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        Use of the differential quadrature method for the buckling analysis of cylindrical shell panels

        Redekop, D.,Makhoul, E. Techno-Press 2000 Structural Engineering and Mechanics, An Int'l Jou Vol.10 No.5

        Buckling loads are determined for thin isotropic circular cylindrical shell panels subject to radial pressure using the new differential quadrature method. The Budiansky stability theory serves as the basis of the analysis. For this problem involving four boundary lines a two-dimensional approach is used, and a detailed convergence study is carried out to determine the appropriate analysis parameters for the method. Numerical results are determined for a total of twelve cylindrical shell panel cases for a number of different boundary support conditions. The results are compared with analytical and finite element method results. Conclusions are drawn about the technical significance of the results and the solution process.

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        비골을 이용한 3차원적 하악골 재건 시 가상모의수술 및 입체조형기법을 이용한 골절단 가이드의 활용: 증례보고

        Nam, Woong,Makhoul, Nicholas,Ward, Brent,Helman, Joseph I.,Edwards, Sean 대한악안면성형재건외과학회 2012 Maxillofacial Plastic Reconstructive Surgery Vol.34 No.5

        The osseous or osteocutaneous free fibula flap has become the gold standard for most mandibular reconstructions because of its favorable osseous characteristics. However, disadvantages, such as the time-consuming reconstructive step, difficulty in performing the osteotomies to precisely recreate the shape of the missing segment of mandible and poor bone-to-bone contact play a role in making the surgeons look for alternative flaps. With the advent of computerized design software, which accurately plans complex 3-dimensional reconstructions, has become a process that is more efficient and precise. However, the ability to transfer the computerized plan into the surgical field with stereolithographic models and guides has been a significant development in advancing reconstruction in the maxillofacial regions. The ability to "pre-plan" the case, mirror and superimpose natural structures into diseased and deformed areas, as well as the ability to reproduce these plans with good surgical precision has decreased overall operative time, and has helped facilitate functional and esthetic reconstruction. We describe a complex case treated with this technique, showing the power and elegance of computer assisted maxillofacial reconstruction from the University of Michigan, Oral and Maxillofacial Surgery.

      • KCI등재

        Practical Vitamin D Supplementation Using Machine Learning

        Tyler Fugere,Zhongning Jim Chen,Issam Makhoul 대한골대사학회 2020 대한골대사학회지 Vol.27 No.2

        Background: Patients with breast cancer are at increased risk of developing osteoporosis. Maintaining normal levels of vitamin D may decrease the risk of osteoporosis, and vitamin D levels must be corrected in patients who develop osteoporosis before beginning bone modifying agents. Therefore, it is important to correct insufficient vitamin D levels in a timely manner. In clinical practice, current guidelines for replacement regimens often fail to rapidly correct vitamin D levels. The goal of this study was to review data in order to predict what replacement regimen(s) were most effective at repleting vitamin D levels. Methods: For this retrospective cohort study, data was collected from medical records of 2,164 female patients with breast cancer with Institutional Review Board approval. Total level change per week was the primary outcome and was compared for the most commonly used vitamin D replacement regimens adjusted for age, race, body mass index, creatinine clearance, endocrine therapy, and initial level. Results: Higher weekly doses of vitamin D supplementation had a more significant impact on the rate of correction compared to lower daily doses. Generalized linear model was used to develop an online calculator that predicts time to vitamin D level correction adjusted for significant patient characteristics for 5 common replacement regimens as well as no intervention. Conclusions: When choosing a vitamin D replacement regimen for patients with vitamin D deficiency, we recommend clinicians use the online calculator to ensure that the chosen regimen will enable the patient to reach vitamin D sufficiency in a timely manner.

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