http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A novel pathogenic PSEN1 variant in a patient with dystonia-parkinsonism without dementia
Maria Chiara Malaguti 대한파킨슨병및이상운동질환학회 2024 Journal Of Movement Disorders Vol.17 No.1
The PSEN1 gene is located on chromosome 14 and encodes the presenilin 1 protein, which is a key component of the γsecretase complex that is involved in the cleavage of amyloid precursor protein (APP) in amyloid beta (Aβ) peptides
de Abreu, Andre LP,Gimenes, Fabricia,Malaguti, Natalia,Pereira, Monalisa W,Uchimura, Nelson S,Consolaro, Marcia EL Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
To determine the prevalence of human papillomavirus (HPV) among women with atypical squamous cells of undetermined significance (ASC-US) referred to colposcopy and the implications for clinical management in low- and middle-income countries (LMIC), the present study was conducted. We included 200 women living in $Maring{\acute{a}}$/Brazil referred to colposcopy service between August 2012 and March 2013 due to an abnormal cytology from ASC-US until high-grade intraepithelial lesion (HSIL). HPV was detected and genotyped by polymerase chain reaction (PCR). The mean age was $36.8{\pm}10.5$ years, and women with and without ASC-US had similar mean ages ($37.4{\pm}11.5$ and $36.4{\pm}9.96$ years, respectively). The highest prevalence of ASC-US occurred at 20-24 years (40%). HPV-DNA was positive in 164 (82.0%) women.Of the 57 women with ASC-US, 30 (52.6%) were HPV-DNA-positive and 21 (70%) were high-risk HPV-positive (HR-HPV); the latter was similar to women without ASC-US (76.9%) but with other abnormal cytological findings present. Our data demonstrated that performing tests for HR-HPV can be used for management of women with ASC-US to support the decision of which women should be referred for an immediate or later colposcopy. The same conclusions can be applied to other LMICs for which HPV testing for primary screening has not been adopted.
AN OFF-NUCLEUS NONSTELLAR BLACK HOLE IN THE SEYFERT GALAXY NGC 5252
Kim, Minjin,Ho, Luis C.,Wang, Junfeng,Fabbiano, Giuseppina,Bianchi, Stefano,Cappi, Massimo,Dadina, Mauro,Malaguti, Giuseppe,Wang, Chen IOP Publishing 2015 The Astrophysical journal Vol.814 No.1
<P>We report the discovery of an ultraluminous X-ray source (ULX; CXO J133815.6+043255) in NGC 5252. This ULX is an off-nuclear point. source, which is 22 '' away from the center of NGC 5252, and has an X-ray luminosity of 1.5 x 10(40) erg s(-1). It is one of the rare examples of a ULX, which exhibits clear counterparts in radio, optical, and UV bands. A follow-up optical spectrum of the ULX shows strong emission lines. The redshift of the [O III] emission line coincides with the systematic velocity of NGC 5252, suggesting that the ULX is gravitationally bound to NGC 5252. The flux of [O III] appears to be correlated with both X-ray and radio luminosity in the same manner as ordinary active galactic nuclei (AGNs), indicating that the [O III] emission is intrinsically associated with the ULX. Based on the multiwavelength data, we argue that the ULX is unlikely to be a background AGN. A more likely option is an accreting black hole with a mass of >= 10(4) M-circle dot, which might be a stripped remnant of a merging dwarf galaxy.</P>