100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in Rats

Marcelo Lourenço Silva,Josie Resende Torres Silva,Wiliam Alves Prado 사단법인약침학회 2016 Journal of Acupuncture & Meridian Studies Vol.9 No.4

Preemptive analgesia involves introducing an analgesic before noxious stimulation. Electroacupuncture (EA) activates descending mechanisms that modulate nociceptive inputs into the spinal dorsal horn. This study evaluated whether preoperative EA is more effective than postoperative EA in reducing incision pain in rats. The nociceptive threshold to mechanical stimulation was utilized to examine the effects of an intraperitoneal injection of saline (0.1 mL/kg) or naloxone (1 mg/kg) on antinociception induced by a 20-minute period of 2-Hz or 100-Hz EA applied to the Zusanli (ST36) and Sanyinjiao (SP6) acupoints before surgical incision, or 10 minutes after or 100 minutes after surgical incision of the hind paw. The extent of mechanical hyperalgesia after the incision was significantly attenuated by the application of 100-Hz EA preoperatively, but not by its application at 10 minutes or 100 minutes postoperatively. By contrast, 2-Hz EA was effective against postoperative hyperalgesia when applied 10 minutes or 100 minutes after surgery but not when it was applied preoperatively. Only the effect of 2-Hz EA applied 10 minutes after surgery was sensitive to naloxone. The present study showed for the first time that 100-Hz EA, but not 2-Hz EA, exerts a nonopioidergic preemptive effect against postincision pain in rats.

Pseudocholangiocarcinoma Sign: Management of Portal Cavernoma Biliopathy with Fully-Covered Self-Expandable Metal Stent

Luís C Lourenço,David V Horta,Catarina G Rodrigues,Jorge Canena,Jorge Reis 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.3

Brief report

Evaluation of the Hypotensive Potential of Bovine and Porcine Collagen Hydrolysates

Mariza Faria,Elizabete Lourenço da Costa,José Antônio Rocha Gontijo,Flávia Maria Netto 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.3

Angiotensin-converting enzyme (ACE) inhibitory activity and antihypertensive activity of bovine and porcine collagen hydrolysates in spontaneously hypertensive rats (SHR) were investigated. The hydrolyzed collagens were subjected to ultrafiltration using membranes with cutoffs of 30–50 kDa (permeate P1), 5–8 kDa (permeate P2), or 1–2 kDa (permeate P3) in order to obtain products with a narrower range of molecular size. The hydrolyzed bovine and porcine collagens and their permeates showed low ACE inhibitory activity (50% inhibitory concentration [IC50] = 5.42–15.58 mg of protein/mL). However, after in vitro gastrointestinal digestion, a significant increase in the ACE inhibitory potency of the hydrolyzed collagens was observed (IC50 = 0.97–4.02 mg of protein/mL). Permeates had a higher ACE inhibitory activity and hypotensive activity than non-ultrafiltered hydrolysates. The P1 permeate of bovine and porcine collagen and the P3 fraction of the porcine collagen hydrolysate exhibited the best antihypertensive activity in vivo, promoting a maximum reduction in blood pressure of 22 mm Hg, 21.33 mm Hg, and 21.33 mm Hg, respectively, while lisinopril promoted a maximum reduction of 51.00 mm Hg. These results suggest that the commercial collagen hydrolysates of bovine and porcine origin may be a potential source of bioactive peptides.

Experimental and numerical analysis of RC structure with two leaf cavity wall subjected to shake table

Onur Onat,Paulo B. Lourenço,Ali Koçak 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.55 No.5

This paper presents finite element (FE) based pushover analysis of a reinforced concrete structure with a two-leaf cavity wall (TLCW) to estimate the performance level of this structure. In addition to this, an unreinforced masonry (URM) model was selected for comparison. Simulations and analyses of these structures were performed using the DIANA FE program. The mentioned structures were selected as two storeys and two bays. The dimensions of the structures were scaled 1:1.5 according to the Cauchy Froude similitude law. A shake table experiment was implemented on the reinforced concrete structure with the two-leaf cavity wall (TLCW) at the National Civil Engineering Laboratory (LNEC) in Lisbon, Portugal. The model that simulates URM was not experimentally studied. This structure was modelled in the same manner as the TLCW. The purpose of this virtual model is to compare the respective performances. Two nonlinear analyses were performed and compared with the experimental test results. These analyses were carried out in two phases. The research addresses first the analysis of a structure with only reinforced concrete elements, and secondly the analysis of the same structure with reinforced concrete elements and infill walls. Both researches consider static loading and pushover analysis. The experimental pushover curve was plotted by the envelope of the experimental curve obtained on the basis of the shake table records. Crack patterns, failure modes and performance curves were plotted for both models. Finally, results were evaluated on the basis of the current regulation ASCE/SEI 41-06.

Influence of Maximal Strength on Bench Press and Trunk Rotation in Adapted Shot-put: A Pilot Investigation

Denise Soares,Joana Lourenço,Ana Filipa Silva,Fábio Flôres 한국운동생리학회 2023 운동과학 Vol.32 No.2

PURPOSE: Shot-put is a complex ballistic movement that involves segments’ translational and rotational motions. Its goal is to release the shot at maximum forward velocity (strength) at an angle of approximately 40º (rotation). Considering the adapted shot-put, those two components could be more limited in action. Therefore, the present study aimed to examine the correlations among the one-repetition maximum (1RM) test in the bench press (BP1RM) and trunk rotation (TR1RM) and the throwing distance of the adapted shotput and body composition (Fat mass and Fat-free mass [FFM]), and the throwing distance of the adapted shot-put (TD) and 1RM results. METHODS: Eighteen non-professional athletes were evaluated, and their anthropometric data were obtained (bio-impedance measurements). Afterward, the participants performed the BP1RM and TR1RM exercises. Finally, they performed the adapted shot-put in similar conditions as the official competitions, where three trials of ASP were performed, and the best of these trials were assessed. RESULTS: The results showed a significant relationship between the throwing distance and 1RM results for both exercises (BP1RM (p=0.040) and TR1RM (p=0.002)) and with the amount of FFM (p=0.045). Concerning FFM relationships, the results showed a positive relationship with both 1RM exercises (BP1RM (p=0.034) and TR1RM (p=0.003)). The Fat Mass results demonstrated an inverse correlation only with BP1RM (p=0.035). CONCLUSIONS: The results suggest that physical preparation, including BP1RM and TR1RM exercises, are fundamental to improving adapted shot-put performance. This showed preliminary indicators of which variables may influence the adapted shot-put that might help coaches and athletes to improve their performance. Nevertheless, those results should be carefully considered since the movement evaluated was very complex, especially when performed by participants unfamiliar with them, and because the same analysis included both sexes.

Contamination and persistence of polycyclic aromatic hydrocarbons (PAHs) in rice grains after drying in direct-fired dryer

Maurício Albertoni Scariot,Lauri Lourenço Radünz,Rafaela Roberta Morelato,Liziara da Costa Cabrera,Jonas Simões Dugatto,Rafael Gomes Dionello,André Luiz Radünz 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.7

The objective of this work was to study PAHs contamination in rice grains subjected to different milling types, after drying at different air temperatures in a direct-fired dryer and using firewood with different moisture contents as a heating source. In addition to verifying the persistence of these compounds after storage. Drying of rice grains was performed in a cross-flow dryer at air temperatures of 55 and 65 ºC. As heating source firewood containing different moisture contents was used. The presence of nine PAHs was detected. The drying air temperature, as well as the storage time, did not significantly influence the PAHs contamination of grains. The highest PAHs contamination was observed in grains from the brown subgroup. Grain polishing promoted a reduction in the PAH concentration. The grains subjected to parboilization showed a higher PAHs concentration. The use of firewood with higher moisture content promoted greater PAHs contamination in the grains.

Dietary Soy Isoflavones Prevent Metabolic Disturbs Associated with a Deleterious Combination of Obesity and Menopause

Luciano Evangelista dos Santos Filho,Grazielle Prates Lourenço dos Santos,Jussara Andrade Silva,Fernanda de Abreu Silva,Mirlana Neves Silva,Amanda Alves de Almeida,Raildo da Silva Coqueiro,Cândido Cel 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.2

This study aimed to evaluate the effects of soy isoflavone supplementation (25 mg/kg) on insulin resistance and inflammation in adipose tissue in an experimental model of menopause–obesity. Twenty-four female Wistar rats were ovariectomized (O) and distributed among the groups: OSD—ovariectomized rats submitted to normocaloric standard diet (n = 6); OHF—ovariectomized rats submitted to high-fat diet (n = 9); and OHFI—ovariectomized rats submitted to high-fat diet with isoflavones (n = 9). Weight gain, body adiposity, food and caloric intake, blood pressure, and glucose tolerance were assessed. After 24 weeks, the rats were euthanized; the thoracic blood collected for serum insulin determination and the homeostatic model assessment-insulin resistance) (HOMA-IR) and homeostatic model assessment-β cell (HOMA-β) indices were calculated. Abdominal adipose tissues were removed, weighed, and fixed for immunohistochemical and morphometric studies. Isoflavones decreased weight gain and blood pressure without changing the food and caloric intake (P < .05). Isoflavones did not affect the weight of the abdominal adipose tissue depots (P < .05). Although they did not alter glucose tolerance, the isoflavones reduced HOMA-IR and HOMA-β, serum insulin levels, in addition to reducing adipocytes' size (P < .05). The number of macrophages, lymphocytes, and crown-like structures in adipose tissue was lower in the group treated with isoflavones (P < .05). In conclusion, our data show that dietary soy isoflavones' supplementation prevents many of well-known deleterious combination of obesity and menopause on metabolism, such as body overweight, adipocyte hypertrophy, and hypertension, as well as insulin resistance and adipose tissue inflammation.

Calibration of the X-ray Diffraction Technique in Measuring In-service Stresses in Corrugated Steel Bars

Santiago Sánchez-Beitia,Daniel Luengas-Carreño,Paulo B. Lourenço 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.6

The X-ray diff raction technique for determining residual stresses in construction steels has been commonly used in the international scientifi c community for decades. Taking advantage of the concepts on which the technique is based, the authors have previously calibrated and used the technique for the in situ determination of the stress states of metallic structures in service. This article presents an advance in the latter utility by means of the laboratory calibration of the X-ray diff raction technique in corrugated steel. The interaction between radiation and steel is complex, so, in the scientifi c community, it is considered pertinent to resort to empirical and experimental calibration processes. Two bars of corrugated steel were subjected to increasing tensile loads. The load states introduced in the testing machine were compared with those determined by X-ray diff raction. The correlation between the values of the loads applied and those determined by the proposed technique is excellent. The experimental conditions of the calibration tests are precisely detailed so that they are easily reproducible. This work represents a necessary fi rst step in employing the technique in the buildings or civil works.

Effectiveness of Invisalign?? aligners in the treatment of severe gingival recession: A case report

Marcio Antonio de Figueiredoa,Fá,bio Lourenç,o Romanoa Murilo Fernando Neuppmann Feresa,Maria Bernadete Sasso Stuania,Ana Carla Raphaelli,Nahá,s-Scocateb,Mí,rian Aiko Nakane Matsumoto 대한치과교정학회 2021 대한치과교정학회지 Vol.51 No.4

In this report, we demonstrate the effectiveness of the Invisalign?? system in the treatment of severe gingival recession and bone dehiscence through torque, translation, and intrusion movements in a young woman. Cone-beam computed tomography was used to assess bone parameters and check the teeth during treatment. The root of the mandibular right central incisor, which was buccally positioned and exhibited bone dehiscence of 9.4 mm, was moved toward the center of the alveolar process by using the Invisalign?? system and SmartForce?? features. The patient was monitored by a periodontist throughout the orthodontic treatment period. Her gingival recession reduced, while the bone dehiscence reduced from 9.40 mm to 3.14 mm. Thus, movement of the root into the alveolus promoted bone neoformation and treated the gingival recession. The findings from this case suggest that orthodontic treatment using the Invisalign??system, along with periodontal monitoring, can aid in the treatment of gingival recession and alveolar defects.[Korean J Orthod 2021;51(4):293-300]

Resistance breeding of maize for downy mildew in East Timor

Claudino Ninas Nabais,Soon-Kwon Kim,Lourenço Borges,Albertino Geronimo 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10

Downy mildew (DM) caused by the Peronosclerospora maydis is considered the most damaging disease of maize (Zea mays L.) in South Asia. In East-Timor, it has been widely spread and considered as the major stress of maize production. It was observed at Loes Research Station and farmers’ field since 2004. All materials exhibited high susceptibility to DM infection at the CIMMYT trial. Only Suwan5 (Thailand), LYDMR (CIMMYT) and Arjuna (Indonesia) showed tolerance. Different trials with 900 crosses were tested at 5 locations; Lospalos, Dili, Comoro, Aileu and Loes in 2006/2007 In 2008, high DM infection was observed at Loes. Crosses of Suwan5, NAI, Arjuna and DMR-ESR-Y (IITA)with tropical and temperate germplasm showed tolerance. The International Corn Foundation (ICF)/KNU team with the Ministry of Agriculture have run breeding research three cycles yearly. By 2007, the joint team developed an open-pollinated variety (OPV) with combined tolerance to DM and drought. The Ministry named it "NAI", means "honorable" in national language. Hybrid breeding for both DM and drought are being developed.