piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination

Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.

Fast Partial Shading Analysis of Large-scale Photovoltaic Arrays via Tearing Method

Zhang, Mao,Zhong, Sunan,Zhang, Weiping The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.5

Partial shading analysis of large-scale photovoltaic (PV) arrays has recently become a theoretically and numerically challenging issue, and it is necessary for PV system designers. The main contributions of this study are the following: 1) A PSIM-based macro-model was employed because it is remarkably fast, has high precision, and has no convergence issues. 2) Three types of equivalent macro-models were developed for the transformation of a small PV sub-array with uniform irradiance to a new macro-model. 3) On the basis of the proposed new macro-model, a tearing method was established, which can divide a large-scale PV array into several small sub-arrays to significantly improve the efficiency improvement of a simulation. 4) Three platforms, namely, PSIM, PSpice, and MATLAB, were applied to evaluate the proposed tearing method. The proposed models and methods were validated, and the value of this research was highlighted using an actual large-scale PV array with 2420 PV modules. Numerical simulation demonstrated that the tearing method can remarkably improve the simulation efficiency by approximately thousands of times, and the method obtained a precision of nearly 6.5%. It can provide a useful tool to design the optimal configuration of a PV array with a given shading pattern as much as possible.

A Canonical Small-Signal Linearized Model and a Performance Evaluation of the SRF-PLL in Three Phase Grid Inverter System

Mao, Peng,Zhang, Mao,Zhang, Weiping The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.5

Phase-locked loops (PLL) based on the synchronous reference frame (SRF-PLL) have recently become the most widely-used for grid synchronization in three phase grid-connected inverters. However, it is difficult to study their performance since they are nonlinear systems. To estimate the performances of a SRF-PLL, a canonical small-signal linearized model has been developed in this paper. Based on the proposed model, several significant specifications of a SRF-PLL, such as the capture time, capture rang, bandwidth, the product of capture time and bandwidth, and steady-state error have been investigated. Finally, a noise model of a SRF-PLL has been put forward to analyze the noise rejection ability by computing the SNR (signal-to-noise ratio) of a SRF-PLL. Several simulation and experimental results have been provided to verify and validate the obtained conclusions. Although the proposed model and analysis method are based on a SRF-PLL, they are also suitable for analyzing other types of PLLs.

Advantages of Laparoscopic Abdominoperineal Resection for Anastomotic Recurrence of Rectal Cancer

Zhang, Xing-Mao,Wang, Zheng,Ma, Sheng-Hui,Zhou, Zhi-Xiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10

Background: Surgery offers the only potential for cure and long-term survival of recurrence of rectal cancer. Few studies about laparoscopic recurrent lesion resection have been reported. This study was designed to evaluate the safety and feasibility of laparoscopic abdomino-perineal resection for anastomotic recurrence of rectal cancer. Materials and Methods: Data for 42 patients with recurrence of rectal cancer were collected retrospectively. Of the 42 patients, 22 underwent laparoscopic surgery (LR group) and 20 received open surgery (OR group). Outcomes between the two groups were compared. Results: Operation time in LR group was shorter compared with the OR group ($164.6{\pm}27.7min$ vs $203.0{\pm}45.3min$); intra-operative blood loss was $119.7{\pm}44.4ml$ and $185.0{\cdot}94.0ml$ in LR group and OR group, respectively (p<0.001); time to first flatus in LR group was shorter than in OR group, and the difference was statistically significant ($2.6{\pm}0.8$ days vs $3.1{\pm}0.8$ days, p=0.013); hospital stay in the LR and OR groups was $8.6{\pm}1.3$ days and $9.8{\pm}2.2$ days; 3-year survival rates in the LR and OR groups were 44.4% and 42.8% (p=0.915) and the 3-year disease-free survival rates were 36.4% and 30.0%, respectively (p=0.737). Conclusions: Laparoscopic abdomino-perineal resection is safe and feasible for anastomotic recurrence of rectal cancer.

A Novel Model of a Li-ion Battery Based on the Manufacturer's Datasheet

Zhang, Xiaoqiang,Zhang, Weiping,Zhang, Mao The Korean Institute of Electrical and Electronic 2017 Transactions on Electrical and Electronic Material Vol.18 No.5

A novel battery model based on the manufacturer datasheet is proposed. According to this model, not only the steady state but also the dynamic charging performance of the Li-ion battery can be analyzed and evaluated. The major advantage of our model is that all the parameters can be directly obtained from the datasheet and no additional experiments are required. Moreover, the transition between charge and discharge stages was analyzed based on our model, and a novel Simulink module was built to predict the energy consumption of a battery-powered system. Experiments were carried out to verify the model accuracy. Although the new model was developed for the Li-ion battery, it is expected to be applicable to other batteries.

Ruin probabilities in the risk model with two compound Binomial processes

Mao-Jun Zhang,Jiang-Xia Nan,Sen Wang 한국전산응용수학회 2008 Journal of applied mathematics & informatics Vol.26 No.1

In this paper, we consider an insurance risk model governed by a compound Binomial arrival claim process and by a compound Binomial arrival premium process. Some formulas for the probabilities of ruin and the distribution of ruin time are given, we also prove the integral equation of the ultimate ruin probability and obtain the Lundberg inequality by the discrete martingale approach.

RUIN PROBABILITIES IN THE RISK MODEL WITH TWO COMPOUND BINOMIAL PROCESSES

Zhang, Mao-Jun,Nan, Jiang-Xia,Wang, Sen Korean Society of Computational and Applied Mathem 2008 Journal of applied mathematics & informatics Vol.26 No.1

In this paper, we consider an insurance risk model governed by a compound Binomial arrival claim process and by a compound Binomial arrival premium process. Some formulas for the probabilities of ruin and the distribution of ruin time are given, we also prove the integral equation of the ultimate ruin probability and obtain the Lundberg inequality by the discrete martingale approach.

Clinical Reference Strategy for the Selection of Treatment Materials for Maxillofacial Bone Transplantation: A Systematic Review and Network Meta-Analysis

Zhang Shuxin,Zhang Xinyi,Li Yanling,Mao Xuran,Liu Rui,Qi Yanxin,Lee Eui-Seok,Jiang Heng Bo 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3

Bone graft materials have mixed effects of bone repair in the field of oral maxillofacial surgery. The qualitative analyses performed by previous studies imply that autogenous odontogenic materials and autogenous bone have similar effects on bone repair in clinical jaw bone transplantation. This retrospective systematic assessment and network meta-analysis aimed to analyze the best effect of clinical application of autogenous odontogenic materials and autogenous, allogeneic, and xenogeneic bone grafts in bone defect repair. A systematic review was performed by searching the PubMed, Cochrane Library, and other journal databases using selected keywords and Medical Subject Headings search terms. 10 Papers (n = 466) that met the inclusion criteria were selected. The assessment of heterogeneity did not reveal any overall statistical difference or heterogeneity (P = 0.051 > 0.05), whereas the comparison between autogenous and allogeneic bone grafts revealed local heterogeneity (P = 0.071 < 0.1). Risk of bias revealed nine unclear studies and one high-risk study. The overall consistency was good (P = 0.065 > 0.05), and the local inconsistency test did not reveal any inconsistency. The publication bias was good. The confidence regarding the ranking of bone graft materials after GRADE classification was moderate. The effects on bone repair in the descending order were as follows: autogenous odontogenic materials, xenogeneic bone, autogenous bone, and allogeneic bone. This result indicates that the autogenous odontogenic materials displayed stronger effects on bone repair compared to other bone graft materials. Autogenous odontogenic materials have broad development prospects in oral maxillofacial surgery.

Response improvement for In2O3–TiO2 thick film gas sensors

Mao Lin Zhang,Jian Ping Song,Zhan Heng Yuan,Cheng Zheng 한국물리학회 2012 Current Applied Physics Vol.12 No.3

In2O3 is introduced into TiO2 by sol-gel method to improve the response/recovery rate and expand the operating temperature, when the In2O3-TiO2 mixed system is exposed to H2/O2. The sensor is fabricated by thick film technology. Influence of In2O3 on the film phase composition, microstructure and sensing characteristics is discussed. Dynamic response properties show that the operating temperature of the mixed system is at 500e800 ℃, which is about 600e800 ℃ for pure TiO2. Response time of the sensor is about 200e260 ms (millisecond) while recovery time is in a narrow range of 60e280 ms at 600e800 ℃. The promoting mechanism is suggested to arise from the introduction of In2O3 and grain size effect of the sensing film. Then In2O3-TiO2 thick films are surface-modified by Pt using chloroplatinic acid. The promoting effect of Pt dispersed on the mixed system is also investigated. In2O3 is introduced into TiO2 by sol-gel method to improve the response/recovery rate and expand the operating temperature, when the In2O3-TiO2 mixed system is exposed to H2/O2. The sensor is fabricated by thick film technology. Influence of In2O3 on the film phase composition, microstructure and sensing characteristics is discussed. Dynamic response properties show that the operating temperature of the mixed system is at 500e800 ℃, which is about 600e800 ℃ for pure TiO2. Response time of the sensor is about 200e260 ms (millisecond) while recovery time is in a narrow range of 60e280 ms at 600e800 ℃. The promoting mechanism is suggested to arise from the introduction of In2O3 and grain size effect of the sensing film. Then In2O3-TiO2 thick films are surface-modified by Pt using chloroplatinic acid. The promoting effect of Pt dispersed on the mixed system is also investigated.

Seniors Have a Better Learning Curve for Laparoscopic Colorectal Cancer Resection

Zhang, Xing-Mao,Wang, Zheng,Liang, Jian-Wei,Zhou, Zhi-Xiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Purpose: This study was designed to evaluate the outcomes of laparoscopic colorectal resection in a period of learning curve completed by surgeons with different experience and aptitudes with a view to making clear whether seniors had a better learning curve compared with juniors. Methods: From May 2010 to August 2012, the first twenty patients underwent laparoscopic colorectal resection completed by each surgeon were selected for analysis retrospectively. A total of 240 patients treated by 5 seniors and 7 juniors were divided into the senior group (n=100) and the junior group (n=140). The short-term outcomes of laparoscopic surgery of the two groups were compared. Results: The mean numbers of lymph nodes harvested were $21.2{\pm}11.0$ in the senior group and $17.3{\pm}11.5$ in the junior group (p=0.010); The mean operative times were $187.9{\pm}60.0min$ as compared to $231.3{\pm}55.7min$ (p=0.006), and blood loss values were $177.0{\pm}100.7ml$ and $234.0{\pm}185ml$, respectively (p=0.001); Conversion rate in the senior group was obviously lower than in the junior group (10.0% vs 20.7%, p=0.027) and the mean time to passing of first flatus were $3.3{\pm}0.9$ and $3.8{\pm}0.9$ days (p=0.001). For low rectal cancer, the sphincter preserving rates were 68.7% and 35.3% (p=0.027). Conclusions: Seniors could perform laparoscopic colorectal resection with relatively better oncological outcomes and quicker recovery, and seniors could master the laparoscopic skill more easily and quickly. Seniors had a better learning curve for laparoscopic colorectal cancer resection compared to juniors.