성대마비환자를 대상으로 시행한 후두근전도검사의 임상적 유용성

최홍식,최영준,문상우,김태만,최홍식,최영준,문상우,김태만 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

그레이브스병에서 치료에 따른 폐동맥압의 변화

남택만,조한수,이진서,송영림,김두만,두영철,박철영,정인경,홍은경,이성진,오기원,김현규,유재명,최문기,유형준,박성우 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

연구배경: 갑상선기능항진증에 의한 갑상선중독증 환자들은 호흡곤란을 호소하며, 그 원인으로 호흡근의 근력 약화, 좌심실부전으로 인한 폐모세혈관의 울혈, 기도저항의 증가, 갑상선종으로 인한 기관의 압박, 호흡기능 이상 등이 거론되고 있다. 폐동맥고혈압이 동반된 그레이브스병 환자가 여러 증례가 보고되었으며, 폐동맥고혈압 환자에게서 갑상선 자가항체와 갑상선기능저하증의 빈도가 높음이 알려지면서 갑상선중독증이 동반된 그레이브스병 환자에게서 관찰되는 호흡곤란의 한 원인으로 폐동맥압 증가가 작용할 가능성이 제시되고 있다. 이에 저자 등은 그레이브스병 환자를 대상으로 폐동맥압을 측정하고 치료 전후의 폐동맥압의 변화를 전향적으로 연구하였다. 방법: 갑상선중독증이 동반된 그레이브스병 환자와 정상 갑상선기능을 나타낸 대조군을 대상으로 갑상선기능검사 및 갑상선 자가항체를 측정하고, 심초음파를 이용하여 치료 전후로 폐동맥압을 측정하여 폐동맥압과 갑상선기능 및 갑상선 자가항체와의 관계, 폐동맥압의 변화 등을 관찰하였다. 결과: 1. 연구대상은 대조군 10명 (남녀비 1:9, 관해 상태의 그레이브스병 3명, 갑상선종 3명, 정상인 4명), 그레이브스병 환자 26명 (남녀비 7:19)이었다. 2. 대조군과 치료 전 그레이브스병 환자의 폐동맥압은 각각 23.5±2.32 mmHg, 29.6±10.3 mmHg이었고, 치료 전의 폐동맥압과 혈청 갑상선자극호르몬 결합억제 면역글로불린 (TBII) 농도는 유의한 양의 상관관계를 보였다. 3. 26명의 그레이브스병 환자 중에서 10명 (38.5%)이 폐동맥고혈압 (기준: 폐동맥압 > 30 mmHg)으로 진단되었다. 4. 치료 전후로 폐동맥압을 측정한 13명은 폐동맥압이 치료 전 29.6±10.3 mmHg에서 치료 후 폐동맥압 22.2±6.48 mmHg로 의미있게 감소하였다. 결론: 갑상선중독증을 보이는 그레이브스병 환자의 약 40% 정도에서 폐동맥고혈압이 발견되어 폐동맥고 혈압은 그레이브스병에 흔하게 동반하는 질환으로 생각된다. 향후 그레이브스병 환자에서 관찰되는 폐동맥압의 증가와 관련한 병인, 발생기전 및 임상적 의의 등에 대한 연구가 필요할 것으로 생각된다. Background: Exertional symptoms, dyspnea and impaired effort tolerance are common in patients with Graves' disease. Proposed explanations include: high-output left heart failure, ineffective oxygen utilization and respiratory muscle weakness. In addition, pulmonary hypertension has also been reported in patients with Graves' disease. A high prevalence of hypothyroidism and positive thyroid autoantibody were also observed in patients with pulmonary arterial hypertension. Therefore, the pulmonary artery pressure in patients with Graves' disease was evaluated. Methods: Two-dimensional and Doppler echocardiographic examinations (Hewlett Packard Sonos 2500) were performed to determine the pulmonary artery (PA) pressure in 26 Graves' disease patients, both before and after treatment (23 patients with propylthiouracil and 3 with RAI), and in 10 euthyroid controls. The changes in the PA pressure after treatment were evaluated in 13 patients with Graves' disease, who became euthyroid after treatment. Results: The pulmonary artery pressure was increased in the untreated Graves' disease patients compared to the normal controls (23.5±2.32 vs. 29.6±10.3 mmHg). 38.5% of the Graves' disease patients (10/26) showed pulmonary arterial hypertension (PA>30 mmHg) and the serum TBII level was higher in the Graves' disease patients with pulmonary arterial hypertension than in those with normal PA pressure (P<0.05). In the Graves' patients who became euthyroid after treatment, the PA pressure was significantly decreased. Conclusion: 38.5% of the untreated Graves' disease patients showed pulmonary arterial hypertension, and the pulmonary artery pressure was significantly decreased in those who became euthyroid after treatment. The pathogenesis and clinical importance of pulmonary arterial hypertension in Graves' disease requires further studies (J Kor Soc Endocrinol 18:465∼472, 2003).

쥐의 성주기에 따른 자궁 비만세포와 성호르몬의 변화

최영자,제갈승주,윤영승,김재만 木浦大學校 基礎科學硏究所 2001 基礎科學硏究誌 Vol.19 No.-

Mast cells reside in connective tissue and mucous tissue that encircle the internal environment of the body, where they mediate inflammatory response encountering foreign materials. Mast cells are also found in uterus tissue which is, in fact, exposed to external world. Because the cells are provoked by invading foreign cells to cause inflammatory response, their response in the uterus should be controled for success in fertilization and implantation, in that the foreign sperms and fertilized egg are willing to invade into the body. In order to confirm such assumption, we investigated the changes in mast cell numbers and their contents in the rat uterus during the estrus cycle and related these to the changes in sex-hormone concentration. The mean number of mast cell at the proestrus and estrus phase was 4.8±2.72 and 5.98±1.55. respectively. The number increased as much as 3 times more then previous phase at the metestrus phase and subsided to half at following the diestrus phase. Those mast cells were subdivided type. Connective tissue type was major at metestrus and diestrus phase. At the following proestrus, however, the muscous type was largely increased and major population was changed to muscous and intermediate type at estrus phase. In the immature uterus of young female, as few as 1.67±0.23 cells were detected and most of them were mucous and intermediate type. The concentration of circulating estradiol-17 β was lowest at the metestrus phase both in free and bound form. The results suggest that estrogen may be involved in inhibiting swarming of mast cells in the uterus and accumulating the contents of secretory vesicles.

웹사이트의 특성과 인터넷 이용성향이 커뮤니케이션 효과에 미치는 영향

최덕철,김영만 慶南大學校 産業經營硏究所 2001 産業經營 Vol.28 No.-

Aluminium板의 環境破壞에 關한 基礎的 硏究

崔壯宇,金榮萬,李龍福 弘益大學校 1982 弘大論叢 Vol.14 No.2

It is known that the most of Enviroment Assisted Fracture affected remarkably by the various environmental effect are brittle fracture, and that the above field is very wide. In this paper, Environment Assisted Fracture is discussed from the view point of fracture mechanics. Aluminium and SUS304 Stainless Steel in solutions of several percentage of MgCl₂(10%, 15%, 20%) at the temperature(60℃±3℃)is investigated according to the crack growth, and the value of K is compared with the K obtained by the changes of deflection according to the crack growth. THe results of the experiment is summarized as following 1)The tendency of crack growth as time goes by is shown as 4 region in both materials. 2)The experimental value of K of SUS304 Stainless Steel is same as the calculated value from the variation of the compliance according to crack growth, but not in Aluminium.

치주질환 심도에 따른 치아동요도와 교합력의 상관관계에 관한 연구

최조우,이만섭,권영혁 慶熙大學校 齒科大學 1993 慶熙齒大論文集 Vol.15 No.1

The purpose of this study was to investigate the change of tooth mobility and bite force according to periodontal disease severity. Tooth mobility and biting force due to change of viscoelastic property of periodontium were influenced by inflammation of periodontal tissue. 30 patients participated in this study, the periodontal disease severity is evaluated with SBI and attachment loss. SBI and attachment loss were examined by periodontal probe. Tooth mobility was tested two times to each tooth using periotest (Siemens Co, Germany) and bite force was evaluated with MPM-3000 (Nihon Kohden Co, Japan Statistical analysis was applied to correlation (r2) and regression analysis. The obtained results were as follows 1. As the attachment loss increased, tooth mobility increased with significance, and they had highly positive correlation (r-2=0.68) on entire dentition. 2. As the SBI increased, tooth mobility increased with significance, and they had positive correlation (r2=0.37) on entire dentition. 3. As the attachment loss increased, bite force decreased with significance, and they had highly negative correlation (r2=0.42) on maxillary anterior dentition but low negative correlation (r2=0.20) on the other portion of dentition. 4. As the SBI increased, bite force decreased with significance, and they had highly negative correlation (r-2=0.31) on maxillary anterior dentition but low negative correlation (rz=0.16) on the other portion of dentition. 5. As tooth mobility increased, bite force decreased with significance, and they had highly negative correlation (r2=0.32) on maxillary anterior dentition but low negative correlation (r2=0.16) on the other portion of dentition.

케이블 TV 광고의 활성화 방안에 관한 연구

崔永萬 東新大學校 1995 論文集 Vol.7 No.-

In the information age cable television broadcasting is the basis of information superhighway industries. This paper begins with the premise that cable television (CATV) advertising should be activated in order to keep the stable development of CATV. This paper consists of five chapters. Chaper 1 is the introduction, dealing with The objectives and methods of the study. Chapter 2 examines the concept,characteristics,and structure of CATV chapter 3 investigates the present situation and advertising enviroment of CATV in Korea. Chapter 4 comes up with the activating strategies of CATV advertising: the strategies of government and those of advertising industries. Finally, chapter 5 forms the conclusion. I suggest in this paper that the government and the advertising industries should work out these strategies: the government should amend the CATV laws and institutions to activate CATV, lower the deliberation standards of CATV advertising, and support CATV advertising by giving the advertising industries all kind of the possible benefit in tax, finance. The advertising industries should urge program providers to arrange the system interconnects to increase the number of audience, make the use of rational media mix as an advertisement-marketing strategy, and arrange the system-operator interconnects of broadcasting companies to raise the number of subscribers. In conclusion, if the above strategies are effectively put into practice, cable television will certainly attain its stable development through CATV advertising.

鐵筋 콘크리트 有孔보의 거동에 관한 실험적 연구(Ⅱ)

최종만,이화직,하영철,곽윤근 國立金烏工科大學校附設生産技術硏究所 1994 産業技術開發硏究 Vol.10 No.-

Openings through beams are required for the passage of utility ducts and pipes, and they are freqently encountered in the design of modern buildings. They are particularly important in multistory buildings where the use of openings in beams can mean lower story heights, leading in turn to a multiplicity of savings. Therefore, the designers are often faced with the necessity of providing adequate openings in the buildings. However, provision of openings may cause problems of excessive cracking and deflection, and may severly affect the strength of a beam. An experimental investigation is carried out on twelve reinforced concrete beams with square openings. The size of opening, and it's location are considered as major variables. The specimens were tested under two point loading. Loads were usually applied in steps of 0.5 ton up to failure to observe the crack initiation and propagation, initial diagonal cracking, midspan deflection, concrete strain and reinforcement strain.

全般管理者로서 中間管理者의 役割 定立과 課題

崔敎元,崔永萬,宋京用 東新大學校 1998 論文集 Vol.10 No.-

In today's enterprises, the complexity and enlargement of the field of the work has led the organization to be specialized, and it makes the communication and the unity more difficult between the posts. Furthermore, the overflowing of informations and knowledges, which is caused by the sudden change of the industrial society, has had an important and direct affect to the manager's behavior and decision. We can see the importance of the middle manager's position in that (1) he has to harmonize not between the top manager and workers so much as between the other middle managers accomplishing their other parts. (2) he has to exchange and hold in common the other part's information and knowledge in the process of the harmonization. (3) he has to make a diagnose and develope the plan for the solution of it, as an organization integrator. In addition to these, the middle manager's job requires the persuading, negotiating, and adjusting skill for other people's action. Therefore, this study is based on the recognition that middle manager's role becomes significant in accordance with the management specialization and it is made so that the relations of the middle manager's role, function, responsibility, and authority may be clear and the middle manager's role be built up concretely as a coordinator and negotiator, linking the upper part with the lower part, not as a mere supervisor. But the responsibility and duty of this class is really unclean. The unbalance between its responsibility and authority gives rise to many problems. The condition of the middle manager is risky, which is caused by the change of the organization This ultimately acts as a cause of impediment and gives a serious effect on the growth of enterprises. So the key manipulating the effectiveness of the organization is correcting the role and function of the middle manager, not only as the bridge of the top management and the lower management but also as a responsible person who contributes to the development of the enterprise with the subordernite's ability concentrated.

치주질환 심도에 따른 조직내 림프구 및 NK 세포의 변화에 관한 면역조직학적 연구

최호근,이만섭,권영혁 慶熙大學校 齒科大學 1993 慶熙齒大論文集 Vol.15 No.1