Changes in Muscular Lipids in Unilateral Isolated Hypertrophy of Gastrocnemius Muscle Can Be Revealed by 1H MR Spectroscopy

Klaus Brechtel,Juergen Machann,Margarete Pick,Juergen F. Schaefer,Claus D. Claussen,Fritz Schick 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.6

Objective: To test whether proton magnetic resonance spectroscopy (1H-MRS) reveals changes in the lipid content of the gastrocnemius muscle (GM) and soleus muscle (SOL) of a patient with unilateral isolated hypertrophy of the right GM. Materials and Methods: 1H-MRS was performed on a 1.5 Tesla (T) wholebody unit. Muscular lipids inside SOL and GM were assessed in both calves of the patient by a STEAM (stimulated echo acquisition mode) localization sequence. Results were compared to a control group of four healthy volunteers. Results: Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8±3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg. Conclusion: Muscular lipids are substrates for metabolism and can be assessed non-invasively by 1H-MRS. 1H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy. Objective: To test whether proton magnetic resonance spectroscopy (1H-MRS) reveals changes in the lipid content of the gastrocnemius muscle (GM) and soleus muscle (SOL) of a patient with unilateral isolated hypertrophy of the right GM. Materials and Methods: 1H-MRS was performed on a 1.5 Tesla (T) wholebody unit. Muscular lipids inside SOL and GM were assessed in both calves of the patient by a STEAM (stimulated echo acquisition mode) localization sequence. Results were compared to a control group of four healthy volunteers. Results: Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8±3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg. Conclusion: Muscular lipids are substrates for metabolism and can be assessed non-invasively by 1H-MRS. 1H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy.

Seminário de música brasileira na aula de português língua adicional: análise interacional da construção conjunta da aprendizagem

GabrieladaSilvaBulla ( Gabriela Da Silva Bulla ),LetíciaSoaresBortolini ( Letícia Soares Bortolini ),GrazielaHoerbeAndrighetti ( Graziela H. Andrighetti ),MargareteSchlatter ( Margarete Schlatter ) 한국포르투갈-브라질학회 2011 포르투갈-브라질 연구 Vol.8 No.2

In this paper, we investigate how institutional identity relations and the selection of learning objects can be interactionally conceived in an additional language classroom oriented to language use as social action (Clark, 1996). Informed by Ethnomethodological Conversation Analysis and Interactional Sociolinguistics, we analyse an eight-minute sequence of interaction featuring participants engaged in the accomplishment of a Portuguese-as-an-additional-language classroom activity, namely a seminar on Brazilian music, in which each student was supposed to lecture on a different musical style. In order to co-construct learning, participants orient to various identities and understandings that are built and negotiated in the course of interaction, configuring different participant frameworks. The analyses show (1) the rearrangement of the lecturer’s speech through the construction of new concepts in interaction (emergent products), and (2) the participants’ efforts to sustain the seminar frame, through the negotiation of conflicting identities of lecturer/audience, teacher/student and Brazilian national/foreigner to Brazil. This paper evidences that, more than requiring the use of the additional language, pedagogical activities such as the one analysed are opportunities for the participants to negotiate identities and modes of participation, define relevant learning objects in the course of interaction, and locally deal with the unexpected.

Tuning with Phosphorylcholine Grafts Improves the Physicochemical Properties of PLL/pDNA Nanoparticles at Neutral pH

Juliana Semensato,Júlio Cesar Fernandes,Mohamed Benderdour,Vera Aparecida de Oliveira Tiera,Aline Margarete Furuyama Lima,Marcio José Tiera 한국고분자학회 2020 Macromolecular Research Vol.28 No.2

The improvement of biological properties of polycations is a fundamental step to overcome their limitations as non-viral gene carriers. This work studied the effect of phosphorylcholine (PC) groups on the physicochemical properties of poly(L-lysine) (PLL)/pDNA nanoparticles. Phosphorylcholine-grafted PLL derivatives (PLL-PC) containing increasing proportions of PC were obtained by the reductive amination reaction with phosphoryl glyceraldehyde and characterized by 1H NMR, FTIR, and GPC measurements. The PLL-PC derivatives were used to prepare polyplexes with pDNA and their properties were evaluated by fluorescence, gel electrophoresis and dynamic light scattering (DLS) measurements. The PLL-PC derivatives were able to interact with pDNA at low N/P ratios in physiological pH to form stable polyplexes having lower zeta potentials, as evidenced by the gel electrophoresis and zeta potentials measurements. A degree of grafting of 10% increased the in vitro transfection efficiency of PLL and a degree of 20 mol% of PC groups provided colloidal stability in physiological saline solution at neutral pH. Overall, the PC-PLL derivatives exhibited improved physicochemical properties and have significant potential for further studies as non-viral gene transfer agents.

Korean Red Ginseng Powder in the Treatment of Melasma

Margaret Song,Je-Ho Mun,Hyun-Chang Ko,Byung-Soo Kim,Moon-Bum Kim(김문범) 고려인삼학회 2011 Journal of Ginseng Research Vol.35 No.2

Exposure to the sun, ultraviolet radiation, and oxidative stress are the chief etiologic factors responsible for melasma. The ingredients of Korean red ginseng powder, which include ginsenoside and phenolic compounds, have antioxidative effects and reduce ultraviolet B-induced pigmentation. This study was designed to evaluate the effectiveness and safety of Korean red ginseng powder in patients with melasma. In 25 female patients, 3 g of Korean red ginseng powder was orally administered for a 24 week period. The level of pigmentation and erythema were determined and clinical improvement was evaluated by the melasma area and severity index (MASI), melasma quality of life scale (MELASQoL), and patient- and investigator-rated global improvement scale. After 24 weeks, the MASI score decreased from 8.8 to 5.6, and MELASQoL showed improvement in 91% of patients (p<0.05). The mean level of pigmentation decreased from 184.3 to 159.7 and erythema levels decreased from 253.6 to 216.4 (p<0.05). Additionally, 74% of the patients showed some improvement in both patient- and investigator-rated global improvement scales at week 24. Korean red ginseng powder was well tolerated by most of the patients. In conclusion, Korean red ginseng powder showed good tolerability and beneficial effects in patients with melasma. The use of Korean red ginseng would be counted as a useful adjunctive therapy for patients with melasma.

The reintegration of Tongan postgraduate scholars after study abroad: knowledge utilisation and resituation

Margaret Franken,Nautalus Tuituiovai Kaho Langi,Christopher Branson 서울대학교 교육연구소 2016 Asia Pacific Education Review Vol.17 No.4

Higher education has seen increasing educational mobility as students finance themselves or get financial support from their families to study abroad (Shields Comp Educ Rev 57(4):609–636, 2013; Verbik and Lazanowski in World education news and reviews. http://www.wes.org/educators/pdf/StudentMobility.pdf, 2007). Another significant source of support, particularly for students in developing countries, is that from international aid scholarships. This research presents the reported experiences of 15 Tongan postgraduate scholars who successfully completed overseas postgraduate studies. The study focuses on the perceptions of qualifications and of scholars, as well as knowledge utilisation and knowledge resituation in and beyond the workplace. Knowledge utilisation, sometimes referred to as knowledge management, is how others support returnees’ to share and make use of their knowledge; while knowledge resituation is a personal and individual process in which knowledge gained in one context is tuned to and made use of in a new context (Eraut in Expertise development: the transition between school and work. Open Universiteit, Heerlen, pp 52–73, 2004a, Pedagogy and practice. Culture and identities. Sage, London, 2008; Franken 2012). Given the challenges the scholars faced, we advocate for a more explicit recognition of what knowledge and skills returning scholars bring home, and a more proactive and strategic use of these by their workplaces in particular.

The Impact of Virgin Coconut Oil and High-Oleic Safflower Oil on Body Composition, Lipids, and Inflammatory Markers in Postmenopausal Women

Margaret Harris,Andrea Hutchins,Lisa Fryda 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.4

This randomized crossover study compared the impact of virgin coconut oil (VCO) to safflower oil (SO) on body composition and cardiovascular risk factors. Twelve postmenopausal women (58.8 ± 3.7 year) consumed 30 mL VCO or SO for 28 days, with a 28-day washout. Anthropometrics included body weight and hip and waist circumference. Fat percent for total body, android and gynoid, fat mass, and lean mass were measured using dual-energy X-ray absorptiometry. Women maintained their typical diet recording 28 days of food records during the study. Results were analyzed with SPSS v24 with significance at P ≤ .05. Comparisons are reported as paired t-test since no intervention sequence effect was observed. VCO significantly raised total cholesterol, TC (+18.2 ± 22.8 mg/dL), low-density lipoprotein (+13.5 ± 16.0 mg/dL), and high-density lipoprotein, HDL (+6.6 ± 7.5 mg/dL). SO did not significantly change lipid values. TC and HDL were significantly different between test oils. The TC/HDL ratio change showed a neutral effect of both VCO and SO. One person had adverse reactions to VCO and increased inflammation. VCO decreased IL-1β for each person who had a detected sample. The impact of VCO and SO on other cytokines varied on an individual basis. This was the first study evaluating the impact of VCO on body composition in Caucasian postmenopausal women living in the United States. Results are suggestive that individuals wishing to use coconut oil in their diets can do so safely, but more studies need to be conducted with larger sample sizes, diverse populations, and more specific clinical markers such as particle size.

P239 : Efficacy and safety of oral acitretin in chronic hand eczema

( Margaret Song ),( Won Ku Lee ),( Gun Wook Kim ),( Hyun Ho Jo ),( Won Jeong Kim ),( Je Ho Mun ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Byung Soo Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Chronic hand eczema (CHE) may severely reduce patient``s quality of life. CHE refractory to topical corticosteroids currently have limited treatment options suited for chronic use. In demand of safe new therapy, oral alitretinoin, 9-cis retinoic acid, was proposed, but the economic burden limits its broad use. Acitretin is a well-known second generation vitamin A derivative, widely used in palmoplantar psoriasis with less cost. Objectives: To assess the efficacy and safety of oral acitretin in chronic hand eczema patients. Methods: A total of 38 patients diagnosed with CHE were enrolled in the prospective open-label study. All patients were administered with oral acitretin, start dose of 10mg twice daily and tapered to 10mg once daily for up to 24 weeks. CHD severity was evaluated using a 5-grade physicial global assessment (PGA) scale and the modified total lesion symptom score (mTLSS). Results: Clinical responses, defined as clear or almost clear, were achieved in up to 34% (10/29) of patients. The proportion achieving PGA of clear, almost clear or mild was 58% (17/29). The improvement was more remarkable in hyperkeratotic type than other types of hand eczema. No serious side effects were reported except of cheilitis in 2 patients and abdominal discomfort in 3 patients. Conclusion: Oral acitretin is well-tolerated with effectively improving chronic hand eczema, especially in hyperkeratotic type.

Yeats’s Double Visions

Margaret Mills Harper 한국예이츠학회 2011 한국예이츠 저널 Vol.36 No.-

예이츠의 작업은 자신의 시와 다른 작품에서 다수의 자아의 창조를 강조한다. 그는 또 집요하게 수정하기 때문에 작품의 의미를 찾는데 각기 다른 작품들 사이의 차이는 중요하다. 그의 철학적 저서 비전 은 특히 다양한 면을 지니며, 개성의 다양한 양상, 영혼의 단계, 역사적 정신적 진실의 여러 면을 강조한다. 비전 에는 낭만적 예이츠의 끝과 모더니스 예이츠의 시작이라는 이중적 양상으로 여길 수 있는 산문 작품, 친절한 달의 침묵 이라는 소책자의 영향이 보인다. 비전 자체도 두 버전이 있다. 1925년과 1935년에 발행된 이 두 책의 차이는 예이츠의 1920년대와 1930년대의 작품의 차이를 보인다. 두 책은 시간을 초월한 진리를 나타내기 보다는 각기 한 시기의 존재로 보게 한다. 두 권이 하나인 비전 을 인정하는 것은, 이 책이 예이츠와 그의 부인 조지 사이의 자동기술의 결과라는 점에서, 공저라는 사실에 주목하게 한다. Yeats’s work stresses the creation of multiple selves in his poetry and other work. Yeats also revised obsessively, and the differences between versions of his works are important in finding their meanings. The philosophical book A Vision is especially many-faceted, emphasizing multiple aspects of the personality, stages of the soul, and versions of historical and spiritual truth. A Vision is influenced by Yeats’s small monograph Per Amica Silentia Lunae, a prose work that we can think of as itself double-facing: the end of the romantic Yeats and the beginning of the modernist Yeats. A Vision is itself two books. The differences between the two books (one version published in 1925 and one in 1937) illustrate differences in Yeats’s work in the 1920s and the 1930s. Each book points to itself as existing in one moment rather than standing for atemporal truth. Recognizing A Vision as a book that is two books also draws attention to the importance of this work as co-authored, in the sense that it is the result of the occult collaboration between Yeats and his wife George.

FCT 9 : Photodynamic therapy combined with laser ablation: promising therapeutic alternative in extrammary Paget`s disease?

( Margaret Song ),( Hyang Suk You ),( Hyunho Jo ),( Jeho Mun ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Hoon Soo Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Surgical treatment is considered as the treatment of choice in extrammary Paget`s disease(EMPD),but there still are demands of alternative treatment due to anatomic location of tumor and extensive surgical defect. Photodynamic therapy (PDT) is promising but limited alternative treatment with inconsistent efficacy in EMPD Objectives: To assess the efficacy of laser ablation followed by photodynamic therapy with methyl-aminolevulinate(MAL) in EMPD Methods: Thirteen patients diagnosed with noninvasive EMPD without distant metastasis were enrolled in the study. All patients received photodynamic therapy with MAL as a photosensitizer and intense pulsed light as a light source, following CO2 laser ablation. Photodynamic therapy after laser ablation was performed 1 to 13 times depending on the presence of remnant lesion Results: Nine male and 4 female patients with mean age of 68.2 were included in the analysis. Reduction in size of EMPD was observed in all patients except one even after first treatment. At 6 months, clinical complete response(CR) was observed in 5 patients (38.5%) and partial response in 7 patients,but only 2 patients eventually reached CR Conclusion: Photodynamic therapy alleviates symptoms and is effective in reducing the size of tumor. Although, it holds limitation in achieving clinical and histological cure, even after multiple treatment, with very long downtime. It should be considered as a conservative or preoperative treatment of EMPD rather than curative treatment.

A Tender Voyage: Children and Childhood in Late Imperial China.

Margaret Mih Tillman 성균관대학교 동아시아학술원 2006 Sungkyun Journal of East Asian Studies Vol.6 No.2

A Tender Voyage: Children and Childhood in Late Imperial China.