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      • SCIESCOPUSKCI등재

        ON THE GALACTIC SPIRAL PATTERNS: STELLAR AND GASEOUS

        MARTOS MARCO,YANEZ MIGUEL,HERNANDEZ XAVIER,MORENO EDMUNDO,PICHARDO BARBARA The Korean Astronomical Society 2004 Journal of The Korean Astronomical Society Vol.37 No.4

        The gas response to a proposed spiral stellar pattern for our Galaxy is presented here as calculated via 2D hydrodynamic calculations utilizing the ZEUS code in the disk plane. The locus is that found by Drimmel (2000) from emission profiles in the K band and at 240 ${\mu}m$. The self-consistency of the stellar spiral pattern was studied in previous work (see Martos et al. 2004). It is a sensitive function of the pattern rotation speed, $\Omega$p, among other parameters which include the mass in the spiral and its pitch angle. Here we further discuss the complex gaseous response found there for plausible values of $\Omega$p in our Galaxy, and argue that its value must be close to $20 km s^{-l}\;kpc^{-1}$ from the strong self-consistency criterion and other recent, independent studies which depend on such parameter. However, other values of $\Omega$p that have been used in the literature are explored to study the gas response to the stellar (K band) 2-armed pattern. For our best fit values, the gaseous response to the 2-armed pattern displayed in the K band is a four-armed pattern with complex features in the interarm regions. This response resembles the optical arms observed in the Milky Way and other galaxies with the smooth underlying two-armed pattern of the old stellar disk populations in our interpretation. The complex gaseous response appears to be related to resonances in stellar orbits. Among them, the 4:1 resonance is paramount for the axisymmetric Galactic model employed, and the set of parameters explored. In the regime seemingly proper to our Galaxy, the spiral forcing appears to be marginally strong in the sense that the 4:1 resonance terminates the stellar pattern, despite its relatively low amplitude. In current work underway, the response for low values of $\Omega$p tends to remove most of the rich structure found for the optimal self-consistent model and the gaseous pattern is ring-like. For higher values than the optimal, more features and a multi-arm structure appears.

      • KCI등재
      • SCIESCOPUSKCI등재
      • KCI등재

        A New Allelic Variant in the PANK2 Gene in a Patient with Incomplete HARP Syndrome

        Myriam Ley Martos,María Jesús Salado Reyes,Rosario Marín Iglesias,Carmen Gutiérrez Moro,Manuel Lubián Gutiérrez,Lorena Estepa Pedregosa 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.3

        Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive disease characterized by iron deposition in the basal ganglia, primarily in the globus pallidus and substantia nigra. Common clinical manifestations include dystonia, parkinsonism, spasticity, neuropsychiatric disorders and retinal degeneration. PKAN is included in the spectrum of disorders related to neurodegeneration with brain iron accumulation (NBIA), which includes eleven diseases.

      • KCI등재

        Dephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular Functions

        Lee, Jihye,Adelmant, Guillaume,Marto, Jarrod A.,Lee, Dong-Hyun Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.8

        Deleted in breast cancer-1 (DBC1) contributes to the regulation of cell survival and apoptosis. Recent studies demonstrated that DBC is phosphorylated at Thr454 by ATM/ATR kinases in response to DNA damage, which is a critical event for p53 activation and apoptosis. However, how DBC1 phosphorylation is regulated has not been studied. Here we show that protein phosphatase 4 (PP4) dephosphorylates DBC1, regulating its role in DNA damage response. PP4R2, a regulatory subunit of PP4, mediates the interaction between DBC1 and PP4C, a catalytic subunit. PP4C efficiently dephosphorylates pThr454 on DBC1 in vitro, and the depletion of PP4C/PP4R2 in cells alters the kinetics of DBC1 phosphorylation and p53 activation, and increases apoptosis in response to DNA damage, which are compatible with the expression of the phosphomimetic DBC-1 mutant (T454E). These suggest that the PP4-mediated dephosphorylation of DBC1 is necessary for efficient damage responses in cells.

      • KCI등재

        Enhancement of Soft Soil Behaviour by using Floating Bottom Ash Columns

        Razieh Moradi,Aminaton Marto,Ahmad Safuan A Rashid,Mohammad Moeen Moradi,Abideen Adekunle Ganiyu,Mohamad Hafeezi Abdullah,Suksun Horpibulsuk 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.6

        The current disposition worldwide is for sustainable construction, and the application of by-products is one of the ways to achieve it. In this research, bottom ash was used as a substitute material in a granular column to decrease settlement and enhance the bearing capacity of soft soil. Bottom ash is a derivate of the coal burning process, it has similar engineering properties to sand and fine gravel. A set of reduced scale physical modelling tests were performed on floating bottom ash columns to assess the improvement in the bearing capacity of the composite ground. The results clearly showed that the bearing capacity of the model soil was greatly improved with the installation of bottom ash column sand. There was an obvious enhancement of the load capacity of the granular columns when they were encased. The usage of bottom ash instead of aggregate or sand for granular columns will reduce the project cost and it aligns with the goal of sustainable construction development.

      • THE ROLE OF BRANDS IN ONLINE VS. OFFLINE CHANNELS

        Óscar González-Benito,Mercedes Martos-Partal,Sonia San Martín 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

        This article addresses the potential of reputable brands to overcome the lack of tangibility that characterizes the process of e-commerce. In a sequential argument, the authors propose that (1) the brand becomes more important in online than in offline channels, as a consequence of the intangibility or lack of physical contact in online purchasing processes; (2) the limitations associated with the need for touch and the lack of access to the physical product during the buying process does not have equal importance across all product categories; and (3) the role of the brand in online channels thus is more relevant if the product category is associated with a higher need for touch. To provide empirical evidence regarding the hypotheses, we performed an experiment that combined three treatments: (1) leader versus non-leader brand, (2) online versus offline channel, and (3) product category with higher versus lower need for touch. We show that the most recognized brands exert a positive effect on product evaluations, regardless of the technical characteristics and other objective product attributes. This advantage may be greater in online channels, though only for product categories for which the lack of physical contact with the product during the purchase process is an important limitation. In such cases, brand associations can compensate for intangibility during purchase.We also confirm that the product categories differ in their level of need for touch and the extent to which consumers desire physical contact with the product during the buying process. These results demonstrate that building strong brands is a key competitive advantage for manufacturers. Brand reputation becomes even more crucial when selling products in electronic channels, at least if the product itself entails a greater need for touch prior to purchase. For such products, strong brands can make up for the intangibility of e-commerce, so this effort represents a key competitive strategy in such channels. Moreover, leading brands can leverage their competitive advantage to enhance their performance in the increasingly prominent realm of e-commerce. E-retailers need to make careful decisions regarding the configuration of the assortment, taking into account the nature of the product category. They should strengthen their focus on developing highly recognizable brands, because the lack of physical contact is an important purchase inhibitor in this shopping channel. However, the brand criterion may be less important if the choice between online and offline shopping is not particularly affected by the opportunity to touch or feel the products.

      • “TO BE OR NOT TO BE" IS NOT THE ONLY QUESTION IN ADVERTISING FLYERS: HOW AND WHERE BEING ALSO MATTERS

        Álvaro Garrido Morgado,Óscar González Benito,Mercedes Martos Partal 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07

        This study focuses on analyzing the variables that moderate the effectiveness of the advertising flyers, one of the most used tools in retailing, to improve product sales. In previous literature, studies analyzed and confirmed the effectiveness of flyers to increase the traffic store, the general store sales or the synergistic effect of them to highlight and improve the effectiveness of promotions. Despite their confirmed effectiveness on these issues and their large use by retailers and manufacturers, it is missed studies that analyze the variables that may moderate their effectiveness on the sales of the products displayed on it. In fact, only Zhang et al. (2009) tried to analyze if the location in which the product is displayed have an influence on its effectiveness. According to them, they obtained inconclusive results due to their sample size. This study, considering the consumer’s cognitive process, analyzes how the presentation and the position of the product in flyers have an effect on their effectiveness to increase the displayed product’s sales. The results show that (i) the special signage on a displayed product in flyers increases their effectiveness to increase displayed product’s sales, and (ii) not only being highlighted increases the effect of the flyer, but that the product positioning affects decisively. For example, some locations -such as the cover, the top of the pages and areas on the left-, increase the visibility of the product and are more effective than other positions to increase displayed product’s sales. These results are in line with previous studies that indicate the importance of the directionality of reading to capture the customer’s attention in other environments. In sum, as happens inside the store or in the shelf, depending on if the product is displayed with a special signage or in an area where the customers pay more attention due to the standard cognitive process, the effectiveness of the flyers increase. Thus, retailers and manufacturers must consider how and where to be in the flyer, not just being.

      • QUALITY PERCEPTION INFLUENCES ON THE EFFECTIVENESS OF COMMERCIAL STIMULI

        Alvaro Garrido-Morgado,Oscar Gonzalez-Benito,Mercedes Martos-Partal 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7

        This study focuses on the effectiveness of two commercial stimuli: displays and advertising flyers. While displays work within the point of sale and trigger a more immediate and impulsive purchase decision, advertising flyers work out of the point of sale and, therefore, favor a more reasoned purchase decision. It is used the cue utilization theory that distinguish two dimensions for perceived quality, extrinsic quality (linked to the brand) and intrinsic quality (related with internal product characteristics), in order to analyze the role of quality perception in determining the effectiveness of both commercial incentives for selling products that induce high purchase involvement and perceived risk. The empirical analysis focuses on computer products sold by one of Europe’s largest computer retailers and, combines scanner, observational and survey data. The results show that both dimensions of quality perceptions moderate the influence of displays and advertising flyers on sales, but their impact differ on each commercial stimuli. Extrinsic quality perception increases to a greater extent the effect of displays which is linked to unplanned purchases. However, intrinsic quality perceptions improves to a greater extent the effect of advertising flyers, which encourage are related more closely to planned purchases.

      • THE ROLE OF BRANDS IN ONLINE VS. OFFLINE CHANNELS

        ?scar Gonz?lez-Benito,Mercedes Martos-Partal,Sonia San Mart?n 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

        This article addresses the potential of reputable brands to overcome the lack of tangibility that characterizes the process of e-commerce. In a sequential argument, the authors propose that (1) the brand becomes more important in online than in offline channels, as a consequence of the intangibility or lack of physical contact in online purchasing processes; (2) the limitations associated with the need for touch and the lack of access to the physical product during the buying process does not have equal importance across all product categories; and (3) the role of the brand in online channels thus is more relevant if the product category is associated with a higher need for touch. To provide empirical evidence regarding the hypotheses, we performed an experiment that combined three treatments: (1) leader versus non-leader brand, (2) online versus offline channel, and (3) product category with higher versus lower need for touch. We show that the most recognized brands exert a positive effect on product evaluations, regardless of the technical characteristics and other objective product attributes. This advantage may be greater in online channels, though only for product categories for which the lack of physical contact with the product during the purchase process is an important limitation. In such cases, brand associations can compensate for intangibility during purchase.We also confirm that the product categories differ in their level of need for touch and the extent to which consumers desire physical contact with the product during the buying process. These results demonstrate that building strong brands is a key competitive advantage for manufacturers. Brand reputation becomes even more crucial when selling products in electronic channels, at least if the product itself entails a greater need for touch prior to purchase. For such products, strong brands can make up for the intangibility of e-commerce, so this effort represents a key competitive strategy in such channels. Moreover, leading brands can leverage their competitive advantage to enhance their performance in the increasingly prominent realm of e-commerce. E-retailers need to make careful decisions regarding the configuration of the assortment, taking into account the nature of the product category. They should strengthen their focus on developing highly recognizable brands, because the lack of physical contact is an important purchase inhibitor in this shopping channel. However, the brand criterion may be less important if the choice between online and offline shopping is not particularly affected by the opportunity to touch or feel the products.

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