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PHYTOCHEMICAL SURVEY OF HERB DRUGS(Ⅰ)
Woo, Lin Keun,Kim, Jae Hoon 서울대학교 1963 서울대학교 論文集 Vol.13 No.-
Sixty five species of plants which are used currently as herb drugs in Korea were screened on the presence of alkaloid, phenolic compound, flavonoid, chalcone, lactone, glucoside, carbohydrate, terpenoid, steroid, protein, polypeptide, saponin and organic acid for the further study. For the preliminary report, alkaloids detected by paper chromatography are tabulated.
INFLUENCE OF SAPONIN ON THE ACTIVITIES OF DIGESTIVE ENZYMES
Woo, Won Sick,Woo, Lin Keun 서울대학교 1962 서울대학교 論文集 Vol.11 No.-
저자의 일인 우는 saponin이 emulsin에 의한 amygdalin의 분해작용을 저지함을 보고하였고,_(1) Marsh등도 saponin이 glucuronidase작용을 저지한다고 보고한 바 있다._(2) 저자들은 생약에 광범위하게 분포되어 있는 saponin이 보편적으로 효소작용에 영향을 미치는가를 검토코저 소화효소 amylase, trypsin, pepsin 및 lipase에 대하여 조사하였다. 저자들이 사용한 saponin은 amylase, trypsin, pepsin작용에는 아무런 영향이 없었으나 lipase 작용에 대해서는 저지적으로 작용하는 결과를 얻었으며 따라서 saponin은 임율적으로 효소작용을 억제하지 않음을 밝혔다. The influence of saponin on the actvity of several digestive enzymes has been studied. It has been observed that saponin does not affet on the actvities of amylase and proteinases whereas it inhibites the lipase action.
The synthesis of $^{14}C$-labeled dammarane glycoside of Ginseng
Woo, Lin-Keun The Pharmaceutical Society of Korea 1973 약학회지 Vol.17 No.3
Panax Saponin A (isopropyl-$^{14}C$) was prepared from natural saponin in good yield by the precesses; acetylation, osmium tetroxide oxidation, periodic acid oxidation, Witting process, and saponification.
Characterization of ginseng extracts
Woo, Lin-Keun,Han, Byung-Hoon,Baik, Duck-Woo,Park, Dae-Sic The Pharmaceutical Society of Korea 1973 약학회지 Vol.17 No.3
In order to establish the chemical standards for the quality control of ginsentgextract, an approach for the assay of sapogenin contents in the part of main roots and fibrous side roots was performed by combination of preparative thin layer chromotographic procedure and vanillin-$H_{2}SO_{4}$ color reaction. The contents of dammarane aglycones as funcction of dammarane glycosides in 80%-EtOH extracts were analyzed by the method from the main roots and fibrous side roots of Korean ginseng grown for 4-6 years. The differences by their grown ages in the contents of dammarane glycosides, in the ratio of panaxadiol to panaxatriol contents, and in the mounts of 80% EtOH extract were not significant in the parts of main roots and fibrous side roots of Korean gingeng. Differences due to the part for medicinal uses were highly significant in all parameters mentioned, showing following results ; in the main roots ; 80% EtOH extract, 12.7-15.7 % : the ratio of aglycone composition, 0.955-1.012 : dammarane glycoside (as diglucoside bases), 1.537-1.863 ; in fibrous isde roots ; 80% EtOH extract, 26.0-26.02% : dammarane glycoside, 4.767-5.641 : the ratio, 1.456-1.50.
Woo, Hye Lin,Ji, Hae Ri,Pak, Yeon Kyoung,Lee, Hojung,Heo, Su Jeong,Lee, Jin Moo,Park, Kyoung Sun Wolters Kluwer Health 2018 Medicine Vol.97 No.23
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P><B>Background:</B></P><P>This systematic review aimed to evaluate the current evidence regarding the efficacy and safety of acupuncture on primary dysmenorrhea.</P><P><B>Methods:</B></P><P>Ten electronic databases were searched for relevant articles published before December 2017. This study included randomized controlled trials (RCTs) of women with primary dysmenorrhea; these RCTs compared acupuncture to no treatment, placebo, or medications, and measured menstrual pain intensity and its associated symptoms. Three independent reviewers participated in data extraction and assessment. The risk of bias in each article was assessed, and a meta-analysis was conducted according to the types of acupuncture. The results were expressed as mean difference (MD) or standardized mean difference (SMD) with 95% confidence intervals (CIs).</P><P><B>Results:</B></P><P>This review included 60 RCTs; the meta-analysis included 49 RCTs. Most studies showed a low or unclear risk of bias. We found that compared to no treatment, manual acupuncture (MA) (SMD = −1.59, 95% CI [−2.12, −1.06]) and electro-acupuncture (EA) was more effective at reducing menstrual pain, and compared to nonsteroidal anti-inflammatory drugs (NSAIDs), MA (SMD = −0.63, 95% CI [−0.88, −0.37]) and warm acupuncture (WA) (SMD = −1.12, 95% CI [−1.81, −0.43]) were more effective at reducing menstrual pain. Some studies showed that the efficacy of acupuncture was maintained after a short-term follow-up.</P><P><B>Conclusion:</B></P><P>The results of this study suggest that acupuncture might reduce menstrual pain and associated symptoms more effectively compared to no treatment or NSAIDs, and the efficacy could be maintained during a short-term follow-up period. Despite limitations due to the low quality and methodological restrictions of the included studies, acupuncture might be used as an effective and safe treatment for females with primary dysmenorrhea.</P></▼2>