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기업CEO의 마이크로 블로그가 소비자 구매의도에 미치는 영향에 대한 연구
Ning Lu,민대환(Dai Hwan Min),Li Li Wan 한국경영학회 2014 한국경영학회 통합학술발표논문집 Vol.2014 No.8
참여와 소통 그리고 공유로 대변되는 웹 2.0시대에 들어서 소셜 미디어가 우후죽순처럼 나타났고 사람들은 소셜 미디어를 이용하여 언제 어디서나 실시간으로 의사소통을 할 수 있게 되었다. 결국 소셜 미디어의 대두에 힘입어 전통 매체에서 일방적으로 정보를 소비하던 과거의 소비자들은 이제 소셜 미디어를 활용하여 고유의 컨텐츠를 생산하고 전파하면서 생산자로서의 역할을 수행하고, 또한 의제를 설정하고 여론을 유도함으로써 사회 전반적인 분야에서 자신의 속마음, 혹은 대중의 속마음을 털어놓을 수 있게 되었다.
The modal characteristics of non-uniform multi-span continuous beam bridges
Lu-ning Shi,Wei-ming Yan,Hao-xiang He 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.5
According to the structure characteristics of the non-uniform beam bridge, a practical model for calculating the vibration equation of the non-uniform beam bridge is given and the application scope of the model includes not only the beam bridge structure but also the non-uniform beam with added masses andelastic supports. Based on the Bernoulli-Euler beam theory, extending the application of the modal perturbation method and establishment of a semi-analytical method for solving the vibration equation of thenon-uniform beam with added masses and elastic supports based is able to be made. In the modal subspace of the uniform beam with the elastic supports, the variable coefficient differential equation that describes the dynamic behavior of the non-uniform beam is converted to nonlinear algebraic equations. Extending the application of the modal perturbation method is suitable for solving the vibration equation of the simply supported and continuous non-uniform beam with its arbitrary added masses and elastic supports. The examples, that are analyzed, demonstrate the high precision and fast convergence speed of the method. Further study of the timesaving method for the dynamic characteristics of symmetrical beam and the symmetry of mode shape should be developed. Eventually, the effects of elastic supports and added masseson dynamic characteristics of the three-span non-uniform beam bridge are reported.
Lu, Ning,Wang, Jinguo,Oviedo, uan Pablo,Lian, Guoda,Kim, Moon Jea Korean Society of Microscopy 2015 Applied microscopy Vol.45 No.4
Transition metal dichalcogenides (TMDs) are a class of two-dimensional (2D) materials that have attracted growing interest because of their promising applications. The properties of TMDs strongly depend on the crystalline structure and the number and stacking sequence of layers in their crystals and thin films. Though electrical, mechanical, and magnetic studies of 2D materials are being conducted, there is an evident lack of direct atom-by-atom visualization, limiting insight on these highly exciting material systems. Herein, we present our recent studies on the characterization of 2D layered materials by means of aberration corrected scanning transmission electron microscopy (STEM), in particular via high angle annular dark field (HAADF) imaging. We have identified the atomic arrangements and defects in 2H stacked TMDs, 1T stacked TMDs, distorted 1T stacked TMDs, and vertically integrated heterojunctions of 2D TMDs crystals.
Physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via regulating calcium signaling
( Ning Ding ),( Yanzhu Lu ),( Hanmin Cui ),( Qinyu Ma ),( Dongxia Qiu ),( Xueting Wei ),( Ce Dou ),( Ning Cao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2020 BMB Reports Vol.53 No.3
We investigated the effects of physalin A, B, D, and F on osteoclastogenesis induced by receptor activator of nuclear factor кB ligand (RANKL). The biological functions of different physalins were first predicted using an in silico bioinformatic tool (BATMAN-TCM). Afterwards, we tested cell viability and cell apoptosis rate to analyze the cytotoxicity of different physalins. We analyzed the inhibitory effects of physalins on RANKL-induced osteoclastogenesis from mouse bone-marrow macrophages (BMMs) using a tartrate-resistant acid phosphatase (TRAP) stain. We found that physalin D has the best selectivity index (SI) among all analyzed physalins. We then confirmed the inhibitory effects of physalin D on osteoclast maturation and function by immunostaining of F-actin and a pit-formation assay. On the molecular level, physalin D attenuated RANKLevoked intracellular calcium ([Ca(2+)](i)) oscillation by inhibiting phosphorylation of phospholipase Cγ2 (PLCγ2) and thus blocked the downstream activation of Ca2+/calmodulindependent protein kinases (CaMK)IV and cAMP-responsive element-binding protein (CREB). An animal study showed that physalin D treatment rescues bone microarchitecture, prevents bone loss, and restores bone strength in a model of rapid bone loss induced by soluble RANKL. Taken together, these results suggest that physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via suppressing the PLCγ2-CaMK-CREB pathway. [BMB Reports 2020; 53(3): 154-159]
The modal characteristics of non-uniform multi-span continuous beam bridges
Shi, Lu-Ning,Yan, Wei-Ming,He, Hao-Xiang Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.5
According to the structure characteristics of the non-uniform beam bridge, a practical model for calculating the vibration equation of the non-uniform beam bridge is given and the application scope of the model includes not only the beam bridge structure but also the non-uniform beam with added masses and elastic supports. Based on the Bernoulli-Euler beam theory, extending the application of the modal perturbation method and establishment of a semi-analytical method for solving the vibration equation of the non-uniform beam with added masses and elastic supports based is able to be made. In the modal subspace of the uniform beam with the elastic supports, the variable coefficient differential equation that describes the dynamic behavior of the non-uniform beam is converted to nonlinear algebraic equations. Extending the application of the modal perturbation method is suitable for solving the vibration equation of the simply supported and continuous non-uniform beam with its arbitrary added masses and elastic supports. The examples, that are analyzed, demonstrate the high precision and fast convergence speed of the method. Further study of the timesaving method for the dynamic characteristics of symmetrical beam and the symmetry of mode shape should be developed. Eventually, the effects of elastic supports and added masses on dynamic characteristics of the three-span non-uniform beam bridge are reported.
Prognosis and Clinicopathology of CXCR4 in Colorectal Cancer Patients: a Meta-analysis
Li, Lu-Ning,Jiang, Kai-Tong,Tan, Peng,Wang, Ai-Hua,Kong, Qing-Yin,Wang, Cui-Yue,Lu, Hua-Rong,Wang, Jing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
The chemokine receptor 4 (CXCR4) has been widely used in diagnosis and prognosis of colorectal cancer (CRC). However, there is no current consensus on the impact of CXCR4 on CRC patients. The purpose of this study was to evaluate the prognostic and clinicopathological importance of CXCR4 in CRC patients. Databases, such as PubMed, Cochrane library, CBM and EMBASE updated to 2014 were searched to include eligible articles. We analysed correlations between CXCR4 expression and clinicopathological features and overall survival (OS). A total of 1, 055 CRC patients from twelve studies were included in the study. The pooled odds ratios (ORs) which indicated CXCR4 expression was likely to be associated with TNM stage (OR=0.43, CI=0.34-0.55, P<0.00001), lymph node status (OR=2.23, CI=1.23-4.05, P=0.008) and vascular invasion (OR=2.21, CI=1.11-4.39, P=0.02). Poor overall survival of CRC cancer was found to be significantly related to CXCR4 overexpression (hazard ratio (HR) 1.36 CI=1.17-1.59, P<0.0001), whereas combined ORs revealed that CXCR4 expression had no correlation with gender or differentiation. Based on the published studies, CXCR4 overexpression in patients w ith CRC indicates poor survival outcome and clinicopathological factors.
Ning Liu,Y. F. Zhang,Wen Feng Lu 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.6 No.2
Improving energy efficiency has been one of main objectives in modern manufacturing enterprises. Various approaches aiming at efficient energy management have been proposed/developed, among which minimizing energy consumption by energy-sensible production scheduling techniques has emerged as a promising one. However, reported workshop models are quite simple and unrealistic. This paper studies a more realistic workshop model called ultra-flexible job shop (uFJS). In an uFJS, the sequence among operations for a job can be changed within certain constraints. To formulate this energy-efficient scheduling problem, a mixed-integer linear programming model was developed. To deal with large-sized problems, a specially designed genetic algorithm (GA) was subsequently proposed and implemented. Numerical results showed the proposed GA worked with decent effectiveness and efficiency. Finally, several comparative studies are carried out to further demonstrate its efficacy in terms of energy efficiency improvement. The advantage of the uFJS as compared to other relative simple workshop models is also shown. By considering the flexibility in operation sequencing in each job, the uFJS effectively integrates process planning and scheduling in discrete parts manufacturing system, thus providing a much larger solution space for more energy-efficient solutions. It therefore provides an excellent platform for decision-makers when developing energy-efficient techniques and strategies
Ultrasonic method for measuring the gas holdup of gas-liquid bubbly flow in a small-diameter pipe
Ning-De Jin,Zheng Gong,An Zhao,Lu-Sheng Zhai,Ying-Yu Ren 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.4
Based on ultrasonic sound pressure attenuation, the ultrasonic pulse transmission method is proposed for measuring gas holdup in gas-liquid two-phase bubbly flows. Two ultrasonic transducers are positioned on opposite sides of a vertical upward pipe with an inner diameter of 20 mm. To obtain the relationship between ultrasonic attenuation and gas holdup, the mean value of the first pulse sequence of ultrasonic signals is first extracted as the measured signal. We used the quick closing valve method to obtain the gas holdup as the set value. Second, the relationship between the gas holdup and measured ultrasonic signals was established. The experiment result shows that the ultrasonic attenuation rate is significantly different at low and high gas holdups, as indicated by the bubble size images with a high-speed camera. We also investigated the ultrasonic field distribution using numerical simulation. The bubble size has an important effect on the ultrasonic attenuation coefficient, which provides a further physical explanation and reference for the experimental phenomena.
A New Fuzzy Key Generation Method Based on PHY-Layer Fingerprints in Mobile Cognitive Radio Networks
( Ning Gao ),( Xiaojun Jing ),( Songlin Sun ),( Junsheng Mu ),( Xiang Lu ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.7
Classical key generation is complicated to update and key distribution generally requires fixed infrastructures. In order to eliminate these restrictions researchers have focused much attention on physical-layer (PHY-layer) based key generation methods. In this paper, we present a PHY-layer fingerprints based fuzzy key generation scheme, which works to prevent primary user emulation (PUE) attacks and spectrum sensing data falsification (SSDF) attacks, with multi-node collaborative defense strategies. We also propose two algorithms, the EA algorithm and the TA algorithm, to defend against eavesdropping attacks and tampering attacks in mobile cognitive radio networks (CRNs). We give security analyses of these algorithms in both the spatial and temporal domains, and prove the upper bound of the entropy loss in theory. We present a simulation result based on a MIMO-OFDM communication system which shows that the channel response characteristics received by legitimates tend to be consistent and phase characteristics are much more robust for key generation in mobile CRNs. In addition, NIST statistical tests show that the generated key in our proposed approach is secure and reliable.
Ning Song,Jun Luo,Lian Huang,Xiaoying Chen,Huimin Niu,Lu Zhu Asian Australasian Association of Animal Productio 2023 Animal Bioscience Vol.36 No.10
Objective: α<sub>S1</sub>-Casein is more closely associated with milk allergic reaction than other milk protein components. microRNA (miRNA) is a class of small non-coding RNAs that modulate multiple biological progresses by the target gene. However, the post-transcriptional regulation of α<sub>S1</sub>-casein expression by miRNA in ruminants remains unclear. This study aims to explore the regulatory roles of miR-380-3p on α<sub>S1</sub>-casein synthesis in goat mammary epithelial cells (GMEC). Methods: α<sub>S1</sub>-Casein gene and miR-380-3p expression was measured in dairy goat mammary gland by quantitative real-time polymerase chain reaction (qRT-PCR). miR-380-3p overexpression and knockdown were performed by miR-380-3p mimic or inhibitor in GMEC. The effect of miR-380-3p on α<sub>S1</sub>-casein synthesis was detected by qRT-PCR, western blot, luciferase and chromatin immunoprecipitation assays in GMEC. Results: Compared with middle-lactation period, α<sub>S1</sub>-casein gene expression is increased, while miR-380-3p expression is decreased during peak-lactation of dairy goats. miR-380-3p reduces α<sub>S1</sub>-casein abundance by targeting the 3'-untranslated region (3'UTR) of α<sub>S1</sub>-casein mRNA in GMEC. miR-380-3p enhances β-casein expression and signal transducer and activator of transcription 5a (STAT5a) activity. Moreover, miR-380-3p promotes β-casein abundance through target gene α<sub>S1</sub>-casein, and activates β-casein transcription by enhancing the binding of STAT5 to β-casein gene promoter region. Conclusion: miR-380-3p decreases α<sub>S1</sub>-casein expression and increases β-casein expression by targeting α<sub>S1</sub>-casein in GMEC, which supplies a novel strategy for reducing milk allergic potential and building up milk quality in ruminants.