http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Masanobu Yoshida,Eiji Hiraki,Mutsuo Nakaoka 전력전자학회 2003 JOURNAL OF POWER ELECTRONICS Vol.3 No.4
This paper presents a novel prototype of three-phase voltage source type zero voltage soft-switching inverter with the auxiliary resonant snubbers suitable for high-power applications with IGBT power module packages in order to reduce their switching power losses as well as electromagnetic conductive and radiative noises. A proposed single inductor-assisted resonant AC link snubber circuit topology as one of some auxiliary resonant commutation snubbers developed previously to achieve the zero voltage soft-switching (ZVS) for the three-phase voltage source type sinewave PWM inverter operating under the instantaneous space voltage vector modulation is originally demonstrated as compared with the other types of resonant AC link snubber circuit topology. In addition to this, its operation principle and unique features are described in this paper Furthermore, the practical basic operating performances of the new conceptual Instantaneous space voltage vector modulation resonant AC link snubber-assisted three-phase voltage source type soft-switching PWM inverter using IGBT power module packages are evaluated and discussed on the basis of switching voltage and current waveforms, output line to line voltage quality, power loss analysis, actual power conversion efficiency and electromagnetic conductive and radiative noises from an experimental point of view, comparing with those of conventional three-phase voltage source hard-switching PWM inverter using IGBT power modules.
Masanobu Haraguchi,Masahiko Noguchi,Masamitsu Fujii,Masuo Fukui,Toshihiro Okamoto 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.47 No.1
We have developed a two-dimensional finite-difference time-domain (FDTD) program for simulating nonlinear optical response of nano metal cylinders coated with a Kerr material which is related to localized surface plasmons. In FDTD calculations, we have employed cylindrical coordinates.For comparison, linear and nonlinear results obtained by the local subcell method in rectangular coordinates will be given. Finally, we have obtained an optical bistability of the field intensity at a nano Ag cylinder coated with a Kerr material.
Masanobu Tsubaki,Tomoya Takeda,Takuya Matsuda,Akihiro Kimura,Remi Tanaka,Sakiko Nagayoshi,Tadafumi Hoshida,Kazufumi Tanabe,Shozo Nishida 생화학분자생물학회 2023 BMB Reports Vol.56 No.2
Chronic myeloid leukemia (CML) has a markedly improvedprognosis with the use of breakpoint cluster region-abelson 1(BCR-ABL1) tyrosine kinase inhibitors (BCR-ABL1 TKIs). However,approximately 40% of patients are resistant or intolerantto BCR-ABL1 TKIs. Hypoxia-inducible factor 1α (HIF-1α) is ahypoxia response factor that has been reported to be highlyexpressed in CML patients, making it a therapeutic target forBCR-ABL1 TKI-sensitive CML and BCR-ABL1 TKI-resistant CML. In this study, we examined whether HIF-1α inhibitors inducecell death in CML cells and BCR-ABL1 TKI-resistant CML cells. We found that echinomycin and PX-478 induced cell death inBCR-ABL1 TKIs sensitive and resistant CML cells at similar concentrationswhile the cell sensitivity was not affected with imatinibor dasatinib in BCR-ABL1 TKIs resistant CML cells. In addition,echinomycin and PX-478 inhibited the c-Jun N-terminalkinase (JNK), Akt, and extracellular-regulated protein kinase 1/2(ERK1/2) activation via suppression of BCR-ABL1 and Met expressionin BCR-ABL1 sensitive and resistant CML cells. Moreover,treatment with HIF-1α siRNA induced cell death by inhibitingBCR-ABL1 and Met expression and activation of JNK,Akt, and ERK1/2 in BCR-ABL1 TKIs sensitive and resistant CMLcells. These results indicated that HIF-1α regulates BCR-ABL andMet expression and is involved in cell survival in CML cells,suggesting that HIF-1α inhibitors induce cell death in BCR-ABL1TKIs sensitive and resistant CML cells and therefore HIF-1α inhibitorsare potential candidates for CML treatment.
Masanobu Shinozuka,Pai H. Chou,김세환,Hong Rok Kim,Debasis Karmakar,Lu Fei 국제구조공학회 2010 Smart Structures and Systems, An International Jou Vol.6 No.5
This paper presents the results of a pilot study and verification of a concept of a novel methodology for damage detection and assessment of water distribution system. The unique feature of the proposed noninvasive methodology is the use of accelerometers installed on the pipe surface, instead of pressure sensors that are traditionally installed invasively. Experimental observations show that a sharp change in pressure is always accompanied by a sharp change of pipe surface acceleration at the corresponding locations along the pipe length. Therefore, water pressure-monitoring can be transformed into acceleration-monitoring of the pipe surface. The latter is a significantly more economical alternative due to the use of less expensive sensors such as MEMS (Micro-Electro-Mechanical Systems) or other acceleration sensors. In this scenario, monitoring is made for Maximum Pipe Acceleration Gradient (MPAG) rather than Maximum Water Head Gradient (MWHG). This paper presents the results of a small-scale laboratory experiment that serves as the proof of concept of the proposed technology. The ultimate goal of this study is to improve upon the existing SCADA (Supervisory Control And Data Acquisition) by integrating the proposed non-invasive monitoring techniques to ultimately develop the next generation SCADA system for water distribution systems.