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Manbok Jeong 한국임상수의학회 2023 한국임상수의학회지 Vol.40 No.4
A 4-year-old female Munchkin cat presented with a 2-day history of a large mass in the left eye. On the first presentation, slit lamp biomicroscopy re- vealed a large corneal bulla occupying around 40% of the corneal surface along the visual axis. Based on the results, a diagnosis of feline acute bullous keratopathy was made. Due to the location of the extensive corneal bulla, autologous lamellar keratoplasty was performed based on prior studies, to both minimize postopera- tive complications that may affect axial vision and address any cosmetic concerns the owner had. The autologous lamellar keratoplasty successfully resolved the cor- neal bulla with no signs of corneal opacities postoperatively. Therefore, autologous lamellar keratoplasty may be a useful surgical treatment for feline acute bullous keratopathy from both the tectonic and optical points of view.
Primary Angle-Closure Glaucoma in a Maltipoo Dog
Manbok Jeong 한국임상수의학회 2023 한국임상수의학회지 Vol.40 No.3
A two-year-old spayed female Maltipoo dog was presented with a two-month duration of glaucoma in the right eye. On the first presentation, menace response and dazzle reflex were absent in the right eye, but it was pres- ent in the left eye. Slit-lamp biomicroscopy showed buphthalmia, mild corneal edema, and conjunctival and episcleral hyperemia in the right eye. The intraoc- ular pressures were 70 mmHg and 30 mmHg in the right and left eyes, respec- tively. On the gonioscopic and high-resolution ultrasound examinations, both the iridocorneal angle and ciliary cleft were completely closed in the right eye. However, gonioscopy revealed an opened iridocorneal angle even with some broader base of pectinate ligament fiber, but high-resolution ultrasound showed a narrowed ciliary cleft and increased contact of the iris base with the limbal cor- nea in the left eye. Based on these results, a diagnosis of primary angle-closure glaucoma was made in both eyes. This case report highlighted the importance of evaluating the ciliary cleft with high-resolution ultrasound as a critical diag- nostic and prognostic role in canine glaucoma.
Treatment of descemetocele with combined deep keratotomy with a nictitating membrane flap in a dog
Manbok Jeong 대한수의학회 2023 大韓獸醫學會誌 Vol.63 No.2
A 10-year-old, spayed female, Maltese dog presented with a 2-day history of severe left eye squint. Slit-lamp biomicroscopy showed a deep corneal defect stained into a doughnut shape together with hypopyon in the anterior chamber. Based on these results, a diagnosis of descemetocele and uveitis in the left eye was made. Deep keratotomy combined with a nictitating membrane flap effectively resolved the descemetocele without complications. The surgical procedures performed on this patient were easy and effective, and could be used as an alternative to graft surgery for descemetocele treatment.
Contributed Mini Review : Naturally occurring reoviruses for human cancer therapy
( Manbok Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.8
Naturally occurring reoviruses are live replication-proficient viruses that specifically infect human cancer cells while sparing their normal counterpart. Since the discovery of reoviruses in 1950s, they have shown various degrees of safety and efficacy in pre-clinical or clinical applications for human anti-cancer therapeutics. I have recently discovered that cellular tumor suppressor genes are also important in determining reoviral tropism. Carcinogenesis is a multi-step process involving the accumulation of both oncogene and tumor suppressor gene abnormalities. Reoviruses can exploit abnormal cellular tumor suppressor signaling for their oncolytic specificity and efficacy. Many tumor suppressor genes such as p53, ataxia telangiectasia mutated (ATM), and retinoblastoma associated (RB) are known to play important roles in genomic fidelity/maintenance. Thus, a tumor suppressor gene abnormality could affect host genomic integrity and likely disrupt intact antiviral networks due to the accumulation of genetic defects which in turn could result in oncolytic reovirus susceptibility. This review outlines the discovery of oncolytic reovirus strains, recent progresses in elucidating the molecular connection between oncogene/tumor suppressor gene abnormalities and reoviral oncotropism, and their clinical implications. Future directions in the utility of reovirus virotherapy is also proposed in this review. [BMB Reports 2015; 48(8): 454-460]
소형풍력발전기 브레이크 패드 마모 및 디스크 온도 측정 센서 개발
김만복(Manbok Kim) 한국신재생에너지학회 2021 한국신재생에너지학회 학술대회논문집 Vol.2021 No.7
신재생 에너지에 대한 중요도가 증가와 동시에 풍력 발전 사업으로 인한 발전량도 증가하고 있는 추세이다. 하지만 풍력발전기의 유지보수에 대한 모니터링 시스템의 발전은 풍력산업의 발전에 비해 상대적으로 가야할 길이 멀다. 최근까지도 풍력발전기 내부에서 원인불명의 화재사고가 빈번하게 일어나고 있다. 풍력발전기의 유지보수에서 가장 중요한 것은 브레이크 시스템이다. 강풍이나 태풍으로 인해 블레이드 고속회전으로 풍력발전기의 손상을 예방할 수 있는 것이 바로 제동장치이다. 하지만 자동장치에서 브레이크 패드나 브레이크 디스크에 문제를 미리 모니터링하지 못했을 경우 심각한 사고를 야기할 수 있다. 따라서 본 논문에서는 풍력발전기의 브레이크 시스템 중 브레이크 패드의 마모량을 미리 파악할 수 있는 센서와 브레이크 디스크의 온도를 측정하는 센서를 개발하여 풍력발전기의 브레이크 시스템의 패도 마모량과 브레이크 디스크의 온도를 실시간으로 모니터링할 수 있는 설계를 구현하였다.