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Biochemical Properties of an Extracellular Trehalase from Malbranchea pulchella var. Sulfurea
Marita Gimenez Pereira,Luis Henrique Souza Guimarães,Rosa Prazeres Melo Furriel,Maria de Lourdes,Hector Francisco Terenzi,Joao Atilio Jorge 한국미생물학회 2011 The journal of microbiology Vol.49 No.5
The thermophilic fungus Malbranchea pulchella var. sulfurea produced good amounts of extracellular trehalase activity when grown for long periods on starch, maltose or glucose as the main carbon source. Studies with young cultures suggested that the main role of the extracellular acid trehalase is utilizing trehalose as a carbon source. The specific activity of the purified enzyme in the presence of manganese (680 U/mg protein) was comparable to that of other thermophilic fungi enzymes, but many times higher than the values reported for trehalases from other microbial sources. The apparent molecular mass of the native enzyme was estimated to be 104 kDa by gel filtration and 52 kDa by SDS-PAGE, suggesting that the enzyme was composed by two subunits. The carbohydrate content of the purified enzyme was estimated to be 19% and the pI was 3.5. The optimum pH and temperature were 5.0-5.5 and 55°C, respectively. The purified enzyme was stimulated by manganese and inhibited by calcium ions, and insensitive to ATP and ADP, and 1 mM silver ions. The apparent K_M values for trehalose hydrolysis by the purified enzyme in the absence and presence of manganese chloride were 2.70±0.29 and 2.58±0.13 mM, respectively. Manganese ions affected only the apparent V_(max), increasing the catalytic efficiency value by 9.2-fold. The results reported herein indicate that Malbranchea pulchella produces a trehalase with mixed biochemical properties, different from the conventional acid and neutral enzymes and also from trehalases from other thermophilic fungi.
( Marita K. Cardinal ) 대한무용학회 2015 대한무용학회논문집 Vol.73 No.4
Wellness is essential to dancers’ optimal performance and lifetime health. However, dance environments are not always conducive to healthy behaviors. Research in dance medicine and science over the past several decades exposes health-related issues of dancers such as disordered eating, performance anxiety, and a myriad of musculoskeletal injuries. Previous studies have examined wellness-related concerns of dancers in higher education dance programs in the United States. Although not yet optimal, there has been an increase in the acceptance of “dancer wellness” as a necessary component of dancers’ education in the United States. However, little is known about how dancer wellness is perceived by higher education dance students outside the United States, particularly in non-Eurocentric countries. Therefore, the purpose of this study was to compare dance students’ perceptions of seven wellness dimensions, including social, physical, intellectual, career, emotional, environmental, and spiritual. Participants included students from academic institutions in the United States and Hong Kong. As part of intact classes or workshops, students examined these seven wellness dimensions and discussed their thoughts and concerns specific to dance and their experiences in dance contexts. Both similarities and differences of the students’ perspectives on these seven wellness dimensions are shared. By listening to students and identifying their unique wellness needs, academic programs can make changes in educational curricula to more effectively foster improved health and well-being of dancers. A sample dancer wellness program that has been incorporated into a dance education program in the United States is described.
Marita C Bautista,Sheng-Fang Jiang,Mary Anne Armstrong,Debbie Postlethwaite,Dan Li 대한위암학회 2014 Journal of gastric cancer Vol.14 No.4
Purpose: Gastric cancer often occurs in the elderly but is uncommon in young individuals. Whether young patients have different clinical behaviors and outcomes from those of older patients remain unclear. Materials and Methods: We identified 1,366 cases of newly diagnosed noncardia gastric adenocarcinoma from the Kaiser Permanente Northern California Cancer Registry between 2000 and 2010. We then compared the clinicopathological features and survival amongthe different age groups. Results: The male : female ratio differed significantly between the younger and older patient groups (0.84 in age <50 years vs. 1.52>60 years, P<0.01). More younger patients were Hispanic (54% patients <40 years vs. 19% patients ≥70 years, P<0.0001), while more older patients were Caucasian (49% patients ≥70 years vs. 15% patients <40 years; P<0.0001). The diffuse/mixed histological type was more prevalent in younger patients (70% patients <40 years vs. 27% patients ≥70 years; P<0.0001), whereas the intestinal type was more frequent in older patients (71% in patients ≥70 years vs. 30% in patients <40 years; P<0.0001). Poorly differentiated adenocarcinoma was more common in the younger patients (80% in patients <40 years vs. 60% in patients ≥70 years; P=0.016). Survival rates at 1, 2, and 5 years gradually declined with increasing age (overall P=0.0002). Conclusions: Young patients with gastric cancer had more aggressive disease but higher overall survival rates than older patients. Younger Hispanic patients and older Caucasian patients were more likely to be diagnosed with gastric cancer. These differences may be due tobiological predisposition and/or environmental exposure.
A Scoping Review of Components of Physician-induced Demand for Designing a Conceptual Framework
Marita Mohammadshahi,Shahrooz Yazdani,Alireza Olyaeemanesh,Ali Akbari Sari,Mehdi Yaseri,Sara Emamgholipour Sefiddashti 대한예방의학회 2019 Journal of Preventive Medicine and Public Health Vol.52 No.2
Objectives: The current study presents a new conceptual framework for physician-induced demand that comprises several influential components and their interactions. Methods: This framework was developed on the basis of the conceptual model proposed by Labelle. To identify the components that influenced induced demand and their interactions, a scoping review was conducted (from January 1980 to January 2017). Additionally, an expert panel was formed to formulate and expand the framework. Results: The developed framework comprises 2 main sets of components. First, the supply side includes 9 components: physicians’ incentive for pecuniary profit or meeting their target income, physicians’ current income, the physician/population ratio, service price (tariff), payment method, consultation time, type of employment of physicians, observable characteristics of the physician, and type and size of the hospital. Second, the demand side includes 3 components: patients’ observable characteristics, patients’ non-clinical characteristics, and insurance coverage. Conclusions: A conceptual framework that can clearly describe interactions between the components that influence induced demand is a critical step in providing a scientific basis for understanding physicians’ behavior, particularly in the field of health economics.
Bautista, Marita C.,Jiang, Sheng-Fang,Armstrong, Mary Anne,Postlethwaite, Debbie,Li, Dan The Korean Gastric Cancer Association 2014 Journal of gastric cancer Vol.14 No.4
Purpose: Gastric cancer often occurs in the elderly but is uncommon in young individuals. Whether young patients have different clinical behaviors and outcomes from those of older patients remain unclear. Materials and Methods: We identified 1,366 cases of newly diagnosed noncardia gastric adenocarcinoma from the Kaiser Permanente Northern California Cancer Registry between 2000 and 2010. We then compared the clinicopathological features and survival among the different age groups. Results: The male : female ratio differed significantly between the younger and older patient groups (0.84 in age <50 years vs. 1.52>60 years, P<0.01). More younger patients were Hispanic (54% patients <40 years vs. 19% patients ${\geq}70$ years, P<0.0001), while more older patients were Caucasian (49% patients ${\geq}70$ years vs. 15% patients <40 years; P<0.0001). The diffuse/mixed histological type was more prevalent in younger patients (70% patients <40 years vs. 27% patients ${\geq}70$ years; P<0.0001), whereas the intestinal type was more frequent in older patients (71% in patients ${\geq}70$ years vs. 30% in patients <40 years; P<0.0001). Poorly differentiated adenocarcinoma was more common in the younger patients (80% in patients <40 years vs. 60% in patients ${\geq}70$ years; P=0.016). Survival rates at 1, 2, and 5 years gradually declined with increasing age (overall P=0.0002). Conclusions: Young patients with gastric cancer had more aggressive disease but higher overall survival rates than older patients. Younger Hispanic patients and older Caucasian patients were more likely to be diagnosed with gastric cancer. These differences may be due to biological predisposition and/or environmental exposure.
A Scoping Review of Components of Physician-induced Demand for Designing a Conceptual Framework
Mohammadshahi, Marita,Yazdani, Shahrooz,Olyaeemanesh, Alireza,Sari, Ali Akbari,Yaseri, Mehdi,Sefiddashti, Sara Emamgholipour The Korean Society for Preventive Medicine 2019 Journal of Preventive Medicine and Public Health Vol.52 No.2
Objectives: The current study presents a new conceptual framework for physician-induced demand that comprises several influential components and their interactions. Methods: This framework was developed on the basis of the conceptual model proposed by Labelle. To identify the components that influenced induced demand and their interactions, a scoping review was conducted (from January 1980 to January 2017). Additionally, an expert panel was formed to formulate and expand the framework. Results: The developed framework comprises 2 main sets of components. First, the supply side includes 9 components: physicians' incentive for pecuniary profit or meeting their target income, physicians' current income, the physician/population ratio, service price (tariff), payment method, consultation time, type of employment of physicians, observable characteristics of the physician, and type and size of the hospital. Second, the demand side includes 3 components: patients' observable characteristics, patients' non-clinical characteristics, and insurance coverage. Conclusions: A conceptual framework that can clearly describe interactions between the components that influence induced demand is a critical step in providing a scientific basis for understanding physicians' behavior, particularly in the field of health economics.