What do patients with psoriasis think about the causes of their disease and use for psoriasis?

Müzeyyen Gönül,Seray Külcü Çakmak,Ülker Gül,Zeynep Bıyıklı 셀메드 세포교정의약학회 2012 TANG Vol.2 No.1

There are few reports about the beliefs of psoriasis patients related to their disorder and therapy modalities except for the medical ones. We aimed to investigate the beliefs of psoriasis patients about their disorders, where they had attended therapies unrelated to dermatologists and what modality of unconventional therapies they used for psoriasis in Turkey. The study was performed on 141 psoriasis patients. The age, sex, education status and the number of visits to the dermatology clinics were recorded. How the patients decided to visit the dermatology clinic (themselves, directed by others), where they attended for treatment of psoriasis outside of the dermatologist, what they think about the causes of their disease and what they used for treatment of psoriasis were asked. The mean age of the patients was 33.44 ± 15.13 years. The patients whose ages were over 30 years significantly more went to dermatology clinics. 68.1% of the patients attended the dermatology clinic based on the individual decision, 18.4% were directed by family members and 5.7% by friends. 45.4% of the patients believed that stress was the cause of their disease. 54.6% of the patients had used at least one type of unconventional therapy for psoriasis. The most frequently used unconventional therapy forms were herbal (24.1%) and spiritual therapies (22%). One conclusion is psoriasis patients need education about their diseases. Dermatologists should have information about the tendencies of the patients and approach the patients with sensitivity and empathy and give objective knowledge about psoriasis.

Eruptive xanthomas: Might be traditional hawthorn vinegar induced?

Müzeyyen Gönül,Seray Külcü Çakmak,Esra Özhamam 셀메드 세포교정의약학회 2013 TANG Vol.3 No.4

Eruptive xanthomas that are characterized by yellowish red papules results from hyperlipidemia, particularly hypertriglyceridemia. The hyperlipidemia responsible for this disorder can be caused by a primary genetic defect, a secondary disorder, or both. Some medications such as estrogen or retinoid treatments may cause eruptive xantomas by increasing serum lipids. We present a case eruptive xantomas triggered by hawthorn vinegar.

Statistical Investigation of the Effects of w/c, Cement Dosage and Fibers on Bond Strength and Carbonation Coefficient of Hybrid Fiber Concretes

Muzeyyen Balcikanli Bankir 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.11

Fiber reinforced concretes are preferred due to high tensile strength in structural elements. Alongside to tensile strength, supplying good adherence with concrete and its durability against time are also expected properties. A four-factor experimental test program was created in this study to investigate the effect of fiber type and quantity on the strength and durability performance of hybrid fiber concretes (FRC). In addition to steel fiber ratio (STF) and glass fiber ratio (GF), basic criteria of concrete such as water/cement ratio and cement dosage were chosen as independent variables. Flexural and compressive strength, bond strength, stripping time of steel reinforcement and 180, 270 and 360-day carbonation depths of FRC were investigated experimentally. The Carbonation coefficients of each FRC were calculated and a correlation was obtained for a general “Ke” carbonation coefficient by Multi Linear Regression.Average of K was 0.219 mm√days. Stripping time of steel reinforcement from FRC was two times longer in samples containing only STF than samples containing only GF. With the dual combination of STF and GF, this time has been increased approximately 4 times.

Clinical and Laboratory Findings of Pigmented Purpuric Dermatoses

( Muzeyyen Gonul ),( Seray Kulcu Cakmak ),( Nimet Ozcan ),( Isil Deniz Oguz ),( Ulker Gul ),( Zeynep Bıyıkll ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.5

Background: Pigmented purpuric dermatoses (PPD) are chronic, recurrent group of disorders characterized by petechial and pigmentary macules usually localized on the lower limbs. Its etiopathogenesis is unknown. There are very few clinical and etiological studies on PPD in the literature. Objective: We aim to examine the etiopathogenetic factors of PPD retrospectively. Methods: Demographic characteristics, history of co-morbid disorders and drug usage, hepatitis markers, levels of serum lipids, findings of Doppler ultrasonography in lower extremities, and patch test resultsof the 24 patients of PPD were examined retrospectively. The patch test results, history of drug use, and co-morbid disorders of the patients were compared with those of thecontrol groups. Results: The male-to-female ratio was 1 : 2, and 83.3% of the patients had Schamberg disease. Seventeen patients had co-morbid disorders and 16 used various drugs, but there was no statistically significant difference between the controls and patients. One patient was positive for hepatitis B surface antigen and 1, for anti-hepatitis C virus antibody. Nine had elevated total cholesterol levels, and 5 had elevated triglyceride levels. Further, 30% of them were positive for at least 1 allergen, while 16% of the controlsubjects were positive for at least 1 allergen, but statistically significant difference was not found between the 2 groups. Variable degrees of venous insufficiency were detected in 75% of the patients on Doppler ultrasonography of the lower extremities. Conclusion: Venous insufficiency and hypercholesterolemiamight be the basic predisposing factors for PPD. Further studies are needed to show if diabetes mellitus and hypertension may cause perivascular inflammation in PPD. (Ann Dermatol 26(5) 610∼614, 2014)

Approximation behaviour of the generalized Kantorovich-type operators by multiple generating functions

A. Olgun,MÜZEYYEN ÖZHAVZALI 장전수학회 2011 Advanced Studies in Contemporary Mathematics Vol.21 No.2

The purpose of this study is to investigate approximation behaviour of the generalized Kantorovich-type operators by multiple generating functions. For this aim, …rstly, we introduce bivariate gener-alization of Kantorovich-type operators and study their approximation behaviour with the help of a Korovkin type theorem. Secondly, we com-pute the rate of convergence of these operators by means of the modules of continuity and the elements of Lipschitz class. Also, we give the r-th order generalization of these operators. In the last part, we give some applications to the di¤erential equations.

CONSUMER ARROGANCE: A CROSS-CULTURAL VALIDATION IN TURKEY AND ROMANIA

Betul Balikcioglu,Muzeyyen Arslan 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07

Consumer arrogance is conceptualized and defined by Ruvio & Shoham (2016) as people's proclivity for demonstrating their social superiority through the acquisition, utilization, or display of consumer goods. This new notion rooted from the symbolic meaning of consumption that suggesting consumers use products as symbols to create self-identity, to maintain their self-concept, to express their self, to convey personal and social achievements and to reflect their social status to others (Holman, 1981; Belk, 1988; Hirschman & LaBarbera, 1990). This research examines the cross-cultural validity of the Ruvio & Shoham‘s (2016) consumer arrogance scale in Turkey and Romania. Data were collected from 192 Turkish and 176 Romanian students. Confirmatory factor analysis was used to test the four-factor solution. The scale demonstrates internal consistency and validity within the two countries and across countries. The cross-cultural validation tested via configural, metric and covariance methods. The results indicated that the consumer arrogance scale is consistent across countries and it can be established as a second order construct. The nomological validity with structural equation modelling results support that consumer arrogance is predicted by materialism in both countries. This cross-national study extended consumer arrogance scale in a collectivist cultural setting and contributes to enriching cross-cultural validation research as well as consumer behavior understanding.

Effectiveness of physiotherapy and minimal invasive technics on functional status and quality of life in geriatric patients with low back pain

Özlem Ülger,Aynur Demirel,Müzeyyen Oz,Altan Şahin 한국운동재활학회 2018 JER Vol.14 No.6

Serotonin Expression in Lichen Planus Lesions and Its Relationship with Depression/Anxiety

( Gokce Isil Kurmus ),( Muzeyyen Gonul ),( Filiz Canpolat ),( Demet Yilmazer ),( Eylem Sahin Cankurtaran ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

Background: Psychological factors such as stress, depression, and anxiety have been documented to contribute to the development of lesions in lichen planus (LP). Objective: To evaluate the relationship between serotonin expression in LP lesions and depression/anxiety. Methods: Forty patients (22 females, 18 males) with LP and 20 healthy control subjects were included in this study. The severity of LP was assessed with the palmar method (using the measurement of affected body surface area [BSA]). The depression and anxiety scores were measured with Beck's depression inventory (BDI) and Beck's anxiety inventory (BAI). The expression of serotonin was determined via immunohistochemistry in LP lesions and in the control group skin using a monoclonal antibody to serotonin. Results: The skin biopsies of the LP patients had significantly higher levels of serotonin than those of the control subjects (p<0.001). In the LP patients, and there was a positive correlation between serotonin expression and LP severity (p=0.022). Based on the results from the BDI and BAI, there was a significant relationship between the severity of depression/anxiety and intensity of serotonin expression (p <0.001). Conclusion: Data from this study suggest that serotonin may have a possible role in the pathogenesis of LP. Further, the relationship between serotonin expression in acute cutaneous lesions and the depression/anxiety scores indicates that serotonin may be a mediator for the association of LP and depression/anxiety simultaneously. There is a need for more specific studies showing the expression of serotonin in the lichen planus to demonstrate the cause or effect. (Ann Dermatol 31(2) 146∼153, 2019)

Prevalence of herbal therapy usage in patients with psoriasis in Turkey

Keseroglu, Havva Ozge,Gonul, Muzeyyen,Kurmus, Gokce Isil Cellmed Orthocellular Medicine and Pharmaceutical 2015 셀메드 (CellMed) Vol.5 No.2

Many patients with psoriasis look for treatment options other than conventional treatment to control their disease with less side effects. We evaluated the prevalence and characteristics of herbal therapy usage among patients with psoriasis in Turkey. A self-prepared questionnaire about herbal therapies was applied to the psoriatic patients attended our dermatology clinic between October 2013 and December 2013. A total of 100 patients (55 male, 45 female; 7 - 80 years of age) were included in this study. Fortynine percent of patients used at least one form of herbal therapies. Juniperus oxycedrus and Aloe vera were found to be the most frequently used plants. 36.7% of the patients get benefit from herbal therapy. Only 12.2% of patients had informed their clinicians during or after herbal therapy usage. 22.4% of the patient had continued conventional treatment during herbal therapies. Side effects related with herbal therapy were developed in 26.5% of the patients. The risk of side effects was found to be 5.23 times more in patients using phytotherapies systemically compared with ones using topically. Our results show that herbal therapy usage is common among patients with psoriasis in Turkey. Since herbal therapies have the potential of interacting with the medical treatment modalities and causing life threatening allergic reactions, clinicians should be aware of plants used in psoriasis and possible adverse reactions related with them and also should not forget asking about herbal therapy history.

Preparation of Prolonged Release Clarithromycin Microparticles for Oral Use and Their In Vitro Evaluation

Genc, Lutfi,Demirel, Muzeyyen,Yazan, Yasemin The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.10

Prolonged release micro particles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, particle size distribution, X-ray diffraction, thermal behavior, active agent content and in vitro dissolution from the microparticles were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. All the formulations obtained showed prolonged release when compared to pure clarithromycin. Microparticles prepared by spray-drying method had a slower release compared to those of casting drying method. Spray-drying method seems to be a more suitable method to prepare microparticles for prolongation in release.