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- 저자 : Lunghi (검색결과 4 건)
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Gianmarco Lunghi,Elena Pasqualetto,Benedetto Rocchio,Alessandro Mariotti,Maria Vittoria Salvetti 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.34 No.1
The high-Reynolds number flow around a rectangular cylinder, having streamwise to crossflow length ratio equal to 5 is analyzed in the present paper. The flow is characterized by shear-layer separation from the upstream edges. Vortical structures of different size form from the roll-up of these shear layers, move downstream and interact with the classical vortex shedding further downstream in the wake. The corresponding mean flow is characterized by a recirculation region along the lateral surface of the cylinder, ending by mean flow reattachment close to the trailing edge. The mean flow features on the cylinder side have been shown to be highly sensitive to set-up parameters both in numerical simulations and in experiments. The results of 21 Large Eddy Simulations (LES) are analyzed herein to highlight the impact of the lateral mean recirculation characteristics on the near-wake flow features and on some bulk quantities. The considered simulations have been carried out at Reynolds number Re=DU_∞/ν=40 000, being D the crossflow dimension, U_∞ the freestream velocity and ν the kinematic viscosity of air; the flow is set to have zero angle of attack. Some simulations are carried out with sharp edges (Mariotti et al. 2017), others with different values of the rounding of the upstream edges (Rocchio et al. 2020) and an additional LES is carried out to match the value of the roundness of the upstream edges in the experiments in Pasqualetto et al. (2022). The dimensions of the mean recirculation zone vary considerably in these simulations, allowing us to single out meaningful trends. The streamwise length of the lateral mean recirculation and the streamwise distance from the upstream edge of its center are the parameters controlling the considered quantities. The wake width increases linearly with these parameters, while the vortexshedding non-dimensional frequency shows a linear decrease. The drag coefficient also linearly decreases with increasing the recirculation length and this is due to a reduction of the suctions on the base. However, the overall variation of C_D is small. Finally, a significant, and once again linear, increase of the fluctuations of the lift coefficient is found for increasing the mean recirculation streamwise length.
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Experimental characterization of the lateral and near-wake flow for the BARC configuration
Elena Pasqualetto,Gianmarco Lunghi,Benedetto Rocchio,Alessandro Mariotti,Maria Vittoria Salvetti 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.34 No.1
We experimentally investigate the high-Reynolds flow around a rectangular cylinder of aspect ratio 5:1. This configuration is the object of the international BARC benchmark. Wind tunnel tests have been carried out for the flow at zero angle of attack and a Reynolds number, based on the crossflow cylinder length and on the freestream velocity, equal, to 40 000. Velocity measurements are obtained by using hot-wire anemometry along 50 different cross-flow traverses on the cylinder side and in the near wake. Differential pressure measurements are acquired on multiple streamwise sections of the model. The obtained measurements are in a good agreement with the state-of-the-art experiments. For the first time among the several contributions to the BARC benchmark, detailed flow measurements are acquired in the region near the cylinder side and in the near-wake flow. The edges and the thickness of the shear layers detaching from the upstream edges are derived from velocity measurements. Furthermore, we compute the flow frequencies characterizing the roll-up of the shear layers, the evolution of vortical structures near the cylinder side and the vortex shedding in the wake.
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Maria Gemelli,Elena Maria Elli,Chiara Elena,Alessandra Iurlo,Tamara Intermesoli,Margherita Maffioli,Ester Pungolino,Maria Cristina Carraro,Mariella D’Adda,Francesca Lunghi,Michela Anghileri,Nicola Pol 대한혈액학회 2020 Blood Research Vol.55 No.3
BackgroundGeneric formulations of imatinib mesylate have been introduced in Western Europe since 2017 to treat patients with chronic myeloid leukemia (CML). However, results on the safety and efficacy of generic formulations are contrasting. The aim of this study was to investigate the safety and efficacy of generic imatinib in CML patients treated in 12 Italian institutes.MethodsThis is an observational, retro-prospective analysis of patients with CML for whom the treatment was switched from brand to generic imatinib. We analyzed and compared the variation in quantitative PCR values before and after the switch, and the proportion of patients who maintained molecular response after changing from brand to generic imatinib. Adverse events (AEs) were also evaluated. ResultsTwo hundred patients were enrolled. The median PCR value after the switch was reduced by 0.25 compared to the values before the switch. A significant difference was found be-tween median PCR values before and after the switch in favor of generic imatinib (P= 0.003). Molecular responses remained stable in 69.0%, improved in 25.5%, and wors-ened in 5.5% of patients. AEs were similar in the pre- and post-switch periods; however, a significant difference was found in favor of generic imatinib for muscular cramps (P<0.0001), periorbital edema (P=0.0028), edema of the limbs (P<0.0001), fatigue (P=0.0482), and diarrhea (P=0.0027).ConclusionOur data indicate that generic imatinib does not have deleterious effects on CML control and present an acceptable safety profile, similar or better than brand imatinib.
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