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Behaviour of flush end-plate beam-to-column joints under bending and axial force
Luís Simões da Silva,Luciano R. O. de Lima,Pedro C. G. da S. Vellasco,Sebastião A. L. de Andrade 국제구조공학회 2004 Steel and Composite Structures, An International J Vol.4 No.2
Steel beam-to-column joints are often subjected to a combination of bending and axial forces. The level of axial forces in the joint may be significant, typical of pitched-roof portal frames, sway frames or frames with incomplete floors. Current specifications for steel joints do not take into account the presence of axial forces (tension and/or compression) in the joints. A single empirical limitation of 10% of the beam’s plastic axial capacity is the only enforced provision in Annex J of Eurocode 3. The objective of the present paper is to describe some experimental and numerical work carried out at the University of Coimbra to try to extend the philosophy of the component method to deal with the combined action bending moment and axial force.
Dot Idea (.IDEA): A New Concept for an Incubation Program and Open Innovation Based on User Needs
Luís Felipe Maldaner,Luísa Simon,Carlos Eduardo de Souza Aranha 세계과학도시연합 2018 World Technopolis Review Vol.7 No.2
This paper discussed the application process of the Dot Idea program. The Dot Idea program is an incubation and open innovation program co-created by Unitec, an incubator at Tecnosinos Tech Park, and an SAP innovation team. The main objective of this study was to cover an existing gap in the literature regarding the practical application of an open innovation methodology. Many companies seek interaction with external parties to enable advancement toward identified innovation opportunities. Technology clusters, parks, and incubators have played an important role in promoting connections and interaction. Consequently, the Dot Idea program emerged as a result of a joint effort to create a program using a design science research methodology aiming to foster new businesses and strengthen Brazil and Latin America as a hub to develop new solutions for traditional organizations. In regards to lessons learned, the Dot.health trial had some success but also experienced difficulties; these related to the relationships between startups and a hospital’s internal teams, and startups’ needs to be funded from the beginning in order to be fully dedicated to a project.
Effect of MAP and Vacuum Sealing on Sensory Qualities of Drysalted Olive
Nurcan Değirmencioğlu,Ozan Gürbüz,Ali Değirmencioğlu,Yasemin Şahan,Hasan Özbey 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.5
The ‘Gemlik’ olive, grown in Turkey, is the main variety used in the production of commercial table olives. The aim of the present work was to determine the effect on sensory qualities of dry-salted olives of the ‘Gemlik’ cultivar packed with vacuum sealing or modified atmosphere packaging and stored at 4 or 20^oC. Storage temperature did not have a significant effect on the sensory profile (p>0.05). However, with the exception of the color attribute, somewhat higher overall scores were given to samples stored at 4^oC. In both vacuum sealing and modified atmosphere packaging (MAP) samples stored at 4^oC, the lack of oxygen and dipping the olives in 10 ppm chlorine solution before dry-salting, prevented the growth of yeast and mold and therefore both rancidity and softness attributes scored higher points by panelists.
Eduardo Luís Menezes de Almeida,Eduard J. Kerkhoven,Wendel Batista da Silveira 한국생물공학회 2024 Biotechnology and Bioprocess Engineering Vol.29 No.1
Non-conventional yeasts are promising cell factories to produce lipids and oleochemicals, metabolites of industrial interest ( e.g ., organics acids, esters, and alcohols), and enzymes. They can also use diff erent agro-industrial by-products as substrates within the context of a circular economy. Some of these yeasts can also comprise economic and health burdens as pathogens. Genome-scale metabolic models (GEMs), networks reconstructed based on the genomic and metabolic information of one or more organisms, are great tools to understand metabolic functions and landscapes, as well as propose engineering targets to improve metabolite production or propose novel drug targets. Previous reviews on yeast GEMs have mainly focused on the history and the evaluation of Saccharomyces cerevisiae modeling paradigms or the accessibility and usability of yeast GEMs. However, they did not describe the reconstruction strategies, limitations, validations, challenges, and research gaps of non-conventional yeast GEMs. Herein, we focused on the reconstruction of available non- Saccharomyces GEMs, their validation, underscoring the physiological insights, as well as the identifi cation of both metabolic engineering and drug targets. We also discuss the challenges and knowledge gaps and propose strategies to boost their use and novel reconstructions.
Therapeutic Feasibility of the Natural Products in the Heart Complaints: An Overview
Priscila de Souza,Luísa Nathália Bolda Mariano,Rita de Cássia M. V. A. F. da Silva,Francielli Gasparotto,Emerson Luiz Botelho Lourenço,Guilherme Donadel,Thaise Boeing,Arquimedes Gasparotto Junior 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.12
Heart pain is the most frequent complaint leading patients to seek medical help. Functional heart symptoms, especially chest pain, are prevalent and, according to the International Classification of Diseases (ICD-10), are described as “somatoform autonomous functional disorders of the cardiovascular system.” The problem lies in the fact that pain does not always have a somatic background, that is, it may be related to crucial underlying heart disease. The population does not know how to differentiate somatic pain from significant ischemic symptoms, and based on the patient's complaints, traditional medicine ends up treating other underlying cardiac diseases. Many unsuccessful unconventional therapies have been proposed in recent years, including herbal medicines that seek to disrupt the disease's pathogenesis. The present review summarizes research carried out in the last 5 years on natural products' heart complaints, including myocardial ischemia, arrhythmia, and heart failure. Several herbal medicines may be used as a replacement or complementary treatment strategy. A total of 17 medicinal plants have shown promising results in preclinical studies. However, human clinical trials are scarce; only two have been presented. Generally, the data are bland, and many issues have been raised about herbal therapies' safety, efficacy, and mode of action. Besides, relevant clinical trials, future perspectives, and possible clinical applications are discussed.
2D evaluation of crack openings using smeared and embedded crack models
André Luís Gamino,Osvaldo Luís Manzoli,José Luiz Antunes de Oliveira e Sousa,Túlio Nogueira Bittencourt 사단법인 한국계산역학회 2010 Computers and Concrete, An International Journal Vol.7 No.6
This work deals with the determination of crack openings in 2D reinforced concrete structures using the Finite Element Method with a smeared rotating crack model or an embedded crack model. In the smeared crack model, the strong discontinuity associated with the crack is spread throughout the finite element. As is well known, the continuity of the displacement field assumed for these models is incompatible with the actual discontinuity. However, this type of model has been used extensively due to the relative computational simplicity it provides by treating cracks in a continuum framework, as well as the reportedly good predictions of reinforced concrete members’ structural behavior. On the other hand, by enriching the displacement field within each finite element crossed by the crack path, the embedded crack model is able to describe the effects of actual discontinuities (cracks). This paper presents a comparative study of the abilities of these 2D models in predicting the mechanical behavior of reinforced concrete structures. Structural responses are compared with experimental results from the literature, including crack patterns, crack openings and rebar stresses predicted by both models.
Bacarin Carolina de Carvalho,Nicácio Gabriel Montoro,Cerazo Letícia Maria de Lima,Peruchi Luíza Guimarães,Cassu Renata Navarro 사단법인약침학회 2022 Journal of Acupuncture & Meridian Studies Vol.15 No.2
Background: Yamamoto New Scalp Acupuncture (YNSA) is a therapy based on the stimulation of points on the scalp and applied to treat different states of pain. Objectives: To investigate the analgesic efficacy of YNSA for dogs undergoing radical unilateral mastectomy with ovariohysterectomy. Methods: Twenty-four dogs were randomly distributed into two treatments (n = 12, per group): bilateral stimulation of basic B, D, and E points (YNSA group) and no application of acupuncture (control group). All dogs were sedated with morphine; anesthesia was induced with propofol and maintained with isoflurane. Fentanyl was intraoperatively administered to control cardiovascular responses to surgical stimulation. Postoperative pain was assessed using an interactive visual analog scale (IVAS) and the short-form of the Glasgow Composite Pain Scale (CMPS-SF). Morphine was administered as rescue analgesia. Data were analyzed using t-tests, Fisher’s exact test, Mann–Whitney U test, and Friedman test (p < 0.05). Results: Intraoperatively, the number of dogs requiring supplemental analgesic and the number of doses of fentanyl were lower in the YNSA group than in the control group (p = 0.027-0.034). The IVAS pain scores recorded from 0.5 h to 1 h post-extubation in the YNSA group were lower than those in the control group (p = 0.021-0.023). Postoperative rescue analgesia and CMPS-SF pain scores did not differ between the groups. Conclusion: YNSA decreases intraoperative fentanyl requirements and provides minimal postoperative analgesic benefits to dogs undergoing unilateral mastectomy with ovariohysterectomy.
Eco-Friendly Manufacturing of Nano-TiO2 Coated Cotton Textile with Multifunctional Properties
Mirele Horsth de Paiva Teixeira,Luís Antônio Lourenço,Wagner Artifon,Celso Junior de Castro Vieira,Sergio Yesid Gómez González,Dachamir Hotza 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1
In this work, multifunctional cotton fabrics were developed by immobilizing TiO2 nanoparticles (TiO2-NPs) usingan eco-friendly bath through a highly-scalable technique. The effects of TiO2-NPs, cross-linking agent, catalyst and curingtemperatures were assessed by analysis of variance and surface response methodology. The results disclose an excellentperformance of treated textiles for various applications: flame-retardant (char content enhanced by 1000 %), photocatalyticdecontamination (>90 % of contaminant abatement and feasibility for multiple reuses), self-cleaning of intense stains (up to80 % of stain vanishing), bacterial inhibition without TiO2 UV-activation (≈25 % of bacteria growth reduction). Moreover,those properties were durable for at least five domestic laundering cycles.
Letiele Bruck de Souza,Amanda Leitão Gindri,Thainara de Andrade Fortes,Jefferson Enderle,Rafael Roehrs,Vanusa Manfredini,Elton Luís Gasparotto Denardin 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.2
The Asteraceae family is widely known for its therapeutic, aromatic, and nutritional properties. Chaptalia nutans (C. nutans), a member of the family, is widely used in folk medicine in southern Brazil. In this study, we aim to assess compounds present in root extracts of C. nutans, and evaluate their antioxidant capacity and toxicity. To determine the chemical composition of the extract, was performed through Liquid Chromatography coupled with Mass Spectroscopy. Antioxidant capacity, toxicity (Artemia salina biosassay), cytotoxicity, genotoxicity (Allium cepa test), and neurotoxicity (Drosophila melanogaster model) were evaluated. A large number of bioactive phytoconstituents were determined to be present, such as alkaloids, coumarins, flavonoids, terpenes, and especially phenolic compounds, which may explain the antioxidant capacity of the extract. Extracts had the capacity to protect cells from protein and lipid damage, and inhibit the formation of oxygen radicals. The A. salina bioassay revealed that extracts were only slightly toxic. In A. cepa, cells exposed to 1.5 mg/mL extract were protected against chromosomal damage caused by glyphosate, and had mitotic index values that were reduced by 49%. A concentration of 10 mg/mL extract did not kill flies, and when coadministered with paraquat (PQ) (52.5%) produced a mortality rate of only 18.75%. These findings indicated that the extract had the potential to protect against PQ-induced neurotoxicity. Taken together, these data reveal for the first time that the root extract of C. nutans is a rich source of natural antioxidants. The extract may be useful in the food and pharmaceutical industries.