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Malek B. Hannouf,Eric Winquist,Salaheddin M. Mahmud,Muriel Brackstone,Sisira Sarma,George Rodrigues,Peter K. Rogan,Jeffrey S. Hoch,Gregory S. Zaric 대한암학회 2018 Cancer Research and Treatment Vol.50 No.1
Purpose The purpose of this study was to estimate the incidence of occult gastrointestinal (GI) primary tumours in patients with metastatic cancer of uncertain primary origin and evaluate their influence on treatments and overall survival (OS). Materials and Methods We used population heath data from Manitoba, Canada to identify all patients initially diagnosed with metastatic cancer between 2002 and 2011. We defined patients to have “occult” primary tumour if the primary was found at least 6 months after initial diagnosis. Otherwise, we considered primary tumours as “obvious.” We used propensity-score methods to match each patient with occult GI tumour to four patients with obvious GI tumour on all known clinicopathologic features. We compared treatments and 2-year survival data between the two patient groups and assessed treatment effect on OS using Cox regression adjustment. Results Eighty-three patients had occult GI primary tumours, accounting for 17.6% of men and 14% of women with metastatic cancer of uncertain primary. A 1:4 matching created a matched group of 332 patients with obvious GI primary tumour. Occult cases compared to the matched group were less likely to receive surgical interventions and targeted biological therapy, and more likely to receive cytotoxic empiric chemotherapeutic agents. Having an occult GI tumour was associated with reduced OS and appeared to be a nonsignificant independent predictor of OS when adjusting for treatment differences. Conclusion GI tumours are the most common occult primary tumours in men and the second most common in women. Patients with occult GI primary tumours are potentially being undertreated with available GI site-specific and targeted therapies.
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FAR INFRARED GALAXIES IN AKARI'S EYE
Malek, K.,Pollo, A.,Takeuchi, T.T.,Giovannoli, E.,Buat, V.,Burgarella, D.,Malkan, M. The Korean Astronomical Society 2012 天文學論叢 Vol.27 No.4
We present the results of Spectral Energy Distribution (SED) fitting of far-infrared galaxies detected in the AKARI Deep Field-South (ADF-S) Survey and discuss their physical properties. Additionally, we perform a comparison between photometric redshifts estimated using only optical and both optical and infrared data. We conclude that our sample consists mostly of nearby galaxies rich in dust and young stars. We observe an improvement in the estimation of photometric redshifts when the IR data are included, comparing to a standard approach based mainly on the optical to UV photometry.
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Design for Viability of Complex Engineered Systems under Uncertainty
Malek Tahoori,Jafar Gheidar-Kheljani,Mohammad Hossein Karimi Gavara 대한산업공학회 2017 Industrial Engineeering & Management Systems Vol.16 No.4
Complex Engineered Systems generally operate in uncertain environments. Uncertainty can affect the system value delivery through different ways. Viability is the Modern non-functional properties represented as a response to decreasing the impact of dynamic complexities on systems value delivery, therefore system designers used viability principles as an option for executing a design decision or feature in order to respond to variations in the operational context. As there may be numerous system architectures based on different adaptable options, assessing the viability of these architectures under uncertainty as for the basis of compression and selecting the optimized one is an important problem now a day. In this paper for surmounting above problem, a 9 step model is proposed which calculate the viability of assumed architecture under uncertainty by representing the regions in the system that is mostly impacted by the operational uncertainties. To represent the applicability of proposed model a simplified example of Synthetic Aperture Radar satellite observed, the viability of assumed system has been calculated and then some viable options imposed to the system architecture. The recalculated viability value of the assumed system and monitoring of all process steps by experts have shown the applicability and logicality of the model.
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Malek, Md Abdul,Kim, BoWha,Jung, Hae-Jin,Song, Young-Chul,Ro, Chul-Un American Chemical Society 2011 ANALYTICAL CHEMISTRY - Vol.83 No.20
<P>Our previous work on the speciation of individual mineral particles of micrometer size by the combined use of attenuated total reflectance FT-IR (ATR-FT-IR) imaging and a quantitative energy-dispersive electron probe X-ray microanalysis technique (EPMA), low-<I>Z</I> particle EPMA, demonstrated that the combined use of these two techniques is a powerful approach for looking at the single-particle mineralogy of externally heterogeneous minerals. In this work, this analytical methodology was applied to characterize six soil samples collected at arid areas in China, in order to identify mineral types present in the samples. The six soil samples were collected from two types of soil, i.e., loess and desert soils, for which overall 665 particles were analyzed on a single particle basis. The six soil samples have different mineralogical characteristics, which were clearly differentiated in this work. As this analytical methodology provides complementary information, the ATR-FT-IR imaging on mineral types, and low-Z particle EPMA on the morphology and elemental concentrations, on the same individual particles, more detailed information can be obtained using this approach than when either low-Z particle EPMA or ATR-FT-IR imaging techniques are used alone, which has a great potential for the characterization of Asian dust and mineral dust particles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2011/ancham.2011.83.issue-20/ac201956h/production/images/medium/ac-2011-01956h_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac201956h'>ACS Electronic Supporting Info</A></P>
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Malek Alshukur,Alex Fotheringham,Hugh R. Gong 한국섬유공학회 2020 Fibers and polymers Vol.21 No.2
This article investigates how the bending stiffness of the core thread and the effect threads affect the average values and the variability of the structural properties of resultant fancy yarns. The Design of Experiment technique was used to study the effects of individual factors and the interactions of factors. The analysis indicated that that the bending stiffness of the effect thread was a main factor. Increases in the effect thread bending stiffness led to significant increases of the size of fancy profile and reductions of the number of fancy profiles. Additionally, there was a strong interaction effect between the bending stiffness of the core thread and the bending stiffness of the effect thread which influenced the structures of the resultant fancy yarns. It was also found that variations in the bending stiffness of the input threads were reflected in similarvariations in the size and number of fancy profiles. The study is important for engineering the structure and the variation in structural properties of fancy yarns by selecting appropriate input threads.
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Malek, Mahrooz,Pourashraf, Maryam,Gilani, Mitra Modares,Gity, Masoumeh Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
Background: The aim of this study was to assess the role of the presence of a choline peak in 3 Tesla 1H magnetic resonance spectroscopy (MRS) for differentiating benign from malignant adnexal masses. Materials and Methods: A total of 46 adnexal masses (23 malignant and 23 benign) underwent 1H MRS study prior to surgery to assess the presence of choline peak. Results: A choline peak was detected in 16 malignant masses (69.5%) and was absent in the other 7 (30.5%). A choline peak was only detected in 6 (26%) of the benign adnexal masses. The presence of an MRS choline peak had a sensitivity of 69.5%, a specificity of 74%, a positive predictive value (PPV) of 72.7%, and a negative predictive value (NPV) of 71% for diagnosing malignant adnexal masses. A significant difference between the frequency of mean choline peaks in benign and malignant adnexal masses was observed (P value < 0.01). Conclusions: A 1H MRS choline peak is seen in malignant adnexal masses more frequently than the benign masses, and may be helpful for diagnosing malignant adnexal masses.
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IL-17A Levels in the Sera of Patients with Gastric Cancer Show Limited Elevation
Malek-Hosseini, Zahra,Taherinejad, Marziye,Malekzadeh, Mahyar,Ghaderi, Abbas,Doroudchi, Mehrnoosh Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Background: Inflammation plays a major role in the development and progression of gastric and other gastrointestinal tumors. The IL-17 family of cytokines has been under investigation as targets of immunotherapy. Materials and Methods: We investigated the levels of IL-17A inflammatory cytokine in the sera of 57 patients with gastric cancer (GC) and 90 healthy age/sex matched controls using ELISA methods. Results: In only 5 (8.8%) of the patients' sera was IL-17A detectable. No IL-17A was apparent in the sera of healthy controls. The maximum concentration of IL-17A in patients was 7.004 pg/ml. Vascular and lymphatic invasions were only seen in one of the 5 positive cases. Although all of them were in the age group >60 years, no correlation was seen between age and IL-17A level. These results are somewhat different from our findings for colorectal cancer (CRC) in the same population. Conclusions: It is possible that the inflammopathology of CRC and GC are rather different, at least in Fars, a southern province of Iran.
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Climate effect on tree-ring widths of Fagus orientalis in the Caspian forests, northern Iran
Malek Haghshenas,Mohammad Reza Marvi Mohadjer,Pedram Attarod,Kambiz Pourtahmasi,Jeff Feldhaus,Seyed Mohammad Moein Sadeghi 한국산림과학회 2016 Forest Science And Technology Vol.12 No.4
This study aims at understanding the impacts of climate factors on the annual growth variations of oriental beech (Fagus orientalis Lipsky) at the Kheyrud Forest Research Station located in the Caspian forests of northern Iran. To this end, 18 disc samples were randomly taken from altitudes of 1038 to 1152 m above sea level. Tree rings were measured using TSAP-win software and a LINTABII machine. Since false and missing rings are typical in beech trees, skeleton plots were created to enhance crossdating accuracy. Chronologies were observed for a total of 15 samples. Meteorological data for rainfall and air temperature were recorded at the Nowshahr Meteorological Station, located near the study sites. Results showed a significant correlation between mean annual air temperature and radial growth (R D 0.54). Within the growing season, August temperatures reveal a significant correlation with tree ring (R D 0.41) while the highest association was observed in the previous December (R D 0.44) and the least association was found in February (R D 0.31). Excluding March (R D 0.33), there appeared to be no significant correlation between precipitation accumulated during and prior to the growing season and tree ring. In addition to oriental beech, there are many other species important to this region that may be sensitive to increasing temperatures.
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Malek, Mahrooz,Pourashraf, Maryam,Mousavi, Azam Sadat,Rahmani, Maryam,Ahmadinejad, Nasrin,Alipour, Azam,Hashemi, Firoozeh Sadat,Shakiba, Madjid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: The aim of this study was to evaluate and compare the accuracy of diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC) value, and time-intensity curve (TIC) type analysis derived from dynamic contrast-enhanced MR imaging (DCE-MRI) in differentiating benign from malignant adnexal masses. Materials and Methods: 47 patients with 56 adnexal masses (27 malignant and 29 benign) underwent DWI and DCE-MRI examinations, prior to surgery. DWI signal intensity, mean ADC value, and TIC type were determined for all the masses. Results: High signal intensity on DWI and type 3 TIC were helpful in differentiating benign from malignant adnexal masses (p<0.001). The mean ADC value was significantly lower in malignant adnexal masses (p<0.001). An ADC value< $1.20{\times}10^{-3}mm^2/s$ may be the optimal cutoff for differentiating between benign and malignant tumors. The negative predictive value for low signal intensity on DWI, and type 1 TIC were 100%. The pairwise comparison among the receiver operating characteristic (ROC) curves showed that the area under the curve (AUC) of TIC was significantly larger than the AUCs of DWI and ADC (p<0.001 for comparison of TIC and DWI, p<0.02 for comparison of TIC and ADC value). Conclusions: DWI, ADC value and TIC type derived from DCE-MRI are all sensitive and relatively specific methods for differentiating benign from malignant adnexal masses. By comparing these functional MR techniques, TIC was found to be more accurate than DWI and ADC.
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