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Aldose reductase inhibition of Rosa hybrida petals and its active component, kaempferol
Norman G. Quilantang,Carlo A. Limbo,이주성,Sonia D. Jacinto,Sung-Kwon Moon,Sanghyun Lee 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.3
The aldose reductase inhibitory activity of extracts from Rosa hybrida petals was evaluated, and a bioactive fl avonoid,kaempferol, was isolated from petals via bioassay-guided isolation. Kaempferol was isolated from the ethyl acetate fractionof R. hybrida and was shown to exhibit strong inhibition against aldose reductase (IC 50 = 0.02 μM). Quantitative analyses ofkaempferol in R. hybrida petals, diff erent fl ower parts, and diff erent Rosa species were also performed using high-performanceliquid chromatography. This study is the fi rst to establish that R. hybrida contains kaempferol and that the light-pinkpetals of this edible rose species exhibit the highest content of the naturally occurring aldose reductase inhibitor. The resultsof this study suggested the potential role of R. hybrida petals in the treatment and management of diabetic complicationsvia aldose reductase inhibition.