Foot and Ankle Motion after Tibiotalocalcaneal Arthrodesis: Comparison with Tibiotalar Arthrodesis Using a Multi-Segment Foot Model

Linying Cao,Min Gyu Kyung,Gil Young Park,Il-Ung Hwang,Ho Won Kang,Dong Yeon Lee 대한정형외과학회 2022 Clinics in Orthopedic Surgery Vol.14 No.4

Background: Tibiotalocalcaneal arthrodesis is an established surgical procedure for treating patients with end-stage ankle joint arthritis and subtalar joint arthritis. Although it greatly relives pain, a major drawback is loss of range of motion. Although it is known to restrict an additional subtalar joint compared to tibiotalar arthrodesis, there is a lack of gait analysis studies comparing the two methods. This study aimed to evaluate the differences in kinematics of the foot and ankle joints between tibiotalar and tibiotalocalcaneal arthrodesis. We also compared preoperative and postoperative statuses for each surgical method. Methods: The study included 12 and 9 patients who underwent tibiotalar and tibiotalocalcaneal arthrodesis, respectively, and 40 healthy participants were included in the control group. The DuPont foot model was used to analyze intersegmental foot and ankle kinematics during gait. Results: Compared to controls, both tibiotalar and tibiotalocalcaneal arthrodesis resulted in slow gait speed with reduced stride length, increased step width, and decreased range of sagittal plane motion. Both fusion methods showed similar range of motion in all segments and planes following surgery. Coronal positions showed more supination of the forefoot and pronation of the hindfoot segment after each operation, particularly tibiotalocalcaneal arthrodesis. Gait after tibiotalocalcaneal arthrodesis did not significantly differ from that after tibiotalar arthrodesis, but there was a tendency of more pronation in the hindfoot segment. Conclusions: Both fusion methods limited foot and ankle motion in similar ways. Comparing tibiotalar and tibiotalocalcaneal arthrodesis suggests that additionally fusing the subtalar joint does not cause greater movement restriction in patients. Objectively comparing tibiotalar and tibiotalocalcaneal arthrodesis will facilitate further understanding of the effect of tibiotalocalcaneal arthrodesis on movement and the value of subtalar joint motion for improved preoperative counselling.

廣州市歷史文化街區的公共設施物滿意度分析

康琳英 ( Linying Kang ),尹甲根 ( Gabgeun Yoon ) 사단법인 아시아문화학술원 2020 인문사회 21 Vol.11 No.5

近年來, 城市歷史文化街區的保護越來越受到各國重視, 公共設施物是人們對街區的歷史文化認知和文化傳承的重要載體之一. 本研究的目的是驗證公共設施物的設計方向性和有效性. 本研究探討了廣州市歷史文化街區的公共設施物的特性要素及使用後評價的設計評價概念定義, 並對專家對設計評價的標準進行了研究. 通過先行研究中對公共設施物設計評價方法的研究和比較分析, 提取出評價尺度語. 研究結果顯示, 作為研究對象的5個歷史文化個街區中, 從公共設施物的特性要素來看, 功能性評價最高, 其次是安全性、普遍性、認同性等. 研究結果建議, 今後在廣州市歷史文化街區的公共設施物設計時, 要註重公共設施物的審美性和可持續性, 將研究轉化為推動城市振興的重要手段. In recent years, the protection of urban historical and cultural blocks has received more and more attention from various countries. Public facilities are one of the important carriers of people’s historical and cultural cognition and cultural inheritance of blocks. The purpose of this research is to verify the design direction of public facilities And effectiveness. This research explores the characteristics of the public facilities in Guangzhou’s historical and cultural districts and the definition of the design evaluation concept for post-use evaluation, and studies the standards for design evaluation by experts. The research and comparative analysis of design evaluation methods extract the evaluation scale language. The results of the study show that among the five historical and cultural blocks as the research object, in terms of the characteristic elements of public facilities, the functional evaluation is the highest, followed by safety, Universality, identity, etc. The research results suggest that in the future in the design of public facilities in Guangzhou’s historical and cultural districts, attention should be paid to the aesthetics and sustainability of public facilities, and the research should be transformed into an important means to promote urban revitalization.

Prognostic Threshold of Neuroendocrine Differentiation in Gastric Carcinoma: a Clinicopathological Study of 945 Cases

Yi Zou,Linying Chen,Xingfu Wang,Yupeng Chen,Liwen Hu,Saifan Zeng,Pengcheng Wang,Guoping Li,Ming Huang,Liting Wang,Shi He,Sanyan Li,Lihui Jian,Sheng Zhang 대한위암학회 2019 Journal of gastric cancer Vol.19 No.1

Purpose: The significance of neuroendocrine differentiation (NED) in gastric carcinoma (GC) is controversial, leading to ambiguous concepts in traditional classifications. This study aimed to determine the prognostic threshold of meaningful NED in GC and clarify its unclear features in existing classifications. Materials and Methods: Immunohistochemical staining for synaptophysin, chromogranin A, and neural cell adhesion molecule was performed for 945 GC specimens. Survival analysis was performed using the log-rank test and univariate/multivariate models with percentages of NED (PNED) and demographic and clinicopathological parameters. Results: In total, 275 (29.1%) cases were immunoreactive to at least 1 neuroendocrine (NE) marker. GC-NED was more common in the upper third of the stomach. PNED, and Borrmann's classification and tumor, lymph node, metastasis stages were independent prognostic factors. The cutoff PNED was 10%, beyond which patients had significantly worse outcomes, although the risk did not increase with higher PNED. Tumors with ≥10% NED tended to manifest as Borrmann type III lesion with mixed/diffuse morphology and poorer histological differentiation; the NE components in this population mainly grew in insulae/nests, which differed from the predominant growth pattern (glandular/acinar) in GC with <10% NED. Conclusions: GC with ≥10% NED should be classified as a distinct subtype because of its worse prognosis, and more attention should be paid to the necessity of additional therapeutics for NE components.

Observations on the ultrastructure of extrusomes in the hypotrichous ciliate Architricha indica (Protist, Ciliophora)

Xiaocui Zhang,Xinpeng Fan,Linying Yang,Yiwen Wang,Bing Ni,Saleh A. Al-Farraj,Fukang Gu 한국통합생물학회 2014 Animal cells and systems Vol.18 No.2

Extrusomes of different categories in ciliates have been suggested to have different structures and functions. To investigate the characteristics of extrusomes in the hypotrichous ciliate, we examined Architricha indicausing scanning and transmission electron microscopy and electron microscopic enzymo-cytochemistry. Theresults showed that the mature extrusomes were ellipsoidal vesicles with structureless cavities on their anteriorparts and arranged in rows beneath the pellicle; the extruded structures of extrusomes were cyathiform and canremain outside of the cell surface after extrusion. These findings differ distinctly from that of previouslyreported extrusomes in other ciliates and thus suggest a new type of extrusomes. These organelles originatedfrom endoplasmic reticulum in the deeper part of the cytoplasm, underwent a serious of development,gradually migrated to the cortical cytoplasm and finally positioned in their functional areas. In contrast withlower forms of ciliates, density, arrangement, and localization of extrusomes in A. indica showed obviousdifferences between the ventral and dorsal surface of cells. This may be in some way related to thedifferentiation of the dorsoventral cortex, and functional ciliature happened to the hypotrichous ciliates. Inaddition, the extrusomes may perform protective or defensive function, which associates with the activity ofmitochondria and contributes to the pellicle retrieval or renewal.

Prognostic Threshold of Neuroendocrine Differentiation in Gastric Carcinoma: a Clinicopathological Study of 945 Cases

Zou, Yi,Chen, Linying,Wang, Xingfu,Chen, Yupeng,Hu, Liwen,Zeng, Saifan,Wang, Pengcheng,Li, Guoping,Huang, Ming,Wang, Liting,He, Shi,Li, Sanyan,Jian, Lihui,Zhang, Sheng The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.1

Purpose: The significance of neuroendocrine differentiation (NED) in gastric carcinoma (GC) is controversial, leading to ambiguous concepts in traditional classifications. This study aimed to determine the prognostic threshold of meaningful NED in GC and clarify its unclear features in existing classifications. Materials and Methods: Immunohistochemical staining for synaptophysin, chromogranin A, and neural cell adhesion molecule was performed for 945 GC specimens. Survival analysis was performed using the log-rank test and univariate/multivariate models with percentages of NED ($P_{NED}$) and demographic and clinicopathological parameters. Results: In total, 275 (29.1%) cases were immunoreactive to at least 1 neuroendocrine (NE) marker. GC-NED was more common in the upper third of the stomach. $P_{NED}$, and Borrmann's classification and tumor, lymph node, metastasis stages were independent prognostic factors. The cutoff $P_{NED}$ was 10%, beyond which patients had significantly worse outcomes, although the risk did not increase with higher $P_{NED}$. Tumors with ${\geq}10%$ NED tended to manifest as Borrmann type III lesion with mixed/diffuse morphology and poorer histological differentiation; the NE components in this population mainly grew in insulae/nests, which differed from the predominant growth pattern (glandular/acinar) in GC with <10% NED. Conclusions: GC with ${\geq}10%$ NED should be classified as a distinct subtype because of its worse prognosis, and more attention should be paid to the necessity of additional therapeutics for NE components.

The Role of Short Chain Fatty Acids in Irritable Bowel Syndrome

Wenxi Jian,Jiali Wu,Shefeng Zhu,Linying Xin,Chaohui Yu,Zhe Shen 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.4

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is characterized by abdominal pain and disordered bowel habits. The etiology of IBS is multifactorial, including abnormal gut-brain interactions, visceral hypersensitivity, altered colon motility, and psychological factors. Recent studies have shown that the intestinal microbiota and its metabolites short chain fatty acids (SCFAs) may be involved in the pathogenesis of IBS. SCFAs play an important role in the pathophysiology of IBS. We discuss the underlying mechanisms of action of SCFAs in intestinal inflammation and immunity, intestinal barrier integrity, motility, and the microbiota-gut-brain axis. Limited to previous studies, further studies are required to investigate the mechanisms of action of SCFAs in IBS and provide more precise therapeutic strategies for IBS.

Risk Assessment of Breast Cancer in Guangdong, China: A Community-based Survey

Lin, Ying,Shao, Nan,Zhang, Yun-Jian,Wu, Zhuang-Hong,Li, Zhi-Bin,Ren, Ze-Fang,Wang, Shen-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Objectives: Compared with Western countries, the incidence rates for breast cancer in China are still low. However, breast cancer appears to be hitting Chinese women at a much younger age, with a peak between 40 and 50 years. Furthermore, breast tumors of Asian women have molecular and genetic characteristics that are different from those of Caucasian women. Methods: A community-based study was designed to evaluate the relationship between lifestyles and breast cancer risk in Chinese women residing in Guangzhou. 16,314 subjects completed the questionnaire. Potential confounding factors included sociodemographic characteristics. Results: 33 individuals reported a history of breast cancer, yielding a prevalence rate of 202.3/100000. Associations between subjects' demographic and breast cancer risk factors were assessed. Breast cancer is associated with family history of breast cancer, X-rays received, benign breast disease and hyperlipoidemia or hypercholesteremia with elevated odds ratios. Conclusions: Family history of breast cancer, X-ray received benign breast disease and hyperlipoidemia or hypercholesteremia were significantly associated with risk of breast cancer and may havepotential for breast cancer risk assessment.

Advancing Rights for All Persons Regardless of Sexual and Gender Identity

Lini Zurlia 동아시아재단 2023 Global Asia Vol.18 No.2

The Future of Women & LGBT under the Religion Institutions in Indonesia

Lini Zurlia 이화여자대학교 아시아여성학센터 2015 이화여자대학교 아시아여성학센터 학술대회자료집 Vol.2015 No.7

Algebraic Solution to Minimum-Time Velocity Planning

Gabriele Lini,Aurelio Piazzi,Luca Consolini 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.4

The paper poses the problem of minimum-time velocity planning subject to a jerk amplitude constraint and to arbitrary velocity/acceleration boundary conditions. This problem which is relevant in the field of autonomous robotic navigation and also for inertial one-dimensional mechatronics systems is dealt with an algebraic approach based on Pontryagin’s Maximum Principle. The exposed complete solution shows how this time-optimal planning can be reduced to the problem of determining the positive real roots of a quartic equation. An algorithm that is suitable for real-time applications is then presented. The paper includes detailed examples also highlighting the special cases of this planning problem.