Protective Effects of Persimmon Leaf and Fruit Extracts against Acute Ethanol-Induced Hepatotoxicity

Ma, Jie,Liu, Xiao-Yu,Noh, Kyung-Hee,Kim, Myo-Jeong,Song, Young-Sun The Korean Society of Food Science and Nutrition 2007 Preventive Nutrition and Food Science Vol.12 No.4

Persimmon is well-known as a Korean traditional medicine for alleviating coughs and enhancing blood circulation; it is also used for treatment of hypertension, cancer, diabetes and atherosclerosis. To evaluate the protective properties of persimmon leaf methanol extract (PLME) and persimmon fruit methanol extract (PFME) administration on acute ethanol-induced hepatotoxicity, C57BL/6 male mice were gavaged with or without persimmon extracts for 1 week. Hepatotoxicity was then induced by gavage of 5 g/kg BW ethanol. After 12 hr of ethanol administration, blood and liver were collected and analyzed for biochemical markers of hepatotoxicity. The results showed PLME and PFME treatments decreased the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) compared with ethanol control. Both PLME and PFME reduced serum lactate dehydrogenase (LDH) activity, but elevated alcohol dehydrogenase (ADH) activity. Serum triglyceride (TG) and hepatic cholesterol levels were significantly decreased when treated with PLME and PFME. Liver malondialdehyde (MDA) levels were significantly decreased in PLME and PFME groups compared with ethanol control. Furthermore, the administration of PLME and PFME significantly increased the activities of catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-red). In summary, PLME and PFME appeared to prevent hepatic injury by accelerating alcohol metabolism by increasing alcohol-metabolizing enzyme activities, by activating the antioxidative enzyme system against oxidative stress, and by decreasing fat accumulation, which is evidenced by decreased hepatotoxic indices in serum.

Chatbot Design Method Using Hybrid Word Vector Expression Model Based on Real Telemarketing Data

( Jie Zhang ),( Jianing Zhang ),( Shuhao Ma ),( Jie Yang ),( Guan Gui ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.4

In the development of commercial promotion, chatbot is known as one of significant skill by application of natural language processing (NLP). Conventional design methods are using bag-of-words model (BOW) alone based on Google database and other online corpus. For one thing, in the bag-of-words model, the vectors are Irrelevant to one another. Even though this method is friendly to discrete features, it is not conducive to the machine to understand continuous statements due to the loss of the connection between words in the encoded word vector. For other thing, existing methods are used to test in state-of-the-art online corpus but it is hard to apply in real applications such as telemarketing data. In this paper, we propose an improved chatbot design way using hybrid bag-of-words model and skip-gram model based on the real telemarketing data. Specifically, we first collect the real data in the telemarketing field and perform data cleaning and data classification on the constructed corpus. Second, the word representation is adopted hybrid bag-of-words model and skip-gram model. The skip-gram model maps synonyms in the vicinity of vector space. The correlation between words is expressed, so the amount of information contained in the word vector is increased, making up for the shortcomings caused by using bag-of-words model alone. Third, we use the term frequency-inverse document frequency (TF-IDF) weighting method to improve the weight of key words, then output the final word expression. At last, the answer is produced using hybrid retrieval model and generate model. The retrieval model can accurately answer questions in the field. The generate model can supplement the question of answering the open domain, in which the answer to the final reply is completed by long-short term memory (LSTM) training and prediction. Experimental results show which the hybrid word vector expression model can improve the accuracy of the response and the whole system can communicate with humans.

Flow separation control of two kinds of microvortex generators for a supersonic spinning projectile

Jie Ma,Zhen-gui Huang,Zhihua Chen,Da-wen Xue,Jun-li Han 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.1

Previous studies have shown that Microvortex generators (MVGs) can effectively control the flow separation of supersonic boundary layer. To improve the flight stability of a spinning projectile, two kinds of MVGs, micro ramps and vanes, are applied to control the flow separation of an original standard 155 mm projectile, respectively. Numerical simulations were performed with the use of Detached eddy simulation (DES) method, and the flow fields of the projectile with and without micro MVGs were simulated, the characteristics of the boundary layer and aerodynamic data of three cases were compared and discussed. The numerical results reveal that the effect of the MVGs control is obvious, but their mechanisms are different, and the vanes are more effective than the ramp in the boundary layer control. However, they can both improve the lift and pitching moment of the projectile, and eliminate their oscillations; as a result, its flight stability and firing dispersion can be enhanced. Our results can provide important guidance for improving the flight quality of supersonic projectiles.

Assessment Based on the Forecast Error for the Transition Period between the Jianghuai Meiyu and North China Rainy Seasons in 2016

Jie Ma,Zhiping Zong,Li Jianping,Ruiqing Ding 한국기상학회 2021 Asia-Pacific Journal of Atmospheric Sciences Vol.57 No.3

During the transition period between the Jianghuai Meiyu and North China rainy seasons in 2016, there was a high-impact rainstorm event, connecting these two rainy seasons. However, both the short and medium range forecasts predicted a rain band that was too far south; this error can have serious implications for flood preparedness. This study discusses the causes of the forecast error using the ECMWF deterministic and ensemble models. The results show that the prediction of a too-weak westerly trough at the 500-hPa level is the dominant factor. Specifically, a weaker predicted 500-hPa westerly trough reduces the strength of the low vortex at 850 hPa; correspondingly, the shear line to the east of the vortex and the Meiyu front are weaker and farther south, and the monsoon is also weaker, which causes the large area of humidity convergence to be shifted southward. Finally, the heavy rainfall is located farther south with weaker intensity. And vice visa, when a stronger westerly trough is predicted, the location of rain band will be northward. This conclusion may be useful for meteorological decision making in medium range and will help to improve capabilities of risk reduction.

Fabrication of Large Area Photonic Crystals with Periodic Defects by One-Step Holographic Lithography

Jie Ma,Kam Sing Wong,Shan Li,Zhe Chen,Jianying Zhou,Yongchun Zhong 한국광학회 2015 Current Optics and Photonics Vol.19 No.1

A one-step fabrication of a photonic crystal (PC) with functional defects is demonstrated. Using multi-beamphase-controlled holographic lithography with a diffracting optical element, large area one dimensional (1D)and two dimensional (2D) PCs with periodic defects were fabricated. The uniform area is up to 2 mm2,and tens of defect channels have been introduced in the 1D and 2D PC structure. This technique givesrise to substantial reduction in the fabrication complexity and significant improvement in the spatialaccuracy of introducing functional defects in photonic crystals. This method can also be used to designand fabricate three dimensional (3D) PCs with periodic defects.

Protective Effects of Persimmon Leaf and Fruit Extracts against Acute Ethanol-Induced Hepatotoxicity

Jie Ma,Xiao-yu Liu,Kyung-Hee Noh,Myo-Jeong Kim,Young-Sun Song 한국식품영양과학회 2007 Preventive Nutrition and Food Science Vol.12 No.4

Persimmon is well-known as a Korean traditional medicine for alleviating coughs and enhancing blood circulation; it is also used for treatment of hypertension, cancer, diabetes and atherosclerosis. To evaluate the protective properties of persimmon leaf methanol extract (PLME) and persimmon fruit methanol extract (PFME) administration on acute ethanol-induced hepatotoxicity, C57BL/6 male mice were gavaged with or without persimmon extracts for 1 week. Hepatotoxicity was then induced by gavage of 5 g/㎏ BW ethanol. After 12 hr of ethanol administration, blood and liver were collected and analyzed for biochemical markers of hepatotoxicity. The results showed PLME and PFME treatments decreased the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) compared with ethanol control. Both PLME and PFME reduced serum lactate dehydrogenase (LDH) activity, but elevated alcohol dehydrogenase (ADH) activity. Serum triglyceride (TG) and hepatic cholesterol levels were significantly decreased when treated with PLME and PFME. Liver malondialdehyde (MDA) levels were significantly decreased in PLME and PFME groups compared with ethanol control. Furthermore, the administration of PLME and PFME significantly increased the activities of catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-red). In summary, PLME and PFME appeared to prevent hepatic injury by accelerating alcohol metabolism by increasing alcohol-metabolizing enzyme activities, by activating the antioxidative enzyme system against oxidative stress, and by decreasing fat accumulation, which is evidenced by decreased hepatotoxic indices in serum.

Preparation of superparamagnetic ZnFe₂O₄ submicrospheres via a solvothermal method

Ma, Jie,Chen, Bingjie,Chen, Bingkun,Zhang, Shuping Techno-Press 2017 Advances in nano research Vol.5 No.2

Superparamagnetic Zinc ferrite submicropheres are firstly synthesized via a one-pot solvothermal approach at $200-215^{\circ}C$ for 4-8 hours. $ZnCl_2$, $FeCl_3$ and NaAc are used as precursors with ethylene glycol solvent. The X-ray diffraction (XRD) data indicate that $ZnFe_2O_4$ nanoparticles with the grain size around $15{\pm}3nm$ can be successfully synthesized via the one-pot method. The scanning/transmission electronic microscope (SEM/TEM) images further show the samples are submicrospheres self-assembled by nanoparticles with size about 375-500 nm changed with reaction conditions. Room-temperature vibration magnetic strength measurements (VMS) demonstrates the as-obtained $ZnFe_2O_4$ submicrospheres show prefect superparamagnetism, whose coercivity force and remanence are practically nil. The reaction temperature and time influence on the crystallinity, diameter, saturated magnetic intensity and morphology of the particles.

Role of TGF-β1 in Human Colorectal Cancer and Effects after Cantharidinate Intervention

Ma, Jie,Gao, Hai-Mei,Hua, Xin,Lu, Ze-Yuan,Gao, Hai-Cheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

Effects of transforming growth factor-beta (TGF-${\beta}$) were investigated in human colorectal cancer, and the influence of cantharidinate in inhibiting TGF-${\beta}1$ expression was explored. Relationships among TGF-${\beta}1$ and sex, age, tumor size, tumor location, tumor stage were also analyzed. H&E and immunohistochemistry staining were employed to assess colorectal cancer and TGF-${\beta}1$ expression, respectively. Then, HCT-116 CRC cells were randomly divided into four groups, controls, no serum-treated, chemotherapy and cantharidinate-treated. Immunohistochemistry and real-time PCR were employed to assess the expression of TGF-${\beta}1$ in CRC cells. Our data showed that the expression of TGF-${\beta}1$ might be associated with tumor size and tumor location (P<0.05). The expression of TGF-${\beta}1$ in CRC groups was higher than in adjacent groups (P<0.05). In addition, the expression of TGF-${\beta}1$ in cantharidinate-treated group was much lower than in CRC group (P<0.05). Taken together, these results suggest that TGF-${\beta}1$ plays an important role in CRC development. Cantharidinate might inhibit the expression of TGF-${\beta}1$ and control the development of colorectal cancer.

Brain Metabolic Network Redistribution in Patients with White Matter Hyperintensities on MRI Analyzed with an Individualized Index Derived from 18F-FDG-PET/MRI

Ma Jie,Hua Xu-Yun,Zheng Mou-Xiong,Wu Jia-Jia,Huo Bei-Bei,Xing Xiang-Xin,Gao Xin,Zhang Han,Xu Jian-Guang 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.10

Objective: Whether metabolic redistribution occurs in patients with white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is unknown. This study aimed 1) to propose a measure of the brain metabolic network for an individual patient and preliminarily apply it to identify impaired metabolic networks in patients with WMHs, and 2) to explore the clinical and imaging features of metabolic redistribution in patients with WMHs. Materials and Methods: This study included 50 patients with WMHs and 70 healthy controls (HCs) who underwent 18F-fluorodeoxyglucose-positron emission tomography/MRI. Various global property parameters according to graph theory and an individual parameter of brain metabolic network called “individual contribution index” were obtained. Parameter values were compared between the WMH and HC groups. The performance of the parameters in discriminating between the two groups was assessed using the area under the receiver operating characteristic curve (AUC). The correlation between the individual contribution index and Fazekas score was assessed, and the interaction between age and individual contribution index was determined. A generalized linear model was fitted with the individual contribution index as the dependent variable and the mean standardized uptake value (SUVmean) of nodes in the whole-brain network or seven classic functional networks as independent variables to determine their association. Results: The means ± standard deviations of the individual contribution index were (0.697 ± 10.9) x 10-3 and (0.0967 ± 0.0545) x 10-3 in the WMH and HC groups, respectively (p < 0.001). The AUC of the individual contribution index was 0.864 (95% confidence interval, 0.785–0.943). A positive correlation was identified between the individual contribution index and the Fazekas scores in patients with WMHs (r = 0.57, p < 0.001). Age and individual contribution index demonstrated a significant interaction effect on the Fazekas score. A significant direct association was observed between the individual contribution index and the SUVmean of the limbic network (p < 0.001). Conclusion: The individual contribution index may demonstrate the redistribution of the brain metabolic network in patients with WMHs.

On The Way of Becoming Expert-SSU Student Journalist`s Self-Directed Learning

( Jie Yao Ma ),( Tsung Jen Shih ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1

Purpose: It is important to equip our students with the requisite skills they need to become professional. However, currently there is a discrepancy between what journalism education provides and what the industry needs. The crux of this problem lies in the missing of strategic procedural knowledge in journalism education. Upon realizing this hiatus in journalism education, the researcher develops this study, to examining the Self-Directed Leaning (SDL) mechanism adopted by the Student Sports Union (SSU). From the result of this study, the researcher gather already graduated SSU journalists` SDL experience, and to convert these tacit knowledge into documentation for future generations of young journalism graduates to refer to. Method: To discover extra knowledge regarding to SSU journalists` learning experience, and to understand their SDL process comprehensively, the researcher employed semi-structured in-depth interview in this study. The selection of interviewees focus on gradated SSUs` actual performance while they were in the organization, and their career performance after they graduated. Result: Through constantly accessing authentic sports events, SSU student journalists are better able to combine theory and practice together. The SDL journey allows students to proceduralize their knowledge from "knowing what" (declarative knowledge) to "knowing how" (procedural knowledge), and move towards the path of becoming expert. According to the result of the study, SSU`s SDL matches with Spear`s interactive model. This means (1). Opportunities people find in their own environments. (2). Past or new knowledge. And (3). Chance occurrences are three important elements for SSU journalists to form their SDL. Conclusion: To survive in the dynamic environment of journalism, it is important to provide students more practical trainings for them to bridge the gap between theory and practice. In this case, SDL is a useful method for students to gain the knowledge, skill and experience they need to become professional.