild, and 86% of patients completed the treatment. Overall survival at 1 and 2 years for patients in the exposed group was 64% and 35% vs. 50% and 28% in the non-exposed group, respectively (p = 0.11; power 72%; hazard ratio = 0.53; 95% confidence interval, 0.24–1.18). Conclusion: We observed a tendency for survival improvement in patients with postoperative RT. However, we’ve not had enough power to demonstrate this difference, possibly due to the small sample size. It is indispensable to develop randomized and prospective trials to guide more specific treatment lines in this patients.
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( Yvelise Ferro ),( Ilaria Car ),( Elisa Mazza ),( Francesco Provenzano ),( Carmela Colica ),( Carlo Torti ),( Stefano Romeo ),( Arturo Pujia ),( Tiziana Montalcini ) 대한간학회 2017 Clinical and Molecular Hepatology(대한간학회지) Vol.23 No.3
Background/Aims: Although the detrimental effects of several dietary components on the promotion of non- alcoholic fatty liver disease are well known, no studies have assessed the role of dietary vitamin B6. Moreover, studies on the associations between dietary components or body composition indices and liver steatosis assessed by transient elastography are rare. Our aim was to identify the nutritional factors and anthropometric parameters associated with liver steatosis. Methods: In this cross-sectional study, we enrolled 168 individuals (35% obese) who underwent a liver steatosis assessment by Controlled Attenuation Parameter measurement and nutritional assessment. Results: Tertiles of vitamin B6 intake were positively associated with hepatic steatosis (B=1.89, P =0.026, confidence interval [CI] 0.03-0.80) as well as with triglycerides, glucose, alanine aminotransferase (ALT), and body mass index . In obese individuals, after multivariable analysis, the Controlled Attenuation Parameter score was still associated with triglycerides, ALT, and total protein intake (B=0.56, P=0.01, CI 0.10-1.02). Participants in tertile I (low intake) had a lower Controlled Attenuation Parameter than those in tertile III (P =0.01). Conclusions: We found a positive association between hepatic steatosis or Controlled Attenuation Parameter score and vitamin B6/total protein intake, probably related to the high intake of meat. Vitamin B6 might have a pathogenic role related to the increase of hepatic steatosis. (Clin Mol Hepatol 2017;23:249-259)
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