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Masaya Igase,Sakuya Inanaga,Shoma Nishibori,Kazuhito Itamoto,Hiroshi Sunahara,Yuki Nemoto,Kenji Tani,Hiro Horikirizono,Munekazu Nakaichi,Kenji Baba,Satoshi Kambayashi,Masaru Okuda,Yusuke Sakai,Masashi 대한수의학회 2024 Journal of Veterinary Science Vol.25 No.1
Background: The anti-programmed death 1 (PD-1) antibody has led to durable clinical responses in a wide variety of human tumors. We have previously developed the caninized anti-canine PD-1 antibody (ca-4F12-E6) and evaluated its therapeutic properties in dogs with advance-staged oral malignant melanoma (OMM), however, their therapeutic effects on other types of canine tumors remain unclear. Objective: The present clinical study was carried out to evaluate the safety profile and clinical efficacy of ca-4F12-E6 in dogs with advanced solid tumors except for OMM. Methods: Thirty-eight dogs with non-OMM solid tumors were enrolled prospectively and treated with ca-4F12-E6 at 3 mg/kg every 2 weeks of each 10-week treatment cycle. Adverse events (AEs) and treatment efficacy were graded based on the criteria established by the Veterinary Cooperative Oncology Group. Results: One dog was withdrawn, and thirty-seven dogs were evaluated for the safety and efficacy of ca-4F12-E6. Treatment-related AEs of any grade occurred in 13 out of 37 cases (35.1%). Two dogs with sterile nodular panniculitis and one with myasthenia gravis and hypothyroidism were suspected of immune-related AEs. In 30 out of 37 dogs that had target tumor lesions, the overall response and clinical benefit rates were 6.9% and 27.6%, respectively. The median progression-free survival and overall survival time were 70 days and 215 days, respectively. Conclusions: The present study demonstrated that ca-4F12-E6 was well-tolerated in non-OMM dogs, with a small number of cases showing objective responses. This provides evidence supporting large-scale clinical trials of anti-PD-1 antibody therapy in dogs.
산삼 체세포배양근의 에탄올 농도 및 추출 시간에 따른 최적 추출조건
Masaya Nakamura,Jong Hwan Ra,Ju Sung Kim 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.05
Background : From 2000 years ago, Panax ginseng is identified as precious pharmaceutical plant. Depend on growing environment, the name would be vary. For instance, it is called "mountain cultured ginseng (jangnoesam)" which is artificially grown ginseng, "Cultured ginseng (jaebaesam)" which refer to the ginseng grown in the forest, and lastly "Wild ginseng (sansam)" which inhabits in deep mountain. The main active compounds in the Panax ginseng is called ginsenoside and many researches have been performing in biological field. However, most studies focus on functional ability of ginseng. In this study, to seek the suitable extraction condition and antioxidant activity, cell cultured Panax ginseng was extracted according to different ethanol concentration and extraction time. Methods and Results : To establish the optimal extraction condition, the sample was pulverized into 500 μm and added 10% (v/v), 30% (v/v), 50% (v/v), 70% (v/v) and, 90% (v/v) EtOH. After that, the samples are extracted in different time by ultrasonic bath (Power sonic 520, Hwashin Co., Korea). The extracts was filtered by Whatman No. 2 filtering paper. Eventually, the saponin was separated by n-butanol as the ginsenoside, the combination of terpenoid and sugar. The extraction yield of 90% cell cultured panax ginseng EtOH extract was 7.36±0.33%, which was the lowest extraction yield and simultaneously, 10% EtOH extract showed 1.8 times more yield that of 90% EtOH extract. The saponin extraction yield revealed 10% and 70% EtOH extract showed 1.64±0.06% and 3.13±0.08%, respectively. Conclusion : The suitable extraction yield in cell cultured panax ginseng and saponin were evaluated by different extraction condition such as ethanol concentration and extraction time. As a result, when 10% EtOH was applied as solvent, the yield was doubles of 90% EtOH extract. As ethanol became high concentrations, the extraction yield was gradually increased. Among them, crude saponin, the main active compounds in Panax ginseng was extracted the most by 70% EtOH and that value was 3.13±0.08%.
Computational Time Reduction of Fractal Image Coding by Using Low Density Parity Check Code
Masaya Ohta,Yuma Masui,Katsumi Yamashita 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
In this report, the fractal image coding is improved. The computational time for encoding is reduced by using LDPC (low density parity check) code which is one of error correcting techniques and needs few computational time. From some numerical experiments to evaluate its performance, the proposed method achieves to reduce computational time compared with conventional fractal image coding.
Left Subclavian Artery Occlusion: Femoro-Axillary Artery Retrograde Bypass
Masaya Nakashima,Hideaki Kobayashi,Masayoshi Kobayashi 대한혈관외과학회 2016 Vascular Specialist International Vol.32 No.2
The treatment tactics for subclavian artery occlusion include the more commonly used endovascular therapy rather than surgical intervention. We present a case of a 61-year-old woman with dialysis-dependent chronic renal failure who experienced left finger necrosis in the left upper extremity. To salvage the limb, we performed femoral-to-axillary (fem-ax) artery bypass using an autologous saphenous vein graft. However, 10 months later, she experienced coldness in the left forearm. Angiography revealed chronic total occlusion of the venous bypass. Despite emergent thrombectomy, redo fem-ax artery bypass operation was performed using a prosthetic graft. Upper limb salvage can be achieved by fem-ax artery retrograde bypass. The treatment tactics for subclavian artery occlusion include the more commonly used endovascular therapy rather than surgical intervention. We present a case of a 61-year-old woman with dialysis-dependent chronic renal failure who experienced left finger necrosis in the left upper extremity. To salvage the limb, we performed femoro-axillary (fem-ax) artery bypass using an autologous saphenous vein graft. However, 10 months later, she experienced coldness in the left forearm. Angiography revealed chronic total occlusion of the venous bypass. Despite emergent thrombectomy, redo fem-ax artery bypass operation was performed using a prosthetic graft. Upper limb salvage can be achieved by fem-ax artery retrograde bypass.
Effect analysis of incense on autonomic nerve activity and improvement of working task
Masaya Kawada,Shin’ichi Tachiwana,Kazushi Iwasa,Takehiko Iwasa,Keisuke Suzuki 대한인간공학회 2016 대한인간공학회 학술대회논문집 Vol.2016 No.06
In recent years, the effects of fragrance on the mental and physical condition are being discussed. It has been reported that the fragrance has the effects to reduce mental stress and to improve the mental concentration on human. All of these reports investigated the effects of aroma oil on human. Therefore, in this study, we investigated the effects of the incense on the mental and physical condition. The incense is traditional fragrance in Japan. We analyzed the activation of sympathetic nerve in terms of CSI (Cardiac Sympathetic Index) and the activation of parasympathetic nerve in terms of CVI (Cardiac Vagal Index) in order to investigate the fluctuation of autonomic nerve system. At the same time, we analyzed oxyHb concentration which is an index of active state of brain in order to investigate concentration on the mental task. Through these investigations, it was clarified that the incense has the effect to make mind and body relaxed at rest because value of CVI increased when incense was presented. It was suggested that the incense has the effect to quiet down brain because brain blood flow decreased when incense was presented at rest. In addition, it was clarified that the incense improve mental concentration because the performance of work improved when incense was presented. Furthermore, we confirmed the possibility that the restraint of the fluctuation of the sympathetic nerve is related to improvement of the mental concentration because the fluctuation of the value of CSI becomes small at the time of work when incense was presented.
A Filter Model as Input Section of the ITD Model for Sound Source Localization in the Barn Owl
Masaya KYOUGOKU,Yoshifumi SEKINE 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
The sound localization of barn owls with respect to horizontal and vertical direction is based on analysis of the interaural differences in arrival time and the intensity of sound, respectively. So, we are studying the sound source localization system of birds in the field of engineering. In this paper we suggest a filter model, which analyzes algorithms in bird’s brains. The model outputs waveforms with information (time or intensity difference) by using a hardware neuron model. As a result, it is shown in the filter model that by changing the parameters of the synapse, information can be selected from the mixed signal.
Catheter-Directed Thrombolysis for Persistent Sciatic Artery Presenting with Acute Limb Ischemia
Masaya Nakashima,Masayoshi Kobayashi 대한혈관외과학회 2022 Vascular Specialist International Vol.38 No.4
Persistent sciatic artery (PSA) is a rare congenital peripheral artery disorder that is usually detected incidentally on computed tomographic examination. PSA can also cause iliac aneurysm and acute thromboembolism, which are potentially associated with rest pain, claudication, and limb-threatening ischemia. Patients with PSA and leg ischemia should be treated with revascularization and appropriate management of PSA aneurysm. The authors often choose emergent bypass surgery or endovascular intervention for aneurysmal rupture and acute lower-extremity arterial occlusion. This report describes an emergency procedure using catheter-based thrombolysis for acute limb ischemia in a patient with PSA.