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β-Adrenergic Receptor and Insulin Resistance in the Heart
Mangmool, Supachoke,Denkaew, Tananat,Parichatikanond, Warisara,Kurose, Hitoshi The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.1
Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-regulation of the sympathetic nervous system, resulting in enhanced stimulation of ${\beta}$-adrenergic receptor (${\beta}$AR). Overstimulation of ${\beta}$ARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the ${\beta}$AR and the insulin sensitivity and the mechanism by which ${\beta}$AR overstimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that ${\beta}$ARs overstimulation leads to induction of insulin resistance in the heart.
β-Adrenergic Receptor and Insulin Resistance in the Heart
( Supachoke Mangmool ),( Tananat Denkaew ),( Warisara Parichatikanond ),( Hitoshi Kurose ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.1
Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-reg-ulation of the sympathetic nervous system, resulting in enhanced stimulation of β-adrenergic receptor (βAR). Overstimulation of βARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the βAR and the insulin sensitivity and the mechanism by which βAR over-stimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that βARs overstimulation leads to induction of insulin resistance in the heart.
Myofibroblasts and inflammatory cells as players of cardiac fibrosis
Hitoshi Kurose,Supachoke Mangmool 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.8
On myocardial infarction, many cells are injuredor died owing to arterial occlusion. Intracellular moleculesreleased from injured or dead cells initiate inflammatoryresponses that play important roles in cardiac remodelingincluding fibrosis. Fibrosis is an excess accumulation ofextracellular collagen. Currently, drugs used to treat cardiacfibrosis are not commercially available. Myofibroblastsare responsible for the production and secretion ofcollagen. Infiltrating inflammatory cells interact withfibroblasts or other cells and promote myofibroblast formation. Inflammatory cells also modulate the activities ofmyofibroblasts. Regulation of collagen production is criticalfor modulating the progression of fibrosis. Hence, themanipulation of activities of inflammatory cells andmyofibroblasts will provide promising therapeutic targetsfor treatment of cardiac fibrosis.
Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity
Motohiro Nishida,Tomohiro Tanaka,Supachoke Mangmool,Kazuhiro Nishiyama,Akiyuki Nishimura 한국지질동맥경화학회 2020 지질·동맥경화학회지 Vol.9 No.1
Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response to changes in the vessel environment. Abnormal phenotypic switching of VSMCs is a distinctive characteristic of vascular disorders, including atherosclerosis, pulmonary hypertension, stroke, and peripheral artery disease; however, how the control of VSMC phenotypic switching is dysregulated under pathological conditions remains obscure. Canonical transient receptor potential (TRPC) channels have attracted attention as a key regulator of pathological phenotype switching in VSMCs. Several TRPC subfamily member proteins—especially TRPC1 and TRPC6—are upregulated in pathological VSMCs, and pharmacological inhibition of TRPC channel activity has been reported to improve hypertensive vascular remodeling in rodents. This review summarizes the current understanding of the role of TRPC channels in cardiovascular plasticity, including our recent finding that TRPC6 participates in aberrant VSMC phenotype switching under ischemic conditions, and discusses the therapeutic potential of TRPC channels.
A Novel Nucleic Lateral Flow Assay for Screening phaR-Containing Bacillus spp.
( Nay Yee Wint ),( Khine Kyi Han ),( Wariya Yamprayoonswat ),( Pattarawan Ruangsuj ),( Supachoke Mangmool ),( Chamras Promptmas ),( Montri Yasawong ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.1
Polyhydroxyalkanoate (PHA) synthase is a key enzyme for PHA production in microorganisms. The class IV PHA synthase is composed of two subunits: PhaC and PhaR. The PhaR subunit, which encodes the phaR gene, is only present in class IV PHA synthases. Therefore, the phaR gene is used as a biomarker for bacteria that contain a class IV PHA synthase, such as some Bacillus spp. The phaR gene was developed to screen phaR-containing Bacillus spp. The phaR screening method involved two steps: phaR gene amplification by PCR and phaR amplicon detection using a DNA lateral flow assay. The screening method has a high specificity for phaR-containing Bacillus spp. The lowest amount of genomic DNA of B. thuringiensis ATCC 10792 that the phaR screening method could detect was 10 pg. This novel screening method improves the specificity and sensitivity of phaR gene screening and reduces the time and cost of the screening process, which could enhance the opportunity to discover good candidate PHA producers. Nevertheless, the screening method can certainly be used as a tool to screen phaR-containing Bacillus spp. from environmental samples.