Hydroxychloroquine, Interleukin-6 Receptor Antagonists and Corticoid Treatments of Acute COVID-19 Infection: Psychiatric Symptoms and Mental Disorders 4 Months Later

Matthieu Gasnier(Matthieu Gasnier ),Walid Choucha(Walid Choucha ),David Montani(David Montani ),Nicolas Noël(Nicolas Noël ),Céline Verstuyft(Céline Verstuyft ),Francois Radiguer(Francois Radiguer ),Xa 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4

Objective: Psychiatric symptoms and mental disorders are common after Coronavirus Disease-19 (COVID-19). Some drugs used to treat acute COVID-19 have psychiatric side effects. We assessed the psychiatric symptoms and mental disorders of patients treated for acute COVID-19 with hydroxychloroquine (HCQ), interleukin-6 receptor antagonists (anti-IL-6), and corticoids (CTC). Methods: We evaluated 177 patients in a day hospital 4 months after acute infection. Results: In a multivariate analysis, HCQ was associated with significant anxiety symptoms (odds ratio [OR] = 5.9, 95% confidence interval [95% CI] = 1.8−20.0, p = 0.003) and mental disorders (OR = 4.1, 95% CI = 1.2−13.9, p = 0.02). In a bivariate analysis with propensity matched cohorts, HCQ was associated with significant anxiety symptoms (9 patients [50.0%] with significant symptoms in the HCQ group versus 15 [20.1%] in the control group, OR = 3.8, 95% CI = 1.3−11.3, p = 0.01). Anti-IL-6 and CTC were not associated with significant psychiatric symptoms or mental disorders. Conclusion: We recommend monitoring psychiatric symptoms, especially anxiety, in patients treated with HCQ during COVID-19 infection. Further studies with larger samples and prospective assessments are needed to confirm our results.

Ductile Fracture of TRIP780 Sheets under Multi-axial Loading

Matthieu Dunand,Dirk Mohr 한국소성가공학회 2010 기타자료 Vol.2010 No.6

The loading path to fracture in multi-axial experiments is determined through hybrid experimental-numerical analysis. A series of multi-axial fracture experiments are carried out on specimens extracted from TRIP780 steel sheets. It involves three different types of full-thickness specimens: notched tensile specimens, tensile specimens with central hole and disc specimens for punch testing. The experimental program characterizes the onset of fracture over a wide range of stress states between uniaxial tension and equi-biaxial tension. Using an anisotropic Hill’48 plasticity model, the evolution of local stress and strain fields is evaluated through detailed finite element analysis of each experiment. The accuracy of this hybrid experimental-numerical loading history identification is evaluated by comparing the local digital image correlation measurements with the FE predictions. In particular, uncertainties affecting the identification of the state of loading at the onset of fracture are quantified.

External Anal Sphincter Fatigability: An Electromyographic and Manometric Study in Patients With Anorectal Disorders

( Matthieu Grasland ),( Nicolas Turmel ),( Camille Pouyau ),( Camille Leroux ),( Audrey Charlanes ),( Camille Chesnel ),( Frédérique Le Breton ),( Samer Sheikh-ismael ),( Gérard Amarenco ),( Claire He 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.1

Background/Aims External anal sphincter (EAS) plays an important role in fecal and gas voluntary continence. Like every muscle, it can be affected by repeated efforts due to fatigability (physiological response) and/or fatigue (pathological response). No standardized fatiguing protocol and measure method to assess EAS fatigability has existed. The aim is to test a simple, standardized protocol for fatiguing and measuring EAS fatigability and fatigue to understand better the part of EAS fatigability in the pathophysiology of fecal incontinence. Methods Patients with anorectal disorders evaluated with anorectal manometry were included. They had to perform 10 repetitions of maximum voluntary contraction (MVC) of 20 seconds. Measurement was made with an anorectal manometry catheter and a surface recording electromyography (EMG). The primary outcome was the difference in EMG root mean square between the first and the last MVC. Secondary outcomes were differences in other EMG and manometry parameters between the first and the last MVC. Difficulties and adverse effects were recorded. Results Nineteen patients underwent the fatiguing protocol. All patients completed the entire protocol and no complications were found. No difficulty was declared by the examiner. A significant decrease in root mean square was found between the first and last MVC (0.01020 ± 0.00834 mV vs 0.00661 ± 0.00587 mV; P = 0.002), in maximum anal pressure area under the curve of continuous recordings of anal pressure and mean and total EMG power (P < 0.05). Conclusions This protocol is simple and minimally invasive to measure EAS fatigue and fatigability. We highlighted a fatigue of EAS in many patients with anorectal disorders. (J Neurogastroenterol Motil 2021;27:119-126)

PREPARATION OF PLASTIC SCINTILLATORS AND THEIR APPLICATION TO GAS DETECTION

Matthieu HAMEL 대한방사선방어학회 2019 대한방사선방어학회 학술발표회 논문요약집 Vol.2019 No.04

Anterior Cruciate Ligament Reconstruction: The Long Road from Science to Clinical Relevance

( Matthieu Ollivier ) 대한슬관절학회 2018 대한슬관절학회지 Vol.30 No.2

A New Look on an Old Issue: Comprehensive Review of Neurotransmitter Studies in Cerebrospinal Fluid of Patients with Schizophrenia and Antipsychotic Effect on Monoamine’s Metabolism

Matthieu Gasnier,Pierre Ellul,Marion Plaze,Pierre Abdel Ahad 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.3

Neurotransmitters metabolism has a key role in the physiopathology of schizophrenia as demonstrated by studies measuring monoamine metabolites in patient’s cerebrospinal fluid (CSF) since the beginning of the antipsychotic use. This comprehensive review aims to understand the anomalies of CSF monoamines in schizophrenia and their correlation with clinical and paraclinical features. We also review the influence of antipsychotic treatment on CSF monoamines and discuss the connection with metabolic and inflammatory processes. Studies comparing CSF homovanillic acid (HVA) levels between patients and controls are miscellaneous, due to the heterogeneity of samples studies. However, low HVA is associated with more positive symptoms and a poorer outcome and negatively correlated with brain ventricle size. Based on humans and animals’ studies, antipsychotic treatments increase HVA during the first week of administration and decrease progressively over the time with a fall-off after withdrawal. 5‐hydroxyindolacetic acetic acid levels do not seem to be different in the patient’s CSF compared to controls. Considering metabolic co-factors of neurotransmitters synthesis, there is evidence supporting an increase of kynurenic acid in the CSF of patients with schizophrenia. Few studies explore folate metabolism in CSF. Literature also emphasizes the relationship between folate metabolism, inflammation and monoamine’s metabolism. Those results suggest that the CSF monoamines could be correlated with schizophrenia symptoms and treatment outcome. However, further studies, exploring the role of CSF monoamines as biomarkers of disease severity and response to treatment are needed. They should assess the antipsychotic prescription, inflammatory markers and folate metabolism as potential confounding factors.

Stress Fracture after Arthroscopic Lesser Trochanter Resection: Diagnosis and Therapy

Baert Matthieu,Vandekerckhove Maxence,Vanlommel Jan 대한고관절학회 2024 Hip and Pelvis Vol.36 No.1

We report on the case of a 52-year-old female who presented with a stress fracture after undergoing an endoscopic resection of the lesser trochanter in ischiofemoral impingement, which was resistant to maximal conservative treatment. To the best of our knowledge, this complication has not been previously described. Non–weight-bearing and intravenous alendronic acid were prescribed for management. No additional surgery was required. The patient was pain free with the ability to perform sports on the same level as before and had no complaints.

High-Performance Nanowire Hydrogen Sensors by Exploiting the Synergistic Effect of Pd Nanoparticles and Metal-Organic Framework Membranes

Weber, Matthieu,Kim, Jae-Hun,Lee, Jae-Hyoung,Kim, Jin-Young,Iatsunskyi, Igor,Coy, Emerson,Drobek, Martin,Julbe, Anne,Bechelany, Mikhael,Kim, Sang Sub American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.40

<P>Herein, we report the fabrication of hydrogen gas sensors with enhanced sensitivity and excellent selectivity. The sensor device is based on the strategic combination of ZnO nanowires (NWs) decorated with palladium nanoparticles (Pd NPs) and a molecular sieve metal-organic framework (MOF) nanomembrane (ZIF-8). The Pd NPs permit the sensors to reach maximal signal responses, whereas the ZIF-8 overcoat enables for an excellent selectivity. Three steps were employed for the fabrication: (i) coating of a miniaturized sensor with vapor-grown ZnO NWs, (ii) decoration of these NWs with Pd NPs by atomic layer deposition, and (iii) partial solvothermal conversion of the tuned NWs surface to ZIF-8 nanomembrane. The microstructure and composition investigations of the ZIF-8/Pd/ZnO nanostructured materials confirmed the presence of both metallic Pd NPs and uniform ZIF-8 thin membrane layer. The integration of these nanomaterials within a miniaturized sensor device enabled the assessment of their performance for H<SUB>2</SUB> detection at concentrations as low as 10 ppm in the presence of various gases such as C<SUB>6</SUB>H<SUB>6</SUB>, C<SUB>7</SUB>H<SUB>8</SUB>, C<SUB>2</SUB>H<SUB>5</SUB>OH, and CH<SUB>3</SUB>COCH<SUB>3</SUB>. Remarkably high-response signals of 3.2, 4.7, and 6.7 (<I>R</I><SUB>a</SUB>/<I>R</I><SUB>g</SUB>) have been measured for H<SUB>2</SUB> detection at only 10, 30, and 50 ppm, whereas no noticeable response toward other tested gases was detected, thus confirming the excellent H<SUB>2</SUB> selectivity obtained with such a sensor design. The results obtained showed that the performance of gas sensors toward H<SUB>2</SUB> gas can be greatly increased by both the addition of Pd NPs and the use of ZIF-8 coating, acting as a molecular sieve membrane. Furthermore, the presented strategy could be extended toward the sensing of other species by a judicious choice of both the metallic NPs and MOF materials with tuned properties for specific molecule detection, thus opening a new avenue for the preparation of highly selective sensing devices.</P> [FIG OMISSION]</BR>

Verification of photon transport capability of UNIST Monte Carlo code MCS

Lemaire, Matthieu,Lee, Hyunsuk,Ebiwonjumi, Bamidele,Kong, Chidong,Kim, Wonkyeong,Jo, Yunki,Park, Jinsu,Lee, Deokjung Elsevier 2018 Computer physics communications Vol.231 No.-

<P><B>Abstract</B></P> <P>A photon transport capability has been implemented and verified in the Monte Carlo code MCS of Ulsan National Institute of Science and Technology for the purpose of radiation shielding studies. The MCS photon fixed-source mode simulates the transport of photons between 1 keV and 20 MeV for all elements from hydrogen to fermium. The specific physics for the main four photo-atomic reactions (Rayleigh scattering, Compton scattering, photoelectric effect and pair production) and three secondary processes of photon production (positron–electron annihilation, atomic relaxation and electron/positron bremsstrahlung) are reviewed. Verification results against Monte Carlo codes MCNP6.1 and SERPENT2.1.29 are presented. The verification cases include the comparison of energy distributions of photon flux in an infinite medium, of spatial distributions of photon flux in a cylinder, of the spatial distribution of photon body-equivalent dose in a spent nuclear fuel transport cask, and of photon KERMA (Kinetic Energy Released per MAss) in photon detector calibration geometries. Good calculation/calculation agreement is observed overall, with some marked differences in the detailed photon flux comparison at given energy ranges traced back to differences in photon physics implementation. MCS can from now on be applied for the purpose of advanced photon studies and corresponding validation against experimental shielding benchmarks will follow in the future.</P>

Multi-physics steady-state analysis of OECD/NEA modular high temperature gas-cooled reactor MHTGR-350

Lemaire, Matthieu,Lee, Hyunsuk,Tak, Nam-il,Lee, Hyun Chul,Lee, Deokjung Atomic Energy Society of Japan 2017 Journal of nuclear science and technology Vol.54 No.6

<P>This paper presents the application results of MCS/GAMMA+ to multi-physics analysis of OECD/NEA modular high temperature gas-cooled reactor (MHTGR) benchmark Phase I Exercise 3. It is a part of international R&D efforts lead by the Next Generation Nuclear Plant (NGNP) US project to improve the neutron-physics and thermal-fluid simulation of (high temperature gas-cooled reactors) HTGRs, one of the next generations of safer nuclear reactors. Accurate and validated analysis tools are indeed a crucial requirement for safety analysis and licensing of nuclear reactors. To guide this effort, a numerical benchmark on the MHTGR was created by the NGNP project and formally approved in 2012 for international participation by the OECD/NEA. The benchmark defines a common set of exercises and the comparison of solutions obtained with different analysis tools is expected to improve the understanding of simulation methods for HTGRs. The coupled neutronics/thermal-fluid solution presented in this paper was obtained with the neutron transport Monte Carlo code MCS developed by Ulsan National Institute of Science and Technology and the thermal-fluid code GAMMA+ developed by Korean Atomic Energy Research Institute. The purpose of this paper is to present the GAMMA+/MCS coupled system, the calculation methodology, and the obtained solutions.</P>