IN VIVO AND IN VITRO EVALUATION OF SKELETAL MUSCLE TROPHISM IN HEMOPHILIC SUBJECTS

Mariani, G.,Mazzuca, N.,Molea, N.,Bianchi, R.,Panicucci, F.,Chicca, M. G. Del,Pitruzzello, S.,Positano, M.,Clerico, A.,Gandini, S. 대한핵의학회 1984 핵의학 분자영상 Vol.18 No.1

Screening of Anti-Melanogenesis Activities of Mongolian Herbal Plant Extracts

Mariani ABDUL HAMID,Odontuya GENDARAM,Chang Seo PARK 한국생물공학회 2011 한국생물공학회 학술대회 Vol.2011 No.4

Mangosteen leaf extract increases melanogenesis in B16F1 melanoma cells by stimulating tyrosinase activity in vitro and by up-regulating tyrosinase gene expression.

Hamid, Mariani Abdul,Sarmidi, Mohamad Roji,Park, Chang Seo D.A. Spandidos 2012 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.29 No.2

<P>Melanin synthesis is stimulated by various effectors, including α-melanocyte stimulating hormone (α-MSH), cyclic AMP (cAMP)-elevating agents (forskolin, isobutylmethylxantine, glycyrrhizin) and ultraviolet light. Our investigation focused on the identification of the melanogenic efficacy of mangosteen (Garcinia mangostana) leaf extract with regard to its effects on melanogenesis in B16F1 melanoma cells, since it has been known to possess strong anti-oxidant activities. The mangosteen leaf extract was found to stimulate melanin synthesis and tyrosinase activity in a dose-dependent manner without any significant effects on cell proliferation. Cytotoxicity of the extract was measured using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; the highest concentration of the extract that did not affect cell viability was 32 ?g/ml. Formation of melanin from cultured B16F1 melanoma induced by extract treatment was estimated using spectrophotometry. In order to clarify the subsequent mechanism of tyrosinase activation by the extract, the levels of tyrosinase expression in B16F1 melanoma were examined using an intracellular tyrosinase assay and tyrosinase zymography. Up-regulation of intracellular tyrosinase expression seemed to correlate with an increase in microphtalmia-associated transcription factor (MITF) protein levels since MITF is the key factor for genes involved in melanogenesis. Both of the results showed that tyrosinase activity was markedly enhanced from extract-treated cells. The overall results suggest that mangosteen leaf extract may be a promising candidate for the treatment of hypopigmentation disorder and useful for self-tanning cosmetic products.</P>

Mangosteen (Garcinia Mangostana) Leaves Extract Increased Melanogenesis in B16F1 Melanoma Cell Line

Abdul Hamid MARIANI,Roji Sarmidi MOHAMAD,Chang Seo PARK 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.4

Zeno autobiographer

( Maria Anna Mariani ) 한국이탈리아어문학회(구 한국이어이문학회) 2013 이탈리아어문학 Vol.0 No.40

This essay is focused on La coscienza di Zeno by Italo Svevo. It is structured in four parts and it starts with a general introduction to the author, sketching of him an actualized and not conventional image. This first part insists on the peculiar linguistic condition of Svevo, who-treating Italian as a foreign language-could be compared to a stranger writer in his own country. The essay continues by concentrating on La coscienza di Zeno, that is a peculiar kind of autobiography, written by an imaginary character who does not coincide with the author. Even though La coscienza is a work of fiction, it shares many of the elements that define an authentic autobiography. For instance, the book is crossed with reflections on memory and identity, which are the crucial problems of the autobiographic genre. By adopting a comparative method, but never forgetting the rigour of Literary Theory, this essay compares passages from La coscienza with excerpts from canonical autobiographies (mainly Elias Canetti`s one) and tries to open a wide-range perspective for an actualized and problematic study of Italo Svevo`s work.

Pressuring of acupoints as a complement to the stifle diseases diagnosis in horses

Luiza P.R. Mariani,Flávia Sampaio,Andressa B. Silveira,Luis F. Bastos,Saulo H. Weber,Pedro V. Michelotto 사단법인약침학회 2019 Journal of Acupuncture & Meridian Studies Vol.12 No.5

Diseases of the stifle joint remain a challenge for veterinarians. The objective of this study was to achieve a valuable acupuncture suggestive diagnosis to be considered for stifle joint diseases in horses. Thirty-nine nonlame horses involved in different activities were assessed. Acupuncture was independently performed by two evaluators. Reactions of the animal when pressurizing the point suggestive of stifle disease (PSSD), Bladder-20 and/or Bladder-21, were considered as the inclusion criteria for inclusion in the stifle group (SG, n Z 31), and the animals with no reactions were assigned to the control group (n Z 8). Radiographic and ultrasonographic examinations were performed and evaluated by two independent professionals blinded to the group allocation. Thermographic examination of the PSSD and stifles was also performed, after acclimatization. The ultrasound scores and radiographic findings were higher in the SG than in the control group. Thermography evidenced increased temperature in the PSSD and stifles in the SG. The minimum acupuncture diagnostic criteria for stifle joint disease had a sensitivity of 87.5% and a specificity of 57.0%, and the addition of the acupoints Gallbladderedorsal tuber coxae, Gallbladder-27, and Spleen-13 to the minimum diagnostic criteria improved sensitivity and specificity. In conclusion, assessing the reaction at the demonstrated acupoints can facilitate a diagnosis of a potential stifle lesion.

Capacity Building for Village Government Officials through the Implementation of 6th Act of 2014: Focusing on the Ponorogo District, East Java, Indonesia

윈다 에카 마리아니(Windha Eka Mariani),김기수(Kim Kisu) 영남대학교 박정희새마을연구원 2017 새마을학연구 Vol.2 No.1

인프라개발에서 도시와 농촌 지역의 격차를 줄이고 농촌마을의 개발을 증대시키기 위해 인도네시아 정부는 농촌지역에 대한 2014 6차 법안을 제정하였다. 이 법안은 또한 대통령의 비전 및 미션과 83,000달러의 새로운 기금을 바탕으로 한 Working Cabinet 2014-1019의 정책 방향에 의해 지원받고 있다. 그러나 포노로그 지구에서는 여전히 정부공무원들의 부적절한 역량이 관찰되고 있다. 본 연구의 목적은 마을수준의 공무원들의 역량 향상에 대한 Bapemas & Pemdes Ponorogo의 역할을 알아보고, 이것이 직면하고 있는 제약들을 발견하고, 또한 역량개발이 마을수준의 공무원들의 성과에 미치는 영향에 대해 알아본다. 연구 결과는 Bapemas & Pemdes Ponorogo는 포노로그 지구에서 마을 수준의 공무원들의 역량개발 프로그램들의 계획자, 실행자, 평가자 및 조정자로서 중요한 역할을 한다 사실을 보여준다. Bapemas & Pemdes Ponorogo는 a) 마을 개발계획; b) 마을 재정관리; c) 마을 수준에서의 법규 개발 d) 마을 거버넌스의 책임성 등과 관련된 훈련 및 개발 프로그램들을 수행한다. 이외에도 Bapemas & Pemdes Ponorogo는 2014 6차 법안의 실행과 기타 기술적 규제들과 관련된 정보에 마을 공무원들이 접근할 수 있게 한다. 그러나 인적자원의 부족 및 심리적 미준비로 인해 Bapemas & Pemdes Ponorogo는 또한 2014 6차 법안의 기술적 규제 면에서 관료적 시스템의 미준비에 대한 장애에 직면하고 있다. 본 연구에서는 또한 삼품(Sampung) 구청지역(sub-district)에서의 마을 공무원들을 위한 훈련 및 개발 프로그램의 실행은 공무원들의 성과에 정의 영향을 미치는 것으로 나타났다. 이는 훈련과 성과 사이에 통계적으로 유의한 정의 상관관계가 있음을 의미한다. 또한 마을 공무원들의 성과에 중요하게 영향을 미치는 훈련 요인으로는 태도 및 행위 변화와 관련된 훈련 및 훈련 교재들에 대한 요구평가로 나타났다. Based on data from the National Statistic Agency in 2015, 46.7% of Indonesians live in the rural areas. In fact, there is a gap between the rural and urban area in terms of physical/infrastructure development. In order to bridge the gap and increase development in the village, the Indonesian government legislated the 6th Act of 2014 on Village. The law was supported also by the vision and mission of the President and policy direction on Working Cabinet 2014-2019 by emerging village fund program which allocated 1 billion IDR ($83,000). However, very vague facts on the inadequate capacity of the government officials has been observed in the Ponorogo District. The objective of this research is to identify the role of Bapemas & Pemdes Ponorogo in improving the capacity of village-level government officials and to discover the constraints faced by the Bapemas & Pemdes Ponorogo as well as to identify the impact of capacity building on the village-level government officials’ performance. The results showed that Bapemas & Pemdes Ponorogo plays important roles as planner, implementer, evaluator and coordinator for village-level government officials’ capacity building programs in Ponorogo. Bapemas & Pemdes Ponorogo conducts training and development programs related to: a) Village development plan; b) Village finance management; c) Forming laws in the village level; and d) Village governance accountability. Besides the training and development program Bapemas & Pemdes Ponorogo also equipped the village officials with access to information related to the implementation of the 6th Act of 2014 and other technical regulations. Aside from the lack of human resources and unpreparedness of psychology, Bapemas & Pemdes Ponorogo also faced the barrier on the unpreparedness of the bureaucratic system in terms of the technical regulation of 6th Act of 2014. Research findings also showed that there is a moderate correlation in the implementation of training and development program for village officials in Sampung Sub-District which gives positive impact to village officials’ performance. It means that there is positive correlation between training and performance, if one variable increases the other will also increase. Furthermore, training indicators that affect significantly on performance of village officials are the Need Assessment of the Training and Training Materials that are related with attitudinal and behavioral change.

REVIEW OF REACTOR NEUTRINO OSCILLATION EXPERIMENTS

World Scientific 2012 Modern Physics Letters A Vol.27 No.8

<P> In this document we will review the current status of reactor neutrino oscillation experiments and present their physics potentials for measuring the θ13 neutrino mixing angle. The neutrino mixing angle θ13 is currently a high-priority topic in the field of neutrino physics. There are currently three different reactor neutrino experiments, DOUBLE CHOOZ, DAYA BAY and RENO and a few accelerator neutrino experiments searching for neutrino oscillations induced by this angle. A description of the reactor experiments searching for a nonzero value of θ13 is given, along with a discussion of the sensitivities that these experiments can reach in the near future. </P>

Dirichlet’s and Thomson’s Principles for Non-selfadjoint Elliptic Operators with Application to Non-reversible Metastable Diffusion Processes

Landim, C.,Mariani, M.,Seo, I. Springer-Verlag 2019 Archive for rational mechanics and analysis Vol.231 No.2

Supporting Preschool Children’s Early Writing with Self-Regulated Learning Strategies

Siew Kim Siew,Mariani Binti Md Nor 환태평양유아교육연구학회 2019 Asia-Pacific journal of research in early childhoo Vol.13 No.2

Research suggests that early writing is crucial in the development of young children’s literacy skills and links to their conventional literacy outcomes in elementary school and beyond. In order to enhance the will and the skills to express thoughts explicitly and effectively in early writing among preschool children, self-regulated learning (SRL) was suggested. This experimental study involved seventy-five preschool children, aged from five to six years old in Malaysia, aimed to investigate the effectiveness of SRL strategies on early writing performance. In this study, quantitative data collection was engaged and supported with qualitative data through interviews to obtain a deep insight of the findings results. Two-way repeated measure ANCOVA was employed and confirmed the effectiveness SRL intervention performance in early writing. In regression analyses, strategy such as planning and goal setting was confirmed as strong predictor for early writing performance. Data from the interview revealed that various SRL strategies were engaged by out-performing children from the experimental group and contributed to their early writing performance. The findings of this research provide a useful insight into early writing instructions in Malaysian context.