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Mayank Joshi,Sambit Prasanajit Naik,Asmita Mohanty,Arun Bhadran,Drishya Girishbai,Swakangkha Ghosh 한국지질과학협의회 2023 Geosciences Journal Vol.27 No.2
On April 28 2021, an earthquake of MW 6.4 occurred near Sonitpur, Assam, India. The epicenter was 43 km away from Tezpur, Assam with a focal depth of 34 km. The National Center for Seismology (NCS), Delhi reported the maximum intensity of MMI–V whereas the United States Geological Survey (USGS) reported the maximum intensity of MMI–VII. Preliminary reports suggest a reverse slip component for the earthquake, which occurred close to the previously reported Kopili fault. This fault is the cause of two damaging earthquakes in the past i.e., 1869 Cachar earthquake and the 1943 earthquake. The April 28 2021, Sonitpur earthquake caused widespread liquefaction, building damage, and lateral spreading as far as 90 km from the epicenter. The present study reports preliminary damages and ground effects observed soon after the earthquake along with a comparative analysis with previously reported damages around the area during the historical earthquakes. The farthest reported liquefaction occurred during the earthquake was plotted with other case studies which were well in agreement with the previous literature. The possible reason for the extensive liquefaction and ground cracks is inferred to be due to site amplification within a sedimentary basin. Therefore, the occurrence of the 2021Sonitpur, Assam earthquake emphasizes the seismic hazard scenario for the Brahmaputra Basin and Bengal Basin, which further requires more detailed study in terms of paleoseismology, liquefaction hazard zonation and seismic hazard assessment. In addition, the damages to the buildings highlight the implementation of proper building codes considering the liquefaction hazard zonation map for the study area.
Synthesis and Anticancer Activity of Some Novel 1,3-Diaryl/heteroarylprop-2-en-1-one Derivatives
Mayank Kinger,Jeong Hoon Park,Jun Young Lee,김상욱 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.8
In the present investigation, a series of some novel 1,3-diaryl/heteroarylprop-2-en-1-one derivatives (3a-j) have been synthesized and evaluated for their in vitro cytotoxicity against three cancer cell lines, two hepatocarcinoma cell lines HUH-7, Hep-3b and one leukemia cancer cell line MOLT-4. Based on these results, structure-activity relationship (SAR) was studied on modification of R1 and R2 to identify the compound with maximum potency. Amongst the compounds, 3b and 3d strongly inhibited the growth of Hep-3b and MOLT- 4 cells with IC50 value of 3.39 and 3.63 μM respectively. The results obtained from the inhibitory study had further been supported by the reactive oxygen species (ROS) measurement using flow cytometry in MOLT-4 cells. These observations collectively reveal that compounds comprising 1,3-diarylprop-2-en-1-one framework with pyrazole ring at position-3 and heteroaryl/aryl substituents at position-1 can be used as promising anticancer agents.
The Challenge of Designing Stroke Trials That Change Practice: MCID vs. Sample Size and Pragmatism
Mayank Goyal,Rosalie McDonough,Marc Fisher,Johanna Ospel 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.1
Randomized controlled trials (RCT) are the basis for evidence-based acute stroke care. For an RCT to change practice, its results have to be statistically significant and clinically meaningful. While methods to assess statistical significance are standardized and widely agreed upon, there is no clear consensus on how to assess clinical significance. Researchers often refer to the minimal clinically important difference (MCID) when describing the smallest change in outcomes that is considered meaningful to patients and leads to a change in patient management. It is widely accepted that a treatment should only be adopted when its effect on outcome is equal to or larger than the MCID. There are however situations in which it is reasonable to decide against adopting a treatment, even when its beneficial effect matches or exceeds the MCID, for example when it is resource-intensive and associated with high costs. Furthermore, while the MCID represents an important concept in this regard, defining it for an individual trial is difficult as it is highly context specific. In the following, we use hypothetical stroke trial examples to review the challenges related to MCID, sample size and pragmatic considerations that researchers face in acute stroke trials, and propose a framework for designing meaningful stroke trials that have the potential to change clinical practice.
Variant anatomy of the buccal nerve
Mayank Patel,Joe Iwanaga,Shogo Kikuta,Rod J. Oskouian,R. Shane Tubbs 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.1
Knowledge of the anatomy and variations of the nerves of the oral cavity is important to surgeons who operate this region. Herein, we report a rare case of a buccal nerve with two distinct roots. The anatomy of this case and its clinical applications is discussed.
Mayank Patel,Abhishek Jha,Tatjana Antic,Sarah M. Nielsen,Jane E. Churpek,Alexander Ling,Karel Pacak 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.5
Although rare, a metastatic renal cell carcinoma could present with 68Ga-DOTATATE avidity. A 66-year-old man with von Hippel-Lindau syndrome (VHL) presented with 68Ga-DOTATATE uptake in the pancreatic head, splenic hilar region, and multiple osseous sites, including the right lateral portion of the T9 vertebrae. Biopsy of the T9 lesion confirmed metastatic renal cell carcinoma. Various VHL-associated cancers may display 68Ga-DOTATATE avidity, which can change and guide clinical decisions for the patient.
An improved privacy preservation technique in health-cloud
Mayank Kumar Kundalwal,Kakali Chatterjee,Ashish Singh 한국통신학회 2019 ICT Express Vol.5 No.3
In today’s cloud computing environment, health-cloud preserve the person specific sensitive information for several purposes such as bio-medical research, health insurance companies, medical data analysis, etc. When any authorized person access these clouds, the released data should not compromise any individuals’ privacy and it remains useful as well. In the health-cloud system, the data must be released in such a way that any individuals’ identity cannot be revealed. The database management system alone cannot ensure any individual’s privacy. The Access Control (AC) models are also not able to protect the data from indirect access or multiple queries. To remove such issues inference control is one of the techniques which ensures the data confidentiality from indirect data access. In this paper, we have proposed a hybrid technique which includes two different inference control techniques, query set size restriction and k-anonymity to ensure individuals’ privacy. A query set size restriction is used to prevent the sensitive data from inference attacks, whereas k-anonymity is implemented to protect the data from linking attacks. Both these techniques reach a certain privacy level with satisfactory data utilization. We have also generated a rule set to increase the privacy of healthcare data.
EXPERIMENTAL STUDY ON DEVELOPMENT OF EX-VESSEL DEBRIS BED WITH INCLINED BOTTOM SURFACE
Mayank Modak,Hyun Sun Park 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.12
In case of severe accidents in light water reactors (LWRs), the coolability of relocated corium from the reactor vessel is a significant safety issue. The failure in cooling and stabilizing of the molten core in the containment vessel can threaten the integrity of the containment boundary. Current study is an extension to the previous work of Kim et al. (2016) in which the previous model for development of an ex-vessel corium debris bed will be modified by incorporating the effect of bottom surface inclinations. This paper reports the experimental part of the study describing the spreading of the debris bed in terms of two-phase flow, debris injection parameters, and bottom inclined surface geometrical parameters is discussed.