Investigation of the optical potentials for the 40Ca(α,t)41Sc reaction at 40 MeV

Mazumder U. K.,Somadder A.,Hoque E.,Das S. K. 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.80 No.7

The 40Ca(α,t)41Sc reaction has been studied at a 40 MeV incident energy. The angular distributions of the eight states of the reaction are analyzed using the full finite-range (FFR) distorted-wave Born approximation (DWBA) for both the bound and the unbound states of the 41Sc nucleus using the normal optical, Michel and molecular potentials. The spectroscopic factors that have been extracted for the three optical potentials are compared with the previous local zero-range (LZR) and local finite-range (LFR) calculations of the 40Ca(α,t)41Sc reaction for the normal optical potential. The χ2 values of all the potentials for different l transfers are calculated to estimate the quality of fits. The present analysis shows that the Michel and the molecular potentials fit the data more satisfactorily than the normal optical potential.

Evaluation of in vitro antioxidant activities of the methanol extracts of Glinus oppositifolius and Trianthema decandra

Mazumder, Upal Kanti,Gupta, Malaya,Haldar, Pallab Kanti,Kandar, Chandi Charan Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.3

Glinus oppositifolius and Trianthema decandra belonging to the Ficoidaceae family were commonly used by tribal peoples for the treatment of liver disorders and cancer. The preliminary phytochemical screening of those plants showed the presence of flavonoids, terpenoids, tannins and saponins. The aim of this study was to evaluate the in vitro antioxidant activities of the methanol extracts of Glinus oppositifolius (MEGO) and Trianthema decandra (METD). The antioxidative capacities of MEGO and METD were determined by the following four complementary assay; DPPH radical scavenging assay, superoxide anion generation by xanthine-xanthine Oxidase assay, hydroxyl radical scavenging assay and $Fe^{2+}$-ascorbate induced by lipid peroxidation assay. The $IC_{50}$ values of the both extracts were calculated from the inhibition curve. The $IC_{50}$ MEGO and METD in DPPH, superoxide anion, hydroxyl radical scavenging and lipid peroxidation assay are 1.85, 7.31, 13.95, 22.82 and 2.21, 9.78, 14.87, 19.76 ${\mu}g/ml$ respectively. Both the extracts exhibited a significant antioxidant effects.

Hydroxycoumarin OT-55 kills CML cells alone or in synergy with imatinib or Synribo: Involvement of ER stress and DAMP release

Mazumder, Aloran,Lee, Jin-Young,Talhi, Oualid,Cerella, Claudia,Chateauvieux, Sé,bastien,Gaigneaux, Anthoula,Hong, Che Ry,Kang, Hyoung Jin,Lee, Youngjo,Kim, Kyu-Won,Kim, Dong-Wook,Shin, Hee-Young Elsevier 2018 Cancer letters Vol.438 No.-

<P><B>Abstract</B></P> <P>We synthetized and investigated the anti-leukemic potential of the novel cytostatic bis(4-hydroxycoumarin) derivative OT-55 which complied with the Lipinski's rule of 5 and induced differential toxicity in various chronic myeloid leukemia (CML) cell models. OT-55 triggered ER stress leading to canonical, caspase-dependent apoptosis and release of danger associated molecular patterns. Consequently, OT-55 promoted phagocytosis of OT-55-treated CML cells by both murine and human monocyte-derived macrophages. Moreover, OT-55 inhibited tumor necrosis factor α-induced activation of nuclear factor-кB and produced synergistic effects when used in combination with imatinib to inhibit colony formation <I>in vitro</I> and Bcr-Abl<SUP>+</SUP> patient blast xenograft growth in zebrafish. Furthermore, OT-55 synergized with omacetaxine in imatinib-resistant KBM-5 R cells to inhibit the expression of Mcl-1, triggering apoptosis. In imatinib-resistant K562 R cells, OT-55 triggered necrosis and blocked tumor formation in zebrafish in combination with omacetaxine.</P> <P><B>Highlights</B></P> <P> <UL> <LI> OT-55 inhibits cell proliferation and viability in CML. </LI> <LI> OT-55 induces ER stress, ecto-CRT, ecto-ERp57, ATP and HMGB1 elease leading to immunogenic cell death. </LI> <LI> OT-55-treated CML cells are phagocytosed by macrophages. </LI> <LI> OT-55 synergizes with imatinib in CML. </LI> <LI> OT-55 synergizes with Synribo in Bcr-Abl mutated CML. </LI> </UL> </P>

Natural scaffolds in anticancer therapy and precision medicine

Mazumder, Aloran,Cerella, Claudia,Diederich, Marc Elsevier 2018 BIOTECHNOLOGY ADVANCES Vol.36 No.6

<P>The diversity of natural compounds is essential for their mechanism of action. The source, structures and structure activity relationship of natural compounds contributed to the development of new classes of chemotherapy agents for over 40 years. The availability of combinatorial chemistry and high-throughput screening has fueled the challenge to identify novel compounds that mimic natures chemistry and to predict their macromolecular targets. Combining conventional and targeted therapies helped to successfully overcome drug resistance and prolong disease-free survival. Here, we aim to provide an overview of preclinical investigated natural compounds alone and in combination to further improve personalization of cancer treatment.</P>

In situ CCVD synthesis of carbon nanotubes within zeolite crystal coated porous ceramic foam

MAZUMDER, Sangram,ZHAO, Wei,PARK, Jung Gyu,SARKAR, Naboneeta,KIM, Sukyoung,KIM, Ik Jin CERAMIC SOC OF JAPAN 2015 JOURNAL- CERAMIC SOCIETY JAPAN Vol.123 No.1438

<P>In this study, consolidated zeolite crystal coated porous ceramic foams containing a large quantity of carbon nanotubes (CNTs) within micro-metre sized pores were prepared. An alumina-silica porous ceramic body, having an average pore size of less than 100 mu m, was produced by the direct foaming technique. Well-shaped zeolite crystals having an average size of 180 nm were synthesized and homogeneously coated on the porous ceramic body by an in situ process. An Fe-supported zeolite/ceramic matrix, which is used for CNT synthesis, was prepared using ion-exchange by immersing the zeolite-coated porous ceramic body into FeCl2 aqueous solution. The CNTs were synthesized by a catalytic chemical vapour deposition (CCVD) process for four different reaction times. Both acicular-shaped and randomly bundled networks of multi-walled carbon nanotubes (MWCNTs) were synthesized using these different reaction times. Moreover, the yield of CNTs produced showed a tendency to increase with increasing reaction time. (C)2015 The Ceramic Society of Japan. All rights reserved.</P>

Effect of Levels of Concentrate Supplement on Live Weight Gain and Carcass Characteristics in Sheep on Restricted Grazing

Mazumder, M.A.R.,Hossain, M.M.,Akhter, S. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.1

Sixteen local sheep (8 male + 8 female) of about six months old with average live weight 10.78 $({\pm}1.11)$ kg were allocated into four treatments. The treatments (T) are : $T_0$ = Restricted grazing without concentrate; $T_1$, $T_2$ and $T_3$ = Grazing + 100, 200 and 300 g concentrate per sheep daily. Live weight of grazing (7.30 hrs daily) sheep was recorded in each week. The uncastrated male sheep were slaughtered for carcass and non-carcass parameters. Statistically significant (p < 0.05) differences were observed in live weight gain (g/day) among the treatments ($T_0=15.71$; $T_1=22.66$; $T_2 =32.66$ and $T_3=40.47$). The dressing % were : ($T_0=32.75$, $T_1=38.50$, $T_2=36.90 $ and $T_3=37.75$). The warm carcass weight represented 37.21% of live weight. Significant (p < 0.01) correlation were observed for live weight with carcass weight (r = 0.99) and dressing % (r = 0.88). Concentrate supplement increase live weight gain in sheep on grazing. Live weight is a good indicator to assess carcass characteristics.

In-silico characterization and structure-based functional annotation of a hypothetical protein from Campylobacter jejuni involved in propionate catabolism

Mazumder, Lincon,Hasan, Mehedi,Rus’d, Ahmed Abu,Islam, Mohammad Ariful Korea Genome Organization 2021 Genomics & informatics Vol.19 No.4

Campylobacter jejuni is one of the most prevalent organisms associated with foodborne illness across the globe causing campylobacteriosis and gastritis. Many proteins of C. jejuni are still unidentified. The purpose of this study was to determine the structure and function of a non-annotated hypothetical protein (HP) from C. jejuni. A number of properties like physiochemical characteristics, 3D structure, and functional annotation of the HP (accession No. CAG2129885.1) were predicted using various bioinformatics tools followed by further validation and quality assessment. Moreover, the protein-protein interactions and active site were obtained from the STRING and CASTp server, respectively. The hypothesized protein possesses various characteristics including an acidic pH, thermal stability, water solubility, and cytoplasmic distribution. While alpha-helix and random coil structures are the most prominent structural components of this protein, most of it is formed of helices and coils. Along with expected quality, the 3D model has been found to be novel. This study has identified the potential role of the HP in 2-methylcitric acid cycle and propionate catabolism. Furthermore, protein-protein interactions revealed several significant functional partners. The in-silico characterization of this protein will assist to understand its molecular mechanism of action better. The methodology of this study would also serve as the basis for additional research into proteomic and genomic data for functional potential identification.

SEM and ESEM techniques used for analysis of asphalt binder and mixture: A state of the art review

Mazumder, Mithil,Ahmed, Raju,Wajahat Ali, Ahmed,Lee, Soon-Jae Elsevier 2018 Construction and Building Materials Vol.186 No.-

<P><B>Abstract</B></P> <P>This paper reviews techniques and analyses performed on microstructure of the asphalt binder and mixture using Scanning Electron Microscopy (SEM) and Environmental Scanning Electron Microscopy (ESEM). An extensive insight on the SEM and ESEM principle and techniques, different sample preparation methods and instrument techniques for capturing the micromorphology of the binder and mixture have been presented. The difference between SEM and ESEM in terms of challenges and limitation regarding the analysis of bitumen has been explained. In depth discussions on the surface properties, fracture morphology, network structure, dispersion, phase morphology, structural and strength mechanism, adhesion, deform mechanism and the formation of fibril structures of asphalt binder and mixture have been provided. Recommendations and useful techniques are outlined for future research to obtain any correlation between the microstructure and physical/rheological properties of the asphalt binder/mixture.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This paper reviews techniques and analyses performed on microstructure of the asphalt binder and mixture using Scanning Electron Microscopy (SEM) and Environmental Scanning Electron Microscopy (ESEM). </LI> <LI> The principle and techniques of SEM and ESEM, different sample preparation methods, used instrument techniques for different binder and mixture types, limitation of instrument and their effects on network structure, deformation mechanism, dispersion, phase and formation of fibril structures are discussed in this paper. </LI> </UL> </P>

Indication of colder condition within Holocene period in a freshwater lake in Vestfold Hills area, East Antarctica region

Abhijit Mazumder,Pawan Govil,Rasik Ravindra,Neloy Khare 한국지질과학협의회 2013 Geosciences Journal Vol.17 No.2

We represent Paleoenvironmetal condition of Vestfold Hills region, based on the relative abundance of a single diatom species Fragilariopsis curta, a dominating sea-ice taxon. Increase in relative abundance of F. curta in a core from Vestfold Hills representing Holocene climatic history before 3820 years BP and 5560 year BP indicates the prevalence of colder climatic conditions, as this species is known to prefer the icier condition to thrive.

Mechanical properties of in-situ growth carbon nanotubes reinforced porous ceramics by direct foaming

Sangram Mazumder,박정규,Naboneeta Sarkar,이기성,Bijay Basnet,김익진 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.12

This paper reports the formation of carbon nanotubes (CNTs) reinforced porous Al2O3 ceramics by a novel combination ofthree processes. Porous ceramics are developed using direct foaming. Cobalt nanoparticles as catalysis agents aresimultaneously synthesized and dispersed by colloidal process to prepare the suitable catalyst material for carbon nanotubessynthesis. The catalytic chemical vapour deposition (CCVD) technique is used to directly synthesize CNTs within the porousceramics and the effect of growth time on the morphology, crystallinity and yield of CNTs are investigated. Hertzianindentations are used to evaluate the damage behaviour under constrained loading conditions. The mechanical behaviour fromindentation load-displacement curves is compared according to CNTs contents in the samples.