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Manju Pandey,Prabhash Mishra,Debdulal Saha,K. Sengupta,S. S. Islam 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.2
Porous alumina thin film has been investigated in order to find its sensitivity in the trace moisture level. Alumina, with two different phases were obtained using sol-gel process and fired between 400°C to 1000°C. FESEM, BET, AFM and XRD techniques were employed for microstructural characterization of the sintered thin film in two phases. A detailed analysis is done to assess the superiority of gamma (γ) - over alpha (α) phase using impedance spectroscopy. It was observed that gamma phase is more sensitive towards trace level moisture sensing.
Manju Chandran,Aye Chan Maung,Ambrish Mithal,Rajeev Parameswaran 대한골다공증학회 2020 Osteoporosis and Sarcopenia Vol.6 No.3
COVID-19, the acute respiratory tract infection (RTI) caused by the Coronavirus, Sars-CoV-2, has swept around the world. No country has been spared from its onslaught. Treatments that can reduce the risk of infection and mortality from the disease are desperately needed. Though high quality randomized controlled trials are lacking, some observational and interventional studies that explore the link between vitamin D and RTIs exist. Vitamin D modulates both innate as well as adaptive immunity and may potentially prevent or mitigate the complications associated with RTIs. Evidence linking vitamin D to COVID-19 include that the outbreak occurred in winter in the northern hemisphere at a time when vitamin D levels are lowest in resident populations, that blacks and minority ethnic individuals who are known to have lower levels of vitamin D appear to be disproportionately affected and have more severe complications from the disease, that vitamin D deficiency has been shown to contribute to acute respiratory distress syndrome and that case fatality rates increase with age and in populations with comorbid conditions such as diabetes, hypertension, and cardiovascular disease, all of which are associated with lower vitamin D levels. This narrative review summarizes the current knowledge about the epidemiology and pathophysiology of COVID-19, the evidence linking vitamin D and RTIs, especially COVID-19, the mechanistic reasons behind the possible protective effect of vitamin D in COVID-19, and the evidence with regard to vitamin D supplementation in RTIs. It concludes with some recommendations regarding supplementation of vitamin D in patients with COVID-19.
Protective effect of silymarin in streptozotocin-induced diabetic dyslipidaemia in rats
Manju Sharma,K. K. Pillai,Tarique Anwer,Abul Kalam Najmi,Syed Ehtaishamul Haque,Yasmin Sultana 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.3
The present study investigated the effect of silymarin, a flavonoid, on streptozotocin (STZ) - induced diabetic dyslipidaemia in rats. Experimental diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Silymarin (25 mg/kg and 50 mg/kg) was orally administered to diabetic rats for a period of 15 days. Blood glucose levels, serum lipid profile and liver glycogen levels were estimated following the established procedures. Biochemical observations were supplemented with histological examination of liver sections. Oral administration of silymarin to diabetic rats significantly (P < 0.001) decreased the blood glucose levels (259.99 ± 23.64 vs. 99.90 ±2.62 [25 mg] & 89.17 ± 3.32 [50 mg]). The most interesting finding was the significant (p < 0.001)increase in HDL-cholesterol levels (26.99 ± 0.61 vs. 40.55 ± 0.52 [25 mg] & 41.12 ± 0.37 [50 mg])whereas, there was a significant decrease in serum total cholesterol (TCh), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) cholesterol levels observed in silymarin treated diabetic rats. STZ treatment caused significant degeneration of liver parenchyma,which was normalized to near normal morphology by administration of silymarin. The findings indicate that silymarin effectively improved the overall lipid profile and restored the glycogen stores in the liver of STZ-induced diabetic rats, in a dose dependent manner. The results indicate existence of abnormalities in lipid metabolism in STZ-induced diabetic rats and suggest a protective effect of silymarin in this animal model.
Manju Sharma,KK Pillai,Abul K Najmi,Tarique Anwer,Yasmin Sultana 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.1
Free radicals are known to play important role in pathophysiology of hepatic disorders and antioxidants are employed along with other chemotherapeutic agents in treatment of such diseases. In search of natural antioxidant, successive extracts of Hypericum (H.) hookerianum (Family: Hypericaceae) were evaluated by in vitro and in vivo methods. Extracts of aerial parts of H. hookerianum were subjected for 1,1-diphenyl 2-picryl hydrazyl radical scavenging activity (DPPH assay), nitric oxide radicals scavenging assay and thiobarbituric acid reactive substances (TBARS) assay. Methanolic extract was found to be more active than other extracts in DPPH and in vitro TBARS assay with IC50 at 5.82 ± 1.33 μg/ml and 49.78 ± 3.79 μg/ml respectively. While petroleum ether extract showed more potentials in scavenging the nitric oxide radicals with IC50 220.97 ± 2.69 μg/ml. The administration of CCl4 to the control animals caused decrease in the level of catalase and superoxide dismutase, together with significant increase in the level of TBARS in liver and kidney. Reversal of these changes towards normal group was observed by administration of H. hookerianum methanolic extract at 50 and 100 mg/kg body weight, while other extracts were found to be less active.
Manju Siliwal,Sanjay Molur,Robert Raven 국립중앙과학관 2015 Journal of Asia-Pacific Biodiversity Vol.8 No.1
The new genus, Damarchilus gen. nov., is proposed with descriptions of two new species, Damarchilus nigricus sp. nov. and Damarchilus rufus sp. nov., from northeast India. External characters for the new genus and new species are examined and illustrated. In addition, the natural history of the species is provided.
Clinical aspects and management of osteoporosis and fragility fractures in patients with diabetes
Manju Chandran 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.3
Both diabetes and osteoporosis are assuming epidemic proportions throughout the world. Accumulating data suggest that both types 1 and 2 diabetes are associated with an increased risk of fragility fractures. This increased risk appears to be largely independent of bone mineral density (BMD) which is most often noted to be low in type 1 diabetes and normal or increased in type 2 diabetes. This review explores the clinical characteristics of bone fragility in patients with diabetes and highlights studies that have evaluated BMD and fracture prediction tools in these patients. It also briefly reviews the current management principles of osteoporosis in diabetes, with special emphasis on the impact of diabetes medications on bone health as well as explores the efficacy of currently available antiosteoporosis pharmacotherapy in the diabetic population.
Strain induced structural transformation, mechanical and phonon stability in silicene derived 2D-SiB
Manju M.S.,Siby Thomas,Anees P.,Sang Uck Lee,Ajith K. M. 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.90 No.-
Two-dimensional monolayer SiB is a silicene derivative exhibiting buckling of atoms similar to that seenin silicene. This manuscript presents a systematic study of the strain-dependent variation of thestructural, mechanical, and dynamical properties of SiB. Strain was applied in the uniaxial armchair,uniaxial zigzag, and biaxial directions within the range of0.2 to 0.3. The resultant strain energy plotindicates anisotropic behavior of SiB in these directions. The SiB showed a mechanical strength that washigher than its counterpart, silicene, by an order of 30%. The elastic constant data from the undeformedSiB indicated an anisotropic nature, which was also seen with all the strain directions. Charge densitycontours, along with Bader charge analysis, confirmed the ionic nature of SiB in its original form. Thisnature became covalent as the strain varied from the compressive to the tensile regime in the uniaxialzigzag and biaxial directions. The majorfinding described in this manuscript is a newflat conformationhaving orthorhombic symmetry in contrast to the buckled structure. In addition, this material wasobserved to attain stability with the application of uniaxial tensile armchair and zigzag directionalstrains. Ab-initio molecular dynamics simulation confirmed the thermal stability of SiB in its newconformation.
Topological studies of molecular interactions of formamide with propanol and butanol at 298.15 K
Manju Rani,Sanjeev Maken 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.5
Molar excess volumes have been measured at 298.15 K for formamide + 1-propanol, 2-propanol, 1-butanol, 2-methyl-1-propanol or 2-methyl-2-propanol mixtures. For an equimolar mixture, molar excess volumes follow the sequence: 1-butanol > 1-propanol > 2-methyl-1-propanol > 2-methyl-2-propanol > 2-propanol. The excess molar volume (VEm ) values have been fitted to Redlich–Kister polynomial equation and other volumetric properties like apparent molar volume, partial molar volume,excess partial molar volume were calculated. The excess volume data have also been rationalized by graph-theoretical arguments. It has been observed that VEm calculated by this approach agree well with the corresponding experimental values. This analysis has further yielded information about the state of aggregation of pure components that is consistent with the existing views on their nature of association. The infrared spectral studies lend further credence to the graph theoretical arguments.