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        • The Typical Application of Building Energy Consumption Monitoring and Energy Management : A Case Study

          Liang,Zhao,Ruobing,Liang,Jili,Zhang 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.1

          Building energy consumption monitoring and management system plays a vital role in the advance of building energy conservation, because it offers abundant online real time data, which are mainly used to further analyze energy saving potential and put forward a feasibility methodology for implementation. In addition to its extreme importance in decreasing energy consumption and saving costs, the platform can also help to find the anomalies of the main equipment. In this paper, we first introduce the structure of the monitoring platform, and then put forward an error analysis principle to improve the precision of heat meters. A case study is given for a building in “hot summer and cold winter” area, including the installation of various measuring meters and data verification. Finally, the energy consumption data of the building from January to December in 2013 were analyzed.

        • KCI등재

          SDC4 Gene Silencing Favors Human Papillary Thyroid Carcinoma Cell Apoptosis and Inhibits Epithelial Mesenchymal Transition via Wnt/β-Catenin Pathway

          Liang-Liang,Chen,Ge-Xin,Gao,Fei-Xia,Shen,Xiong,Chen,Xiao-Hua,Gong,Wen-Jun,Wu 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.9

          As the most common type of endocrine malignancy, papillary thyroid cancer (PTC) accounts for 85-90% of all thyroid cancers. In this study, we presented the hypothesis that SDC4 gene silencing could effectively attenuate epithelial mesenchymal transition (EMT), and promote cell apoptosis via the Wnt/β-catenin signaling pathway in human PTC cells. Bioinformatics methods were employed to screen the determined differential expression levels of SDC4 in PTC and adjacent normal samples. PTC tissues and adjacent normal tissues were prepared and their respective levels of SDC4 protein positive expression, in addition to the mRNA and protein levels of SDC4, Wnt/β-catenin signaling pathway, EMT and apoptosis related genes were all detected accordingly. Flow cytometry was applied in order to detect cell cycle entry and apoptosis. Finally, analyses of PTC migration and invasion abilities were assessed by using a Transwell assay and scratch test. In PTC tissues, activated Wnt/β-catenin signaling pathway, increased EMT and repressed cell apoptosis were determined. Moreover, the PTC K1 and TPC-1 cell lines exhibiting the highest SDC4 expression were selected for further experiments. In vitro experiments revealed that SDC4 gene silencing could suppress cell migration, invasion and EMT, while acting to promote the apoptosis of PTC cells by inhibiting the activation of the Wnt/β-catenin signaling pathway. Besides, si-β-catenin was observed to inhibit the promotion of PTC cell migration and invasion caused by SDC4 overexpression. Our study revealed that SDC4 gene silencing represses EMT, and enhances cell apoptosis by suppressing the activation of the Wnt/β-catenin signaling pathway in human PTC.

        • SCIESCOPUSKCI등재후보

          Reports : IGF1 potentiates BMP9-induced osteogenic differentiation in mesenchymal stem cells through the enhancement of BMP/Smad signaling

          ( Liang Chen ), ( Xiang Zou ), ( Ran-xi Zhang ), ( Chang-jun Pi ), ( Nian Wu ), ( Liang-jun Yin ), ( Zhong-liang Deng ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.2

          Engineered bone tissue is thought to be the ideal alternative for bone grafts in the treatment of related bone diseases. BMP9 has been demonstrated as one of the most osteogenic factors, and enhancement of BMP9-induced osteogenesis will greatly accelerate the development of bone tissue engineering. Here, we investigated the effect of insulin-like growth factor 1 (IGF1) on BMP9-induced osteogenic differentiation, and unveiled a possible molecular mechanism underling this process. We found that IGF1 and BMP9 are both detectable in mesenchymal stem cells (MSCs). Exogenous expression of IGF1 potentiates BMP9-induced alkaline phosphatase (ALP), matrix mineralization, and ectopic bone formation. Similarly, IGF1 enhances BMP9-induced endochondral ossification. Mechanistically, we found that IGF1 increases BMP9-induced activation of BMP/Smad signaling in MSCs. Our findings demonstrate that IGF1 can enhance BMP9-induced osteogenic differentiation in MSCs, and that this effect may be mediated by the enhancement of the BMP/Smad signaling transduction triggered by BMP9. [BMB Reports 2016; 49(2): 122-127]

        • MiR-454 Prompts Cell Proliferation of Human Colorectal Cancer Cells by Repressing CYLD Expression

          Liang,,Hong-Liang,Hu,,Ai-Ping,Li,,Sen-Lin,Xie,,Jia-Ping,Ma,,Qing-Zhu,Liu,,Ji-Yong Asian Pacific Organization for Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

          Previous studies have shown that miR-454 plays an important role in a variety of biological processes in various human cancer cells. However, the underlying mechanisms of this microRNA in colorectal cancer (CRC) cells remain largely unknown. In the present study, we investigated the miR-454 role in CRC cell proliferation. We found that miR-454 expression is markedly upregulated in CRC tissues and CRC cells compared with the matched tumor adjacent tissues and the FHC normal colonic cell line. Ectopic expression of miR-454 promoted the proliferation and anchorage-independent growth of CRC cells, whereas inhibition of miR-454 reduced this effect. Bioinformatics analysis further revealed cylindromatosis (CYLD), a putative tumor suppressor as a potential target of miR-454. Data from luciferase reporter assays showed that miR-454 directly binds to the 3'-untranslated region (3'-UTR) of CYLD mRNA and repressed expression at both transcriptional and translational levels. In functional assays, CYLD-silenced in miR-454-in-transfected SW480 cells have positive effect to promote cell proliferation, suggesting that direct CYLD downregulation is required for miR-454-induced CRC cell proliferation. In sum, our data provide compelling evidence that miR-454 functions as an onco-miRNA, playing a crucial role in the promoting cell proliferation in CRC, and its oncogenic effect is mediated chiefly through direct suppression of CYLD expression.

        • KCI등재

          Water temperature and salinity tolerance of embryos and spat of the mussel, Musculista senhousia

          Liang,,Zhuo,Liang,Kim,,Young-Hun,Zhang,,Zhi,Fang,Lim,,Sang-Min,Kang,,Kyoung-Ho The Malacological Society of Korea 2009 The Korean Journal of Malacology Vol.25 No.3

          The effects of water temperature and salinity on embryonic development and spat survival of mussel Musculista senhousia were investigated. Embryos were incubated in water ranging from 0 to $35^{\circ}C$ and with salinity from 5‰ to 40‰. Mussel spat were tested in water from 0 to $40^{\circ}C$ and with salinity from 0‰ to 100‰. The optimal conditions for mussel embryos were $20-25^{\circ}C$ and salinity from 25‰ to 35‰, based on Within this temperature range, higher temperatures correponded to a shorter duration of the embryonic period. Optimisation of mussel spat survival was at $25-35^{\circ}C$ and salinity from 30‰ to 40‰; both values are higher than those for embryo, which hinted M. senhousia embryos are more vulnerable than spat. Temperatures below $15^{\circ}C$ were lethal for embryos, making temperature a feasible method with which to control the large population of M. senhousia in ark-shell farm during its spawning period.

        • SCOPUS

          Application of the Feedback for the Sideslip Angle Change in Hypersonic Vehicle

          Liang-liang,Yin,Yi-min,Huang,Chun-zhen,Sun,Jie,Jia,Yong,Yang 보안공학연구지원센터 2016 International Journal of Control and Automation Vol.9 No.11

          This paper designs the feedback controller for the unstable Dutch Roll and severe kinematic coupling of the hypersonic vehicle at high angle of attack and large mach number. This paper deduces the mechanism of improving the stability of the Dutch Roll and illustrates the mechanism of restraining the kinematic coupling using controller based on the linear small perturbation equations. And an easy analysis is made about the signal of controller. Finally, the relational tests are conducted in simulations using controller. The simulation result shows that the controller can improve the damp of the Dutch Roll, weaken the influence of kinematic coupling, restrain the variety of sideslip and improve the equality of sideslip.

        • 유압모터의 토크맥동 특성에 관한 이론적 검토

          유량량(Liang-liang Liu), 장주섭(J. S. Jang) 유공압건설기계학회 2012 유공압건설기계학회 학술대회논문집 Vol.2012 No.6

          Hydrostatic pumps and motors occupy an important position in hydraulic system. There are a lot of researches on characteristics of hydraulic pumps, but not hydraulic motors. So in order to know the characteristics of hydraulic motors we had this research. The purpose of this study is to derive and analyze the theoretical calculation of hydraulic axial piston motor torque and torque ripples. Then, analyzed the differences between torque ripples with dead place and without dead place on the valve plate, and modeling a hydraulic motor with AMESim software. Finally, theoretical calculation of hydraulic motor torque ripples was verified from the viewpoint of simulation.

        • KCI등재후보

          Water temperature and salinity tolerance of embryos and spat of the mussel, Musculista senhousia

          Zhuo,Liang,Liang,김영훈,임상민,강경호,Zhi-Fang,Zhang 한국패류학회 2009 The Korean Journal of Malacology Vol.25 No.3

          The effects of water temperature and salinity on embryonic development and spat survival of mussel Musculista senhousia were investigated. Embryos were incubated in water ranging from 0 to 35℃ and with salinity from 5‰ to 40‰. Mussel spat were tested in water from 0 to 40℃ and with salinity from 0‰ to 100‰. The optimal conditions for mussel embryos were 20-25℃ and salinity from 25‰ to 35‰, based on Within this temperature range, higher temperatures correponded to a shorter duration of the embryonic period. Optimisation of mussel spat survival was at 25-35℃ and salinity from 30‰ to 40‰; both values are higher than those for embryo, which hinted M. senhousia embryos are more vulnerable than spat. Temperatures below 15℃ were lethal for embryos, making temperature a feasible method with which to control the large population of M. senhousia in ark-shell farm during its spawning period.

        • KCI등재

          SDC4 Gene Silencing Favors Human Papillary Thyroid Carcinoma Cell Apoptosis and Inhibits Epithelial Mesenchymal Transition via Wnt/β-Catenin Pathway

          Chen,,Liang-Liang,Gao,,Ge-Xin,Shen,,Fei-Xia,Chen,,Xiong,Gong,,Xiao-Hua,Wu,,Wen-Jun Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.9

          As the most common type of endocrine malignancy, papillary thyroid cancer (PTC) accounts for 85-90% of all thyroid cancers. In this study, we presented the hypothesis that SDC4 gene silencing could effectively attenuate epithelial mesenchymal transition (EMT), and promote cell apoptosis via the $Wnt/{\beta}-catenin$ signaling pathway in human PTC cells. Bioinformatics methods were employed to screen the determined differential expression levels of SDC4 in PTC and adjacent normal samples. PTC tissues and adjacent normal tissues were prepared and their respective levels of SDC4 protein positive expression, in addition to the mRNA and protein levels of SDC4, $Wnt/{\beta}-catenin$ signaling pathway, EMT and apoptosis related genes were all detected accordingly. Flow cytometry was applied in order to detect cell cycle entry and apoptosis. Finally, analyses of PTC migration and invasion abilities were assessed by using a Transwell assay and scratch test. In PTC tissues, activated $Wnt/{\beta}-catenin$ signaling pathway, increased EMT and repressed cell apoptosis were determined. Moreover, the PTC K1 and TPC-1 cell lines exhibiting the highest SDC4 expression were selected for further experiments. In vitro experiments revealed that SDC4 gene silencing could suppress cell migration, invasion and EMT, while acting to promote the apoptosis of PTC cells by inhibiting the activation of the $Wnt/{\beta}-catenin$ signaling pathway. Besides, $si-{\beta}-catenin$ was observed to inhibit the promotion of PTC cell migration and invasion caused by SDC4 overexpression. Our study revealed that SDC4 gene silencing represses EMT, and enhances cell apoptosis by suppressing the activation of the $Wnt/{\beta}-catenin$ signaling pathway in human PTC.

        • SCIESCOPUSKCI등재후보

          IGF1 potentiates BMP9-induced osteogenic differentiation in mesenchymal stem cells through the enhancement of BMP/Smad signaling

          Chen,,Liang,Zou,,Xiang,Zhang,,Ran-Xi,Pi,,Chang-Jun,Wu,,Nian,Yin,,Liang-Jun,Deng,,Zhong-Liang Korean Society for Biochemistry and Molecular Biol 2016 BMB Reports Vol.49 No.2

          Engineered bone tissue is thought to be the ideal alternative for bone grafts in the treatment of related bone diseases. BMP9 has been demonstrated as one of the most osteogenic factors, and enhancement of BMP9-induced osteogenesis will greatly accelerate the development of bone tissue engineering. Here, we investigated the effect of insulin-like growth factor 1 (IGF1) on BMP9-induced osteogenic differentiation, and unveiled a possible molecular mechanism underling this process. We found that IGF1 and BMP9 are both detectable in mesenchymal stem cells (MSCs). Exogenous expression of IGF1 potentiates BMP9-induced alkaline phosphatase (ALP), matrix mineralization, and ectopic bone formation. Similarly, IGF1 enhances BMP9-induced endochondral ossification. Mechanistically, we found that IGF1 increases BMP9-induced activation of BMP/Smad signaling in MSCs. Our findings demonstrate that IGF1 can enhance BMP9-induced osteogenic differentiation in MSCs, and that this effect may be mediated by the enhancement of the BMP/Smad signaling transduction triggered by BMP9.

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