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Multiphysics and Multiscale Analysis for Chemotherapeutic Drug
Zhang, Linan,Kim, Sung Youb,Kim, Dongchoul Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>This paper presents a three-dimensional dynamic model for the chemotherapy design based on a multiphysics and multiscale approach. The model incorporates cancer cells, matrix degrading enzymes (MDEs) secreted by cancer cells, degrading extracellular matrix (ECM), and chemotherapeutic drug. Multiple mechanisms related to each component possible in chemotherapy are systematically integrated for high reliability of computational analysis of chemotherapy. Moreover, the fidelity of the estimated efficacy of chemotherapy is enhanced by atomic information associated with the diffusion characteristics of chemotherapeutic drug, which is obtained from atomic simulations. With the developed model, the invasion process of cancer cells in chemotherapy treatment is quantitatively investigated. The performed simulations suggest a substantial potential of the presented model for a reliable design technology of chemotherapy treatment.</P>
Linan Zhang,Dongchoul Kim 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
In the present study, we investigate the processes of cancer cell invasion and the effect of chemotherapeutic drug on cancer treatment. Invasion, the ability of cancer cells break out of tissue compartments and secrete the matrix degrading enzymes (MDEs). There are two steps are proposed to describe the sequence of cancer cells invasion. Firstly, cancer cells are secreting the MDEs, and then the extracellular matrix (ECM) is degraded by the MDEs. Chemotherapy aims to kill these abnormal or cancer cells, however normal cells and healthy tissues are also adversely affected. The semi-implicit Fourier spectral scheme is adopted for high efficiency and numerical stability. A three-dimensional model consists of cancer cells, the ECM, the MDEs and chemotherapeutic drug is developed.
Computational analysis of matrix-degrading enzymes in cancer-cell invasion
Linan Zhang,김동철 한국바이오칩학회 2011 BioChip Journal Vol.5 No.1
Invasion is one of the hallmarks of cancer cells. Cancer cells secrete enzymes and invade the surrounding matrix. In this paper, a new model primary study on the invasive process of cancer cells is presented. Our three-dimensional haptotaxis model consists of a cancer-cell population, matrix-degrading enzymes (MDEs), and the extracellular matrix (ECM), and it describes two procedures for invasion by cancer cells. In the first step, cancer cells secrete MDEs, and in the next step, the secreted MDEs degrade the ECM. The simulation results thoroughly reveal that the degradation of the ECM is an influential process in cancer-cell invasion.
Linan Zhang,Dongchoul Kim 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
A three dimensional model for a fabrication of silicon on nothing (SON) structure with designed guidance based on phase field model has been presented. Microstructure morphological evolution of silicon substrate induced by the temperature has been introduced and suggested as a great possibility for the evolution dynamics. The numerical simulations represent an efficient verification on the experimental work and present the cavity formed in the silicon substrate via only surface diffusion which is driven by the minimization of surface energy. The aim of this paper is providing a reliable design on controlling the fabrication process of silicon when the annealing is performed, and the calculated results are well consistent with the experimental works.
The effect of matrix-degrading enzymes on cancer cell invasion
Linan Zhang,Dongchoul Kim 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.4
Cancer cell has the capacity to secrete the enzymes and invade the surrounding matrix. In this paper, we report the effect of the matrix degrading enzymes (MDEs). Two steps are proposed to describe the sequence of cancer cells invasion. The first step is cancer cells secrete MDEs which can locally degrade the ECM. The second step is the ECM is degraded and cancer cells migrate to the region of the ECM which is degraded by MDEs. The semi-implicit Fourier spectral scheme is adopted for high efficiency and numerical stability. A three-dimensional haptotaxis model consists of cancer cells, MDEs and the ECM. The results reveal the effect of MDEs on cancer cell invasion.
Linan Zhang,Dongchoul Kim(김동철) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
Cancer-cell invasion is a complex biological process involving cell migration through the extracellular matrix (ECM). In this paper, a three-dimensional haptotaxis model to simulate the migration of a population of cancer cells has been proposed. The migration of the cancer cells relates with the hapto-attractant and the effect of the energy between cells and (ECM). The diffuse interface model, which incorporates the haptotaxis mechanism and interface energies, is employed. The semi-implicit Fourier spectral scheme is adopted for efficient evaluation of the simulation. The simulation results thoroughly reveal the dynamics of cancer-cells migration.