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Effects of Injection of IL-1α on Tooth Eruption in the Rat
Wise, G.E.,Lumpkin, S.J.,Huang, H. Korean Academy of Oral Biology and the UCLA Dental 2000 International Journal of Oral Biology Vol.25 No.2
It has been postulated that interleukin-1α(IL-1α) is an initiator of tooth eruption because of its ability to enhance the gene expression of CSF-1, MCP-1 and NF_κB, molecules involved in the signaling pathway leading to tooth eruption. Although IL-1α is localized in the stellate reticulum, its receptors are present in the adjacent dental follicle, the site of CSF-1, MCP-1 and NF_κB production. Thus, to directly examine the effect of IL-1α on tooth eruption, newborn rats were injected with IL-1α at a concentration of ㎍/g body weight on days 1, 3, 5, 10 and 12 postnatally. The results showed that IL-1α injections accelerated the time of eruption by almost 3 days for mandibular incisors and 2 days for maxillary incisors. such injections accelerated the eruption time for the first mandibular molar by almost 1 day. Eyelid opening time was accelerated by 2.5 days in the IL-1α injected rats but average growth was stunted by almost 0.7g/day as compared to controls. These effects of IL-1α parallel effects of EGF on incisor eruption. eyelid opening and growth. The effects EGF could be mediated through IL-1α, especially since it has been previously shown that EGF enhances both IL-1α and IL-1α receptor gene expression. Because CSF-a accelerates molar eruption but not incisor eruption, the major effect of IL-1α on enhancing incisor eruption may be through its stimulating the expression of MCP-1 and NF_κB. to that end, we demonstrate in this study that IL-1α heightens translation of NF_κB and MCP-1 in cultured dental follicle cells.