Clinical Characteristics and Treatment Outcomes of Chronic Pulmonary Aspergillosis: a Retrospective Analysis of 70 Patients

( Byung Woo Jhun ),( Kyeong Man Jeon ),( Jung Seop Eom ),( Ji Hyun Lee,),( Gee Young Suh ),( Man Pyo Chung ),( O Jung Kwon ),( Won Jung Koh ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Backgroud: Chronic pulmonary aspergillosis (CPA) is uncommon and there are few data on the clinical characteristics, optimal therapeutic strategies, and outcomes. Methods: We retrospectively reviewed the records of patients with newly diagnosed CPA and assessed the clinical, radiologic, and laboratory responses, and outcomes between January 2008 and January 2012. Results: A total of 70 CPA patients were included. Median age was 55 years and 51 patients (72.9% ) were men. Fifty-seven patients (81.4%) had a history of pulmonary tuberculosis and 32 patients (45.7%) had non-tuberculosis mycobacterium (NTM) lung disease, 17 of whom had a history of NTM treatment and 15 was under NTM treatment. Sixty-nine patients (98.6%) received oral itraconazole, except one with oral voriconazole for a median duration of 6.2 months. Symptomatic improvement occurred in 52 patients (74.3%), radiologic improvement occurred in 29 (41.4%), and laboratory tests improved more than 60% of all patients. Thirty-six patients (51.4%) achieved treatment success, defined as symptomatic improvement after at least 6 months of therapy regardless of radiological improvement, and 4 of whom needed retreatment after a median of 8.4 months. There was no difference in clinical characteristics and outcomes according to NTM status and 10 (14.3%) discontinued therapy due to adverse reactions. Death occurred in 10 (14.3%) and median follow-up duration was 11.2 months. Conclusion: Antifungal therapy for about 6 months and reassessment of disease might be feasible treatment strategy in managing patients with CPA.

서비스 시스템의 분포형태 조사 및 적합도 검정시 유의수준의 영향 분석

문기주,양승만 대한설비관리학회 2003 대한설비관리학회지 Vol.8 No.2

It is common to use an empirical distribution if the collected field data set is not accepted by a goodness of fitness test for a simulation study. However, a theoretical distribution is recommend to use for model building to the shortcomings of reproducing the observed data only. It is true that the possibility of passing a goodness of fit test for a set of observed data collected in the field is relatively low. In addition, determination of significance level for a theoretical distribution examination is not a simple question, either. It can be claimed that the level of significance determines whether the goodness of fit test for a observed data set is passed or not. Therefore, it is a very interesting issue that observing the effects with various levels of significance value in a simulation model. In this paper, the results of goodness of fit tests with observed data sets are presented. Also, a single line single server simulation model is constructed to examine the effect of significance level. Some selected data sets passing the Goodness of Fit test with certain levels of significance are used for this analysis.

3구간 종속 가변속도하에서 배송차량의 최적운영 방안에 관한 연구

문기주,양승만 대한설비관리학회 2004 대한설비관리학회지 Vol.9 No.2

The vehicle routing problem with time-varying speed(VRPTVS) is difficult to handle with regular Traveling Salesman Problem(TSP) approaches due to the varying speeds. A 3 service zone partitioning method is developed in this research to adapt the government supplied traffic information as well as possible computing time reductions. The vehicle speed in each of the 3 splitted service zones based on the time window becomes fixed vehicle speed. A regular TSP algorithm for not coning back to the origin is applied for the delivery points in each zone and then 3 routes are connected for one initial completed vehicle route. A pairwise exchange method is applied to reduce the traveling time.

Clinical characteristics and treatment outcomes of chronic necrotizing pulmonary aspergillosis: a review of 43 cases

Nam, Hae-Seong,Jeon, Kyeongman,Um, Sang-Won,Suh, Gee Young,Chung, Man Pyo,Kim, Hojoong,Kwon, O. Jung,Koh, Won-Jung Elsevier 2010 INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES Vol.14 No.6

<P><B>Abstract</B></P><P><B>Objectives</B></P><P>Chronic necrotizing pulmonary aspergillosis (CNPA) is uncommon, and the optimal therapeutic regimen has not been established. In a retrospective cohort study, we investigated the clinical characteristics and treatment outcomes of patients with CNPA.</P><P><B>Methods</B></P><P>We reviewed the medical records of all patients who had been diagnosed with CNPA at our institution over the last 10 years.</P><P><B>Results</B></P><P>Forty-three patients were identified. Their median age was 60 years (interquartile range (IQR) 45–65 years), and 34 (79%) of the patients were men. The most common underlying lung disease was pulmonary tuberculosis (<I>n</I>=40, 93%). After CNPA was diagnosed, all patients were treated with antifungal drugs, including oral itraconazole (<I>n</I>=39, 91%) or intravenous amphotericin B (<I>n</I>=4, 9%). Seventeen (40%) patients discontinued therapy early (<3 months), 14 patients due to death and three to loss of follow-up. Twenty-six (60%) patients received oral itraconazole at a daily dose of 200–400mg for more than 3 months. The median treatment duration was 6 months (IQR 6–12 months). In these 26 patients, clinical improvement was observed in 15 (58%) and radiological improvement was observed in 11 (42%). Ten (38%) patients showed no improvement. Twenty-two (51%) patients died, including 18 (42%) CNPA-related deaths, during a median follow-up of 15 months (IQR 2.5–32 months). The median survival time was 62 months.</P><P><B>Conclusions</B></P><P>CNPA is difficult to treat and often has a poor outcome. Further studies with more patients are needed to identify the optimal therapy for patients with CNPA.</P>

해마 theta리듬과 pyramidal neuron의 세포내 특성과의 상관관계

권오흥,조진화,남순현,김현정,최병주,김영진,이만기 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.4

Eledctrophysiological phenomena of pyramidal cells in the CAI area of the dorsal hippocampus were recorded from and filled with neurobiotin in anesthetized rats. The electropharmacological properties of membrane as well as the cellular-synaptic generation of rhythmic slow activity (theta)were examined. The intracellular response characteristics of these pyramidal cells were distinctly different from responses of inteneurons. Pyramidal cells had a high resting membrane potential, a low input resistance, and a large amplitude action potential. A afterhyperpolarization was followed a single action potential. Most of pyramidal cells did not display a spontaneous firing. Pyramidal cells displayed weak inward rectification and anodal break excitation. The slope of the frequency-current relation was 53.4 Hz/nA for the first interspike interval and 15.9 Hz/nA for the last intervals, suggesting the presence of spike frequency adaptation. Neurobiotin-filled neurons showed pyramidal morphology. Cells were generally bipolar dendritc processes ramifying in stratum lacunosum-moleculare, radiatum, and oriens. Commissural stimulation discharged pyramidal cells, followed by excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs). The frequency of theat-related membrane potential oscillation was voltage-independent in pyramidal neurons. At strong depolarization levels (less than 30 mV) pyramidal cells emitted sodium spike oscillation, phase-locked to theta. The observations provide direct evidence that theta-related rhythmic hyperpolarization of principal cells is brought by the rhythmically discharging interneurons. Furthermore, the findings in which interneurons were also paced by rhythmic inhibitory postsynaptic potentials during theta suggest that they were periodically hyperpolarized by their GABAergic septal afferents.

6축 휠 동력계의 구조설계 및 평가

김만기(Man Gee Kim),주진원(Jin Won Joo) 대한기계학회 2016 大韓機械學會論文集A Vol.40 No.1

자동차 주행 중 도로면으로부터 차량 바퀴에 전달되는 동하중을 측정하기 위해 휠 동력계가 사용된다. 본 논문에서는 전단 변형과 굽힘 변형을 이용한 두 가지 타입의 6축 휠 동력계를 설계하고 비교평가하였다. 유한요소해석을 이용하여 휠 동력계 기본 구조에 대한 전단 변형 거동과 굽힘 변형 거동을 분석하였으며 이로부터 전단형 휠 동력계와 굽힘형 휠 동력계를 설계하였다. 변형률 해석을 반복 수행하여 각 하중에 대한 출력변형률이 미리 결정된 비슷한 값이 되도록 하고 상호간섭 변형률이 최소화 되도록 설계를 수정하고 브리지 회로를 구성하였다. 전단형 휠 동력계는 균일한 변형률 분포를 얻을 수 있어 제작시 안정된 특성치를 얻을 수 있는 반면에, 굽힘형 휠 동력계는 각 하중에 대한 출력 변형률값이 더 일정하여 균일한 감도의 좋은 성능을 얻을 수 있을 것으로 예측된다. Wheel dynamometers are used to measure dynamic load that is conveyed from the road to a vehicle while driving. In this paper, two types of six-component wheel dynamometers utilizing shear deformation and bending deformation were designed and evaluated. Prior to designing the shear and bending type wheel dynamometers, the shear and bending deformation behaviors of the basic structure of the wheel dynamometer itself were analyzed using finite element analysis. Strain analysis was performed repeatedly in order to obtain a similar output sensing strain for each load component. The design was modified with a bridge circuit in order to minimize coupling strain. The results indicated that the shear type dynamometer was expected to obtain stable characteristics due to uniform strain distribution while the bending type dynamometer was expected to obtain high-quality sensitivity performance due to consistent output sensitivity.

Bronchoscopic Findings of Pulmonary Paragonimiasis

( Kyeong Man Jeon ),( Jae Uk Song ),( Sang Won Um ),( Won Jung Koh ),( Gee Young Suh ),( Man Pyo Chung ),( O Jung Kwon ),( Joung Ho Han ),( Ho Joong Kim ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.6

Background: Pulmonary paragonimiasis is a subacute to chronic inflammatory disease of the lung caused by lung flukes that result in prolonged inflammation and mechanical injury to the bronchi. However, there are few reports on the bronchoscopic findings of pulmonary paragonimiasis. This report describes the bronchoscopic findings of pulmonary paragonimiasis. Methods: The bronchosocpic findings of 30 patients (20 males, median age 50 years) with pulmonary paragonimiasis between May 1995 and December 2007 were reviewed retrospectively. Results: The diagnoses were based on a positive serologic test results for Paragonimus-specific antibodies in 13 patients (43%), or the detection of Paragonimus eggs in the sputum, bronchial washing fluid, or lung biopsy specimens in 17 patients (57%). The bronchoscopic examinations revealed endobronchial lesions in 17 patients (57%), which were located within the segmental bronchi in 10 patients (59%), lobar bronchi in 6 patients (35%) and main bronchi in 1 patient (6%). The bronchoscopic characteristics of endobronchial lesions were edematous swelling of the mucosa (16/17, 94%) and mucosal nodularity (4/17, 24%), accompanied by bronchial stenosis in 16 patients (94%). Paragonimus eggs were detected in the bronchial washing fluid of 9 out of the 17 patients with endobronchial lesions. The bronchial mucosal biopsy specimens showed evidence of chronic inflammation with eosinophilic infiltration in 6 out of 11 patients (55%). However, no adult fluke or ova were found in the bronchial tissue. Conclusion: Bronchial stenosis with mucosal changes including edematous swelling and mucosal nodularity is the most common bronchoscopic finding of pulmonary paragonimiasis.

비결핵 항산균 폐질환의 진단에서 기관지내시경술의 유용성

전경만 ( Kyeong Man Jeon ),고원중 ( Won Jung Koh ),권오정 ( O Jung Kwon ),강은해 ( Eun Hae Kang ),서지영 ( Gee Young Suh ),정만표 ( Man Pyo Chung ),김호중 ( Ho Joong Kim ),김태성 ( Tae Sung Kim ),이경수 ( Kyung Soo Lee ),이남용 ( 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.57 No.3

Clinical Characteristics and Treatment Outcomes in Patients with Relapsing Polychondritis involving Airways

( Gooh Yeon Hong ),( Kyung Jong Lee ),( Kyeong Man Jeon ),( Won Jung Koh ),( Gee Young Suh ),( Man Pyo Chung ),( O Jung Kwon ),( Ho Joong Kim ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Objectives: To investigate the clinical characteristics, management modalities and outcomes in patients with relapsing polychondritis (RP) involving airways. Methods: Medical records of RP patients involving airways were collected at the Samsung Medical Center from August 2004 to December 2011. Clinical manifestations including rheumatologic record, diagnostic tests, treatment modalities and clinical outcomes were retrospectively investigated. Results: Twelve patients (5 women and 7 men) with a median age of 48 yr (IQR, 44-60 yr) were included. All patients had airway involvement including trachea (100%), main bronchi (83%) and larynx (25%). Rheumatologic manifestation were frequent including inflammatory arthritis (50%), auricular chondritis (42%), keratoconjuntivitis(42%), nasal chondritis (42%), saddle nose (25%) and sensorineural hearing loss (17%). All patients were treated with high-dose corticosteroids (1,000 mg per day) for acute exacerbation and maintained with oral prednisolone (5-40 mg per day) with weekly methotrexate (2.5-15 mg per week) during follow up. Among the 12 patients, mechanical ventilation was required in 1 patient. Currently, 9 patients have survived without ventilator support and 8 patients without tracheostomy. Two patients underwent tracheostomy with endobronchial stenting. During follow up (median, 24months [IQR 7-50]), clinical outcome was favorable in 9 patients, but 3 patients died of pneumonia and respiratory failure. Conclusions: High doses of corticosteroids on acute exacerbation followed by maintenance-dose prednisolone with methotrexate could be recommended as a therapeutic option in patients with RP involving airways. Airway intervention is sometimes required in experienced hands.

가스배관재의 탄소성파괴인성에 미치는 측면홈 영향

임만배(MAN-BAE LIM),차귀준(GEE-JUN CHA),윤한기(HAN-KI YOON),공유식(YU-SIK KONG),김정호(JUNG-HO KIM) 한국해양공학회 2001 韓國海洋工學會誌 Vol.15 No.3

SG-365 steel is an important material and used for manufacturing a pressure vessel which the gas piping. In this investigation, the elastic plastic fracture toughness of this material is evaluated by the an unloading compliance method according to the ASTM E813-97 and E1152-97 method on the smooth and side groove 1CT specimens. The effect of smooth and side groove is studied on the elastic plastic fracture toughness. The side grooved specimen is very useful in estimation of the JIC. Because it is much easier than the smooth specimen to the onset of the ductile tearing by the R curve method Besides, it improves the accuracy of toughness values, decreases the scattering of them and tunneling and shear lip by the side groove.