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A case of autoimmune enteropathy with CTLA4 haploinsufficiency
( Haruka Miyazaki ),( Namiko Hoshi ),( Michitaka Kohashi ),( Eri Tokunaga ),( Yuna Ku ),( Haruka Takenaka ),( Makoto Ooi ),( Nobuyuki Yamamoto ),( Suguru Uemura ),( Noriyuki Nishimura ),( Kazumoto Iij 대한장연구학회 2022 Intestinal Research Vol.20 No.1
Autoimmune enteropathy (AIE) is a rare disease, characterized by intractable diarrhea, villous atrophy of the small intestine, and the presence of circulating anti-enterocyte autoantibodies. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and mutations in FOXP3, which is a master gene of regulatory T cells (Tregs), are major causes of AIE. Recent studies have demonstrated that mutations in other Treg-associated genes, such as CD25 and CTLA4, show an IPEX-like phenotype. We present the case of a 13-year-old girl with CTLA4 haploinsufficiency, suffering from recurrent immune thrombocytopenic purpura and intractable diarrhea. We detected an autoantibody to the AIE-related 75 kDa antigen (AIE-75), a hallmark of the IPEX syndrome, in her serum. She responded well to a medium dose of prednisolone and a controlled dose of 6-mercaptopurine (6-MP), even after the cessation of prednisolone administration. Serum levels of the soluble interleukin-2 receptor and immunoglobulin G (IgG) were useful in monitoring disease activity during 6-MP therapy. In conclusion, autoimmune-mediated mechanisms, similar to the IPEX syndrome, may be involved in the development of enteropathy in CTLA4 haploinsufficiency. Treatment with 6-MP and monitoring of disease activity using serum levels of soluble interleukin-2 receptor and IgG is suggested for such cases. (Intest Res 2022;20:144-149)
Rectangle Region Based Stereo Matching for Building Reconstruction
Wang, Jing,Miyazaki, Toru,Koizumi, Hirokazu,Iwata, Makoto,Chong, Jong-Wha,Yagyu, Hiroyuki,Shimazu, Hideo,Ikenaga, Takeshi,Goto, Satoshi The Institute of Electronics and Information Engin 2007 JUCT : Journal of Ubiquitous Convergence Technolog Vol.1 No.1
Feature based stereo matching is an effective way to perform 3D building reconstruction. However, in urban scene, the cluttered background and various building structures may interfere with the performance of building reconstruction. In this paper, we propose a novel method to robustly reconstruct buildings on the basis of rectangle regions. Firstly, we propose a multi-scale linear feature detector to obtain the salient line segments on the object contours. Secondly, candidate rectangle regions are extracted from the salient line segments based on their local information. Thirdly, stereo matching is performed with the list of matching line segments, which are boundary edges of the corresponding rectangles from the left and right image. Experimental results demonstrate that the proposed method can achieve better accuracy on the reconstructed result than pixel-level stereo matching.
Kazunori Iwanaga,Yutaka Kawabata,Makoto Miyazaki,Masawo Kakemi 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
The purpose of this study was to quantitativelyclarify the effect of alky-chain length of a triglyceride in anemulsion on the partitioning of highly lipophilic compoundsinto the lymph fluid after their oral administration. Highly lipophilic anthraquinone derivatives were orallyadministered in emulsions to rats. Emulsions composed oflong-, medium-, and short-chain triglycerides (LCT, MCT,and SCT emulsions, respectively) were used. The concentrationsof the compounds in plasma and lymph fluidwere periodically determined and their partitioning to thelymph was calculated using a mathematical model. Intestinalabsorption of all compounds was enhanced and theplasma concentrations of the compounds were found to bein the following order: LCT emulsion[MCT emulsion[SCT emulsion. The amounts of each compound recoveredin the lymph were not in agreement with their lipophilicity. Quantitative analysis revealed that the partitioning of thecompounds to the lymph may be determined by the solubilityof the compound in the triglyceride in the form of anemulsion and the amount of triglyceride transferred to thelymph fluid. These results suggest a possibility that theamount of a compound absorbed via the lymph route afteroral administration can be quantitatively controlled by theformulations.
Kazunori Iwanaga,Kaori Arimune,Makoto Miyazaki,Makio Shibano,Masahiko Taniguchi,Kimiye Baba,Masawo Kakemi 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.6
While a great deal of information of drug-drug interactions is known, most concern Western drugs. Relatively little is known of the interactions between Western drugs and traditional drugs such as Kampo extract medicines (Japanese medicines modified from traditional Chinese medicines). This study investigated the effects of the marketed Kampo extract medicines, Senkyu-cha-cho-san and Sokei-kakketsu-to, on the intestinal absorption of CYP or P-glycoprotein (P-gp) in vivo. Midazolam, a CYP3A substrate drug, or talinolol, a P-gp substrate drug, was orally administered to rats with each of these Kampo extract medicines. Senkyu-cha-chosan or Sokei-kakketsu-to administered as a standard regimen did not obviously affect Cmax and area under the curve (AUC) of midazolam, although both Kampo extract medicines contained notopterol, a potent CYP3A4 inhibitor in vitro. The results implied a lack of potent drug–drug interactions between both Kampo extract medicines and CYP3A substrate drugs. Concomitant administration of each Kampo extract medicine unexpectedly showed the tendency to decrease Cmax and AUC of talinolol. Decreased intestinal absorption of talinolol might be caused, not by the inhibition of P-gp, but by the inhibition of organic anion transporting peptides by both Kampo extract medicines.
Iwanaga, Kazunori,Kawabata, Yutaka,Miyazaki, Makoto,Kakemi, Masawo 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
The purpose of this study was to quantitatively clarify the effect of alky-chain length of a triglyceride in an emulsion on the partitioning of highly lipophilic compounds into the lymph fluid after their oral administration. Highly lipophilic anthraquinone derivatives were orally administered in emulsions to rats. Emulsions composed of long-, medium-, and short-chain triglycerides (LCT, MCT, and SCT emulsions, respectively) were used. The concentrations of the compounds in plasma and lymph fluid were periodically determined and their partitioning to the lymph was calculated using a mathematical model. Intestinal absorption of all compounds was enhanced and the plasma concentrations of the compounds were found to be in the following order: LCT emulsion>MCT emulsion>SCT emulsion. The amounts of each compound recovered in the lymph were not in agreement with their lipophilicity. Quantitative analysis revealed that the partitioning of the compounds to the lymph may be determined by the solubility of the compound in the triglyceride in the form of an emulsion and the amount of triglyceride transferred to the lymph fluid. These results suggest a possibility that the amount of a compound absorbed via the lymph route after oral administration can be quantitatively controlled by the formulations.
Process optimization of preparing honeycomb-patterned polystyrene films by breath figure method
Yanqiong Zheng,Yuki Kubowaki,Makoto Kashiwagi,Koji Miyazaki 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.1
Honeycomb-patterned polystyrene film is prepared by breath figure method. Pore size with a few hundred nano-meter to several micro-meter diameters is generated by controlling various parameters, such as the polymer concentration, humidity, casting area and solvent. The pore size becomes larger with increasing humidity and temperature difference between air and substrate. Porous film can be formed by drying under high humidity. The density of solvents affect the pore shape and pore depth. Video observation indicates that in the formation process of the porous pattern water droplet condenses gradually on the surface, along with the migration of the droplet formation boundary line from the edge to the center, when the boundary line reaches the center, hexagonally packed porous template is completed.
Rectangle Region Based Stereo Matching for Building Reconstruction
Jing Wang,Toru Miyazaki,Hirokazu Koiziuni,Makoto Iwata,Jongwha Chong,Hiroyuki Yagyu,Hideo Shimazu,Takeshi Ikenaga,Satoshi Goto 대한전자공학회 2007 JUCT : Journal of Ubiquitous Convergence Technolog Vol.1 No.1
Feature based stereo matching is an effective way to perform 3D building reconstruction. However, in urban scene, the cluttered background and various building structures may interfere with the performance of building reconstruction. In this paper, we propose a novel method to robustly reconstruct buildings on the basis of rectangle regions. Firstly, we propose a multi-scale linear feature detector to obtain the salient line segments on the object contours. Secondly, candidate rectangle regions are extracted from the salient line segments based on their local information. Thirdly, stereo matching is performed with the list of matching line segments, which are boundary edges of the corresponding rectangles from the left and right image. Experimental results demonstrate that the proposed method can achieve better accuracy on the reconstructed result than pixel-level stereo matching.
The Role of Physical Activity in Overweight and Obesity in Japanese
( Hiroaki Tanaka ),( Mayumi Yoshioka ),( Makoto Ayabe ),( Takuya Yahiro ),( Hiroyuki Higuchi ),( Yasuki Higaki ),( Jonny St Amand ),( Hideo Miyazaki ),( Yutaka Yoshitake ),( Munehiro Shindo ) 대한비만학회 2004 The Korean journal of obesity Vol.13 No.3