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Manuella Santos Carneiro Almeida,Andrea dos Anjos Pontual,Rejane Targino Beltrao,Ricardo Villar Beltrao,Maria Luiza dos Anjos Pontual 대한구강악안면방사선학회 2013 Imaging Science in Dentistry Vol.43 No.1
Purpose: This study investigated the possible correlation between the mineralization of the second molars and the chronological age of a sample population of the state of Paraiba, Brazil. Materials and Methods: One thousand eight hundred fifty-four digitized panoramic images using a scanner of a private dental radiology service were obtained in six months. Of these, 457 were selected from patients aged 4.6 to 16 years who met certain criteria. The images were assessed twice by a radiologist with 5 years experience. A minimum interval of 30 days between the evaluations of the same patient was established. To analyze the relationship between chronological age, calcification level proposed by Demirjian et al in 1973, gender, and tooth, a multiple linear regression model was adjusted, taking age as the response variable (p⁄0.05). Results: The gender and calcification level were significantly correlated with the age of the patients (p⁄0.05). There was a significant difference between the average age of the patients’ upper teeth compared to the lower ones in both genders (p⁄0.05). The dental development occurred earlier in female individuals than in male ones, and there was no significant difference between the right and left second permanent molars. Conclusion: It was observed that ethnic variables are related to certain parameters of age and sex identification in the Brazilian population, providing important information for forensic evaluations.
Almeida, Manuella Santos Carneiro,Pontual, Andrea Dos Anjos,Beltrao, Rejane Targino,Beltrao, Ricardo Villar,Pontual, Maria Luiza Dos Anjos Korean Academy of Oral and Maxillofacial Radiology 2013 Imaging Science in Dentistry Vol.43 No.1
Purpose: This study investigated the possible correlation between the mineralization of the second molars and the chronological age of a sample population of the state of Paraiba, Brazil. Materials and Methods: One thousand eight hundred fifty-four digitized panoramic images using a scanner of a private dental radiology service were obtained in six months. Of these, 457 were selected from patients aged 4.6 to 16 years who met certain criteria. The images were assessed twice by a radiologist with 5 years experience. A minimum interval of 30 days between the evaluations of the same patient was established. To analyze the relationship between chronological age, calcification level proposed by Demirjian et al in 1973, gender, and tooth, a multiple linear regression model was adjusted, taking age as the response variable (p<0.05). Results: The gender and calcification level were significantly correlated with the age of the patients (p<0.05). There was a significant difference between the average age of the patients' upper teeth compared to the lower ones in both genders (p<0.05). The dental development occurred earlier in female individuals than in male ones, and there was no significant difference between the right and left second permanent molars. Conclusion: It was observed that ethnic variables are related to certain parameters of age and sex identification in the Brazilian population, providing important information for forensic evaluations.
Oral Disease-Modifying Therapies for Multiple Sclerosis
김우준,Manuella Edler Zandoná,김수현,김호진 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.1
Classical multiple sclerosis (MS) treatments using first-line injectable drugs, although widelyapplied, remain a major concern in terms of therapeutic adherence and efficacy. New oral drugsrecently approved for MS treatment represent significant advances in therapy. The oral route ofadministration clearly promotes patient satisfaction and increases therapeutic compliance. However, these drugs may also have safety and tolerability issues, and a thorough analysis ofthe risks and benefits is required. Three oral drugs have been approved by regulatory agenciesfor MS treatment: fingolimod, teriflunomide, and dimethyl fumarate. This article reviews themechanisms of action, safety, and efficacy of these drugs and two other drugs that have yieldedpositive results in phase III trials: cladribine and laquinimod.
Zandoná,, Manuella Edler,Kim, Su-Hyun,Hyun, Jae-Won,Park, Boram,Joo, Jungnam,Kim, Ho Jin SAGE Publications 2014 Multiple sclerosis journal: clinical and laborator Vol.20 No.14
<P>We evaluated whether the location of the initial attack predicted the locations of subsequent events in neuromyelitis optica spectrum disorder (NMOSD). In the retrospective analysis from 164 patients with NMOSD, increased odds of a second attack occurring in the initial event location were seen in all locations (odds ratio [OR] brain: 16.00; brainstem: 4.42; optic nerve: 4.08; and spinal cord: 4.59), as was a positive linear trend when evaluating the number of previous events in the same location as the third event location (OR brain: 62.52; brainstem: 44.55; optic nerve: 6.48; and spinal cord: 2.98). This study suggests early clinical events of NMOSD tend to recur in the same anatomical location within the central nervous system (CNS).</P>
Amira Guellim,Bertrand Hirel,Olivier Chabrerie,Manuella Catterou,Thierry Tetu,Frédéric Dubois,Hela Ben Ahmed,Thomas Kichey 한국작물학회 2020 Journal of crop science and biotechnology Vol.23 No.4
Drought is one of the major abiotic stresses with a detrimental impact on plant growth and development irrespective of the developmental stage. Thus, identifying the physiological mechanisms driving drought resistance in crops remains challenging. Drought tolerance was evaluated in nine durum wheat cultivars (Triticum durum Desf.) at an early stage of plant development using plants grown under hydroponic conditions. Young wheat plants were subjected to three polyethylene glycol (PEG) treatments (0%, 1.8%, and 2.6%) over 21 days. Nineteen morpho-physiological parameters were then measured to monitor the impact of drought stress caused by the presence of PEG. An integrative analysis allowed the identification of genotypes exhibiting various levels of tolerance to drought, also revealing the impact of water deficiency on key phenotypic and physiological markers. Among the nine wheat genotypes, the landrace INRAT 69 was the most tolerant, whereas the commercial cultivar Ben Bechir was the most sensitive. We also found that amino acid, total soluble sugar, proline, and starch contents were the physiological parameters that were the most representative of drought stress. The use of these parameters as marker traits to select drought-tolerant wheat genotypes at early stages of plant development is discussed.