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      • Quality of Life in Malay and Chinese Women Newly Diagnosed with Breast Cancer in Kelantan, Malaysia

        Yusuf, Azlina,Hadi, Imi Sairi Ab.,Mahamood, Zainal,Ahmad, Zulkifli,Keng, Soon Lean Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

        Background: Breast cancer is the leading cause of cancer-related death among women in Malaysia. A diagnosis is very stressful for women, affecting all aspects of their being and quality of life. As such, there is little information on quality of life of women with breast cancer across the different ethnic groups in Malaysia. The purpose of this study was to examine the quality of life in Malay and Chinese women newly diagnosed with breast cancer in Kelantan. Materials and Methods: A descriptive study involved 58 Malays and 15 Chinese women newly diagnosed with breast cancer prior to treatment. Quality of life was measured using the Malay version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and its breast-specific module (QLQ-BR23). Socio-demographic and clinical data were also collected. All the data were analyzed using SPSS version 20.0. Results: Most of the women were married with at least a secondary education and were in late stages of breast cancer. The Malay women had lower incomes (p=0.046) and more children (p=0.001) when compared to the Chinese women. Generally, both the Malay and Chinese women had good functioning quality-of-life scores [mean score range: 60.3-84.8 (Malays); 65.0-91.1 (Chinese)] and global quality of life [mean score 60.3, SD 22.2 (Malays); mean score 65.0, SD 26.6 (Chinese)]. The Malay women experienced more symptoms such as nausea and vomiting (p=0.002), dyspnoea (p=0.004), constipation (p<0.001) and breast-specific symptoms (p=0.041) when compared to the Chinese. Conclusions: Quality of life was satisfactory in both Malays and Chinese women newly diagnosed with breast cancer in Kelantan. However, Malay women had a lower quality of life due to high general as well as breast-specific symptoms. This study finding underlined the importance of measuring quality of life in the newly diagnosed breast cancer patient, as it will provide a broader picture on how a cancer diagnosis impacts multi-ethnic patients. Once health care professionals understand this, they might then be able to determine how to best support and improve the quality of life of these women during the difficult times of their disease and on-going cancer treatments.

      • Understanding the Breast Cancer Experience: a Qualitative Study of Malaysian Women

        Yusuf, Azlina,Ab Hadi, Imi Sairi,Mahamood, Zainal,Ahmad, Zulkifli,Keng, Soon Lean Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

        Breast cancer is the most common and leading cause of cancer mortality among Malaysian women. Despite good survival rates, the diagnosis of cancer still invokes the feeling of stress, fear and uncertainty. Because very little is known about the experiences of Malaysian women with breast cancer, a qualitative study using semi-structured interviews to explore the lived experience of newly diagnosed breast cancer. Using a purposive sampling method, 20 Malaysian women newly diagnosed with breast cancer, including Malays (n=10) and Chinese (n=10) were recruited in two main public hospitals in Kelantan. Similarities and divergence in women's experience were identified through thematic analysis of interview transcripts. Three themes emerged from the data: uncertainty experience of the illness, transition process and fatalistic view of breast cancer. In many ways, these findings were parallel with previous studies, suggesting that the experience of breast cancer is to a certain extent similar among women newly diagnosed with breast cancer. This study adds to the sparse literature concerning the experience of illness following breast cancer diagnosis among the Malays and Chinese. More importantly, this study addressed areas that were previously lacking, specifically in depth information on breast cancer experience from a developing country with a multi-ethnic population. The results of this investigation provide preliminary information to healthcare professionals on the impact of illness and cultural influence on survivorship to plan for appropriate education and supportive programme in order to meet the needs of breast cancer women more effectively.

      • KCI등재

        Genetics of Testcrossed Streak Virus Resistance Carotene Quality Protein Maize

        Sunday Ayodele Ige,Bashir Omolaran Bello,Jimoh Mahamood,Michael Afolabi,Aremu Charity,Stephen Abolusoro,Abosede Victoria Adeniyi 한국육종학회 2023 Plant Breeding and Biotechnology Vol.11 No.3

        Development of Provitamin A quality protein maize (PVA-QPM) conferring resistance to maize streak virus (MSV)would reduce the prevalence of the disease, alleviate malnutrition and increase food security in sub-Saharan Africa. This study wasconducted to (i) evaluate early maturing PVA-QPM inbreds and their derived testcross hybrids for grain yield, MSV-resistant,carotenoids, and tryptophan contents, (ii) estimate the combining ability of the MSV-resistant PVA-QPM testcrosses for all traits. Fiveimproved open-pollinated MSV resistance cultivars and five early maturing PVA-QPM inbreds were crossed in a half-diallel fashionwithout reciprocals. The derived forty-five F1 topcrosses, ten parental materials, and two commercial hybrids that served as controlswere tested at the Lower Niger River Basin Development Authority in Oke-Oyi, Nigeria, during rain-fed of the year 2019 and 2020. ThePVA-QPM inbreds from TZEIORQ 13, TZEIORQ 29, and TZEQI 82 that were crossed with MSV resistance AK-9528-DMRSR andPop 28 SR appeared potentially useful combinations for enhancing grain yield, MSV-resistant, carotenoids, and tryptophan contents,Testcrossed TZEQI 82 × AK-9528-DMRSR POP 28 SR, TZEQI 82 × ACR. 91 SUWAN-1-SR C1 and TZEQI 82 × IK.91 TZL COMP3-Y C1 were most outstanding for all measured grain yield and nutrient contents. Additive genetic effects were preponderant overnon-additive genetic effects under artificial infection of MSV disease. These three promising MSV resistance PVA-QPM hybridsshould be evaluated under on-farm multiplication trials for stability performance and adaptation to reduce malnourishment and foodself-sufficiency in SSA. Also, further researches on genomic analyses of the superior testcrosses are desirable.

      • KCI등재

        Differential Response of Maize Inbreeding Depression to (Optimal and Stressed) Environments

        Sunday Ayodele Ige,Bashir Omolaran Bello,Jimoh Mahamood,Michael Afolabi,Aremu Charity,Stephen Abolusoro,Abosede Victoria Adeniyi 한국육종학회 2023 Plant Breeding and Biotechnology Vol.11 No.4

        Inbred lines generated from 10 maize population developed between 1979 and 2008 were used to investigate theinbreeding depression of tropical maize varieties developed at different breeding eras and evaluated in (optimal and stressed) condition. Across all the environments used for this study, estimates of inbred depression (I) for grain yield which ranged from 15.63% foroptimum environment to 35.85 under stem borer infestation, showed differences in the severity of the effects of practicing inbreedingin each of the populations and the different environments. The highest values of inbreeding depression for grain yield were recordedunder stem borer infestation. The effect of inbreeding was the most severe for var. DMR-LSR-W under borer infestation and least forDMR-LSR-Y in stress free environment. This is an indication that the responses of the maize populations to inbreeding as well as therate of attaining homozygosity differed with environments. Across the four different environments under which the genotypes wereevaluated, average inbreeding depression for grain yield were greater relative to other traits considered which should be expected sincegrain yield is a quantitatively inherited trait, governed by many genes each with minor effects.

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