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Jaise Mariya George,Beena Mathew 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.3
β-Cyclodextrin (β-CD) modified gold nanoparticles (AuNP) were rapidly synthesized using microwave assisted procedure. Parameters, such as time, pH and concentrations of β-CD and gold, were optimized for the synthesis of β-CD-AuNP. The addition of enantiomers and racemic mixture of hydroxychloroquine (R-HCQ, S-HCQ and RS-HCQ) drugs and their interaction with β-CD led to a red shift in the surface plasmon resonance of β-CD-AuNP. The changes associated with the introduction of HCQ in β-CD-AuNP were studied using various characterization techniques such as UV-vis, FT-IR, XRD, dynamic light scattering, zeta potential, transmission electron microscopy, fluorescence spectroscopy and electrochemical techniques. The host-guest interaction of β-cyclodextrin with S-HCQ, RHCQ and RS-HCQ resulted in the aggregation of gold nanoparticles. The surface plasmon resonance at 521 nm for β- CD-AuNP was shifted to 600, 620 and 670 nm on the addition of S-HCQ, R-HCQ and RS-HCQ, respectively, with a color change from pink to blue. The selectivity and sensitivity of the developed system for RS-HCQ were investigated and the limit of detection (LOD=3 s/m) was found to be 2.61, 0.15, and 0.85 nM for optical, fluorescence and electrochemical methods, respectively. The successful monitoring of RS-HCQ drug in pharmaceutical samples is possible with these techniques.
대한민국-우크라이나 양국 간 경제 및 무역 관계에 대한 소고
마리아 커시노바 ( Mariya Kosinova ),김주헌 ( Jooheon Kim ) 숙명여자대학교 경제경영연구소 2013 기업경제연구 Vol.42 No.1
본 논문은 한국-우크라이나 사이의 경제협력 관계의 역사와 현황을 분석하고, 양국 관계의 발전을 위한 정책과 전략을 제시하고 있다. 이를 위해 다양한 형태의 문헌과 2차 자료, 그리고 한국 기업의 우크라이나 투자 사례 등을 분석하였다. 특히 해외직접투자(FDI)와 관련하여 본 연구는 준비단계 및 실행단계에서의 FDI 전략을 비교하였으며, 탈 소비에트 국가들의 관련 요인들을 한국의 시장경제 방식과 비교하여 설명하였다. 한국의 많은 새로운 기업들이 해외진출 전략을 수행함에 있어, 본 연구에서 소개한 기업 사례들은 한국 기업의 해외직접투자 전략의 진화과정을 이해하는 데 도움이 될 것이다. 또한 CIS 국가들에 대한 한국 기업의 FDI 전략이나 관련 연구에도 도움을 줄 수 있을 것이다. The article examines the status of economic cooperation between the Republic of Korea and Ukraine and suggests basic policies to improve relations between the two countries. We focused on gathering the relevant information and clarifying the historical development of partnership between Ukraine and Korea to demonstrate the basis created for future development and consolidation of cooperation. The study identifies a contrast between FDI strategy making during the preparation stage and its actual implementing. The specific factors of post-Soviet countries are presented as a comparison to market economy ways of doing business in Korea. As new Korean corporations implement their entry strategies, conducting the comparative analysis to the companies presented in the current study may be helpful for understanding the evolution of FDI strategies of major Korean companies. For the future study we also may suggest the analogue formation of the FDI projects in CIS region.
Anzhela Shurshina,Mariya Afanasyeva,Valentina Chernova,Mariya Lazdina,Elena Kulish 한국고분자학회 2024 Macromolecular Research Vol.32 No.3
The work is devoted to the creation of liquid and soft gel dosage forms of prolonged action. The main task to be solved in the work was to give certain rheological characteristics (namely, pseudoplastic behaviour and pronounced yield strength) to dosage forms based on solutions of pectin, sodium salt of carboxymethylcellulose and sodium salt of chitosan succinate, namely. The study has found that the effect of prolonging the release of the medicinal substance cefazolin from liquid and soft dosage forms based on polysaccharides is directly related to the rheological characteristics of the system and can manifest itself in two cases. First, it is possible for liquid dosage forms in the area of polymer concentrations in solution lower than the concentration at which the cell of meshes C < Ce is formed. In this case, with an increase in the polymer concentration, there is a decrease in the rate of the drug substance release, due to an increase in the adduct of the polymer-drug reaction Secondly, it is possible for soft gel forms in the region of concentrations greater than the concentration at which the cell of meshes C < Ce is formed, when using additives capable of ionotropic gel formation. Calcium and zinc salts were used as such additives in the work. It is in the case when the modifying additive is capable of forming a “bridging” bond between macromolecules and the gel formation is not accompanied by a decrease in the amount of the complex adduct of the reaction, there is a prolongation effect. If the gel is only formed by increasing the polymer content in the solution without the use of an additive, the compression of macromolecular tangles and the strengthening of intramolecular interaction between the polymer units in a concentrated solution results in a significant decrease in the amount of the polymer-drug reaction adduct and accelerated the drug release from the soft dosage form.
Investigation of “Unified Voltage Conditioner-UVC”
Mihail Antchev,Mariya Petkova,Vanjo Gourgoulitsov,Hristo Antchev 전력전자학회 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.2
In this paper, a power electronic converter which is composed of two converters ? bidirectional AC/DC converter and Series Active Power Filter (SAPF), is discussed. Structural schemas and ways of operation of control systems of converters, which are used to eliminate non sinusoidal parts of the network source voltage, are presented. At the same time, the control used stabilizes the value of the voltage feeding the load. Taking in consideration the combined functions which the device executes, it may be called Unified Voltage Conditioner ? UVC.
Neutron spectrum unfolding using two architectures of convolutional neural networks
Maha Bouhadida,Asmae Mazzi,Mariya Brovchenko,Thibaut Vinchon,Mokhtar Z. Alaya,Wilfried Monange,Francois Trompier Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.6
We deploy artificial neural networks to unfold neutron spectra from measured energy-integrated quantities. These neutron spectra represent an important parameter allowing to compute the absorbed dose and the kerma to serve radiation protection in addition to nuclear safety. The built architectures are inspired from convolutional neural networks. The first architecture is made up of residual transposed convolution's blocks while the second is a modified version of the U-net architecture. A large and balanced dataset is simulated following "realistic" physical constraints to train the architectures in an efficient way. Results show a high accuracy prediction of neutron spectra ranging from thermal up to fast spectrum. The dataset processing, the attention paid to performances' metrics and the hyper-optimization are behind the architectures' robustness.
Sreedevi, Aswathy,Quereshi, Mariya Amin,Kurian, Beteena,Kamalamma, Leelamoni Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Background: In India, breast cancer is the leading malignancy among women in a majority of the cancer registries. Therefore it is important to understand screening practices and its predictors, including in rural areas with high female literacy and good health indices. Materials and Methods: A cross-sectional study with multistage sampling was conducted in Vypin Block, Ernakulam district, Kerala, India. Four Panchayats (self administration units) were randomly chosen and a woman in every second household was invited to participate from the tenth ward of each. Thus a total of 809 women were interviewed. Results: The majority of the repondents (82.1%) were not aware of risk factors and about a third (37.9%) were not aware of symptoms of breast cancer. About half of the population studied (46.6%) had undergone screening. Age (35-50 years), being married, health professionals as source of information and working were significant predictors of screening. Logistic regression showed that older women (35-50 yrs) were more likely to practice screening. Out of the never screened, about a third (35%) were desirous of doing it, but had not for various reasons and 53.5% were not willing to screen. The reasons identified for not screening among those desirous of doing it were grouped into knowledge 66 (43.4%), resources 23 (15.1%) and psychosocial 32(21.1%) factors. Unmarried women were significantly more likely to express factors related to all the three domains. Conclusions: This study showed that in spite of the absence of a population-based screening program, about half of the study population had undergone some type of screening. The older women (35-50 years) in particular were significantly more likely to practice screening. At this critical juncture, a high quality breast cancer awareness and screening initiative can help to consolidate the gains and tackle knowledge, resource and psychosocial barriers.
Gyrylova, Svetlana Nikolaevna,Aksenenko, Mariya Borisovna,Gavrilyuk, Dmitriy Vladimirovich,Palkina, Nadezda Vladimirovna,Dyhno, Yuriy Alexandrovich,Ruksha, Tatiana Gennadievna,Artyukhov, Ivan Pavlovic Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Russian rates for melanoma incidence and mortality are relatively low as compared to some other white populations but the tumor is of increasing importance. In this paper, data are based on a retrospective descriptive analysis of melanoma epidemiology and clinicopathological characteristics in Krasnoyarsk Territory belonging to the Siberian Federal District of the Russian Federation. The age-adjusted incidence and mortality rates for the period 1996-2009 were determined with subsequent retrospective analysis of clinicopathological data of 103 primary melanoma cases. Our results showed that incidence and mortality rates in the region under consideration match the Russian national trends and correspond to epidemiological data of the countries of Eastern Europe. Stratification of melanoma cases by age, sex, clinicopathological state and localization revealed a prevalence of lesions on the trunk and lower extremities. Most melanomas diagnosed were of superficial spreading type and the third Clark's level of tumor invasion and stage II according to AJCC. In spite of comparatively low rates of incidence and mortality the trend to increase of melanoma cases in the region under consideration obviously calls for more attention and further investigation.