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RISS 인기검색어
- 검색키워드
- 저자 : Masawo Kakemi (검색결과 3 건)
- 무료
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- 유료
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Iwanaga, Kazunori,Kawabata, Yutaka,Miyazaki, Makoto,Kakemi, Masawo 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
The purpose of this study was to quantitatively clarify the effect of alky-chain length of a triglyceride in an emulsion on the partitioning of highly lipophilic compounds into the lymph fluid after their oral administration. Highly lipophilic anthraquinone derivatives were orally administered in emulsions to rats. Emulsions composed of long-, medium-, and short-chain triglycerides (LCT, MCT, and SCT emulsions, respectively) were used. The concentrations of the compounds in plasma and lymph fluid were periodically determined and their partitioning to the lymph was calculated using a mathematical model. Intestinal absorption of all compounds was enhanced and the plasma concentrations of the compounds were found to be in the following order: LCT emulsion>MCT emulsion>SCT emulsion. The amounts of each compound recovered in the lymph were not in agreement with their lipophilicity. Quantitative analysis revealed that the partitioning of the compounds to the lymph may be determined by the solubility of the compound in the triglyceride in the form of an emulsion and the amount of triglyceride transferred to the lymph fluid. These results suggest a possibility that the amount of a compound absorbed via the lymph route after oral administration can be quantitatively controlled by the formulations.
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Kazunori Iwanaga,Yutaka Kawabata,Makoto Miyazaki,Masawo Kakemi 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
The purpose of this study was to quantitativelyclarify the effect of alky-chain length of a triglyceride in anemulsion on the partitioning of highly lipophilic compoundsinto the lymph fluid after their oral administration. Highly lipophilic anthraquinone derivatives were orallyadministered in emulsions to rats. Emulsions composed oflong-, medium-, and short-chain triglycerides (LCT, MCT,and SCT emulsions, respectively) were used. The concentrationsof the compounds in plasma and lymph fluidwere periodically determined and their partitioning to thelymph was calculated using a mathematical model. Intestinalabsorption of all compounds was enhanced and theplasma concentrations of the compounds were found to bein the following order: LCT emulsion[MCT emulsion[SCT emulsion. The amounts of each compound recoveredin the lymph were not in agreement with their lipophilicity. Quantitative analysis revealed that the partitioning of thecompounds to the lymph may be determined by the solubilityof the compound in the triglyceride in the form of anemulsion and the amount of triglyceride transferred to thelymph fluid. These results suggest a possibility that theamount of a compound absorbed via the lymph route afteroral administration can be quantitatively controlled by theformulations.
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Kazunori Iwanaga,Kaori Arimune,Makoto Miyazaki,Makio Shibano,Masahiko Taniguchi,Kimiye Baba,Masawo Kakemi 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.6
While a great deal of information of drug-drug interactions is known, most concern Western drugs. Relatively little is known of the interactions between Western drugs and traditional drugs such as Kampo extract medicines (Japanese medicines modified from traditional Chinese medicines). This study investigated the effects of the marketed Kampo extract medicines, Senkyu-cha-cho-san and Sokei-kakketsu-to, on the intestinal absorption of CYP or P-glycoprotein (P-gp) in vivo. Midazolam, a CYP3A substrate drug, or talinolol, a P-gp substrate drug, was orally administered to rats with each of these Kampo extract medicines. Senkyu-cha-chosan or Sokei-kakketsu-to administered as a standard regimen did not obviously affect Cmax and area under the curve (AUC) of midazolam, although both Kampo extract medicines contained notopterol, a potent CYP3A4 inhibitor in vitro. The results implied a lack of potent drug–drug interactions between both Kampo extract medicines and CYP3A substrate drugs. Concomitant administration of each Kampo extract medicine unexpectedly showed the tendency to decrease Cmax and AUC of talinolol. Decreased intestinal absorption of talinolol might be caused, not by the inhibition of P-gp, but by the inhibition of organic anion transporting peptides by both Kampo extract medicines.
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