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Towards defi ning a simplifi ed procedure for COTS system-on-chip TID testing
Stefano Di Mascio,Alessandra Menicucci,Gianluca Furano,Tomasz Szewczyk,Luigi Campajola,Francesco Di Capua,Andrea Lucaroni,Marco Ottavi 한국원자력학회 2018 Nuclear Engineering and Technology Vol.50 No.8
The use of System-on-Chip (SoC) solutions in the design of on-board data handling systems is animportant step towards further miniaturization in space. However, the Total Ionizing Dose (TID) andSingle Event Effects (SEE) characterization of these complex devices present new challenges that areeither not fully addressed by current testing guidelines or may result in expensive, cumbersome testconfigurations. In this paper we report the test setups, procedures and results for TID testing of a SoCmicrocontroller both using standard 60Co and low-energy protons beams. This paper specifically pointsout the differences in the test methodology and in the challenges between TID testing with proton beamand with the conventional gamma ray irradiation. New test setup and procedures are proposed whichare capable of emulating typical mission conditions (clock, bias, software, reprogramming, etc.) whilekeeping the test setup as simple as possible at the same time.
Sensitized formation of oxidatively generated damage to cellular DNA by UVA radiation
Cadet, Jean,Douki, Thierry,Ravanata, Jean-Luc,Di Mascio, Paolo Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.7
The survey is aimed at critically reviewing information on the UVA-mediated oxidative reactions to cellular components with emphasis on DNA as the result of mostly photosensitized pathways. It appears clearly that UVA radiation is relatively much more efficient than UVB photons in inducing oxidative processes. The main UVA-induced oxidative degradation pathways of DNA are reported and discussed mechanistically. They are mostly rationalized in terms of a major contribution of singlet molecular oxygen ($^1O_2$) and to a lesser extent of hydroxyl radical (${\cdot}OH$), that in the latter case originates from Fenton-type reactions. This leads to the predominant formation of 8-oxo-7,8-dihydroguanine together with smaller amounts of oxidized pyrimidine bases and DNA strand breaks in UVA-irradiated cells.