Can Recurrence and Progression be Predicted by HYAL-1 Expression in Primary T1 Bladder Cancer?

Mammadov, Elnur,Aslan, Guven,Tuna, Burcin,Bozkurt, Ozan,Yorukoglu, Kutsal Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Background: Molecular prognostic markers have been under investigation for the last decade and no validated marker to date has been proven to be used in daily clinical practice for urinary bladder cancers. The aim of the present study is to evaluate the significance of HYAL-1 expression in prediction of recurrence and progression in pT1 urothelial carcinomas. Materials and Methods: Eighty-nine urothelial carcinoma cases staged as T1 according to 2004 WHO classification were studied. Representative sections from every case were stained immunohistochemically for HYAL-1 and scored between 0 and +3, according to staining density, and graded as low and high for the scores 0-1 and 2-3, respectively. Results: Of the 89 pT1 bladder cancer patients, HYAL-1 expression was high in 92.1% (82 patients; 72 patients +3 and 10 patients +2) and low in 7.9% (only 7 patients; 6 patients +1 and 1 patient 0) of the cases. Of the 89 patients, 38 (42.7%) had recurrence and 22 (24.7%) showed progression. HYAL-1 staining did not show significant characteristics for tumor grade, accompanying CIS, multiplicity, tumor size, age and sex. HYAL-1 expression did not have any prognostic value in estimating recurrence or progression. Conclusions: HYAL-1 expression was found to be high, but did not have any prognostic importance in T1 bladder urothelial carcinomas.

Effect of lutein on methotrexate-induced oxidative lung damage in rats: a biochemical and histopathological assessment

Renad Mammadov,Bahadir Suleyman,Selcuk Akturan,Ferda Keskin Cimen,Nezahat Kurt,Zeynep Suleyman,İsmail Malkoc 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.6

Background/Aims: This study aimed to investigate the effect of lutein on methotrexate (MTX)-induced pulmonary toxicity in rats biochemically and histopathologically. Methods: The rats in the MTX + lutein (MTXL, n = 6) group were given 1 mg/kg of lutein orally. A 0.9% NaCl solution was administered orally to the MTX (n = 6) group and the healthy group (HG, n = 6). One hour later, a single 20 mg/kg dose of MTX was injected intraperitoneally in the MTXL and MTX. Lutein or 0.9% NaCl solution was administered once a day for 5 days. At the end of this period, malondialdehyde (MDA), myeloperoxidase (MPO), total glutathione (tGSH), interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α) were measured in the lung tissues from the animals euthanized with 50 mg/kg thiopental sodium anesthesia. Subsequently, histopathological examinations were performed. Results: The levels of MDA, MPO, IL-1β, and TNF-α in the lung tissue of the MTX were significantly higher than those of the MTXL and HG groups (p < 0.0001), and the amount of tGSH was lower. The histopathological findings in the MTX group, in which the oxidants and cytokines were higher, were more severe. Conclusions: Lutein prevented the MTX-induced oxidative lung damage biochemically and histopathologically. This result indicates that lutein may be useful in the treatment of MTX-induced lung damage.

Using Soil Information in Geospatial Natural Disaster Analysis

Garib Mammadov 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

XIX əsr Qarabağ Ədəbi Mühiti və Xurşudbanu Natəvan

Asim Mammadov,Gunel Mammadova 국제언어문학회 2022 國際言語文學 Vol.- No.52

Khurshidbanu Natavan, the "dürri-yekta"(the only pearl) of the Karabakh khans, signed the history of the 19th century Azerbaijani literature as the author of sad, lyrical poems of the Karabakh poetry. Natavan, who paints beautiful paintings and has beautiful handiwork, is a glorifier of the image of a "sad mother" in literature with her odes written by longing for her 16-year-old son, who passed away too young, and poems on life, eternity and other topics. Khurshidbanu's charity events in Karabakh made the poetess famous not only in her The literary assembly "Majlisi-uns" was chosen according to its connections among the assemblies. The main content of the gathering in the house of Khan's daughter Nateva was the study of literature. Kh. Natavan gained fame in the history of Azerbaijani literature as a lyric poet, the author of sad love ghazals and an artist. A large part of Natavan's work is a series of poems written in 1885-1886 in connection with the poet's personal tragedy. In these works, the lamentation of the unhappy mother, who is deeply saddened by the death of her son, who suffered spiritual shocks and drowned in tears, can be heard. In addition to sad poems, Natavan also included a series of poems about nature in her work. Her poems "Violet", "Carnation", "Rose", "Butterfly", "Nightingale" etc. were loved by the people and songs were composed. The poet has always been remembered with respect among people, and beautiful stories have been created about her. Qarabağ xanlarının “dürri-yekta”sı Xurşidbanu Natəvan Qarabağ şeiriyyətinin həzin ruhlu, lirik şeirlər müəllifi kimi XIX əsr Azərbaycan ədəbiyyatı tarixinə imza atmışdır. Gözəl rəsmlər çəkən, əl işləri göz oxşayan Natəvan həyatdan çox gənc getmiş 16 yaşlı oğlunun həsrətilə yazdığı qəsidələri, həyat, əbədilik və digər mövzularda şeirləri ilə ədəbiyyatda “qəmli ana” obrazının tərənnümçüsüdür. Xurşidbanunun Qarabağda həyata keçirdiyi xeyriyyə tədbirləri şairəni təkcə yaşadığı mahalda deyil, Qarabağdan kənarda da şöhrətləndirmişdir. “Məclisi-üns” ədəbi məclisi məclislər içərisində əlaqələrinə görə seçilirdi. Xan qızı Natəvanın evində toplaşan məclisin əsas məzmununu ədəbiyyatın öyrənilməsi təşkil edirdi. X. Natəvan Azərbaycan ədəbiyyatı tarixində lirik şairə, hüzünlü eşq qəzəllərinin müəllifi və rəssam kimi şöhrət tapmışdır. Natəvan yaradıcılığının böyük bir hissəsini şairin şəxsi faciəsi ilə əlaqədar olaraq 1885-1886-cı illərdə yazdığı silsilə şeirləri təşkil edir. Bu əsərlərdə oğlunun ölümü ilə ağır matəmə batan, mənəvi sarsıntılara məruz qalan və göz yaşları içərisində boğulan bədbəxt ananın ah-naləsi eşidilir. Qəmli şeirlərlə yanaşı Natəvan yaradıcılığına təbiətlə bağlı şeirlər silsiləsi də daxil etmişdir. Onun “Bənövşə”, “Qərənfil”, “Gül”, “Pərvanə”, “Bülbül” və s. şeirləri el arasında sevilmiş, mahnılar bəstələnmişdir. Şairə el arasında hər zaman hörmətlə yad edilmiş, haqqında gözəl rəvayətlər yaranmışdır.

The Armenia–Azerbaijan Nagorno-Karabakh Conflict and New Threats to the International Security Architecture in the Modern Period : Challenges and Responses

Sadir Mammadov 인하대학교 다문화융합연구소 2017 다문화와 교육 Vol.2 No.2

In the work expressed the new treats and dangers in the present international arena, their heavy blows that delivered to the system of international security, maintenance, reasons, development dynamics, raising of mentioned problems in the international law system, including to make an effort for analyzing “hot points” viewpoint of international law expressed in details in the sample of Armenian-Azerbaijan Nagorno-Karabakh conflicts. In the work also given to the attention the investigations on the solution and managing of these problems, including to the positions of a number of specialists. One of the most interesting moment in the scientific work are the lightening of ISIL, cybercrimes, beside with Ukraine crisis, meeting of Europe with the migrants flow for the recent years, and all mentioned problems clarified viewpoint of multi culturological aspects. In the scientific work investigated and analyzed the ethnogenez of ethnic conflicts, and put forward the recommendations about their regulation, and solution. Analyzed the factors of raising the Nagorno-Karabakh conflicts, regulation ways of solution of this problem, and the dangerous double standard policy have infected in the scientific work. Thus, the terrorist threats, as well as “frozen” conflicts, resulted in a need to deepen interstate cooperation in the security sector.

[한국어 번역본] 19세기 카라바흐의 문학 환경과 후르시드바누 나태반

아심 맴매도브(Asim Mammadov),귀넬 맴매도바(Gunel Mammadova) 국제언어문학회 2022 國際言語文學 Vol.- No.52

Convolvulus galaticus, Crocus antalyensis, and Lilium candidum Extracts Show Their Antitumor Activity Through Induction of p53-Mediated Apoptosis on Human Breast Cancer Cell Line MCF-7 Cells

Onur Tokgun,Hakan Akca,Ramazan Mammadov,Candan Aykurt,Go¨khan Deniz 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.11

Conventional and newly emerging treatment procedures such as chemotherapy, catalytic therapy, photodynamic therapy, and radiotherapy have not succeeded in reversing the outcome of cancer diseases to any drastic extent, which has led researchers to investigate alternative treatment options. The extensive repertoire of traditional medicinal knowledge systems from various parts of the world are being re-investigated for their healing properties. It has been reported that several members of the Convolvulaceae, Iridaceae, and Liliaceae families have antitumor activity against some tumor cell lines. Here we first report that Convolvulus galaticus, Crocus antalyensis, and Lilium candidum species have cytotoxic activity on human breast cancer cell line MCF-7 cells. Plant samples were collected and identified, and their cytotoxic effects on the MCF-7 cell line were examined at different concentrations of methanol extracts. We found that all three plants have cytotoxic effects on MCF-7 cells but that C. galaticus has the strongest cytotoxic effect even in the lowest extract concentration tested (0.32 μg/mL). Our results indicate that these plant extracts have cytotoxic effects on human breast carcinoma cell line MCF-7 cells and that this cytotoxic effect comes from p53-mediated stimulation of apoptosis.

Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion-detorsion

Yapanoglu, Turgut,Ozkaya, Fatih,Yilmaz, Ali Haydar,Mammadov, Renad,Cimen, Ferda Keskin,Hirik, Erkan,Altuner, Durdu The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.5

Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD-50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to $720^{\circ}$ degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure. Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta ($IL-1{\beta}$) and tumor necrosis factor alpha ($TNF-{\alpha}$) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/R damage on testes caused by torsion-detorsion.

Infrared Spectroscopy, X-ray Diffraction and Neutron Diffraction Study of BaFe$_{\text{12}\bm{-x}}$Al$_{\bm{x}}$O$_\text{19}$ Solid Solutions

R. E. Huseynov,A. I. Mammadov,R. Z. Mehdiyeva,A. V. Trukhanov,S. V. Trukhanov,V. A. Turchenko,T. P. Hoang,N.T. Dang,S. H. Jabarov 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.74 No.6

The influences of Al doping on the structural, magnetic and dynamical properties of BaFe$_{12-x}$Al$_x$O$_{19}$ solid solutions ($x = 0.1$--1.2) have been studied by using a combination of X-ray diffraction, neutron diffraction and infrared spectroscopy. The magnetic moment of every Fe atom, including combinations, has been defined, and the magnetic moment of Fe$^{3+}$ ions was found to decrease as the concentration of Al$^{3+}$ diamagnetic ions in the combinations increased. Studies carried out by using infrared spectroscopy showed that four oscillations under normal conditions in these combinations. The results obtained by using infrared spectroscopy for BaFe$_{12-x}$Al$_x$O$_{19}$ combinations were compared with the results obtained by using Raman spectroscopy.

A comparative study on ridge waveguide laser diodes with SiO₂ and SiN_x passivation layers

Bengi, A.,Jang, S. J.,Yeo, C. I.,Mammadov, T.,Ö,zç,elik, S.,Lee, Y. T. John Wiley Sons, Ltd. 2010 Surface and interface analysis Vol.42 No.6

<P>In this study, we have reported the fabrication and device characteristics of metal organic chemical vapor deposition (MOCVD) grown 1.3-µm InP-based InGaAsP multiquantum well ridge waveguide laser diodes (LDs) for communication systems. The LD parameters such as threshold current, differential resistivity and output power for SiO<SUB>2</SUB> and SiN<SUB>x</SUB> passivation layers have been compared. Fabricated LDs have a threshold current, differential resistivity and output power values of 42 mA, 20 Ω, 9.3 mW and 51 mA, 25 Ω, 6.8 mW for SiO<SUB>2</SUB> and SiN<SUB>x</SUB> passivation layers, respectively. The analyses showed that the fabricated LD with SiO<SUB>2</SUB> passivation layer has a better performance than the other one in the view of lower threshold current, differential resistivity and higher output power. Copyright © 2010 John Wiley & Sons, Ltd.</P>